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AiP1379 - pAAV-AiE2150m-minBG-SYFP2-WPRE3-BGHpA

Plasmid

#230531

Purpose

AiE2150m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

Feb. 20, 2025

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1307 - pAAV-AiE2016m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214481

Purpose

AiE2016m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

Aug. 21, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1976 - pAAV-AiE2569m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214600

Purpose

AiE2569m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1862 - pAAV-AiE2566m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214561

Purpose

AiE2566m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1731 - pAAV-AiE2386m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214531

Purpose

AiE2386m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1733 - pAAV-AiE2389m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214532

Purpose

AiE2389m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1774 - pAAV-AiE2449m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214540

Purpose

AiE2449m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1333 - pAAV-AiE2115m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214484

Purpose

AiE2115m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1492 - pAAV-AiE2004m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214501

Purpose

AiE2004m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
AiP1332 - pAAV-AiE2114m-minBG-SYFP2-WPRE-BGHpA

Plasmid

#214483

Purpose

AiE2114m is an enhancer sequence, designed to drive AAV-mediated transgene expression in specific populations of brain cells

Depositor

Allen Institute for Brain Science, Bosiljka Tasic

Article

Ben-Simon et al Cell. 2025 May 16:S0092-8674(25)00513-6.

Insert

SYFP2

Use

AAV

Promoter

minBG

Available Since

June 24, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
pAAV-hSyn1-DIO-SEP-GluA1R

Plasmid

#227236

Purpose

Large cargo capacity AAV that expresses SEP tagged AMPA receptor subunit GluA1 Q582R mutant in neurons expressing Cre recombinase

Depositor

Richard Huganir

Article

Hong et al Nature. 2024 Nov;635(8038):398-405. doi:

Insert

SEP-GluA1 Q582R (Gria1 Rat)

Use

AAV

Tags

superecliptic pHluorin

Expression

Mammalian

Mutation

Q582R

Promoter

hSyn1

Available Since

Oct. 15, 2025

Availability

Academic Institutions and Nonprofits only

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pOTTC1079 - pAAV TH gRNA A EF1a EGFP

Plasmid

#113159

Purpose

An AAV vector that expresses guide RNA targeting rat TH and expresses EGFP reporter

Depositor

Brandon Harvey

Article

Back et al Neuron. 2019 Feb 8. pii: S0896-6273(19)3

Insert

gRNA for rat TH

Use

AAV and CRISPR

Expression

Mammalian

Promoter

mU6

Available Since

March 7, 2019

Availability

Academic Institutions and Nonprofits only

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pAAV-CaMKIIa-JEDI3hyp-WPRE

Plasmid

#246637

Purpose

Genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa

Depositor

Francois St-Pierre

Article

Land et al Nat Methods. 2026 Apr 15. doi: 10.1038/s

Insert

JEDI3hyp

Use

AAV

Expression

Mammalian

Promoter

CaMKIIa

Available Since

April 23, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-CaMKIIa-JEDI3hyp-Kv-WPRE

Plasmid

#246638

Purpose

Soma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa

Depositor

Francois St-Pierre

Article

Land et al Nat Methods. 2026 Apr 15. doi: 10.1038/s

Insert

JEDI3hyp-Kv

Use

AAV

Tags

Kv

Expression

Bacterial

Promoter

CaMKIIa

Available Since

April 23, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-CaMKIIa-JEDI3sub-WPRE

Plasmid

#246624

Purpose

Genetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa

Depositor

Francois St-Pierre

Article

Land et al Nat Methods. 2026 Apr 15. doi: 10.1038/s

Insert

JEDI3sub

Use

AAV

Expression

Mammalian

Promoter

CaMKIIa

Available Since

April 23, 2026

Availability

Academic Institutions and Nonprofits only

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DRH001_scAAV-hSyn-iCre-HA

Plasmid

#225086

Purpose

Expression of iCre with an HA tag in neurons driven by human synapsin promoter.

Depositor

Bernardo Sabatini

Article

Hochbaum et al Cell. 2024 Oct 3;187(20):5679-5697.e23.

Insert

iCre

Use

AAV and Cre/Lox

Tags

HA

Expression

Mammalian

Promoter

hSyn

Available Since

Oct. 21, 2024

Availability

Academic Institutions and Nonprofits only

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pAAV-hSyn-GRAB_CRFmut

Plasmid

#208659

Purpose

Expresses the genetically-encoded fluorescent corticotropin-releasing factor (CRF) control sensor GRAB_CRFmut in neurons

Depositor

Yulong Li

Article

Wang et al Science. 2023 Nov 17;382(6672):eabq8173.

Insert

GPCR activation based corticotropin-releasing factor (CRF) contorl sensor GRAB_CRFmut

Use

AAV

Promoter

hSyn

Available Since

Oct. 13, 2023

Availability

Academic Institutions and Nonprofits only

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pAAV CMV-DIO-(mCherry-U6)-shRNA(anti-Crh)

Plasmid

#214732

Purpose

Expresses shRNA against CRH, marked with mCherry, in infected and cre positive cells

Depositor

Félix Leroy

Article

de Leon Reyes et al Cell. 2023 Sep 14;186(19):4152-4171.e31.

Insert

anti-Crh shRNA / mCherry

Use

AAV

Available Since

July 12, 2024

Availability

Academic Institutions and Nonprofits only

Enlarge
pOTTC1535 pscAAV mU6 shRNA(scram) CMV-IE Nuc-EYFP

Plasmid

#135563

Purpose

An AAV vector expressing scrambled shRNA and a nuclear EYFP reporter

Depositor

Christopher Richie

Article

Venniro et al Proc Natl Acad Sci U S A. 2020 Apr 7;117

Inserts

shRNA (scrambled)
Nuc-EYFP

Use

AAV and RNAi

Tags

3xNLS

Expression

Mammalian

Promoter

CMV-IE and mU6

Available Since

Sept. 1, 2021

Availability

Academic Institutions and Nonprofits only

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AiP13780: pAAV-AiE0743m_3xC2-minBG-iCre(R297T)-BGHpA (Alias: CN3780)

Plasmid

#214848

Purpose

Expression of iCre(R297T) in striatal cholinergic neurons

Depositor

Allen Institute for Brain Science, Jonathan Ting

Article

Hunker et al Neuron. 2025 May 21;113(10):1507-1524.e1

Has Service

AAV2

Insert

iCre(R297T)

Use

AAV

Mutation

R297T

Available Since

July 15, 2024

Availability

Academic Institutions and Nonprofits only

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