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HA-Ubiquitin Citations (156)

Originally described in: Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.
Kamitani T, Kito K, Nguyen HP, Yeh ET J Biol Chem. 1997 Nov 7. 272(45):28557-62.
PubMed Journal

Articles Citing HA-Ubiquitin

Articles
Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment. Mookerjee S, Papanikolaou T, Guyenet SJ, Sampath V, Lin A, Vitelli C, DeGiacomo F, Sopher BL, Chen SF, La Spada AR, Ellerby LM. J Neurosci. 2009 Dec 2;29(48):15134-44. doi: 10.1523/JNEUROSCI.4720-09.2009. PubMed
SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. Mittal MK, Singh K, Misra S, Chaudhuri G. J Biol Chem. 2011 Jan 7;286(1):469-79. doi: 10.1074/jbc.M110.164384. Epub 2010 Nov 2. PubMed
Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin. Gao Z, Godbout R. Cell Signal. 2011 Mar;23(3):555-65. doi: 10.1016/j.cellsig.2010.11.007. Epub 2010 Nov 25. PubMed
Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain. Gustin JK, Douglas JL, Bai Y, Moses AV. J Biol Chem. 2012 Apr 27;287(18):14837-50. doi: 10.1074/jbc.M112.349928. Epub 2012 Mar 1. PubMed
FANCL ubiquitinates beta-catenin and enhances its nuclear function. Dao KH, Rotelli MD, Petersen CL, Kaech S, Nelson WD, Yates JE, Hanlon Newell AE, Olson SB, Druker BJ, Bagby GC. Blood. 2012 Jul 12;120(2):323-34. doi: 10.1182/blood-2011-11-388355. Epub 2012 May 31. PubMed
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1alpha. Wu B, Teng H, Yang G, Wu L, Wang R. Br J Pharmacol. 2012 Dec;167(7):1492-505. doi: 10.1111/j.1476-5381.2012.02113.x. PubMed
c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-alpha pathway to PCSK9-mediated LDLR degradation pathway. Xu W, Liu L, Hornby D. Molecules. 2012 Oct 15;17(10):12086-101. doi: 10.3390/molecules171012086. PubMed
Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. Doppler H, Liou GY, Storz P. PLoS One. 2013;8(1):e53676. doi: 10.1371/journal.pone.0053676. Epub 2013 Jan 3. PubMed
Supervillin-mediated suppression of p53 protein enhances cell survival. Fang Z, Luna EJ. J Biol Chem. 2013 Mar 15;288(11):7918-29. doi: 10.1074/jbc.M112.416842. Epub 2013 Feb 4. PubMed
Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin. Miranzo-Navarro D, Magor KE. PLoS One. 2014 Jan 23;9(1):e86968. doi: 10.1371/journal.pone.0086968. eCollection 2014. PubMed
A COFRADIC protocol to study protein ubiquitination. Stes E, Laga M, Walton A, Samyn N, Timmerman E, De Smet I, Goormachtig S, Gevaert K. J Proteome Res. 2014 Jun 6;13(6):3107-13. doi: 10.1021/pr4012443. Epub 2014 May 20. PubMed
BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey MA, Kuum M, Liiv M, Anwar T, Eskelinen EL, Kaasik A. Autophagy. 2014 Jun;10(6):1105-19. doi: 10.4161/auto.28615. PubMed
14-3-3epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. Toyo-oka K, Wachi T, Hunt RF, Baraban SC, Taya S, Ramshaw H, Kaibuchi K, Schwarz QP, Lopez AF, Wynshaw-Boris A. J Neurosci. 2014 Sep 3;34(36):12168-81. doi: 10.1523/JNEUROSCI.2513-13.2014. PubMed
APC/C(Cdh1) controls CtIP stability during the cell cycle and in response to DNA damage. Lafranchi L, de Boer HR, de Vries EG, Ong SE, Sartori AA, van Vugt MA. EMBO J. 2014 Dec 1;33(23):2860-79. doi: 10.15252/embj.201489017. Epub 2014 Oct 27. PubMed
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Rui YN, Xu Z, Chen Z, Zhang S. Autophagy. 2015;11(5):812-32. doi: 10.1080/15548627.2015.1034402. PubMed
Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation. Satpathy S, Wagner SA, Beli P, Gupta R, Kristiansen TA, Malinova D, Francavilla C, Tolar P, Bishop GA, Hostager BS, Choudhary C. Mol Syst Biol. 2015 Jun 2;11(6):810. doi: 10.15252/msb.20145880. PubMed
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-Mediated Degradation. Li Q, Li Y, Gu B, Fang L, Zhou P, Bao S, Huang L, Dai X. J Biol Chem. 2015 Jul 13. pii: jbc.M115.639419. PubMed
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ. Nat Immunol. 2015 Dec;16(12):1215-27. doi: 10.1038/ni.3279. Epub 2015 Oct 19. PubMed
p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. Gonzalez-Teran B, Lopez JA, Rodriguez E, Leiva L, Martinez-Martinez S, Bernal JA, Jimenez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G. Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477. PubMed
Studying Coxiella burnetii Type IV Substrates in the Yeast Saccharomyces cerevisiae: Focus on Subcellular Localization and Protein Aggregation. Rodriguez-Escudero M, Cid VJ, Molina M, Schulze-Luehrmann J, Luhrmann A, Rodriguez-Escudero I. PLoS One. 2016 Jan 28;11(1):e0148032. doi: 10.1371/journal.pone.0148032. eCollection 2016. PubMed
Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy. Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. Hum Mol Genet. 2016 Jun 1;25(11):2143-2157. doi: 10.1093/hmg/ddw081. Epub 2016 Mar 21. PubMed
An E3-ligase-based method for ablating inhibitory synapses. Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh LA, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB. Nat Methods. 2016 Jun 6. doi: 10.1038/nmeth.3894. PubMed

Associated Plasmids

Over-expression of ASIC1a promotes proliferation via activation of the beta-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer. Jin C, Yuan FL, Gu YL, Li X, Liu MF, Shen XM, Liu B, Zhu MQ. Oncotarget. 2017 Apr 18;8(16):25977-25988. doi: 10.18632/oncotarget.10774. PubMed
Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. Izrailit J, Jaiswal A, Zheng W, Moran MF, Reedijk M. Oncogene. 2016 Sep 5. doi: 10.1038/onc.2016.276. PubMed
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY. Neuron. 2016 Oct 19;92(2):407-418. doi: 10.1016/j.neuron.2016.09.022. Epub 2016 Oct 6. PubMed

Associated Plasmids

Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Ni T, Li XY, Lu N, An T, Liu ZP, Fu R, Lv WC, Zhang YW, Xu XJ, Grant Rowe R, Lin YS, Scherer A, Feinberg T, Zheng XQ, Chen BA, Liu XS, Guo QL, Wu ZQ, Weiss SJ. Nat Cell Biol. 2016 Nov;18(11):1221-1232. doi: 10.1038/ncb3425. Epub 2016 Oct 17. PubMed
Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling. Liu H, Zhang Q, Li K, Gong Z, Liu Z, Xu Y, Swaney MH, Xiao K, Chen Y. Oncotarget. 2016 Dec 6;7(49):81223-81240. doi: 10.18632/oncotarget.13219. PubMed
De-ubiquitinating enzyme, USP11, promotes transforming growth factor beta-1 signaling through stabilization of transforming growth factor beta receptor II. Jacko AM, Nan L, Li S, Tan J, Zhao J, Kass DJ, Zhao Y. Cell Death Dis. 2016 Nov 17;7(11):e2474. doi: 10.1038/cddis.2016.371. PubMed
Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells. Wang N, Wang X, Tan HY, Li S, Tsang CM, Tsao SW, Feng Y. Int J Mol Sci. 2016 Nov 15;17(11). pii: E1899. PubMed
Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Du WW, Fang L, Yang W, Wu N, Awan FM, Yang Z, Yang BB. Cell Death Differ. 2017 Feb;24(2):357-370. doi: 10.1038/cdd.2016.133. Epub 2016 Nov 25. PubMed
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Cai H, Liu A. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14751-14756. doi: 10.1073/pnas.1612520114. Epub 2016 Dec 5. PubMed

Associated Plasmids

TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, Takahashi T. Oncogene. 2017 Jun 29;36(26):3740-3748. doi: 10.1038/onc.2016.524. Epub 2017 Feb 13. PubMed
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. Li L, Baxter SS, Gu N, Ji M, Zhan X. J Cell Sci. 2017 Apr 15;130(8):1475-1485. doi: 10.1242/jcs.198937. Epub 2017 Mar 6. PubMed
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G. Mol Cell. 2017 Mar 16;65(6):999-1013.e7. doi: 10.1016/j.molcel.2017.02.019. PubMed
RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. Dong X, Liao W, Zhang L, Tu X, Hu J, Chen T, Dai X, Xiong Y, Liang W, Ding C, Liu R, Dai J, Wang O, Lu L, Lu X. Cancer Lett. 2017 Aug 28;402:153-165. doi: 10.1016/j.canlet.2017.05.024. Epub 2017 Jun 6. PubMed
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, Liu JJ, Feng GK, Chen MS, Zeng YX, Deng R, Zhu XF. Autophagy. 2018;14(4):671-684. doi: 10.1080/15548627.2017.1381804. Epub 2017 Dec 17. PubMed
SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability. Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T. Mol Cell Biol. 2017 Dec 29;38(2). pii: MCB.00129-17. doi: 10.1128/MCB.00129-17. Print 2018 Jan 15. PubMed
Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment. Mohr A, Deedigan L, Jencz S, Mehrabadi Y, Houlden L, Albarenque SM, Zwacka RM. Cell Death Differ. 2018 Feb;25(2):340-352. doi: 10.1038/cdd.2017.164. Epub 2017 Nov 3. PubMed
A Parkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis. Choi DJ, Eun JH, Kim BG, Jou I, Park SM, Joe EH. Glia. 2018 Feb;66(2):445-458. doi: 10.1002/glia.23258. Epub 2017 Nov 6. PubMed
KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Alvarez A, Uribe F, Canales J, Romero C, Soza A, Pena MA, Antonelli M, Almarza O, Cerda O, Toledo H. Front Cell Infect Microbiol. 2017 Oct 24;7:450. doi: 10.3389/fcimb.2017.00450. eCollection 2017. PubMed
FBXO31 Suppresses Gastric Cancer EMT by Targeting Snail1 for Proteasomal Degradation. Zou S, Ma C, Yang F, Xu X, Jia J, Liu Z. Mol Cancer Res. 2018 Feb;16(2):286-295. doi: 10.1158/1541-7786.MCR-17-0432. Epub 2017 Nov 8. PubMed
An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH. Elife. 2017 Nov 15;6. pii: 30126. doi: 10.7554/eLife.30126. PubMed
STX3 represses the stability of the tumor suppressor PTEN to activate the PI3K-Akt-mTOR signaling and promotes the growth of breast cancer cells. Nan H, Han L, Ma J, Yang C, Su R, He J. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1684-1692. doi: 10.1016/j.bbadis.2018.01.031. Epub 2018 Feb 2. PubMed
BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage. Biswas K, Philip S, Yadav A, Martin BK, Burkett S, Singh V, Babbar A, North SL, Chang S, Sharan SK. Nat Commun. 2018 Feb 7;9(1):537. doi: 10.1038/s41467-018-03020-6. PubMed
The HNF-1beta-USP28-Claspin pathway upregulates DNA damage-induced Chk1 activation in ovarian clear cell carcinoma. Ito F, Yoshimoto C, Yamada Y, Sudo T, Kobayashi H. Oncotarget. 2018 Apr 3;9(25):17512-17522. doi: 10.18632/oncotarget.24776. eCollection 2018 Apr 3. PubMed
Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins. Inoue J, Miyata S, Shimizu M, Sato R. Biosci Biotechnol Biochem. 2018 Sep;82(9):1591-1598. doi: 10.1080/09168451.2018.1478715. Epub 2018 May 26. PubMed
The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells. Cai N, Lou L, Al-Saadi N, Tetteh S, Runnels LW. J Biol Chem. 2018 Jul 20;293(29):11491-11504. doi: 10.1074/jbc.RA118.001925. Epub 2018 Jun 4. PubMed
p38delta MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress. Zhang C, Gao J, Li M, Deng Y, Jiang C. J Cell Sci. 2018 Jul 26;131(14). pii: jcs.216671. doi: 10.1242/jcs.216671. PubMed
The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y. J Biol Chem. 2018 Oct 19;293(42):16142-16159. doi: 10.1074/jbc.RA118.003525. Epub 2018 Aug 24. PubMed
A catalogue of somatic NRF2 gain-of-function mutations in cancer. Kerins MJ, Ooi A. Sci Rep. 2018 Aug 27;8(1):12846. doi: 10.1038/s41598-018-31281-0. PubMed
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Shorrock HK, van der Hoorn D, Boyd PJ, Llavero Hurtado M, Lamont DJ, Wirth B, Sleigh JN, Schiavo G, Wishart TM, Groen EJN, Gillingwater TH. Brain. 2018 Oct 1;141(10):2878-2894. doi: 10.1093/brain/awy237. PubMed
E3 ubiquitin ligases LNX1 and LNX2 localize at neuronal gap junctions formed by connexin36 in rodent brain and molecularly interact with connexin36. Lynn BD, Li X, Hormuzdi SG, Griffiths EK, McGlade CJ, Nagy JI. Eur J Neurosci. 2018 Nov;48(9):3062-3081. doi: 10.1111/ejn.14198. Epub 2018 Nov 2. PubMed
Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity. Li S, Ahmad I, Shi J, Wang B, Yu C, Zhang L, Zheng YH. J Virol. 2019 Jan 4;93(2). pii: JVI.01651-18. doi: 10.1128/JVI.01651-18. Print 2019 Jan 15. PubMed
Neuronal Expression of UBQLN2(P497H) Exacerbates TDP-43 Pathology in TDP-43(G348C) Mice through Interaction with Ubiquitin. Picher-Martel V, Renaud L, Bareil C, Julien JP. Mol Neurobiol. 2018 Oct 30. pii: 10.1007/s12035-018-1411-3. doi: 10.1007/s12035-018-1411-3. PubMed
KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001. PubMed
Elevated histone H3 acetylation and loss of the Sp1-HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma. Banerjee A, Mahata B, Dhir A, Mandal TK, Biswas K. J Biol Chem. 2019 Jan 18;294(3):1005-1018. doi: 10.1074/jbc.RA118.004485. Epub 2018 Nov 21. PubMed
Repair pathway for PARP-1 DNA-protein crosslinks. Prasad R, Horton JK, Dai DP, Wilson SH. DNA Repair (Amst). 2019 Jan;73:71-77. doi: 10.1016/j.dnarep.2018.11.004. Epub 2018 Nov 12. PubMed
TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression. Fong KW, Zhao JC, Song B, Zheng B, Yu J. Nat Commun. 2018 Nov 27;9(1):5007. doi: 10.1038/s41467-018-07475-5. PubMed
Miro proteins prime mitochondria for Parkin translocation and mitophagy. Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A. EMBO J. 2019 Jan 15;38(2). pii: embj.201899384. doi: 10.15252/embj.201899384. Epub 2018 Nov 30. PubMed
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication. Ling H, Peng L, Wang J, Rahhal R, Seto E. Cell Rep. 2018 Dec 4;25(10):2851-2865.e3. doi: 10.1016/j.celrep.2018.11.025. PubMed
O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity. Li T, Li X, Attri KS, Liu C, Li L, Herring LE, Asara JM, Lei YL, Singh PK, Gao C, Wen H. Cell Host Microbe. 2018 Dec 12;24(6):791-803.e6. doi: 10.1016/j.chom.2018.11.001. PubMed
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, Gros P, Eichhorn PJA, Lenter M, Boehmelt G, Sidhu SS. Structure. 2019 Apr 2;27(4):590-605.e5. doi: 10.1016/j.str.2019.01.002. Epub 2019 Jan 31. PubMed
Regulation of death receptor signaling by the autophagy protein TP53INP2. Ivanova S, Polajnar M, Narbona-Perez AJ, Hernandez-Alvarez MI, Frager P, Slobodnyuk K, Plana N, Nebreda AR, Palacin M, Gomis RR, Behrends C, Zorzano A. EMBO J. 2019 May 15;38(10). pii: embj.201899300. doi: 10.15252/embj.201899300. Epub 2019 Apr 12. PubMed
Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). Goodman DE, Pretto CD, Krepostman TA, Carnahan KE, Spindler KR. MBio. 2019 Apr 23;10(2). pii: mBio.00668-19. doi: 10.1128/mBio.00668-19. PubMed
TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1. Episkopou H, Diman A, Claude E, Viceconte N, Decottignies A. Mol Cell. 2019 Aug 8;75(3):469-482.e6. doi: 10.1016/j.molcel.2019.05.027. Epub 2019 Jul 2. PubMed
RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Barroso-Gonzalez J, Garcia-Exposito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PubMed
The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels. Dutta P, Islam S, Choppara S, Sengupta P, Kumar A, Kumar A, Wani MR, Chatterjee S, Santra MK. J Biol Chem. 2019 Oct 11;294(41):14879-14895. doi: 10.1074/jbc.RA118.007055. Epub 2019 Aug 14. PubMed
Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mayor-Ruiz C, Jaeger MG, Bauer S, Brand M, Sin C, Hanzl A, Mueller AC, Menche J, Winter GE. Mol Cell. 2019 Aug 22;75(4):849-858.e8. doi: 10.1016/j.molcel.2019.07.013. PubMed
CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCepsilon activation and phosphorylation of XIAP. Baek HS, Kwon YJ, Ye DJ, Cho E, Kwon TU, Chun YJ. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118553. doi: 10.1016/j.bbamcr.2019.118553. Epub 2019 Sep 4. PubMed
Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. Tang X, Fu X, Liu Y, Yu D, Cai SJ, Yang C. Mol Cancer Ther. 2020 Jan;19(1):221-230. doi: 10.1158/1535-7163.MCT-19-0103. Epub 2019 Sep 23. PubMed
The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. Yan Y, Ma J, Wang D, Lin D, Pang X, Wang S, Zhao Y, Shi L, Xue H, Pan Y, Zhang J, Wahlestedt C, Giles FJ, Chen Y, Gleave ME, Collins CC, Ye D, Wang Y, Huang H. EMBO Mol Med. 2019 Nov 7;11(11):e10659. doi: 10.15252/emmm.201910659. Epub 2019 Sep 26. PubMed
Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation. Liu R, Olano LR, Mirzakhanyan Y, Gershon PD, Moss B. Cell Rep. 2019 Oct 22;29(4):816-828.e6. doi: 10.1016/j.celrep.2019.09.039. PubMed
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-beta/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Fukui S, Nagasaka K, Miyagawa Y, Kikuchi-Koike R, Kawata Y, Kanda R, Ichinose T, Sugihara T, Hiraike H, Wada-Hiraike O, Sasajima Y, Ayabe T. Oncotarget. 2019 Oct 15;10(57):5932-5948. doi: 10.18632/oncotarget.27219. eCollection 2019 Oct 15. PubMed
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3. Jia R, Bonifacino JS. Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034. PubMed

Associated Plasmids

NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z. Ziegler CM, Dang L, Eisenhauer P, Kelly JA, King BR, Klaus JP, Manuelyan I, Mattice EB, Shirley DJ, Weir ME, Bruce EA, Ballif BA, Botten J. PLoS Pathog. 2019 Nov 11;15(11):e1008100. doi: 10.1371/journal.ppat.1008100. eCollection 2019 Nov. PubMed
SET8 localization to chromatin flanking DNA damage is dependent on RNF168 ubiquitin ligase. Dulev S, Lin S, Liu Q, Cetintas VB, Batada NN. Cell Cycle. 2020 Jan;19(1):15-23. doi: 10.1080/15384101.2019.1690231. Epub 2019 Nov 24. PubMed
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I. Jureka AS, Kleinpeter AB, Tipper JL, Harrod KS, Petit CM. J Biol Chem. 2020 Jan 24;295(4):1153-1164. doi: 10.1074/jbc.RA119.011410. Epub 2019 Dec 16. PubMed
The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells. Alsanafi M, Kelly SL, McNaughton M, Merrill AH Jr, Pyne NJ, Pyne S. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158631. doi: 10.1016/j.bbalip.2020.158631. Epub 2020 Jan 15. PubMed
Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy. Jo DS, Park SJ, Kim AK, Park NY, Kim JB, Bae JE, Park HJ, Shin JH, Chang JW, Kim PK, Jung YK, Koh JY, Choe SK, Lee KS, Cho DH. Autophagy. 2020 Nov;16(11):1989-2003. doi: 10.1080/15548627.2020.1712812. Epub 2020 Jan 22. PubMed
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH. Nat Commun. 2020 May 8;11(1):2289. doi: 10.1038/s41467-020-16038-6. PubMed
MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons. Abreu AP, Toro CA, Song YB, Navarro VM, Bosch MA, Eren A, Liang JN, Carroll RS, Latronico AC, Ronnekleiv OK, Aylwin CF, Lomniczi A, Ojeda S, Kaiser UB. J Clin Invest. 2020 Aug 3;130(8):4486-4500. doi: 10.1172/JCI136564. PubMed
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. Das S, Chandrasekaran AP, Suresh B, Haq S, Kang JH, Lee SJ, Kim J, Kim J, Lee S, Kim HH, Kim KS, Ramakrishna S. Cell Death Differ. 2020 May 15. pii: 10.1038/s41418-020-0557-5. doi: 10.1038/s41418-020-0557-5. PubMed
A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Li HM, Bi YR, Li Y, Fu R, Lv WC, Jiang N, Xu Y, Ren BX, Chen YD, Xie H, Wang S, Lu T, Wu ZQ. Sci Adv. 2020 Apr 22;6(17):eaaw8500. doi: 10.1126/sciadv.aaw8500. eCollection 2020 Apr. PubMed
Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Li ZL, Zhang HL, Huang Y, Huang JH, Sun P, Zhou NN, Chen YH, Mai J, Wang Y, Yu Y, Zhou LH, Li X, Yang D, Peng XD, Feng GK, Tang J, Zhu XF, Deng R. Nat Commun. 2020 Jul 30;11(1):3806. doi: 10.1038/s41467-020-17395-y. PubMed
The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun. Polakowski N, Pearce M, Kuguyo O, Boateng G, Hoang K, Lemasson I. Virology. 2020 Oct;549:51-58. doi: 10.1016/j.virol.2020.07.013. Epub 2020 Aug 9. PubMed
TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis. Chen M, Amado N, Tan J, Reis A, Ge M, Abreu JG, He X. Elife. 2020 Sep 14;9. pii: 56793. doi: 10.7554/eLife.56793. PubMed
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. Fang C, Woo JA, Liu T, Zhao X, Cazzaro S, Yan Y, Matlack J, Kee T, LePochat P, Kang DE. Autophagy. 2021 Sep;17(9):2144-2165. doi: 10.1080/15548627.2020.1816663. Epub 2020 Oct 12. PubMed
RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain RK, Lee DY, Rusten TE, Chauhan S, Chauhan S. Cancer Res. 2021 Jan 15;81(2):315-331. doi: 10.1158/0008-5472.CAN-20-1871. Epub 2020 Oct 16. PubMed
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway. Zhang T, Periz G, Lu YN, Wang J. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28114-28125. doi: 10.1073/pnas.2014349117. Epub 2020 Oct 26. PubMed
FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1. Mishra M, Thacker G, Sharma A, Singh AK, Upadhyay V, Sanyal S, Verma SP, Tripathi AK, Bhatt MLB, Trivedi AK. Mol Cancer Res. 2021 Feb;19(2):261-273. doi: 10.1158/1541-7786.MCR-20-0268. Epub 2020 Nov 13. PubMed
E3 Ubiquitin Ligase APC/C(Cdh1) Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination. Kaushal K, Woo SH, Tyagi A, Kim DH, Suresh B, Kim KS, Ramakrishna S. Int J Mol Sci. 2020 Nov 18;21(22). pii: ijms21228719. doi: 10.3390/ijms21228719. PubMed
E3 Ubiquitin Ligase APC/C(Cdh1) Regulation of Phenylalanine Hydroxylase Stability and Function. Tyagi A, Sarodaya N, Kaushal K, Chandrasekaran AP, Antao AM, Suresh B, Rhie BH, Kim KS, Ramakrishna S. Int J Mol Sci. 2020 Nov 28;21(23). pii: ijms21239076. doi: 10.3390/ijms21239076. PubMed
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases. Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. Mol Cell Proteomics. 2021 Jan 6;20:100019. doi: 10.1074/mcp.RA120.002414. PubMed
Eugenol protects cells against oxidative stress via Nrf2. Ma L, Liu J, Lin Q, Gu Y, Yu W. Exp Ther Med. 2021 Feb;21(2):107. doi: 10.3892/etm.2020.9539. Epub 2020 Nov 27. PubMed
Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5. Liu Y, Liu X, Zhang N, Yin M, Dong J, Zeng Q, Mao G, Song D, Liu L, Deng H. Acta Pharm Sin B. 2020 Dec;10(12):2299-2312. doi: 10.1016/j.apsb.2020.06.014. Epub 2020 Jun 30. PubMed
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Sci Adv. 2021 Feb 5;7(6). pii: 7/6/eabe3706. doi: 10.1126/sciadv.abe3706. Print 2021 Feb. PubMed
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity. Jia R, Bonifacino JS. J Biol Chem. 2021 Jan-Jun;296:100405. doi: 10.1016/j.jbc.2021.100405. Epub 2021 Feb 10. PubMed

Associated Plasmids

Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell. Mu Y, Maharjan Y, Kumar Dutta R, Wei X, Kim JH, Son J, Park C, Park R. PLoS One. 2021 Feb 19;16(2):e0245799. doi: 10.1371/journal.pone.0245799. eCollection 2021. PubMed
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, Lopez-Giraldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, Gonzalez Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8. PubMed
A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny. Guo R, Yan X, Li Y, Cui J, Misra S, Firth AE, Snijder EJ, Fang Y. PLoS Pathog. 2021 Mar 18;17(3):e1009403. doi: 10.1371/journal.ppat.1009403. eCollection 2021 Mar. PubMed
FBXW8 regulates G1 and S phases of cell cycle progression by restricting beta-TrCP1 function. Islam S, Dutta P, Chopra K, Rapole S, Chauhan R, Santra MK. FEBS J. 2021 Sep;288(18):5474-5497. doi: 10.1111/febs.15828. Epub 2021 Apr 5. PubMed
EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function. Bahl S, Ling H, Acharige NPN, Santos-Barriopedro I, Pflum MKH, Seto E. Cell Death Dis. 2021 May 11;12(5):469. doi: 10.1038/s41419-021-03697-6. PubMed
Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. Rhie BH, Antao AM, Karapurkar JK, Kim MS, Jo WJ, Ramakrishna S, Kim KS. Int J Mol Sci. 2021 May 25;22(11). pii: ijms22115584. doi: 10.3390/ijms22115584. PubMed
Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis. Chandrasekaran AP, Woo SH, Sarodaya N, Rhie BH, Tyagi A, Das S, Suresh B, Ko NR, Oh SJ, Kim KS, Ramakrishna S. Int J Mol Sci. 2021 May 28;22(11). pii: ijms22115766. doi: 10.3390/ijms22115766. PubMed
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis. Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C. Commun Biol. 2021 Jul 16;4(1):884. doi: 10.1038/s42003-021-02391-9. PubMed
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells. Chen Y, Pan C, Wang X, Xu D, Ma Y, Hu J, Chen P, Xiang Z, Rao Q, Han X. Theranostics. 2021 Jun 11;11(16):7640-7657. doi: 10.7150/thno.61178. eCollection 2021. PubMed
Rpsa Signaling Regulates Cortical Neuronal Morphogenesis via Its Ligand, PEDF, and Plasma Membrane Interaction Partner, Itga6. Blazejewski SM, Bennison SA, Ha NT, Liu X, Smith TH, Dougherty KJ, Toyo-Oka K. Cereb Cortex. 2021 Aug 4. pii: 6338536. doi: 10.1093/cercor/bhab242. PubMed
USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B. Antao AM, Kaushal K, Das S, Singh V, Suresh B, Kim KS, Ramakrishna S. Int J Mol Sci. 2021 Aug 7;22(16). pii: ijms22168508. doi: 10.3390/ijms22168508. PubMed
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors. Khateb A, Deshpande A, Feng Y, Finlay D, Lee JS, Lazar I, Fabre B, Li Y, Fujita Y, Zhang T, Yin J, Pass I, Livneh I, Jeremias I, Burian C, Mason JR, Almog R, Horesh N, Ofran Y, Brown K, Vuori K, Jackson M, Ruppin E, Deshpande AJ, Ronai ZA. Nat Commun. 2021 Sep 13;12(1):5397. doi: 10.1038/s41467-021-25664-7. PubMed
HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1. Zhang Q, Kang Y, Wang S, Gonzalez GM, Li W, Hui H, Wang Y, Rana TM. Nat Commun. 2021 Sep 20;12(1):5543. doi: 10.1038/s41467-021-25683-4. PubMed
Identification of Smurf2 as a HIF-1alpha degrading E3 ubiquitin ligase. Zhao S, El-Deiry WS. Oncotarget. 2021 Sep 28;12(20):1970-1979. doi: 10.18632/oncotarget.28081. eCollection 2021 Sep 28. PubMed
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy. Zheng J, Chen X, Liu Q, Zhong G, Zhuang M. J Cell Biol. 2022 Jan 3;221(1). pii: 212749. doi: 10.1083/jcb.202103156. Epub 2021 Nov 8. PubMed
USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2. Chandrasekaran AP, Kaushal K, Park CH, Kim KS, Ramakrishna S. Theranostics. 2021 Sep 27;11(20):9752-9771. doi: 10.7150/thno.63806. eCollection 2021. PubMed
The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner. Valionyte E, Yang Y, Griffiths SA, Bone AT, Barrow ER, Sharma V, Lu B, Luo S. Cell Death Differ. 2021 Dec 3. pii: 10.1038/s41418-021-00912-x. doi: 10.1038/s41418-021-00912-x. PubMed
CD95/Fas suppresses NF-kappaB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism. Guegan JP, Pollet J, Ginestier C, Charafe-Jauffret E, Peter ME, Legembre P. iScience. 2021 Dec 1;24(12):103538. doi: 10.1016/j.isci.2021.103538. eCollection 2021 Dec 17. PubMed
The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells. Kundu S, Nandhu MS, Longo SL, Longo JA, Rai S, Chin LS, Richardson TE, Viapiano MS. Neuro Oncol. 2022 Aug 1;24(8):1230-1242. doi: 10.1093/neuonc/noac001. PubMed
Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development. Yamada S, Sato A, Ishihara N, Akiyama H, Sakakibara SI. iScience. 2021 Dec 10;24(12):103484. doi: 10.1016/j.isci.2021.103484. eCollection 2021 Dec 17. PubMed
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains. Nomura T, Nagao K, Shirai R, Gotoh H, Umeda M, Ono K. Nat Commun. 2022 Jan 10;13(1):96. doi: 10.1038/s41467-021-27707-5. PubMed
Genome-Wide CRISPR/Cas9-Based Screening for Deubiquitinase Subfamily Identifies Ubiquitin-Specific Protease 11 as a Novel Regulator of Osteogenic Differentiation. Kaushal K, Tyagi A, Karapurkar JK, Kim EJ, Tanguturi P, Kim KS, Jung HS, Ramakrishna S. Int J Mol Sci. 2022 Jan 13;23(2). pii: ijms23020856. doi: 10.3390/ijms23020856. PubMed
The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression. Howley BV, Mohanty B, Dalton A, Grelet S, Karam J, Dincman T, Howe PH. Oncogene. 2022 Mar;41(12):1679-1690. doi: 10.1038/s41388-022-02199-9. Epub 2022 Jan 31. PubMed
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. Kim JM, Yang YS, Xie J, Lee O, Kim J, Hong J, Boldyreff B, Filhol O, Chun H, Greenblatt MB, Gao G, Shim JH. Cell Death Differ. 2022 Aug;29(8):1625-1638. doi: 10.1038/s41418-022-00952-x. Epub 2022 Feb 15. PubMed
FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. Qiu B, Zhong Z, Righter S, Xu Y, Wang J, Deng R, Wang C, Williams KE, Ma YY, Tsechpenakis G, Liang T, Yong W. Cell Mol Life Sci. 2022 Mar 4;79(3):175. doi: 10.1007/s00018-022-04167-8. PubMed
Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis. Kaushal K, Kim EJ, Tyagi A, Karapurkar JK, Haq S, Jung HS, Kim KS, Ramakrishna S. Cell Death Differ. 2022 Sep;29(9):1689-1704. doi: 10.1038/s41418-022-00956-7. Epub 2022 Mar 10. PubMed
PRMT5 regulates ATF4 transcript splicing and oxidative stress response. Szewczyk MM, Luciani GM, Vu V, Murison A, Dilworth D, Barghout SH, Lupien M, Arrowsmith CH, Minden MD, Barsyte-Lovejoy D. Redox Biol. 2022 May;51:102282. doi: 10.1016/j.redox.2022.102282. Epub 2022 Mar 11. PubMed
An infection-induced oxidation site regulates legumain processing and tumor growth. Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK. Nat Chem Biol. 2022 Jul;18(7):698-705. doi: 10.1038/s41589-022-00992-x. Epub 2022 Mar 24. PubMed
Sulforaphane suppresses the activity of sterol regulatory element-binding proteins (SREBPs) by promoting SREBP precursor degradation. Miyata S, Kodaka M, Kikuchi A, Matsunaga Y, Shoji K, Kuan YC, Iwase M, Takeda K, Katsuta R, Ishigami K, Matsumoto Y, Suzuki T, Yamamoto Y, Sato R, Inoue J. Sci Rep. 2022 May 24;12(1):8715. doi: 10.1038/s41598-022-12347-6. PubMed
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression. Arshad N, Laurent-Rolle M, Ahmed WS, Hsu JC, Mitchell SM, Pawlak J, Sengupta D, Biswas KH, Cresswell P. bioRxiv. 2022 May 17. doi: 10.1101/2022.05.17.492198. PubMed
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia. Lao L, Bourdeau I, Gagliardi L, He X, Shi W, Hao B, Tan M, Hu Y, Peng J, Coulombe B, Torpy DJ, Scott HS, Lacroix A, Luo H, Wu J. Nucleic Acids Res. 2022 Jun 24;50(11):6343-6367. doi: 10.1093/nar/gkac483. PubMed
Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin. Chandrasekaran AP, Tyagi A, Poondla N, Sarodaya N, Karapurkar JK, Kaushal K, Park CH, Hong SH, Kim KS, Ramakrishna S. Mol Ther. 2022 Nov 2;30(11):3414-3429. doi: 10.1016/j.ymthe.2022.07.019. Epub 2022 Aug 1. PubMed
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP, Sabbagh MF, Shin JY, Yang W, Snowman AM, Albacarys LK, Moghekar A, Pardo-Villamizar CA, Luciano M, Huang J, Bettegowda C, Kwatra SG, Dong X, Lim M, Snyder SH. Sci Adv. 2022 Aug 5;8(31):eabo5633. doi: 10.1126/sciadv.abo5633. Epub 2022 Aug 3. PubMed
Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner. Garcia-Gutierrez L, Fallahi E, Aboud N, Quinn N, Matallanas D. Cell Death Dis. 2022 Aug 8;13(8):692. doi: 10.1038/s41419-022-05147-3. PubMed
Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. Mann G, Sulkshane P, Sadhu P, Ziv T, Glickman MH, Brik A. Molecules. 2022 Jul 29;27(15):4867. doi: 10.3390/molecules27154867. PubMed
CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells. Tyagi A, Kaushal K, Chandrasekaran AP, Sarodaya N, Das S, Park CH, Hong SH, Kim KS, Ramakrishna S. Theranostics. 2022 Aug 8;12(13):5949-5970. doi: 10.7150/thno.72826. eCollection 2022. PubMed
Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Jiang J, Wang Y. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22. PubMed
Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons. Kiryu-Seo S, Matsushita R, Tashiro Y, Yoshimura T, Iguchi Y, Katsuno M, Takahashi R, Kiyama H. EMBO J. 2022 Oct 17;41(20):e110486. doi: 10.15252/embj.2021110486. Epub 2022 Aug 25. PubMed
APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas. Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, Wang TC, Giordano S, Zaika A, McDonald O, Peng D, El-Rifai W. J Exp Clin Cancer Res. 2022 Sep 1;41(1):264. doi: 10.1186/s13046-022-02472-5. PubMed
HDAC6-dependent deacetylation of AKAP12 dictates its ubiquitination and promotes colon cancer metastasis. Deng Y, Gao J, Xu G, Yao Y, Sun Y, Shi Y, Hao X, Niu L, Li H. Cancer Lett. 2022 Nov 28;549:215911. doi: 10.1016/j.canlet.2022.215911. Epub 2022 Sep 17. PubMed
Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation. Espinoza MF, Nguyen KK, Sycks MM, Lyu Z, Quanrud GM, Montoya MR, Genereux JC. J Biol Chem. 2022 Dec;298(12):102597. doi: 10.1016/j.jbc.2022.102597. Epub 2022 Oct 14. PubMed
Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer. Luo M, Zhang Y, Xu Z, Wu C, Ye Y, Liu R, Lv S, Wei Q. Cell Death Discov. 2022 Nov 29;8(1):471. doi: 10.1038/s41420-022-01257-1. PubMed
One-Step Sortase-Mediated Chemoenzymatic Semisynthesis of Deubiquitinase-Resistant Ub-Peptide Conjugates. Singh AK, Murmu S, Krezel A. ACS Omega. 2022 Dec 7;7(50):46693-46701. doi: 10.1021/acsomega.2c05652. eCollection 2022 Dec 20. PubMed
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression. Arshad N, Laurent-Rolle M, Ahmed WS, Hsu JC, Mitchell SM, Pawlak J, Sengupta D, Biswas KH, Cresswell P. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208525120. doi: 10.1073/pnas.2208525120. Epub 2022 Dec 27. PubMed
USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity. Shin J, Kim YH, Lee B, Chang JH, Choi HY, Lee H, Song KC, Kwak MS, Choi JE, Shin JS. Mol Med. 2022 Dec 30;28(1):164. doi: 10.1186/s10020-022-00596-0. PubMed
Hsa-miR-22-3p inhibits liver cancer cell EMT and cell migration/ invasion by indirectly regulating SPRY2. Cui S, Chen Y, Guo Y, Wang X, Chen D. PLoS One. 2023 Feb 7;18(2):e0281536. doi: 10.1371/journal.pone.0281536. eCollection 2023. PubMed
KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle. Chappell DL, Sandhu PK, Wong JP, Bhatt AP, Liu X, Buhrlage SJ, Temple BRS, Major MB, Damania B. J Virol. 2023 Mar 30;97(3):e0176322. doi: 10.1128/jvi.01763-22. Epub 2023 Mar 6. PubMed
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CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. Karapurkar JK, Kim MS, Colaco JC, Suresh B, Sarodaya N, Kim DH, Park CH, Hong SH, Kim KS, Ramakrishna S. J Exp Clin Cancer Res. 2023 May 12;42(1):121. doi: 10.1186/s13046-023-02694-1. PubMed
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The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes. Kastnes M, Aass KR, Bouma SA, Arseth C, Zahoor M, Yurchenko M, Standal T. Front Oncol. 2023 May 29;13:1197542. doi: 10.3389/fonc.2023.1197542. eCollection 2023. PubMed
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A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate Model. Takeda K, Sakai-Sakasai A, Kajinami K, Takeuchi M. Cells. 2023 Dec 14;12(24):2838. doi: 10.3390/cells12242838. PubMed
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