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In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.
Maddalo D, Manchado E, Concepcion CP, Bonetti C, Vidigal JA, Han YC, Ogrodowski P, Crippa A, Rekhtman N, de Stanchina E, Lowe SW, Ventura A
Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
64071Adeno EAAdenovirus for the expression of gRNAs targeting intron 19 of murine Alk and intron 14 of Eml4
64072Adeno Cas9Adenoviral vector for the expression of the Cas9
64073pX333Vector for tandem expression of two sgRNAs from two independent U6 promoters. Cas9 is expressed by Cbh promoter.

Antibodies from Article