New Optogenetic Tools for Cytoskeleton and Membrane Control
Type
Blog Post
Published
Sept. 28, 2023, 1:15 p.m.
... great way to do this is to use CRY2-CIB1 clustering. Fuse either CRY2 or CIB1 to your protein of interest...change and binds the plasma membrane under blue light
CRY2-CIB1 heterodimerizes or forms clusters under blue...other separately, then use blue light to generate CRY2-CIB1 oligomers that trap the fusion protein away...inhibition of Rab protein vesicle trafficking via CRY2-CIB1 clustering. Image adapted from Aljiboury et...vitro, opening up a wide realm of possibilities. The CRY2-SuperPLD module is optogenetically recruited by ...dynamics. Need a refresher on VVDfast, iLID, LOV, CRY2-CIB, and other optogenetic modules? Or want to find...