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pCDNA3-Flag MKK6(glu) Citations (31)

Originally described in: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ Mol Cell Biol. 1996 Mar . 16(3):1247-55.

Articles Citing pCDNA3-Flag MKK6(glu)

COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells. Pham H, Vincenti R, Slice LW. Biochim Biophys Acta. 2008 Jun-Jul;1779(6-7):408-13. doi: 10.1016/j.bbagrm.2008.05.004. Epub 2008 May 13. PubMed
The p38/MAPK pathway regulates microtubule polymerization through phosphorylation of MAP4 and Op18 in hypoxic cells. Hu JY, Chu ZG, Han J, Dang YM, Yan H, Zhang Q, Liang GP, Huang YS. Cell Mol Life Sci. 2010 Jan;67(2):321-33. doi: 10.1007/s00018-009-0187-z. Epub 2009 Nov 14. PubMed
GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes. Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB. J Biol Chem. 2010 Mar 12;285(11):8395-407. doi: 10.1074/jbc.M109.038638. Epub 2010 Jan 4. PubMed
p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly. Khanna P, Yunkunis T, Muddana HS, Peng HH, August A, Dong C. Am J Physiol Cell Physiol. 2010 May;298(5):C1140-50. doi: 10.1152/ajpcell.00242.2009. Epub 2010 Feb 24. PubMed
Thermogenic activation induces FGF21 expression and release in brown adipose tissue. Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F. J Biol Chem. 2011 Apr 15;286(15):12983-90. doi: 10.1074/jbc.M110.215889. Epub 2011 Feb 13. PubMed
Human adipose tissue-derived multilineage progenitor cells exposed to oxidative stress induce neurite outgrowth in PC12 cells through p38 MAPK signaling. Moriyama M, Moriyama H, Ueda A, Nishibata Y, Okura H, Ichinose A, Matsuyama A, Hayakawa T. BMC Cell Biol. 2012 Aug 7;13:21. doi: 10.1186/1471-2121-13-21. PubMed
A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. Bose AK, Janes KA. Mol Cell Proteomics. 2013 Mar;12(3):797-806. doi: 10.1074/mcp.O112.024059. Epub 2012 Dec 11. PubMed

Associated Plasmids

Gestational diabetes induces alterations in the function of neonatal endothelial colony-forming cells. Blue EK, DiGiuseppe R, Derr-Yellin E, Acosta JC, Pay SL, Hanenberg H, Schellinger MM, Quinney SK, Mund JA, Case J, Haneline LS. Pediatr Res. 2014 Feb;75(2):266-72. doi: 10.1038/pr.2013.224. Epub 2013 Nov 14. PubMed
Multiple physical stresses induce gamma-globin gene expression and fetal hemoglobin production in erythroid cells. Schaeffer EK, West RJ, Conine SJ, Lowrey CH. Blood Cells Mol Dis. 2014 Apr;52(4):214-24. doi: 10.1016/j.bcmd.2013.10.007. Epub 2013 Dec 5. PubMed
The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity. Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll RE, Hiepe F, Reth M. J Exp Med. 2014 Mar 10;211(3):427-40. doi: 10.1084/jem.20131196. Epub 2014 Mar 3. PubMed
Transient folate deprivation in combination with small-molecule compounds facilitates the generation of somatic cell-derived pluripotent stem cells in mice. Hu WT, Yan QY, Fang Y, Qiu ZD, Zhang SM. J Huazhong Univ Sci Technolog Med Sci. 2014 Apr;34(2):151-6. doi: 10.1007/s11596-014-1249-5. Epub 2014 Apr 8. PubMed
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. Hedl M, Zheng S, Abraham C. J Immunol. 2014 Jun 15;192(12):5924-32. doi: 10.4049/jimmunol.1302727. Epub 2014 May 19. PubMed
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6). Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL. J Biol Chem. 2014 Aug 1;289(31):21508-18. doi: 10.1074/jbc.M114.560342. Epub 2014 Jun 16. PubMed
Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells. Thalheimer FB, Wingert S, De Giacomo P, Haetscher N, Rehage M, Brill B, Theis FJ, Hennighausen L, Schroeder T, Rieger MA. Stem Cell Reports. 2014 Jun 19;3(1):34-43. doi: 10.1016/j.stemcr.2014.05.010. eCollection 2014 Jul 8. PubMed
Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Mol Cell Biol. 2015 Jan;35(1):26-40. doi: 10.1128/MCB.00503-14. Epub 2014 Oct 13. PubMed
Salinomycin and other polyether ionophores are a new class of antiscarring agent. Woeller CF, O'Loughlin CW, Roztocil E, Feldon SE, Phipps RP. J Biol Chem. 2015 Feb 6;290(6):3563-75. doi: 10.1074/jbc.M114.601872. Epub 2014 Dec 23. PubMed
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages. Zheng S, Hedl M, Abraham C. J Immunol. 2015 Feb 15;194(4):1928-37. doi: 10.4049/jimmunol.1401933. Epub 2015 Jan 7. PubMed
P38/MAPK contributes to endothelial barrier dysfunction via MAP4 phosphorylation-dependent microtubule disassembly in inflammation-induced acute lung injury. Li L, Hu J, He T, Zhang Q, Yang X, Lan X, Zhang D, Mei H, Chen B, Huang Y. Sci Rep. 2015 Mar 9;5:8895. doi: 10.1038/srep08895. PubMed
p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Li L, Gao G, Shankar J, Joshi B, Foster LJ, Nabi IR. Mol Biol Cell. 2015 Nov 1;26(21):3828-40. doi: 10.1091/mbc.E15-02-0120. Epub 2015 Sep 2. PubMed
BMP7 retards peripheral myelination by activating p38 MAPK in Schwann cells. Liu X, Zhao Y, Peng S, Zhang S, Wang M, Chen Y, Zhang S, Yang Y, Sun C. Sci Rep. 2016 Aug 5;6:31049. doi: 10.1038/srep31049. PubMed
IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Hedl M, Yan J, Abraham C. Cell Rep. 2016 Aug 30;16(9):2442-55. doi: 10.1016/j.celrep.2016.07.060. Epub 2016 Aug 18. PubMed
Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-alpha: Crosstalk with p38 Signaling. Adam AP, Lowery AM, Martino N, Alsaffar H, Vincent PA. PLoS One. 2016 Sep 7;11(9):e0161975. doi: 10.1371/journal.pone.0161975. eCollection 2016. PubMed

Associated Plasmids

Deciphering fact from artifact when using reporter assays to investigate the roles of host factors on L1 retrotransposition. Cook PR, Tabor GT. Mob DNA. 2016 Nov 22;7:23. eCollection 2016. PubMed
Irx3 and Bmp2 Regulate Mouse Mesenchymal Cell Chondrogenic Differentiation in Both a Sox9-Dependent and -Independent Manner. Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S. J Cell Physiol. 2017 Jan 6. doi: 10.1002/jcp.25776. PubMed
Delete_Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S244-S262. doi: 10.1074/mcp.O116.063487. Epub 2017 Feb 7. PubMed
Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG. Mol Cell Proteomics. 2018 Apr;17(4):550-564. doi: 10.1074/mcp.RA117.000335. Epub 2017 Dec 18. PubMed
Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. Hori T, Saito K, Moore R, Flake GP, Negishi M. Mol Cancer Res. 2018 Aug;16(8):1309-1318. doi: 10.1158/1541-7786.MCR-18-0118. Epub 2018 May 1. PubMed
Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. Rahman SMT, Zhou W, Deiters A, Haugh JM. J Biol Chem. 2020 Jun 19;295(25):8494-8504. doi: 10.1074/jbc.RA119.012079. Epub 2020 May 5. PubMed
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Kang JW, Yan J, Ranjan K, Zhang X, Turner JR, Abraham C. Gastroenterology. 2020 Jul 18. pii: S0016-5085(20)34953-2. doi: 10.1053/j.gastro.2020.07.024. PubMed
Regulation of the Golgi Apparatus by p38 and JNK Kinases during Cellular Stress Responses. Nordgaard C, Tollenaere MAX, Val AMD, Bekker-Jensen DB, Blasius M, Olsen JV, Bekker-Jensen S. Int J Mol Sci. 2021 Sep 4;22(17). pii: ijms22179595. doi: 10.3390/ijms22179595. PubMed
Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding. Sellers J, Brooks A, Fernando S, Westenberger G, Junkins S, Smith S, Min K, Lawan A. Nutrients. 2021 Nov 4;13(11). pii: nu13113941. doi: 10.3390/nu13113941. PubMed

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