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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.
Maddalo D, Manchado E, Concepcion CP, Bonetti C, Vidigal JA, Han YC, Ogrodowski P, Crippa A, Rekhtman N, de Stanchina E, Lowe SW, Ventura A
Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
64071Adeno EAAdenovirus for the expression of gRNAs targeting intron 19 of murine Alk and intron 14 of Eml4
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64072Adeno Cas9Adenoviral vector for the expression of the Cas9
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64073pX333Vector for tandem expression of two sgRNAs from two independent U6 promoters. Cas9 is expressed by Cbh promoter.
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