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pcDNA3 Flag FKHR Citations (28)

Originally described in: Negative regulation of the forkhead transcription factor FKHR by Akt.
Tang ED, Nunez G, Barr FG, Guan KL J Biol Chem. 1999 Jun 11. 274(24):16741-6.
PubMed Journal

Articles Citing pcDNA3 Flag FKHR

O-GlcNAc regulates FoxO activation in response to glucose. Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW. J Biol Chem. 2008 Jun 13. 283(24):16283-92. PubMed
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14928-33. doi: 10.1073/pnas.0802355105. Epub 2008 Sep 22. PubMed
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW. J Biol Chem. 2009 Feb 20. 284(8):5148-57. PubMed
HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes. Lynch VJ, Brayer K, Gellersen B, Wagner GP. PLoS One. 2009 Sep 3;4(9):e6845. doi: 10.1371/journal.pone.0006845. PubMed
FOXO1A is a target for HER2-overexpressing breast tumors. Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV. Cancer Res. 2010 Jul 1;70(13):5475-85. doi: 10.1158/0008-5472.CAN-10-0176. Epub 2010 Jun 15. PubMed
Evolution of a derived protein-protein interaction between HoxA11 and Foxo1a in mammals caused by changes in intramolecular regulation. Brayer KJ, Lynch VJ, Wagner GP. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E414-20. Epub 2011 Jul 25. PubMed
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. Yuan M, Pino E, Wu L, Kacergis M, Soukas AA. J Biol Chem. 2012 Aug 24;287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7. PubMed
FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. Kibbe C, Chen J, Xu G, Jing G, Shalev A. J Biol Chem. 2013 Aug 9;288(32):23194-202. doi: 10.1074/jbc.M113.473082. Epub 2013 Jun 26. PubMed
FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. J Biol Chem. 2013 Oct 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30. PubMed
SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner. Bollinger LM, Witczak CA, Houmard JA, Brault JJ. Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C278-87. doi: 10.1152/ajpcell.00391.2013. Epub 2014 Jun 11. PubMed
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension. Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26. PubMed
Control of FoxO4 Activity and Cell Survival by TRIM22 Directs TLR3-Stimulated Cells Toward IFN Type I Gene Induction or Apoptosis. Oteiza A, Mechti N. J Interferon Cytokine Res. 2015 Nov;35(11):859-74. doi: 10.1089/jir.2015.0020. Epub 2015 Aug 3. PubMed
Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9. PubMed
Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Diep CH, Knutson TP, Lange CA. Mol Cancer Res. 2015 Nov 17. pii: molcanres.0431.2015. PubMed
FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas. Szydlowski M, Kiliszek P, Sewastianik T, Jablonska E, Bialopiotrowicz E, Gorniak P, Polak A, Markowicz S, Nowak E, Grygorowicz MA, Prochorec-Sobieszek M, Szumera-Cieckiewicz A, Malenda A, Lech-Maranda E, Warzocha K, Juszczynski P. Blood. 2015 Nov 19. pii: blood-2015-06-654111. PubMed
FOXO1 Is Involved in the Effects of Cigarette Smoke Extract on Osteoblastic Differentiation of Cultured Human Periosteum-derived Cells. Sung IY, Park BC, Hah YS, Cho HY, Yun JW, Park BW, Kang YH, Kim HC, Hwang SC, Rho GJ, Kim UK, Woo DK, Oh SH, Byun JH. Int J Med Sci. 2015 Oct 21;12(11):881-90. doi: 10.7150/ijms.13172. eCollection 2015. PubMed
FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism. Sewastianik T, Szydlowski M, Jablonska E, Bialopiotrowicz E, Kiliszek P, Gorniak P, Polak A, Prochorec-Sobieszek M, Szumera-Cieckiewicz A, Kaminski TS, Markowicz S, Nowak E, Grygorowicz MA, Warzocha K, Juszczynski P. Oncogene. 2016 May 2. doi: 10.1038/onc.2016.126. PubMed
IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells. Vaziri-Gohar A, Zheng Y, Houston KD. Mol Cancer Res. 2017 Apr;15(4):489-497. doi: 10.1158/1541-7786.MCR-16-0176. Epub 2017 Jan 17. PubMed
Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway. Chen P, Xu S, Qu J. J Cell Biochem. 2017 Jun 6. doi: 10.1002/jcb.26189. PubMed
FoxO4 negatively controls Tat-mediated HIV-1 transcription through the post-transcriptional suppression of Tat encoding mRNA. Oteiza A, Mechti N. J Gen Virol. 2017 Jul;98(7):1864-1878. doi: 10.1099/jgv.0.000837. Epub 2017 Jul 12. PubMed
CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation. Dall'Acqua A, Sonego M, Pellizzari I, Pellarin I, Canzonieri V, D'Andrea S, Benevol S, Sorio R, Giorda G, Califano D, Bagnoli M, Militello L, Mezzanzanica D, Chiappetta G, Armenia J, Belletti B, Schiappacassi M, Baldassarre G. EMBO Mol Med. 2017 Oct;9(10):1415-1433. doi: 10.15252/emmm.201607012. PubMed
Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy. Guo H, Chitiprolu M, Roncevic L, Javalet C, Hemming FJ, Trung MT, Meng L, Latreille E, Tanese de Souza C, McCulloch D, Baldwin RM, Auer R, Cote J, Russell RC, Sadoul R, Gibbings D. Dev Cell. 2017 Dec 18;43(6):716-730.e7. doi: 10.1016/j.devcel.2017.11.018. PubMed
Exogenous hydrogen sulfide attenuates the development of diabetic cardiomyopathy via the FoxO1 pathway. Ye P, Gu Y, Zhu YR, Chao YL, Kong XQ, Luo J, Ren XM, Zuo GF, Zhang DM, Chen SL. J Cell Physiol. 2018 Dec;233(12):9786-9798. doi: 10.1002/jcp.26946. Epub 2018 Aug 5. PubMed
Tenascin-C Modulates Cell Cycle Progression to Enhance Tumour Cell Proliferation through AKT/FOXO1 Signalling in Pancreatic Cancer. Cai J, Lu W, Du S, Guo Z, Wang H, Wei W, Shen X. J Cancer. 2018 Oct 31;9(23):4449-4462. doi: 10.7150/jca.25926. eCollection 2018. PubMed
FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3. Belli M, Secchi C, Stupack D, Shimasaki S. J Endocr Soc. 2019 Aug 29;3(11):2064-2081. doi: 10.1210/js.2019-00279. eCollection 2019 Nov 1. PubMed
Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama JV. Cancers (Basel). 2020 Jul 16;12(7). pii: cancers12071918. doi: 10.3390/cancers12071918. PubMed
FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice. Lee YK, Diaz B, Deroose M, Lee SX, Belvedere S, Accili D, Leibel RL, Lin HV. Mol Metab. 2021 Feb 10;49:101187. doi: 10.1016/j.molmet.2021.101187. PubMed
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac. Li-Villarreal N, Wong RLY, Garcia MD, Udan RS, Poche RA, Rasmussen TL, Rhyner AM, Wythe JD, Dickinson ME. Development. 2022 Apr 1;149(7). pii: 274922. doi: 10.1242/dev.200131. Epub 2022 Apr 1. PubMed

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