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pCBASceI Citations (114)

Plasmid Article: Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations.
Richardson C, Moynahan ME, Jasin M Genes Dev. 1998 Dec 15. 12(24):3831-42.
PubMed Journal

Articles Citing pCBASceI

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Serrano MA, Li Z, Dangeti M, Musich PR, Patrick S, Roginskaya M, Cartwright B, Zou Y. Oncogene. 2013 May 9;32(19):2452-62. doi: 10.1038/onc.2012.257. Epub 2012 Jul 16. PubMed
Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. Lin ZP, Ratner ES, Whicker ME, Lee Y, Sartorelli AC. Mol Cancer Res. 2014 Mar;12(3):381-93. doi: 10.1158/1541-7786.MCR-13-0480. Epub 2014 Jan 10. PubMed
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Carvalho S, Vitor AC, Sridhara SC, Martins FB, Raposo AC, Desterro JM, Ferreira J, de Almeida SF. Elife. 2014 May 6;3:e02482. doi: 10.7554/eLife.02482. PubMed

Associated Plasmids

Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases. Vriend LE, Jasin M, Krawczyk PM. Methods Enzymol. 2014;546:175-91. doi: 10.1016/B978-0-12-801185-0.00009-X. PubMed
Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining. Jessulat M, Malty RH, Nguyen-Tran DH, Deineko V, Aoki H, Vlasblom J, Omidi K, Jin K, Minic Z, Hooshyar M, Burnside D, Samanfar B, Phanse S, Freywald T, Prasad B, Zhang Z, Vizeacoumar F, Krogan NJ, Freywald A, Golshani A, Babu M. Mol Cell Biol. 2015 Jul 15;35(14):2448-63. doi: 10.1128/MCB.00007-15. Epub 2015 May 11. PubMed
The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair. Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P. Acta Biochim Biophys Sin (Shanghai). 2015 Oct;47(10):834-41. doi: 10.1093/abbs/gmv076. Epub 2015 Aug 18. PubMed
ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Lee SS, Bohrson C, Pike AM, Wheelan SJ, Greider CW. Cell Rep. 2015 Nov 24;13(8):1623-32. doi: 10.1016/j.celrep.2015.10.035. Epub 2015 Nov 12. PubMed
Inhibition of KDM6 activity during murine ESC differentiation induces DNA damage. Hofstetter C, Kampka JM, Huppertz S, Weber H, Schlosser A, Muller AM, Becker M. J Cell Sci. 2016 Feb 15;129(4):788-803. doi: 10.1242/jcs.175174. Epub 2016 Jan 12. PubMed
HELB Is a Feedback Inhibitor of DNA End Resection. Tkac J, Xu G, Adhikary H, Young JT, Gallo D, Escribano-Diaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, Gingras AC, Rottenberg S, Masson JY, Durocher D. Mol Cell. 2016 Feb 4;61(3):405-18. doi: 10.1016/j.molcel.2015.12.013. Epub 2016 Jan 7. PubMed
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance. Krumm A, Barckhausen C, Kucuk P, Tomaszowski KH, Loquai C, Fahrer J, Kramer OH, Kaina B, Roos WP. Cancer Res. 2016 May 15;76(10):3067-77. doi: 10.1158/0008-5472.CAN-15-2680. Epub 2016 Mar 15. PubMed
Histone deacetylase inhibitors decrease NHEJ both by acetylation of repair factors and trapping of PARP1 at DNA double-strand breaks in chromatin. Robert C, Nagaria PK, Pawar N, Adewuyi A, Gojo I, Meyers DJ, Cole PA, Rassool FV. Leuk Res. 2016 Jun;45:14-23. doi: 10.1016/j.leukres.2016.03.007. Epub 2016 Mar 30. PubMed
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. Autophagy. 2016 Oct 2;12(10):1917-1930. Epub 2016 Jul 8. PubMed
Cyclin A2 promotes DNA repair in the brain during both development and aging. Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, Goksel M, Baig FS, Chen S, Griveau A, Michowski W, Wong M, Palanichamy K, Sicinski P, Nelson RJ, Czeisler C, Otero JJ. Aging (Albany NY). 2016 Jul;8(7):1540-70. doi: 10.18632/aging.100990. PubMed
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib. Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D. Gynecol Oncol. 2016 Oct;143(1):143-51. doi: 10.1016/j.ygyno.2016.07.088. Epub 2016 Jul 19. PubMed
CDK1 phosphorylates WRN at collapsed replication forks. Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers JA, Brosh RM Jr, Zolla L, Franchitto A, Pichierri P. Nat Commun. 2016 Sep 16;7:12880. doi: 10.1038/ncomms12880. PubMed
CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Narayanaswamy PB, Tkachuk S, Haller H, Dumler I, Kiyan Y. Cell Death Dis. 2016 Sep 29;7(9):e2383. doi: 10.1038/cddis.2016.291. PubMed
Assessing the Effect of Class I Histone Deacetylase Activity on DNA Double-Strand Break Repair by Homologous Recombination. Krumm A, Roos WP. Methods Mol Biol. 2017;1510:115-123. PubMed
FLT3 and JAK2 Mutations in Acute Myeloid Leukemia Promote Interchromosomal Homologous Recombination and the Potential for Copy Neutral Loss of Heterozygosity. Gaymes TJ, Mohamedali A, Eiliazadeh AL, Darling D, Mufti GJ. Cancer Res. 2017 Apr 1;77(7):1697-1708. doi: 10.1158/0008-5472.CAN-16-1678. Epub 2017 Jan 20. PubMed
TOPBP1(Dpb11) plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1(Rad9). Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB. J Cell Biol. 2017 Mar 6;216(3):623-639. doi: 10.1083/jcb.201607031. Epub 2017 Feb 22. PubMed
Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair. Duheron V, Nilles N, Pecenko S, Martinelli V, Fahrenkrog B. J Cell Sci. 2017 Jul 15;130(14):2306-2316. doi: 10.1242/jcs.198390. Epub 2017 Jun 2. PubMed
High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway. Wallace NA, Khanal S, Robinson KL, Wendel SO, Messer JJ, Galloway DA. J Virol. 2017 Sep 27;91(20). pii: JVI.01084-17. doi: 10.1128/JVI.01084-17. Print 2017 Oct 15. PubMed
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. Chen G, Zhang B, Xu H, Sun Y, Shi Y, Luo Y, Jia H, Wang F. Oncogene. 2017 Dec 14;36(50):6863-6872. doi: 10.1038/onc.2017.297. Epub 2017 Sep 4. PubMed
ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks. Lee KY, Im JS, Shibata E, Dutta A. Mol Cell. 2017 Oct 5;68(1):61-75.e5. doi: 10.1016/j.molcel.2017.08.021. Epub 2017 Sep 21. PubMed
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023. PubMed

Associated Plasmids

The role of Rak in the regulation of stability and function of BRCA1. Kim JL, Ha GH, Campo L, Denning MF, Patel TB, Osipo C, Lin SY, Breuer EK. Oncotarget. 2015 Oct 14;8(49):86799-86815. doi: 10.18632/oncotarget.5717. eCollection 2017 Oct 17. PubMed
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. PubMed
Negative regulation of BRCA1 by transforming acidic coiled-coil protein 3 (TACC3). Kim JL, Ha GH, Campo L, Breuer EK. Biochem Biophys Res Commun. 2018 Feb 5;496(2):633-640. doi: 10.1016/j.bbrc.2018.01.101. Epub 2018 Jan 19. PubMed
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. Cancer Cell. 2018 Mar 12;33(3):401-416.e8. doi: 10.1016/j.ccell.2018.01.019. PubMed
The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D. Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20. PubMed
Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Cell Death Dis. 2018 May 1;9(5):543. doi: 10.1038/s41419-018-0575-0. PubMed
Targeting p38alpha Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells. Canovas B, Igea A, Sartori AA, Gomis RR, Paull TT, Isoda M, Perez-Montoyo H, Serra V, Gonzalez-Suarez E, Stracker TH, Nebreda AR. Cancer Cell. 2018 Jun 11;33(6):1094-1110.e8. doi: 10.1016/j.ccell.2018.04.010. Epub 2018 May 24. PubMed
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs. Okonkwo A, Mitra J, Johnson GS, Li L, Dashwood WM, Hegde ML, Yue C, Dashwood RH, Rajendran P. Mol Nutr Food Res. 2018 Sep;62(18):e1800228. doi: 10.1002/mnfr.201800228. Epub 2018 Jul 19. PubMed
Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy. Murthy V, Dacus D, Gamez M, Hu C, Wendel SO, Snow J, Kahn A, Walterhouse SH, Wallace NA. J Vis Exp. 2018 Jun 8;(136). doi: 10.3791/57653. PubMed
ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells. Kim D, Liu Y, Oberly S, Freire R, Smolka MB. Nucleic Acids Res. 2018 Sep 19;46(16):8311-8325. doi: 10.1093/nar/gky625. PubMed
FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange. Benitez A, Liu W, Palovcak A, Wang G, Moon J, An K, Kim A, Zheng K, Zhang Y, Bai F, Mazin AV, Pei XH, Yuan F, Zhang Y. Mol Cell. 2018 Aug 16;71(4):621-628.e4. doi: 10.1016/j.molcel.2018.06.030. Epub 2018 Jul 26. PubMed
Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate-resistant colon cancer cells. Cai M, Zhang H, Hou L, Gao W, Song Y, Cui X, Li C, Guan R, Ma J, Wang X, Han Y, Lv Y, Chen F, Wang P, Meng X, Fu S. Int J Cancer. 2019 Mar 1;144(5):1037-1048. doi: 10.1002/ijc.31781. Epub 2018 Sep 29. PubMed
Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Cancers (Basel). 2018 Sep 10;10(9). pii: cancers10090320. doi: 10.3390/cancers10090320. PubMed
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome. Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H. J Clin Invest. 2019 Jan 2;129(1):78-92. doi: 10.1172/JCI99751. Epub 2018 Nov 19. PubMed
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress. Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D'Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA. Mol Cell. 2018 Nov 1;72(3):568-582.e6. doi: 10.1016/j.molcel.2018.09.014. Epub 2018 Oct 18. PubMed
PARP Inhibition Induces Enrichment of DNA Repair-Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells. Bellio C, DiGloria C, Foster R, James K, Konstantinopoulos PA, Growdon WB, Rueda BR. Mol Cancer Res. 2019 Feb;17(2):431-445. doi: 10.1158/1541-7786.MCR-18-0594. Epub 2018 Nov 6. PubMed
Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration. Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB. Viruses. 2018 Nov 21;10(11). pii: v10110656. doi: 10.3390/v10110656. PubMed
NF-kappaB and Poly (ADP-ribose) Polymerase 1 Form a Positive Feedback Loop that Regulates DNA Repair in Acute Myeloid Leukemia Cells. Li D, Luo Y, Chen X, Zhang L, Wang T, Zhuang Y, Fan Y, Xu J, Chen Y, Wu L. Mol Cancer Res. 2019 Mar;17(3):761-772. doi: 10.1158/1541-7786.MCR-18-0523. Epub 2018 Dec 17. PubMed
FKBP25 participates in DNA double-strand break repair. Dilworth D, Gong F, Miller KM, Nelson CJ. Biochem Cell Biol. 2019 Jan 8. doi: 10.1139/bcb-2018-0328. PubMed
Autophagic cell death restricts chromosomal instability during replicative crisis. Nassour J, Radford R, Correia A, Fuste JM, Schoell B, Jauch A, Shaw RJ, Karlseder J. Nature. 2019 Jan;565(7741):659-663. doi: 10.1038/s41586-019-0885-0. Epub 2019 Jan 23. PubMed
Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression. Chou FJ, Chen Y, Chen D, Niu Y, Li G, Keng P, Yeh S, Chang C. EBioMedicine. 2019 Feb;40:504-516. doi: 10.1016/j.ebiom.2018.12.050. Epub 2019 Jan 26. PubMed
E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. So CC, Ramachandran S, Martin A. Mol Cell Biol. 2019 Apr 2;39(8). pii: MCB.00488-18. doi: 10.1128/MCB.00488-18. Print 2019 Apr 15. PubMed
The Role of Marek's Disease Virus UL12 and UL29 in DNA Recombination and the Virus Lifecycle. Previdelli RL, Bertzbach LD, Wight DJ, Vychodil T, You Y, Arndt S, Kaufer BB. Viruses. 2019 Jan 28;11(2). pii: v11020111. doi: 10.3390/v11020111. PubMed
Excess growth hormone suppresses DNA damage repair in epithelial cells. Chesnokova V, Zonis S, Barrett R, Kameda H, Wawrowsky K, Ben-Shlomo A, Yamamoto M, Gleeson J, Bresee C, Gorbunova V, Melmed S. JCI Insight. 2019 Feb 7;4(3). pii: 125762. doi: 10.1172/jci.insight.125762. PubMed
Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Alfano L, Caporaso A, Altieri A, Dell'Aquila M, Landi C, Bini L, Pentimalli F, Giordano A. Nucleic Acids Res. 2019 May 7;47(8):4068-4085. doi: 10.1093/nar/gkz076. PubMed
High-risk human papillomavirus oncogenes disrupt the Fanconi anemia DNA repair pathway by impairing localization and de-ubiquitination of FancD2. Khanal S, Galloway DA. PLoS Pathog. 2019 Feb 28;15(2):e1007442. doi: 10.1371/journal.ppat.1007442. eCollection 2019 Feb. PubMed
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. Yin QK, Wang CX, Wang YQ, Guo QL, Zhang ZL, Ou TM, Huang SL, Li D, Wang HG, Tan JH, Chen SB, Huang ZS. J Med Chem. 2019 Mar 28;62(6):3147-3162. doi: 10.1021/acs.jmedchem.9b00083. Epub 2019 Mar 14. PubMed
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination. Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA. DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23. PubMed
Edition of TFAM gene by CRISPR/Cas9 technology in bovine model. de Oliveira VC, Moreira GSA, Bressan FF, Gomes Mariano Junior C, Roballo KCS, Charpentier M, Concordet JP, Meirelles FV, Ambrosio CE. PLoS One. 2019 Mar 7;14(3):e0213376. doi: 10.1371/journal.pone.0213376. eCollection 2019. PubMed
Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. Pfitzer L, Moser C, Gegenfurtner F, Arner A, Foerster F, Atzberger C, Zisis T, Kubisch-Dohmen R, Busse J, Smith R, Timinszky G, Kalinina OV, Muller R, Wagner E, Vollmar AM, Zahler S. Cell Death Dis. 2019 Apr 3;10(4):302. doi: 10.1038/s41419-019-1546-9. PubMed
RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci. Michelini F, Rossiello F, d'Adda di Fagagna F, Francia S. Nat Protoc. 2019 May;14(5):1489-1508. doi: 10.1038/s41596-019-0147-5. Epub 2019 Apr 8. PubMed
N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance. Fukumoto T, Zhu H, Nacarelli T, Karakashev S, Fatkhutdinov N, Wu S, Liu P, Kossenkov AV, Showe LC, Jean S, Zhang L, Zhang R. Cancer Res. 2019 Jun 1;79(11):2812-2820. doi: 10.1158/0008-5472.CAN-18-3592. Epub 2019 Apr 9. PubMed
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed
MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer. Lai J, Yang H, Zhu Y, Ruan M, Huang Y, Zhang Q. BMC Cancer. 2019 Jun 18;19(1):602. doi: 10.1186/s12885-019-5798-7. PubMed
Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Mol Carcinog. 2019 Jun 10. doi: 10.1002/mc.23064. PubMed
CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Jayavaradhan R, Pillis DM, Goodman M, Zhang F, Zhang Y, Andreassen PR, Malik P. Nat Commun. 2019 Jun 28;10(1):2866. doi: 10.1038/s41467-019-10735-7. PubMed

Associated Plasmids

Inhibition of CD4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas. Gottgens EL, Bussink J, Leszczynska KB, Peters H, Span PN, Hammond EM. Int J Radiat Oncol Biol Phys. 2019 Jul 2. pii: S0360-3016(19)33419-4. doi: 10.1016/j.ijrobp.2019.06.2531. PubMed
RIF1 promotes replication fork protection and efficient restart to maintain genome stability. Mukherjee C, Tripathi V, Manolika EM, Heijink AM, Ricci G, Merzouk S, de Boer HR, Demmers J, van Vugt MATM, Ray Chaudhuri A. Nat Commun. 2019 Jul 23;10(1):3287. doi: 10.1038/s41467-019-11246-1. PubMed
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS. Cancer Cell. 2019 Sep 16;36(3):237-249.e6. doi: 10.1016/j.ccell.2019.07.007. Epub 2019 Aug 22. PubMed
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. Jiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO. EMBO J. 2019 Oct 4;38(21):e102718. doi: 10.15252/embj.2019102718. Epub 2019 Sep 23. PubMed
PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Sarraf SA, Sideris DP, Giagtzoglou N, Ni L, Kankel MW, Sen A, Bochicchio LE, Huang CH, Nussenzweig SC, Worley SH, Morton PD, Artavanis-Tsakonas S, Youle RJ, Pickrell AM. Cell Rep. 2019 Oct 1;29(1):225-235.e5. doi: 10.1016/j.celrep.2019.08.085. PubMed
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells. Garcin EB, Gon S, Sullivan MR, Brunette GJ, Cian A, Concordet JP, Giovannangeli C, Dirks WG, Eberth S, Bernstein KA, Prakash R, Jasin M, Modesti M. PLoS Genet. 2019 Oct 4;15(10):e1008355. doi: 10.1371/journal.pgen.1008355. eCollection 2019 Oct. PubMed
Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint. Mak JPY, Ma HT, Poon RYC. Mol Cancer Ther. 2020 Jan;19(1):123-134. doi: 10.1158/1535-7163.MCT-19-0474. Epub 2019 Oct 9. PubMed
ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. Kanakkanthara A, Huntoon CJ, Hou X, Zhang M, Heinzen EP, O'Brien DR, Oberg AL, John Weroha S, Kaufmann SH, Karnitz LM. Nat Commun. 2019 Oct 11;10(1):4632. doi: 10.1038/s41467-019-12610-x. PubMed
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A. Mol Cell. 2020 Jan 2;77(1):26-38.e7. doi: 10.1016/j.molcel.2019.09.024. Epub 2019 Oct 22. PubMed
PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination. Attwood KM, Salsman J, Chung D, Mathavarajah S, Van Iderstine C, Dellaire G. Biochem Cell Biol. 2019 Oct 31. doi: 10.1139/bcb-2019-0115. PubMed
Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K, Bitler BG. Clin Epigenetics. 2019 Nov 27;11(1):165. doi: 10.1186/s13148-019-0758-2. PubMed
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed
Olaparib and enzalutamide synergistically suppress HCC progression via the AR-mediated miR-146a-5p/BRCA1 signaling. Zhao J, Sun Y, Lin H, Chou F, Xiao Y, Jin R, Cai X, Chang C. FASEB J. 2020 Apr;34(4):5877-5891. doi: 10.1096/fj.201903045RR. Epub 2020 Mar 5. PubMed
Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, Clark DJ, Yang A, Hussain A, Rassool F, Qi J. Cell Death Dis. 2020 Apr 1;11(4):214. doi: 10.1038/s41419-020-2405-4. PubMed
High-throughput functional evaluation of BRCA2 variants of unknown significance. Ikegami M, Kohsaka S, Ueno T, Momozawa Y, Inoue S, Tamura K, Shimomura A, Hosoya N, Kobayashi H, Tanaka S, Mano H. Nat Commun. 2020 May 22;11(1):2573. doi: 10.1038/s41467-020-16141-8. PubMed
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