pUC57-LbNOX Citations (23)
Originally described in: Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio.Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK Science. 2016 Apr 8;352(6282):231-5. doi: 10.1126/science.aad4017. Epub 2016 Apr 7. PubMed Journal
Articles Citing pUC57-LbNOX
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| Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Kruger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Bruning JC, Zamboni N, Langer T. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6. PubMed |
| Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport. Ibrahim A, Yucel N, Kim B, Arany Z. Cell Metab. 2020 Aug 4;32(2):309-319.e7. doi: 10.1016/j.cmet.2020.05.018. Epub 2020 Jun 9. PubMed |
| Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Vardhana SA, Hwee MA, Berisa M, Wells DK, Yost KE, King B, Smith M, Herrera PS, Chang HY, Satpathy AT, van den Brink MRM, Cross JR, Thompson CB. Nat Immunol. 2020 Sep;21(9):1022-1033. doi: 10.1038/s41590-020-0725-2. Epub 2020 Jul 13. PubMed |
| Increased demand for NAD(+) relative to ATP drives aerobic glycolysis. Luengo A, Li Z, Gui DY, Sullivan LB, Zagorulya M, Do BT, Ferreira R, Naamati A, Ali A, Lewis CA, Thomas CJ, Spranger S, Matheson NJ, Vander Heiden MG. Mol Cell. 2021 Feb 18;81(4):691-707.e6. doi: 10.1016/j.molcel.2020.12.012. Epub 2020 Dec 30. PubMed |
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell MC, Lopes-Paciencia S, Papadopoli D, Fouillen A, Ponce KJ, Huot G, Mignacca L, Benfdil M, Kalegari P, Wahba HM, Pencik J, Vuong N, Quenneville J, Guillon J, Bourdeau V, Hulea L, Gagnon E, Kenner L, Moriggl R, Nanci A, Pollak MN, Omichinski JG, Topisirovic I, Ferbeyre G.
Mol Cell. 2021 Sep 16;81(18):3848-3865.e19. doi: 10.1016/j.molcel.2021.08.028.
PubMed
Associated Plasmids |
| NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. Levine DC, Kuo HY, Hong HK, Cedernaes J, Hepler C, Wright AG, Sommars MA, Kobayashi Y, Marcheva B, Gao P, Ilkayeva OR, Omura C, Ramsey KM, Newgard CB, Barish GD, Peek CB, Chandel NS, Mrksich M, Bass J. Nat Metab. 2021 Dec;3(12):1621-1632. doi: 10.1038/s42255-021-00498-1. Epub 2021 Dec 13. PubMed |
| Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells. Altea-Manzano P, Vandekeere A, Edwards-Hicks J, Roldan M, Abraham E, Lleshi X, Guerrieri AN, Berardi D, Wills J, Junior JM, Pantazi A, Acosta JC, Sanchez-Martin RM, Fendt SM, Martin-Hernandez M, Finch AJ. Mol Cell. 2022 Dec 1;82(23):4537-4547.e7. doi: 10.1016/j.molcel.2022.10.005. Epub 2022 Nov 2. PubMed |
Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.
Yang R, Yang C, Ma L, Zhao Y, Guo Z, Niu J, Chu Q, Ma Y, Li B.
Nat Commun. 2022 Nov 17;13(1):7031. doi: 10.1038/s41467-022-34850-0.
PubMed
Associated Plasmids |
| Metabolic regulation of species-specific developmental rates. Diaz-Cuadros M, Miettinen TP, Skinner OS, Sheedy D, Diaz-Garcia CM, Gapon S, Hubaud A, Yellen G, Manalis SR, Oldham WM, Pourquie O. Nature. 2023 Jan;613(7944):550-557. doi: 10.1038/s41586-022-05574-4. Epub 2023 Jan 4. PubMed |
| Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade. Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Uribe AH, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodriguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. bioRxiv. 2023 Mar 23:2023.03.21.533091. doi: 10.1101/2023.03.21.533091. Preprint. PubMed |
| Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hurthle Cell Carcinoma of the Thyroid. Frank AR, Li V, Shelton SD, Kim J, Stott GM, Neckers LM, Xie Y, Williams NS, Mishra P, McFadden DG. Cancer Discov. 2023 Aug 4;13(8):1884-1903. doi: 10.1158/2159-8290.CD-22-0982. PubMed |
| Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition. Cazzoli R, Romeo F, Pallavicini I, Peri S, Romanenghi M, Perez-Valencia JA, Hagag E, Ferrucci F, Elgendy M, Vittorio O, Pece S, Foiani M, Westermarck J, Minucci S. Cell Rep. 2023 Jun 27;42(6):112616. doi: 10.1016/j.celrep.2023.112616. Epub 2023 Jun 7. PubMed |
| Lactate activates the mitochondrial electron transport chain independently of its metabolism. Cai X, Ng CP, Jones O, Fung TS, Ryu KW, Li D, Thompson CB. Mol Cell. 2023 Nov 2;83(21):3904-3920.e7. doi: 10.1016/j.molcel.2023.09.034. Epub 2023 Oct 24. PubMed |
| Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodriguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w. Epub 2024 Jan 29. PubMed |
| Metabolic priming by multiple enzyme systems supports glycolysis, HIF1alpha stabilisation, and human cancer cell survival in early hypoxia. Grimm F, Asuaje A, Jain A, Silva Dos Santos M, Kleinjung J, Nunes PM, Gehrig S, Fets L, Darici S, MacRae JI, Anastasiou D. EMBO J. 2024 Apr;43(8):1545-1569. doi: 10.1038/s44318-024-00065-w. Epub 2024 Mar 14. PubMed |
| Respiratory complex I-mediated NAD(+) regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21(Cip1) expression by SIRT3 and SIRT7. Higurashi M, Mori K, Nakagawa H, Uchida M, Ishikawa F, Shibanuma M. Mol Oncol. 2025 Jun;19(6):1775-1796. doi: 10.1002/1878-0261.13808. Epub 2025 Jan 28. PubMed |
| Intrinsic electrical activity drives small-cell lung cancer progression. Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colon CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HPC, Li L. Nature. 2025 Mar;639(8055):765-775. doi: 10.1038/s41586-024-08575-7. Epub 2025 Feb 12. PubMed |
| Lactate dehydrogenase A-coupled NAD(+) regeneration is critical for acute myeloid leukemia cell survival. Erdem A, Kaye S, Caligiore F, Johanns M, Leguay F, Schuringa JJ, Ito K, Bommer G, van Gastel N. bioRxiv [Preprint]. 2025 Mar 7:2025.03.03.641255. doi: 10.1101/2025.03.03.641255. PubMed |
| Lactate dehydrogenase A-coupled NAD(+) regeneration is critical for acute myeloid leukemia cell survival. Erdem A, Kaye S, Caligiore F, Johanns M, Leguay F, Schuringa JJ, Ito K, Bommer G, van Gastel N. Cancer Metab. 2025 May 19;13(1):22. doi: 10.1186/s40170-025-00392-4. PubMed |
| Estrogens protect bone mass by inhibiting NAD(+) metabolism in osteoclasts. Marques-Carvalho A, Adam GO, Chalke A, Resende-Coelho A, Reyes-Castro O, Warren A, Grilo LF, Chini CC, Stronach B, Alturkmani F, Ambrogini E, Chini EN, Kim HN, Almeida M. bioRxiv [Preprint]. 2025 Jul 16:2025.07.11.664289. doi: 10.1101/2025.07.11.664289. PubMed |
| The mevalonate pathway couples lipid metabolism to amino acid synthesis via ubiquinone-dependent redox control. Nguyen TT, Bansal M, Ding J, Sudarshan S, Ding HF. bioRxiv [Preprint]. 2025 Aug 12:2025.08.10.669191. doi: 10.1101/2025.08.10.669191. PubMed |
| Redox-dependent liver gluconeogenesis impacts different intensity exercise in mice. Horiuchi T, Kaneko K, Hosaka S, Uno K, Tomiyama S, Takahashi K, Yamato M, Endo A, Sugawara H, Kawana Y, Asai Y, Kodama S, Imai J, Mizuno S, Takahashi S, Takasaki A, Ono H, Yokote K, Maeda R, Sugiura Y, Katagiri H. Nat Metab. 2025 Oct;7(10):1991-2003. doi: 10.1038/s42255-025-01373-z. Epub 2025 Sep 18. PubMed |
| Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD. Feng T, Luo Q, Liu Y, Jin Z, Skwarchuk D, Lee R, Nam M, Asara JM, Adye DR, Lorenzi PL, Tan L, Pei G, Zhao Z, Zarrin-Khameh N, Paulucci-Holthauzen A, Simons BW, Lee JS, Kopetz S, Yun J. Nat Metab. 2025 Oct;7(10):2018-2032. doi: 10.1038/s42255-025-01368-w. Epub 2025 Sep 19. PubMed |
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