pLV hU6-sgRNA hUbC-dCas9-KRAB-T2a-GFP Citations (37)
Originally described in: Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements.Thakore PI, D'Ippolito AM, Song L, Safi A, Shivakumar NK, Kabadi AM, Reddy TE, Crawford GE, Gersbach CA Nat Methods. 2015 Dec;12(12):1143-9. doi: 10.1038/nmeth.3630. Epub 2015 Oct 26. PubMed Journal
Articles Citing pLV hU6-sgRNA hUbC-dCas9-KRAB-T2a-GFP
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| Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. Bohnsack JP, Patel VK, Morrow AL. J Pharmacol Exp Ther. 2017 Oct;363(1):1-11. doi: 10.1124/jpet.117.242446. Epub 2017 Aug 10. PubMed |
Genome and epigenome engineering CRISPR toolkit for in vivo modulation of cis-regulatory interactions and gene expression in the chicken embryo.
Williams RM, Senanayake U, Artibani M, Taylor G, Wells D, Ahmed AA, Sauka-Spengler T.
Development. 2018 Feb 23;145(4). pii: dev.160333. doi: 10.1242/dev.160333.
PubMed
Associated Plasmids |
| Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis. Liao C, Hardison RC, Kennett MJ, Carlson BA, Paulson RF, Prabhu KS. Blood. 2018 Jun 7;131(23):2568-2580. doi: 10.1182/blood-2017-08-800607. Epub 2018 Apr 3. PubMed |
| Microfluidic Flow Cell Array for Controlled Cell Deposition in Engineered Musculoskeletal Tissues. Ede D, Davidoff N, Blitch A, Farhang N, Bowles RD. Tissue Eng Part C Methods. 2018 Sep;24(9):546-556. doi: 10.1089/ten.TEC.2018.0184. PubMed |
| Genetic compensation triggered by mutant mRNA degradation. El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Gunther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR. Nature. 2019 Apr;568(7751):193-197. doi: 10.1038/s41586-019-1064-z. Epub 2019 Apr 3. PubMed |
KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control.
Dhaliwal NK, Abatti LE, Mitchell JA.
Genes Dev. 2019 Jun 20. pii: gad.324319.119. doi: 10.1101/gad.324319.119.
PubMed
Associated Plasmids |
| Adipose vascular endothelial growth factor B is a major regulator of energy metabolism. Chen Y, Zhao M, Wang C, Wen H, Zhang Y, Lu M, Adlat S, Zheng T, Zhang M, Li D, Lu X, Guo M, Chen H, Zhang L, Feng X, Zheng Y. J Endocrinol. 2020 Mar;244(3):511-521. doi: 10.1530/JOE-19-0341. PubMed |
| CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons. Esvald EE, Tuvikene J, Sirp A, Patil S, Bramham CR, Timmusk T. J Neurosci. 2020 Feb 12;40(7):1405-1426. doi: 10.1523/JNEUROSCI.0367-19.2019. Epub 2020 Jan 8. PubMed |
| Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. Fassmannova D, Sedlak F, Sedlacek J, Spicka I, Grantz Saskova K. Cancers (Basel). 2020 Apr 25;12(5). pii: cancers12051065. doi: 10.3390/cancers12051065. PubMed |
| Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. Moses C, Hodgetts SI, Nugent F, Ben-Ary G, Park KK, Blancafort P, Harvey AR. Sci Rep. 2020 Jul 9;10(1):11393. doi: 10.1038/s41598-020-68257-y. PubMed |
| The Role of DNA Methylation in Transcriptional Regulation of Pro-Nociceptive Genes in Rat Trigeminal Ganglia. Bai G, Ross H, Zhang Y, Lee K, Ro JY. Epigenet Insights. 2020 Sep 10;13:2516865720938677. doi: 10.1177/2516865720938677. eCollection 2020. PubMed |
| Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. Findakly S, Daggubati V, Garcia G, LaStella SA, Choudhury A, Tran C, Li A, Tong P, Garcia JQ, Puri N, Reiter JF, Xu L, Raleigh DR. J Cell Biol. 2021 Jan 4;220(1). pii: 211576. doi: 10.1083/jcb.202002026. PubMed |
| FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation. Furtado GV, Yang J, Wu D, Papagiannopoulos CI, Terpstra HM, Kuiper EFE, Krauss S, Zhu WG, Kampinga HH, Bergink S. Hum Mol Genet. 2021 May 31;30(11):996-1005. doi: 10.1093/hmg/ddab095. PubMed |
| CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy. Das S, Chadwick BP. Sci Rep. 2021 Jun 15;11(1):12598. doi: 10.1038/s41598-021-92096-0. PubMed |
| Distinct subcellular autophagy impairments in induced neurons from Huntington's disease patients. Pircs K, Drouin-Ouellet J, Horvath V, Gil J, Rezeli M, Garza R, Grassi DA, Sharma Y, St-Amour I, Harris K, Jonsson ME, Johansson PA, Vuono R, Fazal SV, Stoker T, Hersbach BA, Sharma K, Lagerwall J, Lagerstrom S, Storm P, Hebert SS, Marko-Varga G, Parmar M, Barker RA, Jakobsson J. Brain. 2021 Dec 22. pii: 6479694. doi: 10.1093/brain/awab473. PubMed |
| A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological CaV3.2 Channelopathies by Promoter-Mediated Transcription Control. Tsortouktzidis D, Troscher AR, Schulz H, Opitz T, Schoch S, Becker AJ, van Loo KMJ. Front Mol Neurosci. 2022 Jan 6;14:667143. doi: 10.3389/fnmol.2021.667143. eCollection 2021. PubMed |
| Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. Benbarche S, Lopez CK, Salataj E, Aid Z, Thirant C, Laiguillon MC, Lecourt S, Belloucif Y, Vaganay C, Antonini M, Hu J, da Silva Babinet A, Ndiaye-Lobry D, Pardieu B, Petit A, Puissant A, Chaumeil J, Mercher T, Lobry C. Sci Adv. 2022 Feb 11;8(6):eabg9455. doi: 10.1126/sciadv.abg9455. Epub 2022 Feb 9. PubMed |
| Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Warwick T, Schulz MH, Gilsbach R, Brandes RP, Seuter S. Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178. PubMed |
| CRISPRi-mediated transcriptional silencing in iPSCs for the study of human brain development. Johansson PA, Adami A, Jakobsson J. STAR Protoc. 2022 Apr 13;3(2):101285. doi: 10.1016/j.xpro.2022.101285. eCollection 2022 Jun 17. PubMed |
| LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment. Tye CE, Ghule PN, Gordon JAR, Kabala FS, Page NA, Falcone MM, Tracy KM, van Wijnen AJ, Stein JL, Lian JB, Stein GS. Sci Rep. 2022 May 11;12(1):7770. doi: 10.1038/s41598-022-11814-4. PubMed |
| Regulation and Role of Neuron-Derived Hemoglobin in the Mouse Hippocampus. Lu Y, Wang J, Tang F, Pratap UP, Sareddy GR, Dhandapani KM, Capuano A, Arvanitakis Z, Vadlamudi RK, Brann DW. Int J Mol Sci. 2022 May 11;23(10). pii: ijms23105360. doi: 10.3390/ijms23105360. PubMed |
| Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer. Akincilar SC, Chua JYH, Ng QF, Chan CHT, Eslami-S Z, Chen K, Low JL, Arumugam S, Aswad L, Chua C, Tan IB, DasGupta R, Fullwood MJ, Tergaonkar V. Nucleic Acids Res. 2022 Jun 14. pii: 6605892. doi: 10.1093/nar/gkac479. PubMed |
| 3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. Le Nabec A, Blotas C, Briset A, Collobert M, Ferec C, Moisan S. Int J Mol Sci. 2022 Jun 23;23(13). pii: ijms23136964. doi: 10.3390/ijms23136964. PubMed |
| Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Khateb M, Perovanovic J, Ko KD, Jiang K, Feng X, Acevedo-Luna N, Chal J, Ciuffoli V, Genzor P, Simone J, Haase AD, Pourquie O, Dell'Orso S, Sartorelli V. Cell Rep. 2022 Aug 16;40(7):111219. doi: 10.1016/j.celrep.2022.111219. PubMed |
| Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19. Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gundisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. PubMed |
| The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis. Kuiper EFE, Gallardo P, Bergsma T, Mari M, Kolbe Musskopf M, Kuipers J, Giepmans BNG, Steen A, Kampinga HH, Veenhoff LM, Bergink S. Nat Cell Biol. 2022 Nov;24(11):1584-1594. doi: 10.1038/s41556-022-01010-x. Epub 2022 Oct 27. PubMed |
| Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation. Wolter JM, Le BD, Matoba N, Lafferty MJ, Aygun N, Liang D, Courtney K, Song J, Piven J, Zylka MJ, Stein JL. Biol Psychiatry. 2023 Jan 1;93(1):8-17. doi: 10.1016/j.biopsych.2022.08.014. Epub 2022 Aug 22. PubMed |
| Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, Bosnjak B, Vlot A, Swertz MA, Ohler U, Geffers R, Illig T, Huehn J, Saliba AE, Sander LE, Forster R, Xu CJ, Cornberg M, Schulte LN, Li Y. Cell Genom. 2023 Feb 8;3(2):100232. doi: 10.1016/j.xgen.2022.100232. Epub 2022 Dec 2. PubMed |
| A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons. Brookes E, Martinez De La Cruz B, Boulasiki P, Au HYA, Varsally W, Barrington C, Hadjur S, Riccio A. iScience. 2022 Dec 1;26(1):105695. doi: 10.1016/j.isci.2022.105695. eCollection 2023 Jan 20. PubMed |
| E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis. Li J, Wang J, Wang Y, Zhao X, Su T. Clin Epigenetics. 2023 Jan 31;15(1):17. doi: 10.1186/s13148-023-01428-6. PubMed |
| Defining A Cohort of Anemia-Activated Cis-Elements Reveals a Mechanism Promoting Erythroid Precursor Function. Zhou Y, Dogiparthi VR, Ray S, Schaefer M, Harris HL, Rowley MJ, Hewitt KJ. Blood Adv. 2023 Feb 21:bloodadvances.2022009163. doi: 10.1182/bloodadvances.2022009163. PubMed |
| Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma. Zhou J, Toh SH, Tan TK, Balan K, Lim JQ, Tan TZ, Xiong S, Jia Y, Ng SB, Peng Y, Jeyasekharan AD, Fan S, Lim ST, Ong CJ, Ong CK, Sanda T, Chng WJ. Mol Cancer. 2023 Apr 10;22(1):69. doi: 10.1186/s12943-023-01767-1. PubMed |
Excitatory amino acid transporter 1 supports adult hippocampal neural stem cell self-renewal.
Rieskamp JD, Rosado-Burgos I, Christofi JE, Ansar E, Einstein D, Walters AE, Valentini V, Bruno JP, Kirby ED.
iScience. 2023 Jun 8;26(7):107068. doi: 10.1016/j.isci.2023.107068. eCollection 2023 Jul 21.
PubMed
Associated Plasmids |
| Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis. Su T, Zhang N, Wang T, Zeng J, Li W, Han L, Yang M. Cancer Res. 2023 Dec 15;83(24):4080-4094. doi: 10.1158/0008-5472.CAN-23-0544. PubMed |
| LINC01638 sustains human mesenchymal stem cell self-renewal and competency for osteogenic cell fate. Gordon JAR, Tye CE, Banerjee B, Ghule PN, van Wijnen AJ, Kabala FS, Page NA, Falcone MM, Stein JL, Stein GS, Lian JB. Sci Rep. 2023 Nov 20;13(1):20314. doi: 10.1038/s41598-023-46202-z. PubMed |
| Modulation of SLFN11 induces changes in DNA Damage response in breast cancer. Raynaud CM, Ahmed EI, Jabeen A, Sanchez A, Sherif S, Carneiro-Lobo TC, Awad A, Awartani D, Naik A, Thomas R, Decock J, Zoppoli G, Bedongnetti D, Hendrickx WRL. Cancer Cell Int. 2023 Nov 24;23(1):291. doi: 10.1186/s12935-023-03144-w. PubMed |
| Development of Polymer-Lipid Hybrid Nanoparticles for Large-Sized Plasmid DNA Transfection. Maeki M, Uno S, Sugiura K, Sato Y, Fujioka Y, Ishida A, Ohba Y, Harashima H, Tokeshi M. ACS Appl Mater Interfaces. 2024 Jan 17;16(2):2110-2119. doi: 10.1021/acsami.3c14714. Epub 2023 Dec 23. PubMed |
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