Predicting Adverse Reactions to Monoclonal Antibody Drugs
Type
Blog Post
Published
Feb. 13, 2024, 2:15 p.m.
...relative immunogenicity score (Mattei et.al., 2022).
Figure 1: Generation of immunogenicity scores...prediction of drug immunogenicity
The goal of in vitro prediction of immunogenicity is to validate the.... Antibodies administered as drugs are still immunogenic, meaning that they elicit an immune response ...the body. Several factors contribute to the immunogenicity of a drug, including the product origin; purity...dose (Lu et.al., 2020). Evaluating a drug’s immunogenicity in-vitro helps researchers understand a drug...However, in silico and in vitro assessment of immunogenicity can help evaluate risk of an antibody.
In...commercially available algorithm to evaluate the immunogenicity of therapeutics in silico. These algorithms...