Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected]. Learn more

SARS-CoV-2 S HexaPro Citations (33)

Originally described in: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Lavinder JJ, Ippolito GC, Maynard JA, Finkelstein IJ, McLellan JS Science. 2020 Sep 18;369(6510):1501-1505. doi: 10.1126/science.abd0826. Epub 2020 Jul 23.
PubMed Journal

Articles Citing SARS-CoV-2 S HexaPro

Articles
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes. Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Park J, Wang N, Amengor D, Lavinder JJ, Ippolito GC, Maynard JA, Finkelstein IJ, McLellan JS. Science. 2020 Sep 18;369(6510):1501-1505. doi: 10.1126/science.abd0826. Epub 2020 Jul 23. PubMed

Associated Plasmids

Synthetic nanobody-SARS-CoV-2 receptor-binding domain structures identify distinct epitopes. Ahmad J, Jiang J, Boyd LF, Natarajan K, Margulies DH. bioRxiv. 2021 Jan 27. doi: 10.1101/2021.01.27.428466. PubMed

Associated Plasmids

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection. Liu H, Yuan M, Huang D, Bangaru S, Zhao F, Lee CD, Peng L, Barman S, Zhu X, Nemazee D, Burton DR, van Gils MJ, Sanders RW, Kornau HC, Reincke SM, Pruss H, Kreye J, Wu NC, Ward AB, Wilson IA. Cell Host Microbe. 2021 May 12;29(5):806-818.e6. doi: 10.1016/j.chom.2021.04.005. Epub 2021 Apr 15. PubMed
Mice Immunized with the Vaccine Candidate HexaPro Spike Produce Neutralizing Antibodies against SARS-CoV-2. Seephetdee C, Buasri N, Bhukhai K, Srisanga K, Manopwisedjaroen S, Lertjintanakit S, Phueakphud N, Pakiranay C, Kangwanrangsan N, Srichatrapimuk S, Kirdlarp S, Sungkanuparph S, Chutipongtanate S, Thitithanyanont A, Hongeng S, Wongtrakoongate P. Vaccines (Basel). 2021 May 12;9(5). pii: vaccines9050498. doi: 10.3390/vaccines9050498. PubMed
Structures of synthetic nanobody-SARS-CoV-2-RBD complexes reveal distinct sites of interaction and recognition of variants. Margulies D, Ahmad J, Jiang J, Boyd L, Zeher A, Huang R, Xia D, Natarajan K. Res Sq. 2021 Jun 16. doi: 10.21203/rs.3.rs-625642/v1. PubMed
Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies. Guttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, Taxer W, Rymarenko O, Schunemann J, Dienemann C, Gunkel P, Mussil B, Krull J, Teichmann U, Gross U, Cordes VC, Dobbelstein M, Gorlich D. EMBO J. 2021 Oct 1;40(19):e107985. doi: 10.15252/embj.2021107985. Epub 2021 Aug 9. PubMed
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants. Schmitz AJ, Turner JS, Liu Z, Zhou JQ, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Altomare CG, Alsoussi WB, Case JB, VanBlargan LA, Lei T, Thapa M, Amanat F, Jeevan T, Fabrizio T, O'Halloran JA, Shi PY, Presti RM, Webby RJ, Krammer F, Whelan SPJ, Bajic G, Diamond MS, Boon ACM, Ellebedy AH. Immunity. 2021 Sep 14;54(9):2159-2166.e6. doi: 10.1016/j.immuni.2021.08.013. Epub 2021 Aug 17. PubMed
Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction. Ahmad J, Jiang J, Boyd LF, Zeher A, Huang R, Xia D, Natarajan K, Margulies DH. J Biol Chem. 2021 Oct;297(4):101202. doi: 10.1016/j.jbc.2021.101202. Epub 2021 Sep 16. PubMed
Expression and characterization of SARS-CoV-2 spike proteins. Schaub JM, Chou CW, Kuo HC, Javanmardi K, Hsieh CL, Goldsmith J, DiVenere AM, Le KC, Wrapp D, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, Nguyen AW, Wang N, Lavinder JJ, Ippolito GC, Maynard JA, McLellan JS, Finkelstein IJ. Nat Protoc. 2021 Nov;16(11):5339-5356. doi: 10.1038/s41596-021-00623-0. Epub 2021 Oct 5. PubMed
SARS-CoV-2 spike-specific memory B cells express markers of durable immunity after non-severe COVID-19 but not after severe disease. Reyes RA, Clarke K, Gonzales SJ, Cantwell AM, Garza R, Catano G, Tragus RE, Patterson TF, Bol S, Bunnik EM. bioRxiv. 2021 Sep 27. doi: 10.1101/2021.09.24.461732. PubMed
Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine. McMillan CLD, Choo JJY, Idris A, Supramaniam A, Modhiran N, Amarilla AA, Isaacs A, Cheung STM, Liang B, Bielefeldt-Ohmann H, Azuar A, Acharya D, Kelly G, Fernando GJP, Landsberg MJ, Khromykh AA, Watterson D, Young PR, McMillan NAJ, Muller DA. Sci Adv. 2021 Oct 29;7(44):eabj8065. doi: 10.1126/sciadv.abj8065. Epub 2021 Oct 29. PubMed
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models. Sheward DJ, Mandolesi M, Urgard E, Kim C, Hanke L, Perez Vidakovics L, Pankow A, Smith NL, Castro Dopico X, McInerney GM, Coquet JM, Karlsson Hedestam GB, Murrell B. Cell Rep Med. 2021 Nov 16;2(11):100450. doi: 10.1016/j.xcrm.2021.100450. Epub 2021 Oct 23. PubMed

Associated Plasmids

Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding. Mannar D, Saville JW, Zhu X, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Kim A, Li W, Dimitrov DS, Subramaniam S. Cell Rep. 2021 Dec 21;37(12):110156. doi: 10.1016/j.celrep.2021.110156. Epub 2021 Dec 4. PubMed
Rapid characterization of spike variants via mammalian cell surface display. Javanmardi K, Chou CW, Terrace CI, Annapareddy A, Kaoud TS, Guo Q, Lutgens J, Zorkic H, Horton AP, Gardner EC, Nguyen G, Boutz DR, Goike J, Voss WN, Kuo HC, Dalby KN, Gollihar JD, Finkelstein IJ. Mol Cell. 2021 Dec 16;81(24):5099-5111.e8. doi: 10.1016/j.molcel.2021.11.024. PubMed

Associated Plasmids

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease. Reyes RA, Clarke K, Gonzales SJ, Cantwell AM, Garza R, Catano G, Tragus RE, Patterson TF, Bol S, Bunnik EM. PLoS One. 2021 Dec 22;16(12):e0261656. doi: 10.1371/journal.pone.0261656. eCollection 2021. PubMed

Associated Plasmids

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants. Saville JW, Mannar D, Zhu X, Srivastava SS, Berezuk AM, Demers JP, Zhou S, Tuttle KS, Sekirov I, Kim A, Li W, Dimitrov DS, Subramaniam S. Nat Commun. 2022 Feb 8;13(1):742. doi: 10.1038/s41467-022-28324-6. PubMed
Cryo-EM structure of the SARS-CoV-2 Omicron spike. Cerutti G, Guo Y, Liu L, Liu L, Zhang Z, Luo Y, Huang Y, Wang HH, Ho DD, Sheng Z, Shapiro L. Cell Rep. 2022 Mar 1;38(9):110428. doi: 10.1016/j.celrep.2022.110428. Epub 2022 Feb 7. PubMed
Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-naive and Experienced Individuals. Uprichard SL, O'Brien A, Evdokimova M, Rowe CL, Joyce C, Hackbart M, Cruz-Pulido YE, Cohen CA, Rock ML, Dye JM, Kuehnert P, Ricks KM, Casper M, Linhart L, Anderson K, Kirk L, Maggiore JA, Herbert AS, Clark NM, Reid GE, Baker SC. Viruses. 2022 Feb 10;14(2). pii: v14020370. doi: 10.3390/v14020370. PubMed
Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. McMillan CLD, Amarilla AA, Modhiran N, Choo JJY, Azuar A, Honeyman KE, Khromykh AA, Young PR, Watterson D, Muller DA. Vaccine. 2022 Aug 12;40(34):4929-4932. doi: 10.1016/j.vaccine.2022.07.013. Epub 2022 Jul 18. PubMed
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization. Mannar D, Saville JW, Sun Z, Zhu X, Marti MM, Srivastava SS, Berezuk AM, Zhou S, Tuttle KS, Sobolewski MD, Kim A, Treat BR, Da Silva Castanha PM, Jacobs JL, Barratt-Boyes SM, Mellors JW, Dimitrov DS, Li W, Subramaniam S. Nat Commun. 2022 Aug 18;13(1):4696. doi: 10.1038/s41467-022-32262-8. PubMed
Selective reversed-phase high-performance liquid chromatography method for the determination of intact SARS-CoV-2 spike protein. Lorbetskie B, White T, Creskey M, Zhang X, Girard M, Tam RY, Sauve S, Lu H. J Chromatogr A. 2022 Sep 13;1680:463424. doi: 10.1016/j.chroma.2022.463424. Epub 2022 Aug 16. PubMed
Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody production. Cortes-Sarabia K, Luna-Pineda VM, Rodriguez-Ruiz HA, Leyva-Vazquez MA, Hernandez-Sotelo D, Beltran-Anaya FO, Vences-Velazquez A, Del Moral-Hernandez O, Illades-Aguiar B. Sci Rep. 2022 Sep 5;12(1):15057. doi: 10.1038/s41598-022-18517-w. PubMed
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. Onnis A, Andreano E, Cassioli C, Finetti F, Della Bella C, Staufer O, Pantano E, Abbiento V, Marotta G, D'Elios MM, Rappuoli R, Baldari CT. J Exp Med. 2023 Feb 6;220(2):e20220906. doi: 10.1084/jem.20220906. Epub 2022 Nov 15. PubMed
Variations within the Glycan Shield of SARS-CoV-2 Impact Viral Spike Dynamics. Newby ML, Fogarty CA, Allen JD, Butler J, Fadda E, Crispin M. J Mol Biol. 2023 Feb 28;435(4):167928. doi: 10.1016/j.jmb.2022.167928. Epub 2022 Dec 21. PubMed
Monoclonal Antibodies Specific for SARS-CoV-2 Spike Protein Suitable for Multiple Applications for Current Variants of Concern. Morgan MS, Yan K, Le TT, Johnston RA, Amarilla AA, Muller DA, McMillan CLD, Modhiran N, Watterson D, Potter JR, Sng JDJ, Lor M, Paramitha D, Isaacs A, Khromykh AA, Hall RA, Suhrbier A, Rawle DJ, Hobson-Peters J. Viruses. 2022 Dec 31;15(1):139. doi: 10.3390/v15010139. PubMed
Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. Loo L, Waller MA, Moreno CL, Cole AJ, Stella AO, Pop OT, Jochum AK, Ali OH, Denes CE, Hamoudi Z, Chung F, Aggarwal A, Low JKK, Patel K, Siddiquee R, Kang T, Mathivanan S, Mackay JP, Jochum W, Flatz L, Hesselson D, Turville S, Neely GG. PLoS Biol. 2023 Feb 9;21(2):e3001967. doi: 10.1371/journal.pbio.3001967. eCollection 2023 Feb. PubMed
Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from Glycoengineering and Native Mass Spectrometry. El-Baba TJ, Lutomski CA, Burnap SA, Bolla JR, Baker LA, Baldwin AJ, Struwe WB, Robinson CV. J Am Chem Soc. 2023 Apr 12;145(14):8021-8032. doi: 10.1021/jacs.3c00291. Epub 2023 Mar 31. PubMed
Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection. Vu MN, Alvarado RE, Morris DR, Lokugamage KG, Zhou Y, Morgan AL, Estes LK, McLeland AM, Schindewolf C, Plante JA, Ahearn YP, Meyers WM, Murray JT, Weaver S, Walker DH, Russell WK, Routh AL, Plante KS, Menachery VD. bioRxiv. 2023 Jul 10:2023.04.17.536926. doi: 10.1101/2023.04.17.536926. Preprint. PubMed
Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection. Guenthoer J, Lilly M, Starr TN, Dadonaite B, Lovendahl KN, Croft JT, Stoddard CI, Chohan V, Ding S, Ruiz F, Kopp MS, Finzi A, Bloom JD, Chu HY, Lee KK, Overbaugh J. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2220948120. doi: 10.1073/pnas.2220948120. Epub 2023 May 30. PubMed
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Martinez-Marmol R, Giordano-Santini R, Kaulich E, Cho AN, Przybyla M, Riyadh MA, Robinson E, Chew KY, Amor R, Meunier FA, Balistreri G, Short KR, Ke YD, Ittner LM, Hilliard MA. Sci Adv. 2023 Jun 9;9(23):eadg2248. doi: 10.1126/sciadv.adg2248. Epub 2023 Jun 7. PubMed
Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity. Yuan M, Feng Z, Lv H, So N, Shen IR, Tan TJC, Teo QW, Ouyang WO, Talmage L, Wilson IA, Wu NC. bioRxiv. 2023 Jun 7:2023.06.06.543969. doi: 10.1101/2023.06.06.543969. Preprint. PubMed
Comparison of DNA vaccines with AS03 as an adjuvant and an mRNA vaccine against SARS-CoV-2. Neeli P, Chai D, Wang X, Sobhani N, Udeani G, Li Y. iScience. 2023 Jun 16;26(7):107120. doi: 10.1016/j.isci.2023.107120. eCollection 2023 Jul 21. PubMed
Adaptation of the binding domain of Lactobacillus acidophilus S-layer protein as a molecular tag for affinity chromatography development. Muruaga EJ, Uriza PJ, Eckert GAK, Pepe MV, Duarte CM, Roset MS, Briones G. Front Microbiol. 2023 Jun 13;14:1210898. doi: 10.3389/fmicb.2023.1210898. eCollection 2023. PubMed

If you have published an article using this material, please email us at [email protected] to have your article added to this page.