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pcDNA3.1-2xFLAG-SREBP-2 Citations (18)

Originally described in: Selective coactivator interactions in gene activation by SREBP-1a and -1c.
Toth JI, Datta S, Athanikar JN, Freedman LP, Osborne TF Mol Cell Biol. 2004 Sep . 24(18):8288-300.
PubMed Journal

Articles Citing pcDNA3.1-2xFLAG-SREBP-2

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation. Cermenati G, Abbiati F, Cermenati S, Brioschi E, Volonterio A, Cavaletti G, Saez E, De Fabiani E, Crestani M, Garcia-Segura LM, Melcangi RC, Caruso D, Mitro N. J Lipid Res. 2012 Feb;53(2):300-10. doi: 10.1194/jlr.M021188. Epub 2011 Dec 7. PubMed
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver. Liu S, Jing F, Yu C, Gao L, Qin Y, Zhao J. PLoS One. 2015 May 1;10(5):e0124951. doi: 10.1371/journal.pone.0124951. eCollection 2015. PubMed
Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). Madsen A, Bozickovic O, Bjune JI, Mellgren G, Sagen JV. Sci Rep. 2015 Nov 9;5:16430. doi: 10.1038/srep16430. PubMed
Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice. Ziros P, Zagoriti Z, Lagoumintzis G, Kyriazopoulou V, Iskrenova RP, Habeos EI, Sykiotis GP, Chartoumpekis DV, Habeos IG. PLoS One. 2016 Sep 1;11(9):e0162024. doi: 10.1371/journal.pone.0162024. eCollection 2016. PubMed
Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. Zheng ZG, Zhou YP, Zhang X, Thu PM, Xie ZS, Lu C, Pang T, Xue B, Xu DQ, Chen Y, Chen XW, Li HJ, Xu X. Biochem Pharmacol. 2016 Dec 15;122:42-61. doi: 10.1016/j.bcp.2016.10.016. Epub 2016 Nov 2. PubMed
SREBP-2-driven transcriptional activation of human SND1 oncogene. Armengol S, Arretxe E, Enzunza L, Llorente I, Mendibil U, Navarro-Imaz H, Ochoa B, Chico Y, Martinez MJ. Oncotarget. 2017 Nov 21;8(64):108181-108194. doi: 10.18632/oncotarget.22569. eCollection 2017 Dec 8. PubMed
MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent. Bjune K, Sundvold H, Leren TP, Naderi S. Atherosclerosis. 2018 Sep;276:28-38. doi: 10.1016/j.atherosclerosis.2018.07.009. Epub 2018 Jul 7. PubMed
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target. Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x. PubMed
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP. Romani P, Brian I, Santinon G, Pocaterra A, Audano M, Pedretti S, Mathieu S, Forcato M, Bicciato S, Manneville JB, Mitro N, Dupont S. Nat Cell Biol. 2019 Mar;21(3):338-347. doi: 10.1038/s41556-018-0270-5. Epub 2019 Feb 4. PubMed

Associated Plasmids

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair. Kusnadi A, Park SH, Yuan R, Pannellini T, Giannopoulou E, Oliver D, Lu T, Park-Min KH, Ivashkiv LB. Immunity. 2019 Aug 20;51(2):241-257.e9. doi: 10.1016/j.immuni.2019.06.005. Epub 2019 Jul 11. PubMed
RORgamma is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, Lam KS, To KF, Kung HJ, Fiehn O, Zhao R, Evans RM, Chen HW. Nat Commun. 2019 Oct 11;10(1):4621. doi: 10.1038/s41467-019-12529-3. PubMed
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. Shen H, Li J, Xie X, Yang H, Zhang M, Wang B, Kent KC, Plutzky J, Guo LW. Life Sci Alliance. 2020 Nov 24;4(1). pii: 4/1/e201900540. doi: 10.26508/lsa.201900540. Print 2021 Jan. PubMed
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Nat Commun. 2021 May 21;12(1):3005. doi: 10.1038/s41467-021-22782-0. PubMed
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC. J Cell Biol. 2021 Sep 6;220(9). pii: 212536. doi: 10.1083/jcb.201910213. Epub 2021 Aug 4. PubMed
MMAB promotes negative feedback control of cholesterol homeostasis. Goedeke L, Canfran-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasuncion MA, Suarez Y, Fernandez-Hernando C. Nat Commun. 2021 Nov 8;12(1):6448. doi: 10.1038/s41467-021-26787-7. PubMed
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. Tang W, Thundyil J, Lim GGY, Tng TJW, Yeow SQZ, Nair A, Chai C, Yao TP, Lim KL. Hum Mol Genet. 2023 Apr 20;32(9):1466-1482. doi: 10.1093/hmg/ddac297. PubMed
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Belmonte JCI, Zhang W, Qu J, Liu GH. Protein Cell. 2024 Feb 1;15(2):98-120. doi: 10.1093/procel/pwad039. PubMed
Carbon dioxide regulates cholesterol levels through SREBP2. Bolshette N, Ezagouri S, Dandavate V, Karavaeva I, Golik M, Wang H, Espenshade PJ, Osborne TF, Han X, Asher G. PLoS Biol. 2023 Nov 15;21(11):e3002367. doi: 10.1371/journal.pbio.3002367. eCollection 2023 Nov. PubMed

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