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pEGFP-Q23 Citations (19)

Originally described in: A molecular investigation of true dominance in Huntington's disease.
Narain Y, Wyttenbach A, Rankin J, Furlong RA, Rubinsztein DC J Med Genet. 1999 Oct;36(10):739-46.
PubMed Journal

Articles Citing pEGFP-Q23

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. Guedes-Dias P, de Proenca J, Soares TR, Leitao-Rocha A, Pinho BR, Duchen MR, Oliveira JM. Biochim Biophys Acta. 2015 Nov;1852(11):2484-93. doi: 10.1016/j.bbadis.2015.08.012. Epub 2015 Aug 21. PubMed
The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. Santarriaga S, Petersen A, Ndukwe K, Brandt A, Gerges N, Bruns Scaglione J, Scaglione KM. J Biol Chem. 2015 Oct 16;290(42):25571-8. doi: 10.1074/jbc.M115.676247. Epub 2015 Sep 1. PubMed
A Method for the Acute and Rapid Degradation of Endogenous Proteins. Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M. Cell. 2017 Nov 13. pii: S0092-8674(17)31255-2. doi: 10.1016/j.cell.2017.10.033. PubMed

Associated Plasmids

Inhibition of PIP4Kgamma ameliorates the pathological effects of mutant huntingtin protein. Al-Ramahi I, Panapakkam Giridharan SS, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ. Elife. 2017 Dec 26;6. pii: 29123. doi: 10.7554/eLife.29123. PubMed
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, Davidson BL, Yang XW, Yoo AS. Nat Neurosci. 2018 Mar;21(3):341-352. doi: 10.1038/s41593-018-0075-7. Epub 2018 Feb 5. PubMed
A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit. Zeng Y, Jones AM, Thomas EE, Nassif B, Silberg JJ, Segatori L. ACS Synth Biol. 2018 Sep 21;7(9):2126-2138. doi: 10.1021/acssynbio.8b00129. Epub 2018 Aug 23. PubMed
Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. Chen JY, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, Chen KY, Liu AYC. J Biol Chem. 2018 Oct 5;293(40):15581-15593. doi: 10.1074/jbc.RA118.002933. Epub 2018 Aug 24. PubMed
GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Chang CC, Lin TC, Ho HL, Kuo CY, Li HH, Korolenko TA, Chen WJ, Lai TJ, Ho YJ, Lin CL. Int J Mol Sci. 2018 Aug 24;19(9). pii: ijms19092505. doi: 10.3390/ijms19092505. PubMed
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA. Free Radic Biol Med. 2019 Jan;130:318-327. doi: 10.1016/j.freeradbiomed.2018.10.446. Epub 2018 Oct 31. PubMed
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity. Echeverria PC, Bhattacharya K, Joshi A, Wang T, Picard D. PLoS One. 2019 Feb 6;14(2):e0208287. doi: 10.1371/journal.pone.0208287. eCollection 2019. PubMed
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. Glaser T, Shimojo H, Ribeiro DE, Martins PPL, Beco RP, Kosinski M, Sampaio VFA, Correa-Velloso J, Oliveira-Giacomelli A, Lameu C, de Jesus Santos AP, de Souza HDN, Teng YD, Kageyama R, Ulrich H. Mol Psychiatry. 2020 Apr 29. pii: 10.1038/s41380-020-0717-5. doi: 10.1038/s41380-020-0717-5. PubMed
Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models. Aravindan S, Chen S, Choudhry H, Molfetta C, Chen KY, Liu AYC. Sci Rep. 2020 Sep 23;10(1):15511. doi: 10.1038/s41598-020-72613-3. PubMed
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Sarraf SA, Shah HV, Kanfer G, Pickrell AM, Holtzclaw LA, Ward ME, Youle RJ. Mol Cell. 2020 Dec 3;80(5):779-795.e10. doi: 10.1016/j.molcel.2020.10.041. Epub 2020 Nov 17. PubMed
Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology. Kim Guisbert KS, Mossiah I, Guisbert E. Int J Mol Sci. 2020 Dec 17;21(24). pii: ijms21249641. doi: 10.3390/ijms21249641. PubMed
Random Lasing Detection of Mutant Huntingtin Expression in Cells. de Armas-Rillo S, Fumagallo-Reading F, Luis-Ravelo D, Abdul-Jalbar B, Gonzalez-Hernandez T, Lahoz F. Sensors (Basel). 2021 May 31;21(11). pii: s21113825. doi: 10.3390/s21113825. PubMed
Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease. Palminha NM, Dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El-Khamisy SF. Cell Mol Life Sci. 2022 Feb 28;79(3):160. doi: 10.1007/s00018-022-04204-6. PubMed
Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation. Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, Wakabayashi K, Yamada M, Kakita A, Shibata N. Neuropathology. 2022 Jun 14. doi: 10.1111/neup.12840. PubMed
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, Nesvizhskii AI, Paulson HL, Wang Y. J Biol Chem. 2022 Aug;298(8):102219. doi: 10.1016/j.jbc.2022.102219. Epub 2022 Jul 1. PubMed
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Mansky RH, Greguske EA, Yu D, Zarate N, Intihar TA, Tsai W, Brown TG, Thayer MN, Kumar K, Gomez-Pastor R. Cell Rep. 2023 Mar 28;42(3):112198. doi: 10.1016/j.celrep.2023.112198. Epub 2023 Mar 3. PubMed

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