Addgene

We narrowed to 476 results for: Rs1;

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lentiSAMv2 rs12189774-guide3

Plasmid

#125498

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs12189774 (VEGFA GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

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lentiSAMv2 rs12189774-guide2

Plasmid

#125497

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs12189774 (VEGFA GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

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lentiSAMv2 rs12189774-guide1

Plasmid

#125496

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs12189774 (VEGFA GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs1401419-guide4

Plasmid

#125489

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs1401419 (CRY2 GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs1401419-guide3

Plasmid

#125488

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs1401419 (CRY2 GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs1401419-guide2

Plasmid

#125487

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs1401419 (CRY2 GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs1401419-guide1

Plasmid

#125486

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs1401419 (CRY2 GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs11257655-guide1

Plasmid

#125460

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs11257655 (CDC123/CAMK1D GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

July 25, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs11257655-guide2

Plasmid

#118205

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs11257655 (CDC123/CAMK1D GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

April 3, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs11257655-guide4

Plasmid

#118207

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs11257655 (CDC123/CAMK1D GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

April 2, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
lentiSAMv2 rs11257655-guide3

Plasmid

#118206

Purpose

CRISPR-mediated activation of human islet enhancer containing T2D-associated variant rs11257655 (CDC123/CAMK1D GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

dCas9-VP64-2A-BlastR

Use

CRISPR and Lentiviral

Tags

Expression

Mammalian

Mutation

Promoter

EF1a core and U6

Available since

April 2, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge
pJet-CMV-IARS1-GFP

Plasmid

#212322

Purpose

EGFP-tagged IARS1

Depositor

Sabine Fuchs

Article

Kok et al Nucleic Acids Res. 2025 Jan 7;53(1):gkae

Insert

IARS (IARS1 Human)

Use

Tags

EGFP

Expression

Mammalian

Mutation

Wildtype

Promoter

CMV

Available since

Nov. 27, 2024

Availability

Academic Institutions and Nonprofits only

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R777-E110 Hs.IRS1-nostop

Plasmid

#70394

Purpose

Gateway ORF clone of human IRS1 [NM_005544.2] without stop codon (for C-terminal fusions)

Depositor

Dominic Esposito

Insert

IRS1 (IRS1 Human)

Use

Gateway entry clone

Tags

Expression

Mutation

Promoter

Available since

March 1, 2016

Availability

Academic Institutions and Nonprofits only

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pAG226 SFRS12 3'UTR mut

Plasmid

#12045

Depositor

David Bartel

Article

Farh et al Science. 2005 Dec 16. 310(5755):1817-21.

Insert

SFRS12 3'UTR mut (SREK1 Human)

Use

Luciferase

Tags

Expression

Mammalian

Mutation

Mutations in microRNA recognition sites (seed mat…

Promoter

Available since

June 8, 2006

Availability

Academic Institutions and Nonprofits only
pEnt R3L2 TetO(sh) mCh-Rs1-2

Plasmid

#24417

Depositor

Edward Hsiao

Article

Hsiao et al Stem Cell Res Ther. 2011 Mar 4. 2(2):11.

Insert

Rs1

Use

Entry vector

Tags

FLAG and mCherry

Expression

Mutation

Human 5HT4B receptor with D100A mutation, generat…

Promoter

Available since

March 14, 2011

Availability

Academic Institutions and Nonprofits only

Enlarge
pCS2-MCRS1-GFP-IRES-mCherry

Plasmid

#231231

Purpose

MCRS1 stability reporter construct for transient expression in mammalian cells. Stability of GFP-fusion protein can be assed by flow cytometry by normalizing to mCherry expression.

Depositor

Michael Rape

Article

Mark et al Cell. 2023 Aug 3;186(16):3460-3475.e23.

Insert

MCRS1 (MCRS1 Human)

Use

Tags

Expression

Mammalian

Mutation

Promoter

Available since

Jan. 21, 2025

Availability

Academic Institutions and Nonprofits only

Enlarge
pJet-CMV-IARS1[W435C]-GFP

Plasmid

#212323

Purpose

EGFP-tagged IARS1 Trp435Cys

Depositor

Sabine Fuchs

Article

Kok et al Nucleic Acids Res. 2025 Jan 7;53(1):gkae

Insert

IARS (IARS1 Human)

Use

Tags

EGFP

Expression

Mammalian

Mutation

Trp435cys

Promoter

CMV

Available since

Nov. 27, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
Exp-pcDNA3.2delCMV(EF1α-tTA/TetO-mCh-Rs1)

Plasmid

#26797

Depositor

Edward Hsiao

Article

Hsiao et al Stem Cell Res Ther. 2011 Mar 4. 2(2):11.

Insert

EF1a-tTA/TetO-mCherry-P2A-Rs1 (HTR4 Human)

Use

Tags

Expression

Mammalian

Mutation

Human 5HT4B receptor with D100A mutation, generat…

Promoter

Available since

Feb. 23, 2011

Availability

Academic Institutions and Nonprofits only

Enlarge
Exp-Rosa-EF1a-tTA-mCh-Rs1-TetO(sh)-2

Plasmid

#24419

Depositor

Edward Hsiao

Article

Hsiao et al Stem Cell Res Ther. 2011 Mar 4. 2(2):11.

Insert

RS1 (HTR4 Human)

Use

Mouse Targeting

Tags

FLAG and mCherry

Expression

Mutation

Human 5HT4B receptor with D100A mutation, generat…

Promoter

Available since

March 14, 2011

Availability

Academic Institutions and Nonprofits only

Enlarge
Lenti-(BB)-hPGK-KRAB-dCas9-P2A-BlastR rs12189774-guide4

Plasmid

#125439

Purpose

CRISPR-mediated repression of human islet enhancer containing T2D-associated variant rs12189774 (VEGFA GWAS locus)

Depositor

Jorge Ferrer

Article

Miguel-Escalada et al Nat Genet. 2019 Jun 28. pii: 10.1038/s41

Insert

KRAB-dCas9-2A-BlastR

Use

CRISPR and Lentiviral

Tags

HA

Expression

Mammalian

Mutation

Promoter

hPGK and U6

Available since

July 24, 2019

Availability

Academic Institutions and Nonprofits only

Enlarge