We narrowed to 32,277 results for: uros

1. pLV.tetO.Nurr1

   Plasmid

   #234848

   Purpose

   3rd generation lentiviral vector, expresses Nurr1 under control of TetON promoter

   Depositor

   Malin Parmar

   Article

   Nolbrant et al Stem Cell Reports. 2020 Oct 13;15(4):869

   Insert

   Nurr1 (Nr4a2 Mouse)
   

   Use

   Lentiviral

   Expression

   Mammalian

   Available Since

   May 15, 2025

   Availability

   Academic Institutions and Nonprofits only

   

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2. pCAGIG-shCdkn1a(#4)

   Plasmid

   #228913

   Purpose

   Knockdown of Cdkn1a in mammalian cells

   Depositor

   Sika Zheng

   Article

   Lin et al Neuron. 2024 Jul 3;112(13):2157-2176.e12

   Insert

   shCdkn1a (Cdkn1a Mouse)
   

   Expression

   Mammalian

   Available Since

   Jan. 7, 2025

   Availability

   Academic Institutions and Nonprofits only

   

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3. pCAG_SRGAP2A_GAP(R527L_K566A)

   Plasmid

   #222617

   Purpose

   Expresses full length SRGAP2 with R527L, K566A mt in the Rac1-specific GAP domain that abrogates the GTPase activating function of SRGAP2 without locking the GAP-domain in a form bound to Rac1-GDP.

   Depositor

   Franck Polleux

   Article

   Fossati et al Neuron. 2016 Jul 20;91(2):356-69. doi: 1

   Insert

   SRGAP2 (SRGAP2 Human)
   

   Tags

   EGFP

   Expression

   Mammalian

   Mutation

   Point mutations R527L and K566A (Rac1-specific GA…

   Available Since

   Oct. 9, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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4. PX459v3-eSpCas9(1.1)

   Plasmid

   #178800

   Purpose

   High-fidelity eSpCas9(1.1) with 2A-Puro, and a golden gate cloning backbone for sgRNA. sgRNA scaffold seqeuence has been modified for increased sgRNA expression (v3).

   Depositor

   Paul Thomas

   Article

   Chey et al BMC Genomics. 2025 Feb 12;26(1):138. doi

   Type

   Empty backbone

   Use

   CRISPR

   Expression

   Mammalian

   Promoter

   Cbh (Cas9-2A Puro) and U6 (gRNA)

   Available Since

   Aug. 9, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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5. PX459v3-SpCas9-HF1

   Plasmid

   #178801

   Purpose

   High-fidelity SpCas9-HF1 with 2A-Puro, and a golden gate cloning backbone for sgRNA. sgRNA scaffold seqeuence has been modified for increased sgRNA expression (v3).

   Depositor

   Paul Thomas

   Article

   Chey et al BMC Genomics. 2025 Feb 12;26(1):138. doi

   Type

   Empty backbone

   Use

   CRISPR

   Expression

   Mammalian

   Promoter

   Cbh (Cas9-2A Puro) and U6 (gRNA)

   Available Since

   Aug. 9, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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6. pAAV-Syn1-DIO-Snca (human A53T)

   Plasmid

   #214201

   Purpose

   For Cre-dependent expression of alpha synuclein (human gene containing A53T mutation)

   Depositor

   Thomas Hnasko

   Article

   Steinkellner et al Brain. 2022 Apr 29;145(3):879-886. doi:

   Insert

   Snca (A53T) (SNCA Human)
   

   Use

   AAV and Cre/Lox

   Expression

   Mammalian

   Mutation

   A53T

   Available Since

   March 29, 2024

   Availability

   Academic Institutions and Nonprofits only

   

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7. lentiCRISPR v2-sgABI2-1

   Plasmid

   #210139

   Purpose

   knock out ABI2 in mammalian cells

   Depositor

   Boyi Gan

   Article

   Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

   Insert

   Abl interactor 2 (ABI2 Human)
   

   Use

   CRISPR

   Available Since

   Nov. 8, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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8. lentiCRISPR v2-sgCYFIP1-1

   Plasmid

   #210137

   Purpose

   knock out CYFIP1 in mammalian cells

   Depositor

   Boyi Gan

   Article

   Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

   Insert

   Cytoplasmic FMR1-interacting protein 1 (CYFIP1 Human)
   

   Use

   CRISPR

   Available Since

   Nov. 8, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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9. lentiCRISPR v2-sgABI2-2

   Plasmid

   #210140

   Purpose

   knock out ABI2 in mammalian cells

   Depositor

   Boyi Gan

   Article

   Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

   Insert

   Abl interactor 2 (ABI2 Human)
   

   Use

   CRISPR

   Available Since

   Nov. 8, 2023

   Availability

   Academic Institutions and Nonprofits only

   

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10. lentiCRISPR v2-sgHSPC300-1

    Plasmid

    #210141

    Purpose

    knock out HSPC300 in mammalian cells

    Depositor

    Boyi Gan

    Article

    Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

    Insert

    Protein BRICK1 (BRK1 Human)
    

    Use

    CRISPR

    Available Since

    Nov. 8, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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11. lentiCRISPR v2-sgHSPC300-2

    Plasmid

    #210142

    Purpose

    knock out HSPC300 in mammalian cells

    Depositor

    Boyi Gan

    Article

    Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

    Insert

    Protein BRICK1 (BRK1 Human)
    

    Use

    CRISPR

    Available Since

    Nov. 8, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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12. lentiCRISPR v2-sgCYFIP1-2

    Plasmid

    #210138

    Purpose

    knock out CYFIP1 in mammalian cells

    Depositor

    Boyi Gan

    Article

    Liu et al Nat Cell Biol. 2023 Mar;25(3):404-414. d

    Insert

    Cytoplasmic FMR1-interacting protein 1 (CYFIP1 Human)
    

    Use

    CRISPR

    Available Since

    Nov. 8, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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13. pSI-218

    Plasmid

    #197139

    Purpose

    All-in-vector of SpCas9 gRNA cloning sites (BsmBI) and CMVp-Target-AID expression unit

    Depositor

    Nozomu Yachie

    Article

    Ishiguro et al Nat Biotechnol. 2025 May 21. doi: 10.103

    Type

    Empty backbone

    Use

    CRISPR

    Tags

    SpCas9-PmCDA1-UGI

    Expression

    Mammalian

    Mutation

    SpCas9(D10A)

    Available Since

    May 9, 2023

    Availability

    Academic Institutions and Nonprofits only

    

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14. pTol2CG NBT:NRGIIIa_R551Q:polyA

    Plasmid

    #193013

    Purpose

    Tol2 transgenic construct that will express human Neuregulin1 Type IIIa R551Q patient variant in neurons

    Depositor

    William Talbot

    Article

    Lysko et al Hum Mutat. 2022 Sep;43(9):1216-1223. doi

    Inserts

    NBT
    NRG1 type IIIa R551Q (NRG1 Human)
    

    Use

    Transposon transgenesis

    Expression

    Mammalian

    Mutation

    ENST00000287842, NM_013956, c.1652G>A, p.(Arg5…

    Available Since

    Dec. 13, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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15. W118-1_hZBTB7B_R363L

    Plasmid

    #180381

    Purpose

    lentiviral transduction of human ZBTB7B gene with a point mutation (R363L) in the first ZF domain

    Depositor

    Huda Zoghbi

    Article

    Lee et al EMBO J. 2021 Apr 1;40(7):e106106. doi: 1

    Insert

    ZBTB7B_R363L (ZBTB7B Human)
    

    Use

    Lentiviral

    Expression

    Mammalian

    Mutation

    R363L

    Promoter

    CMV

    Available Since

    Dec. 1, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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16. W118-1_hZBTB7B_D35N_R49Q

    Plasmid

    #180383

    Purpose

    lentiviral transduction of human ZBTB7B gene with point mutations (D35N and R49Q) in the BTB domain

    Depositor

    Huda Zoghbi

    Article

    Lee et al EMBO J. 2021 Apr 1;40(7):e106106. doi: 1

    Insert

    ZBTB7B_D35N/R49Q (ZBTB7B Human)
    

    Use

    Lentiviral

    Expression

    Mammalian

    Mutation

    D35N/R49Q

    Promoter

    CMV

    Available Since

    Dec. 1, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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17. W118-1_hZBTB7B_R49H

    Plasmid

    #180382

    Purpose

    lentiviral transduction of human ZBTB7B gene with a point mutation (R49H) in the BTB domain

    Depositor

    Huda Zoghbi

    Article

    Lee et al EMBO J. 2021 Apr 1;40(7):e106106. doi: 1

    Insert

    ZBTB7B_R49H (ZBTB7B Human)
    

    Use

    Lentiviral

    Expression

    Mammalian

    Mutation

    R49H

    Promoter

    CMV

    Available Since

    Dec. 1, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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18. pET303C-hSOD1 A4V/C6S

    Plasmid

    #139667

    Purpose

    Expression plasmids containing human A4V/C6S SOD1

    Depositor

    Svetlana Antonyuk

    Article

    Chantadul et al Commun Biol. 2020 Mar 5;3(1):97. doi: 10

    Insert

    Superoxide dismutase-1 (SOD1 Human)
    

    Expression

    Bacterial

    Mutation

    change alanine 4 to valine, change cysteine 6 to …

    Promoter

    T7

    Available Since

    July 13, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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19. pAAV-hSyn-GFP-IRES-hSNCA (A11P/V70P)

    Plasmid

    #185717

    Purpose

    AAV expression of GFP and human α-Synuclein with A11P and V70P mutations from hSyn promoter

    Depositor

    Jun Ding

    Article

    Albarran et al Nat Neurosci. 2023 Jun;26(6):997-1007. d

    Insert

    synuclein, alpha (SNCA Human)
    

    Use

    AAV

    Mutation

    Changed Ala 11 to Pro, Val 70 to Pro

    Promoter

    hSyn

    Available Since

    June 28, 2022

    Availability

    Academic Institutions and Nonprofits only

    

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20. pCMV ShadowY-AURKA-mTurq2

    Plasmid

    #157770

    Purpose

    Expression of AuroraA kinase biosensor under CMV promoter

    Depositor

    Marc Tramier

    Article

    Bertolin et al eLife. 2018 Aug 2;7. pii: 38111. doi: 10

    Insert

    AURKA (AURKA Human)
    

    Tags

    mTurquoise2 and shadowY

    Expression

    Mammalian

    Promoter

    CMV

    Available Since

    March 9, 2021

    Availability

    Academic Institutions and Nonprofits only

    

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