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1036 pcDNA3 Myr HA Akt1 Citations (74)

Originally described in: Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR Proc Natl Acad Sci U S A. 1999 Mar 2. 96(5):2110-5.
PubMed Journal

Articles Citing 1036 pcDNA3 Myr HA Akt1

Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, Kamada S, Saito K, Iiizumi M, Liu W, Ericsson J, Watabe K. Cancer Res. 2008 Feb 15;68(4):1003-11. doi: 10.1158/0008-5472.CAN-07-2489. PubMed
Taurolidine and oxidative stress: a rationale for local treatment of mesothelioma. Aceto N, Bertino P, Barbone D, Tassi G, Manzo L, Porta C, Mutti L, Gaudino G. Eur Respir J. 2009 Dec;34(6):1399-407. doi: 10.1183/09031936.00102308. Epub 2009 May 21. PubMed
Blockade of PAR1 signaling with cell-penetrating pepducins inhibits Akt survival pathways in breast cancer cells and suppresses tumor survival and metastasis. Yang E, Boire A, Agarwal A, Nguyen N, O'Callaghan K, Tu P, Kuliopulos A, Covic L. Cancer Res. 2009 Aug 1;69(15):6223-31. doi: 10.1158/0008-5472.CAN-09-0187. Epub 2009 Jul 21. PubMed
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Okuzumi T, Ducker GS, Zhang C, Aizenstein B, Hoffman R, Shokat KM. Mol Biosyst. 2010 Aug;6(8):1389-402. doi: 10.1039/c003917a. Epub 2010 Jun 28. PubMed
Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate. Razidlo GL, Katafiasz D, Taylor GS. J Biol Chem. 2011 Jun 3;286(22):20005-19. doi: 10.1074/jbc.M110.197749. Epub 2011 Apr 8. PubMed
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A, Castillo-Martin M, Nowak DG, Naguib A, Grace DM, Murn J, Navin N, Atwal GS, Sander C, Gerald WL, Cordon-Cardo C, Newton AC, Carver BS, Trotman LC. Cancer Cell. 2011 Aug 16;20(2):173-86. doi: 10.1016/j.ccr.2011.07.013. PubMed
Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies. Marlow LA, von Roemeling CA, Cooper SJ, Zhang Y, Rohl SD, Arora S, Gonzales IM, Azorsa DO, Reddi HV, Tun HW, Doppler HR, Storz P, Smallridge RC, Copland JA. J Cell Sci. 2012 Sep 15;125(Pt 18):4253-63. doi: 10.1242/jcs.097428. Epub 2012 Jun 20. PubMed
Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. Pande S, Browne G, Padmanabhan S, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. J Cell Physiol. 2013 Aug;228(8):1784-92. doi: 10.1002/jcp.24339. PubMed
Inhibition of BET bromodomain targets genetically diverse glioblastoma. Cheng Z, Gong Y, Ma Y, Lu K, Lu X, Pierce LA, Thompson RC, Muller S, Knapp S, Wang J. Clin Cancer Res. 2013 Apr 1;19(7):1748-59. doi: 10.1158/1078-0432.CCR-12-3066. Epub 2013 Feb 12. PubMed

Associated Plasmids

Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. Ponnurangam S, Standing D, Rangarajan P, Subramaniam D. Mol Cancer Ther. 2013 May;12(5):598-609. doi: 10.1158/1535-7163.MCT-12-0907. Epub 2013 Feb 20. PubMed
A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA. Mol Cancer Ther. 2013 May;12(5):663-74. doi: 10.1158/1535-7163.MCT-12-0785. Epub 2013 Feb 26. PubMed
Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M. J Cell Sci. 2013 Apr 15;126(Pt 8):1832-44. doi: 10.1242/jcs.118992. Epub 2013 Feb 26. PubMed
Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks. Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJ. Cancer Res. 2013 Jun 1;73(11):3393-401. doi: 10.1158/0008-5472.CAN-12-4282. Epub 2013 Apr 30. PubMed
Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Kim SM, Park JH, Kim KD, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS. Phytother Res. 2014 Mar;28(3):423-31. doi: 10.1002/ptr.5010. Epub 2013 May 20. PubMed
Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Li Y, Zhao H, Wang Y, Zheng H, Yu W, Chai H, Zhang J, Falck JR, Guo AM, Yue J, Peng R, Yang J. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. doi: 10.1016/j.taap.2013.05.031. Epub 2013 Jun 5. PubMed
A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-kappaB nexus. Shukla S, Pia Patric IR, Thinagararjan S, Srinivasan S, Mondal B, Hegde AS, Chandramouli BA, Santosh V, Arivazhagan A, Somasundaram K. Cancer Res. 2013 Nov 15;73(22):6563-73. doi: 10.1158/0008-5472.CAN-13-0298. Epub 2013 Sep 27. PubMed
The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Elloul S, Kedrin D, Knoblauch NW, Beck AH, Toker A. Mol Cancer Res. 2014 Mar;12(3):464-76. doi: 10.1158/1541-7786.MCR-13-0398. Epub 2013 Nov 22. PubMed
Paradoxical regulation of hypoxia inducible factor-1alpha (HIF-1alpha) by histone deacetylase inhibitor in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. PLoS One. 2013 Nov 27;8(11):e81333. doi: 10.1371/journal.pone.0081333. eCollection 2013. PubMed
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage. Cam M, Bid HK, Xiao L, Zambetti GP, Houghton PJ, Cam H. J Biol Chem. 2014 Feb 14;289(7):4083-94. doi: 10.1074/jbc.M113.530303. Epub 2013 Dec 23. PubMed
Contribution of tumor heterogeneity in a new animal model of CNS tumors. Chen F, Becker AJ, LoTurco JJ. Mol Cancer Res. 2014 May;12(5):742-53. doi: 10.1158/1541-7786.MCR-13-0531. Epub 2014 Feb 5. PubMed
Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. Sahlberg SH, Spiegelberg D, Glimelius B, Stenerlow B, Nestor M. PLoS One. 2014 Apr 23;9(4):e94621. doi: 10.1371/journal.pone.0094621. eCollection 2014. PubMed
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. Chiang EP, Tsai SY, Kuo YH, Pai MH, Chiu HL, Rodriguez RL, Tang FY. PLoS One. 2014 Jun 24;9(6):e99631. doi: 10.1371/journal.pone.0099631. eCollection 2014. PubMed
Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J, Wang Y. PLoS One. 2014 Jul 3;9(7):e101526. doi: 10.1371/journal.pone.0101526. eCollection 2014. PubMed
Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A(2)alpha via AKT in prostate cancer cells. Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, Liu T, Dong Q. Oncotarget. 2014 Aug 15;5(15):6289-99. PubMed
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. Sci Signal. 2014 Jul 29;7(336):ra71. doi: 10.1126/scisignal.2005076. PubMed
Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. Zheng H, Li Y, Wang Y, Zhao H, Zhang J, Chai H, Tang T, Yue J, Guo AM, Yang J. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):10-20. doi: 10.1016/j.taap.2014.07.018. Epub 2014 Aug 2. PubMed
Retinoblastoma binding protein 2 (RBP2) promotes HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. Qi L, Zhu F, Li SH, Si LB, Hu LK, Tian H. PLoS One. 2014 Aug 27;9(8):e106032. doi: 10.1371/journal.pone.0106032. eCollection 2014. PubMed
The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity. Vanli G, Peltzer N, Dubuis G, Widmann C. Cell Signal. 2014 Dec;26(12):2992-7. doi: 10.1016/j.cellsig.2014.09.009. Epub 2014 Sep 22. PubMed
The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival. Rawat S, Bouchard MJ. J Virol. 2015 Jan 15;89(2):999-1012. doi: 10.1128/JVI.02440-14. Epub 2014 Oct 29. PubMed
Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin. Kim YS, Seol CH, Jung JW, Oh SJ, Hwang KE, Kim HJ, Jeong ET, Kim HR. Cancer Res Treat. 2015 Jan;47(1):90-100. doi: 10.4143/crt.2013.194. Epub 2014 Oct 27. PubMed
Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-beta oligomer-treated hippocampal neurons. Takach O, Gill TB, Silverman MA. Neurobiol Aging. 2015 Mar;36(3):1378-82. doi: 10.1016/j.neurobiolaging.2014.11.018. Epub 2014 Dec 3. PubMed
Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents. Han KY, Hwang JW, Bae GU, Kim SN, Kim YK. Mol Med Rep. 2015 May;11(5):3866-71. doi: 10.3892/mmr.2015.3158. Epub 2015 Jan 8. PubMed
CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-kappaB pathway in multidrug-resistant glioblastoma cells in vitro. Xi G, Hayes E, Lewis R, Ichi S, Mania-Farnell B, Shim K, Takao T, Allender E, Mayanil CS, Tomita T. Oncogene. 2015 Mar 30. doi: 10.1038/onc.2015.78. PubMed
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas. Xie C, Lu H, Nomura A, Hanse EA, Forster CL, Parker JB, Linden MA, Karasch C, Hallstrom TC. Mol Cancer. 2015 Apr 24;14(1):93. PubMed
PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Yu JS, Ramasamy TS, Murphy N, Holt MK, Czapiewski R, Wei SK, Cui W. Nat Commun. 2015 May 22;6:7212. doi: 10.1038/ncomms8212. PubMed
Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin beta1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism. Zhang HF, Alshareef A, Wu C, Li S, Jiao JW, Cao HH, Lai R, Xu LY, Li EM. Oncotarget. 2015 Oct 6;6(30):28949-60. doi: 10.18632/oncotarget.5027. PubMed
Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. J Biol Chem. 2016 Jan 1;291(1):198-214. doi: 10.1074/jbc.M115.668673. Epub 2015 Oct 9. PubMed
Chronic exposure to hexachlorobenzene results in down-regulation of connexin43 in the breast. Delisle A, Ferraris E, Plante I. Environ Res. 2015 Nov;143(Pt A):229-40. doi: 10.1016/j.envres.2015.10.020. Epub 2015 Oct 28. PubMed
Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Lu Q, Yan S, Sun H, Wang W, Li Y, Yang X, Jiang X, Che Y, Xi Z. Cell Death Dis. 2015 Dec 3;6:e2005. doi: 10.1038/cddis.2015.344. PubMed
PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs. Shi Q, Hoffman B, Liu Q. Virology. 2016 Mar;490:99-108. doi: 10.1016/j.virol.2016.01.012. Epub 2016 Feb 6. PubMed
Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. Sun S, Cheng S, Zhu Y, Zhang P, Liu N, Xu T, Sun C, Lv Y. Gene. 2016 Jun 10;584(1):90-6. doi: 10.1016/j.gene.2016.03.020. Epub 2016 Mar 15. PubMed
mTORC1 is necessary but mTORC2 and GSK3beta are inhibitory for AKT3-induced axon regeneration in the central nervous system. Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y. Elife. 2016 Mar 30;5. pii: e14908. doi: 10.7554/eLife.14908. PubMed
Abrus agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death. Panda PK, Behera B, Meher BR, Das DN, Mukhopadhyay S, Sinha N, Naik PP, Roy B, Das J, Paul S, Maiti TK, Agarwal R, Bhutia SK. Mol Carcinog. 2016 May 16. doi: 10.1002/mc.22502. PubMed
PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathways. Lv D, Liu J, Guo L, Wu D, Matsumoto K, Huang L. Am J Cancer Res. 2016 Jan 15;6(2):486-97. eCollection 2016. PubMed
Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. Tiong KH, Tan BS, Choo HL, Chung FF, Hii LW, Tan SH, Khor NT, Wong SF, See SJ, Tan YF, Rosli R, Cheong SK, Leong CO. Oncotarget. 2016 Sep 6;7(36):57633-57650. doi: 10.18632/oncotarget.9328. PubMed
Intrinsic hepatocyte dedifferentiation is accompanied by upregulation of mesenchymal markers, protein sialylation and core alpha 1,6 linked fucosylation. Mehta A, Comunale MA, Rawat S, Casciano JC, Lamontagne J, Herrera H, Ramanathan A, Betesh L, Wang M, Norton P, Steel LF, Bouchard MJ. Sci Rep. 2016 Jun 22;6:27965. doi: 10.1038/srep27965. PubMed
Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation. Diez H, Benitez MJ, Fernandez S, Torres-Aleman I, Garrido JJ, Wandosell F. Biochim Biophys Acta. 2016 Nov;1863(11):2574-2583. doi: 10.1016/j.bbamcr.2016.07.002. Epub 2016 Jul 12. PubMed
BECN1/Beclin 1 sorts cell-surface APP/amyloid beta precursor protein for lysosomal degradation. Swaminathan G, Zhu W, Plowey ED. Autophagy. 2016 Dec;12(12):2404-2419. Epub 2016 Oct 7. PubMed
6-(3,4-Dihydro-1H-isoquinoline-2-yl)-N-(6-methoxypyridine-2-yl) nicotinamide-26 (DIMN-26) decreases cell proliferation by induction of apoptosis and downregulation of androgen receptor signaling in human prostate cancer cells. Choi HE, Shin JS, Leem DG, Kim SD, Cho WJ, Lee KT. Chem Biol Interact. 2016 Dec 25;260:196-207. doi: 10.1016/j.cbi.2016.10.008. Epub 2016 Oct 5. PubMed
A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth. Mayrhofer M, Gourain V, Reischl M, Affaticati P, Jenett A, Joly JS, Benelli M, Demichelis F, Poliani PL, Sieger D, Mione M. Dis Model Mech. 2017 Jan 1;10(1):15-28. doi: 10.1242/dmm.026500. Epub 2016 Nov 24. PubMed
Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. Soo HC, Chung FF, Lim KH, Yap VA, Bradshaw TD, Hii LW, Tan SH, See SJ, Tan YF, Leong CO, Mai CW. PLoS One. 2017 Jan 20;12(1):e0170551. doi: 10.1371/journal.pone.0170551. eCollection 2017. PubMed
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. Lee HM, Lo KW, Wei W, Tsao SW, Chung GTY, Ibrahim MH, Dawson CW, Murray PG, Paterson IC, Yap LF. J Pathol. 2017 May;242(1):62-72. doi: 10.1002/path.4879. Epub 2017 Mar 15. PubMed
Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells. Zhou X, Liu W, Hu X, Dorrance A, Garzon R, Houghton PJ, Shen C. Sci Rep. 2017 May 8;7(1):1535. doi: 10.1038/s41598-017-01729-w. PubMed
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. Figlia G, Norrmen C, Pereira JA, Gerber D, Suter U. Elife. 2017 Sep 7;6. doi: 10.7554/eLife.29241. PubMed
HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Gallagher SJ, Gunatilake D, Beaumont KA, Sharp DM, Tiffen JC, Heinemann A, Weninger W, Haass NK, Wilmott JS, Madore J, Ferguson PM, Rizos H, Hersey P. Int J Cancer. 2018 May 1;142(9):1926-1937. doi: 10.1002/ijc.31199. Epub 2017 Dec 20. PubMed
Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling. Wang L, Guo W, Ma J, Dai W, Liu L, Guo S, Chen J, Wang H, Yang Y, Yi X, Wang G, Gao T, Zhu G, Li C. Autophagy. 2018;14(3):518-533. doi: 10.1080/15548627.2017.1384886. Epub 2017 Dec 31. PubMed
Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation. Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A. Blood. 2018 Apr 5;131(14):1556-1567. doi: 10.1182/blood-2017-07-795278. Epub 2018 Feb 13. PubMed
Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. Chia K, Mazzolini J, Mione M, Sieger D. Elife. 2018 Feb 21;7. pii: 31918. doi: 10.7554/eLife.31918. PubMed
Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Li YJ, Du L, Aldana-Masangkay G, Wang X, Urak R, Forman SJ, Rosen ST, Chen Y. Nucleic Acids Res. 2018 Aug 21;46(14):7108-7123. doi: 10.1093/nar/gky484. PubMed
Connexin 43 C-terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein-protein interactions in glioblastoma. Kuang JY, Guo YF, Chen Y, Wang J, Duan JJ, He XL, Li L, Yu SC, Bian XW. Cancer Sci. 2018 Aug;109(8):2611-2622. doi: 10.1111/cas.13707. Epub 2018 Aug 9. PubMed
Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B. Zhou X, Wang R, Li X, Yu L, Hua D, Sun C, Shi C, Luo W, Rao C, Jiang Z, Feng Y, Wang Q, Yu S. J Clin Invest. 2019 Feb 1;129(2):676-693. doi: 10.1172/JCI120279. Epub 2019 Jan 14. PubMed
mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase. Wu X, Li S, Hu X, Xiang X, Halloran M, Yang L, Williams TM, Houghton PJ, Shen C, He Z. Sci Rep. 2019 Jul 8;9(1):9805. doi: 10.1038/s41598-019-46052-8. PubMed
Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Wallroth A, Koch PA, Marat AL, Krause E, Haucke V. Nat Cell Biol. 2019 Sep;21(9):1093-1101. doi: 10.1038/s41556-019-0377-3. Epub 2019 Aug 26. PubMed
Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Chen G, Park D, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X. Cancer Res. 2019 Dec 15;79(24):6126-6138. doi: 10.1158/0008-5472.CAN-19-0950. Epub 2019 Oct 29. PubMed
Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. Mol Cell Proteomics. 2020 Feb;19(2):294-307. doi: 10.1074/mcp.RA119.001785. Epub 2019 Dec 2. PubMed
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Lee BJ, Boyer JA, Burnett GL, Thottumkara AP, Tibrewal N, Wilson SL, Hsieh T, Marquez A, Lorenzana EG, Evans JW, Hulea L, Kiss G, Liu H, Lee D, Larsson O, McLaughlan S, Topisirovic I, Wang Z, Wang Z, Zhao Y, Wildes D, Aggen JB, Singh M, Gill AL, Smith JAM, Rosen N. Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24. PubMed
Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. Nalairndran G, Chung I, Abdul Razack AH, Chung FF, Hii LW, Lim WM, Looi CK, Mai CW, Leong CO. J Cell Mol Med. 2021 Sep;25(17):8187-8200. doi: 10.1111/jcmm.16684. Epub 2021 Jul 28. PubMed
Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A. Cell Rep. 2021 Aug 3;36(5):109490. doi: 10.1016/j.celrep.2021.109490. PubMed
SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cha Y, Kim T, Jeon J, Jang Y, Kim PB, Lopes C, Leblanc P, Cohen BM, Kim KS. Cell Rep. 2021 Dec 28;37(13):110155. doi: 10.1016/j.celrep.2021.110155. PubMed
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation. Lu WC, Omari R, Ray H, Wang J, Williams I, Jacobs C, Hockaden N, Bochman ML, Carpenter RL. FEBS J. 2022 Jul;289(13):3876-3893. doi: 10.1111/febs.16375. Epub 2022 Feb 11. PubMed
AKT mutant allele-specific activation dictates pharmacologic sensitivities. Shrestha Bhattarai T, Shamu T, Gorelick AN, Chang MT, Chakravarty D, Gavrila EI, Donoghue MTA, Gao J, Patel S, Gao SP, Reynolds MH, Phillips SM, Soumerai T, Abida W, Hyman DM, Schram AM, Solit DB, Smyth LM, Taylor BS. Nat Commun. 2022 Apr 19;13(1):2111. doi: 10.1038/s41467-022-29638-1. PubMed
Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1. Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D. Mol Oncol. 2022 Sep;16(17):3192-3209. doi: 10.1002/1878-0261.13292. Epub 2022 Jul 28. PubMed
Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer. Elakad O, Haupl B, Labitzky V, Yao S, Kuffer S, von Hammerstein-Equord A, Danner BC, Jucker M, Urlaub H, Lange T, Strobel P, Oellerich T, Bohnenberger H. NPJ Precis Oncol. 2022 Jul 19;6(1):52. doi: 10.1038/s41698-022-00296-2. PubMed
Akt1 is involved in HCV release by promoting endoplasmic reticulum-to-endosome transition of infectious virions. Lee WP, Liao SX, Huang YH, Hou MC, Lan KH. Life Sci. 2024 Feb 1;338:122412. doi: 10.1016/j.lfs.2024.122412. Epub 2024 Jan 6. PubMed

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