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HA-HIF1alpha-pcDNA3 Citations (49)

Plasmid Article: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Cancer Cell. 2002 Apr . 1(3):237-46.
PubMed Journal

Articles Citing HA-HIF1alpha-pcDNA3

c-Jun protects hypoxia-inducible factor-1alpha from degradation via its oxygen-dependent degradation domain in a nontranscriptional manner. Yu B, Miao ZH, Jiang Y, Li MH, Yang N, Li T, Ding J. Cancer Res. 2009 Oct 1;69(19):7704-12. doi: 10.1158/0008-5472.CAN-09-0808. Epub 2009 Sep 8. PubMed
NF-kappaB suppresses HIF-1alpha response by competing for P300 binding. Mendonca DB, Mendonca G, Aragao FJ, Cooper LF. Biochem Biophys Res Commun. 2011 Jan 28;404(4):997-1003. doi: 10.1016/j.bbrc.2010.12.098. Epub 2010 Dec 25. PubMed
Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1alpha. Wu B, Teng H, Yang G, Wu L, Wang R. Br J Pharmacol. 2012 Dec;167(7):1492-505. doi: 10.1111/j.1476-5381.2012.02113.x. PubMed
ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression. Fallone F, Britton S, Nieto L, Salles B, Muller C. Oncogene. 2013 Sep 12;32(37):4387-96. doi: 10.1038/onc.2012.462. Epub 2012 Oct 22. PubMed
Proteostasis modulators prolong missense VHL protein activity and halt tumor progression. Yang C, Huntoon K, Ksendzovsky A, Zhuang Z, Lonser RR. Cell Rep. 2013 Jan 31;3(1):52-9. doi: 10.1016/j.celrep.2012.12.007. Epub 2013 Jan 10. PubMed
Mammalian two-hybrid assays for studies of interaction of p300 with transcription factors. Mendonca DB, Mendonca G, Cooper LF. Methods Mol Biol. 2013;977:323-38. doi: 10.1007/978-1-62703-284-1_26. PubMed
HIF-1alpha stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma. Samarajeewa NU, Yang F, Docanto MM, Sakurai M, McNamara KM, Sasano H, Fox SB, Simpson ER, Brown KA. Breast Cancer Res. 2013 Apr 8;15(2):R30. doi: 10.1186/bcr3410. PubMed
Hypoxia-inducible factor-1alpha (HIF-1alpha) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. Yi T, Papadopoulos E, Hagner PR, Wagner G. J Biol Chem. 2013 Jun 28;288(26):18732-42. doi: 10.1074/jbc.M113.471466. Epub 2013 May 10. PubMed
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. David JM, Owens TA, Barwe SP, Rajasekaran AK. Mol Cancer Ther. 2013 Nov;12(11):2296-307. doi: 10.1158/1535-7163.MCT-13-0445. Epub 2013 Sep 4. PubMed
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Roy A, Zhang M, Saad Y, Kolattukudy PE. Am J Physiol Cell Physiol. 2013 Nov 15;305(10):C1021-32. doi: 10.1152/ajpcell.00203.2013. Epub 2013 Sep 18. PubMed
Paradoxical regulation of hypoxia inducible factor-1alpha (HIF-1alpha) by histone deacetylase inhibitor in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. PLoS One. 2013 Nov 27;8(11):e81333. doi: 10.1371/journal.pone.0081333. eCollection 2013. PubMed
HAF drives the switch of HIF-1alpha to HIF-2alpha by activating the NF-kappaB pathway, leading to malignant behavior of T24 bladder cancer cells. Guan Z, Ding C, Du Y, Zhang K, Zhu JN, Zhang T, He D, Xu S, Wang X, Fan J. Int J Oncol. 2014 Feb;44(2):393-402. doi: 10.3892/ijo.2013.2210. Epub 2013 Dec 6. PubMed
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2alpha at the CYP51 promoter. Zhu J, Jiang X, Chehab FF. J Lipid Res. 2014 Mar;55(3):431-42. doi: 10.1194/jlr.M043521. Epub 2013 Dec 18. PubMed
Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. David JM, Owens TA, Inge LJ, Bremner RM, Rajasekaran AK. Mol Cancer Ther. 2014 Apr;13(4):788-99. doi: 10.1158/1535-7163.MCT-13-0891. Epub 2014 Feb 3. PubMed
HIF-1alpha downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic mammalian orthoreovirus. Gupta-Saraf P, Miller CL. Oncotarget. 2014 Jan 30;5(2):561-74. PubMed
SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation. Seo KS, Park JH, Heo JY, Jing K, Han J, Min KN, Kim C, Koh GY, Lim K, Kang GY, Uee Lee J, Yim YH, Shong M, Kwak TH, Kweon GR. Oncogene. 2015 Mar 12;34(11):1354-62. doi: 10.1038/onc.2014.76. Epub 2014 Mar 31. PubMed
Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland. Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, Elenius K. J Biol Chem. 2014 Aug 8;289(32):22459-69. doi: 10.1074/jbc.M113.533497. Epub 2014 Jun 25. PubMed
Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. Imagawa K, de Andres MC, Hashimoto K, Itoi E, Otero M, Roach HI, Goldring MB, Oreffo RO. Arthritis Rheumatol. 2014 Nov;66(11):3040-51. doi: 10.1002/art.38774. PubMed
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. Qi L, Zhu F, Li SH, Si LB, Hu LK, Tian H. PLoS One. 2014 Aug 27;9(8):e106032. doi: 10.1371/journal.pone.0106032. eCollection 2014. PubMed
Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia. Clarke RH, Moosa S, Anzivino M, Wang Y, Floyd DH, Purow BW, Lee KS. PLoS One. 2014 Oct 28;9(10):e111199. doi: 10.1371/journal.pone.0111199. eCollection 2014. PubMed
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1alpha by inhibiting prolyl-4-hydroxylase PHD2. Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q. PLoS One. 2014 Nov 24;9(11):e113865. doi: 10.1371/journal.pone.0113865. eCollection 2014. PubMed
MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1alpha. Xu H, Zhao L, Fang Q, Sun J, Zhang S, Zhan C, Liu S, Zhang Y. PLoS One. 2014 Dec 22;9(12):e115565. doi: 10.1371/journal.pone.0115565. eCollection 2014. PubMed
Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor. Liu Y, Chen C, Qian P, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T, Zhao Y. Nat Commun. 2015 Jan 23;6:5988. doi: 10.1038/ncomms6988. PubMed
Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine. Takarada T, Ogura M, Nakamichi N, Kakuda T, Nakazato R, Kokubo H, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y. Neurochem Res. 2015 May 10. PubMed
Estrogen Receptor beta2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1alpha in Prostate Cancer. Dey P, Velazquez-Villegas LA, Faria M, Turner A, Jonsson P, Webb P, Williams C, Gustafsson JA, Strom AM. PLoS One. 2015 May 26;10(5):e0128239. doi: 10.1371/journal.pone.0128239. eCollection 2015. PubMed
HIF1alpha-Induced by Lysophosphatidic Acid Is Stabilized via Interaction with MIF and CSN5. No YR, Lee SJ, Kumar A, Yun CC. PLoS One. 2015 Sep 9;10(9):e0137513. doi: 10.1371/journal.pone.0137513. eCollection 2015. PubMed
A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Erapaneedi R, Belousov VV, Schafers M, Kiefer F. EMBO J. 2016 Jan 4;35(1):102-13. doi: 10.15252/embj.201592775. Epub 2015 Nov 23. PubMed
PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation. Azoitei N, Becher A, Steinestel K, Rouhi A, Diepold K, Genze F, Simmet T, Seufferlein T. Mol Cancer. 2016 Jan 6;15(1):3. doi: 10.1186/s12943-015-0490-2. PubMed
Protective upregulation of activating transcription factor-3 against glutamate neurotoxicity in neuronal cells under ischemia. Takarada T, Kou M, Hida M, Fukumori R, Nakamura S, Kutsukake T, Kuramoto N, Hinoi E, Yoneda Y. J Neurosci Res. 2016 May;94(5):378-88. doi: 10.1002/jnr.23723. Epub 2016 Feb 22. PubMed
The ETS Factor Myeloid Elf-1-Like Factor (MEF)/Elf4 Is Transcriptionally and Functionally Activated by Hypoxia. Suico MA, Taura M, Kudo E, Gotoh K, Shuto T, Okada S, Kai H. Biol Pharm Bull. 2016;39(4):641-7. doi: 10.1248/bpb.b15-00796. PubMed
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis. Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M. Neoplasia. 2016 Apr;18(4):242-52. doi: 10.1016/j.neo.2016.03.001. PubMed
A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1alpha. Wang F, Zhang H, Xu N, Huang N, Tian C, Ye A, Hu G, He J, Zhang Y. Cancer Biol Ther. 2016 Jun 3:1-9. PubMed
FGF11 induced by hypoxia interacts with HIF-1alpha and enhances its stability. Lee KW, Yim HS, Shin J, Lee C, Lee JH, Jeong JY. FEBS Lett. 2016 Dec 27. doi: 10.1002/1873-3468.12547. PubMed
Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Sperling S, Aung T, Martin S, Rohde V, Ninkovic M. Oncotarget. 2017 May 20. doi: 10.18632/oncotarget.18043. PubMed
XIAP upregulates expression of HIF target genes by targeting HIF1alpha for Lys63-linked polyubiquitination. Park CV, Ivanova IG, Kenneth NS. Nucleic Acids Res. 2017 Jun 28. doi: 10.1093/nar/gkx549. PubMed
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1. Rosner M, Pham HTT, Moriggl R, Hengstschlager M. Nat Commun. 2017 Sep 19;8(1):595. doi: 10.1038/s41467-017-00661-x. PubMed
YBX1 promotes tumor growth by elevating glycolysis in human bladder cancer. Xu L, Li H, Wu L, Huang S. Oncotarget. 2017 Jul 26;8(39):65946-65956. doi: 10.18632/oncotarget.19583. eCollection 2017 Sep 12. PubMed
Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1alpha in human colon cancer cells. Jeon D, Park HJ, Kim HS. Biochem Biophys Res Commun. 2018 Jan 1;495(1):212-216. doi: 10.1016/j.bbrc.2017.11.018. Epub 2017 Nov 4. PubMed
Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells. Sperling S, Aung T, Martin S, Rohde V, Ninkovic M. Oncotarget. 2017 May 20;8(57):96697-96709. doi: 10.18632/oncotarget.18043. eCollection 2017 Nov 14. PubMed
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Senavirathna LK, Huang C, Yang X, Munteanu MC, Sathiaseelan R, Xu D, Henke CA, Liu L. Sci Rep. 2018 Feb 9;8(1):2709. doi: 10.1038/s41598-018-21073-x. PubMed
Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress. Field JT, Martens MD, Mughal W, Hai Y, Chapman D, Hatch GM, Ivanco TL, Diehl-Jones W, Gordon JW. Cell Death Discov. 2018 Sep 21;4:37. doi: 10.1038/s41420-018-0104-z. eCollection 2018. PubMed
Brain injury induces HIF-1alpha-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Bae YH, Joo H, Bae J, Hyeon SJ, Her S, Ko E, Choi HG, Ryu H, Hur EM, Bu Y, Lee BD. Cell Death Dis. 2018 Nov 12;9(11):1125. doi: 10.1038/s41419-018-1180-y. PubMed
Cellular density-dependent increases in HIF-1alpha compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, Mashimo M, Nakamura H, Regan JW, Murayama T, Fujino H. Pharmacol Res Perspect. 2018 Nov 11;6(6):e00441. doi: 10.1002/prp2.441. eCollection 2018 Dec. PubMed
The estrogen receptor variants beta2 and beta5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling. Faria M, Shepherd P, Pan Y, Chatterjee SS, Navone N, Gustafsson JA, Strom A. Oncotarget. 2018 Nov 20;9(91):36273-36288. doi: 10.18632/oncotarget.26345. eCollection 2018 Nov 20. PubMed
Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. Fonseca J, Moradi F, Maddalena LA, Ferreira-Tollstadius B, Selim S, Stuart JA. Oncol Lett. 2019 Jan;17(1):697-705. doi: 10.3892/ol.2018.9526. Epub 2018 Sep 28. PubMed
The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism. Soyal SM, Bonova P, Kwik M, Zara G, Auer S, Scharler C, Strunk D, Nofziger C, Paulmichl M, Patsch W. Mol Neurobiol. 2019 Aug 30. pii: 10.1007/s12035-019-01731-5. doi: 10.1007/s12035-019-01731-5. PubMed
Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes. Khan H, Anshu A, Prasad A, Roy S, Jeffery J, Kittipongdaja W, Yang DT, Schieke SM. Cell Rep. 2019 Dec 3;29(10):3009-3018.e4. doi: 10.1016/j.celrep.2019.11.007. PubMed
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, Lee CW, Kang JS, Kim YH, Lee J, Choi J, Hwang GS, Bang S, Han JM. Cell Metab. 2020 Feb 4;31(2):267-283.e12. doi: 10.1016/j.cmet.2019.11.020. Epub 2019 Dec 19. PubMed
Ginsenoside 20(S)-Rg3 upregulates HIF-1alpha-targeting miR-519a-5p to inhibit the Warburg effect in ovarian cancer cells. Lu J, Chen H, He F, You Y, Feng Z, Chen W, Li X, Zhao L. Clin Exp Pharmacol Physiol. 2020 Aug;47(8):1455-1463. doi: 10.1111/1440-1681.13321. Epub 2020 May 4. PubMed

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