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pAAV9-hSyn-iDianiSnFR_ER

Plasmid

#177758

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn-iDianiSnFR_ER

Use

AAV

Promoter

hSyn

Available Since

Feb. 4, 2022

Availability

Academic Institutions and Nonprofits only

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pAAV9-hSyn-iCyt_F_SnFR_PM

Plasmid

#177755

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn-iCyt_F_SnFR_PM

Use

AAV

Promoter

hSyn

Available Since

Feb. 4, 2022

Availability

Academic Institutions and Nonprofits only

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pAAV9-hSyn-iCytSnFR_PM

Plasmid

#177753

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn-iCytSnFR_PM

Use

AAV

Promoter

hSyn

Available Since

Feb. 4, 2022

Availability

Academic Institutions and Nonprofits only

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pAAV9-hSyn-iCytSnFR_ER

Plasmid

#177752

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn-iCytSnFR_ER

Use

AAV

Promoter

hSyn

Available Since

Feb. 4, 2022

Availability

Academic Institutions and Nonprofits only

Enlarge
pAAV9-hSyn iCyt_BrEt_SnFR_ER

Plasmid

#177756

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn iCyt_BrEt_SnFR_ER

Use

AAV

Promoter

hSyn

Available Since

Dec. 9, 2021

Availability

Academic Institutions and Nonprofits only

Enlarge
pAAV9-hSyn-iCyt_F_SnFR_ER

Plasmid

#177754

Purpose

Develop a family of genetically encoded fluorescent biosensors for nicotinic agonists, termed iDrugSnFRs, thus enabling optical subcellular pharmacokinetics for nicotinic agonists

Depositor

Henry Lester

Article

Nichols et al eLife. 2022 Jan 4;11. pii: 74648. doi: 1

Insert

pAAV9-hSyn-iCyt_F_SnFR_ER

Use

AAV

Promoter

hSyn

Available Since

Dec. 9, 2021

Availability

Academic Institutions and Nonprofits only

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pX601-AAV-CMV::NLS-saCas9-NLS-3xHA-bGHpa;U6::BsaI-sgRNA-lacZ

Plasmid

#175175

Purpose

A single vector containing Cas9 from Staphylococcus aureus (SaCas9) and its sgRNA targeting lacZ

Depositor

Bernardo Sabatini

Article

Melzer et al Cell. 2021 Oct 28;184(22):5622-5634.e25.

Insert

sgRNA-lacZ

Use

AAV and CRISPR

Available Since

Dec. 1, 2021

Availability

Academic Institutions and Nonprofits only

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pAAV-U6-DR36(DjCas13d-SapI)-CMV-intron-MCS-pA

Plasmid

#233031

Purpose

To express a DjCas13d-compatible gRNA

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

DjCas13d-compatible gRNA expression cassette

Use

AAV

Available Since

March 4, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV_EF1a-FLEx(FRT)-GCaMP8m

Plasmid

#252530

Purpose

Expresses the genetically encoded calcium indicator GCaMP8m in Flp-expressing cells under the EF1a promoter for calcium imaging.

Depositor

Gordon Fishell

Article

Mazo et al Res Sq [Preprint]. 2025 Jun 12:rs.3.rs-6

Insert

GCaMP8m

Use

AAV

Expression

Mammalian

Available Since

May 27, 2026

Availability

Academic Institutions and Nonprofits only

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AAV-hSyn1-DIO-optoRet(WT)

Plasmid

#253534

Purpose

optogenetic activation of RET downstream signalling

Depositor

Won Do Heo

Article

Hyeon et al Nat Commun. 2025 Aug 21;16(1):7797. doi:

Insert

DIO-optoRET

Use

AAV

Tags

HA

Promoter

hSyn1

Available Since

April 10, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-CAMKII-DrBphP-PCM

Plasmid

#241775

Purpose

To produce AAV9 encoding CAMKII-DrBphP-PCM

Depositor

Vladislav Verkhusha

Article

Kasatkina et al Nat Commun. 2025 Jul 14;16(1):6469. doi:

Insert

DrBphP-PCM

Use

AAV

Promoter

CAMKII

Available Since

Sept. 16, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-0.5Syn-CasRX-mCherry-pA

Plasmid

#192491

Purpose

To express CasRx

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

CasRx

Use

AAV

Mutation

No

Promoter

0.5Syn

Available Since

Aug. 27, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-intron-DjCas13d-pA

Plasmid

#192495

Purpose

To express DjCas13d

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

DjCas13d

Use

AAV

Mutation

No

Promoter

CMV

Available Since

Aug. 27, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-intron-CasRx-pA

Plasmid

#192487

Purpose

To express CasRx

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

CasRx

Use

AAV

Mutation

No

Promoter

CMV

Available Since

Aug. 27, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CaMKII-ASAP3-WPRE

Plasmid

#240052

Purpose

Constitutive expression of genetically encoded voltage indicator ASAP3

Depositor

Mark Schnitzer

Article

Haziza et al Cell, 188, 1-23, August 7, 2025. doi: 10

Insert

ASAP3

Use

AAV

Promoter

CaMKII

Available Since

July 10, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-(n1)QC2-6 FIQ(c4)-P2A-FusionRed

Plasmid

#229573

Purpose

Expresses (n1)QC2-6 FIQ(c4) and FusionRed in mammalian cells

Depositor

Kiryl Piatkevich

Article

Zhang et al Nat Methods. 2024 Apr;21(4):657-665. doi

Insert

(n1)QC2-6 FIQ(c4)

Use

AAV

Expression

Mammalian

Available Since

July 24, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CAG-fDIO-OFF-ArgiNLS-oScarlet

Plasmid

#220606

Purpose

Flp-independent expression of a single-cell discriminating version of oScarlet fluorescent protein. Flp activity can turn off expression.

Depositor

Sam Golden

Article

Szelenyi et al Proc Natl Acad Sci U S A. 2024 Aug 6;121

Insert

oScarlet

Use

AAV

Tags

ArgiNLS

Expression

Mammalian

Promoter

CAG

Available Since

Aug. 1, 2024

Availability

Academic Institutions and Nonprofits only

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AAV-U6-sgRNA-Scaffold-cTNT-SaCas9-HA-OLLAS

Plasmid

#209781

Purpose

Expresses SaCas9 by the specific cTNT promoter and sgRNA scaffold by U6 promoter

Depositor

Yuxuan Guo

Article

Yang et al Circulation. 2024 May 28;149(22):1778-17

Insert

cTNT

Use

AAV

Tags

HA and OLLAS

Promoter

cTNT

Available Since

May 29, 2024

Availability

Academic Institutions and Nonprofits only

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AAV-U6-msCAMK2d-sgRNA-cTNT-SaCas9-HA-OLLAS

Plasmid

#209782

Purpose

Expresses SaCas9 by the specific cTNT promoter and sgRNA targeted the mouse Camk2d gene by U6 promoter

Depositor

Yuxuan Guo

Article

Yang et al Circulation. 2024 May 28;149(22):1778-17

Insert

sgRNA

Use

AAV

Tags

HA and OLLAS

Promoter

cTNT

Available Since

May 29, 2024

Availability

Academic Institutions and Nonprofits only

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pAAV-DIO-DREADD-Gs

Plasmid

#247959

Purpose

Cre dependant viral expression of HA-DREADD-Gs

Depositor

Giovanni Marsicano

Article

Pagano Zottola et al Nat Neurosci. 2025 Sep;28(9):1844-1857.

Insert

DREADD-Gs

Use

AAV

Tags

HA

Available Since

April 17, 2026

Availability

Academic Institutions and Nonprofits only

Enlarge