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Addgene

Enter a sequence to perform a BLAST-based search of the Addgene plasmid sequence database.

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In Category

We narrowed to 464 results for: LARGE

Showing: 341 - 360 of 464 results

  2. Pipetting Protocol

    Type
    Protocol
    ... liquid. Pro-Tip If pipetting from a relatively large container holding a small volume of liquid, tilt...

  4. 28 Hot Plasmid Technologies from 2015

    Type
    Blog Post
    ...modulate biological processes, but it did not show large changes in binding affinity with light stimulation...advantageous compared to other viral systems due to its large cargo capacity, minimal cytotoxicity, and broad ... CRISPR-Display uses the dCas9 enzyme to deploy large RNA cargos to specific DNA loci. In CRISPR-Display...

  7. CRISPR 101: Epigenetics and Editing the Epigenome

    Type
    Blog Post
    ...) NLS-Sa dCas9-NLS-LSD1. LSD1 is a particularly large protein, and this fusion allows for packaging into...genomic targets. These two vectors are part of the larger pMVP/pMAGIC cloning system, which contains Cas9...

  8. Deep Dive: Statistical Tests (Comparisons)

    Type
    Blog Post
    ... to reduce false positive rates and control for large numbers of comparisons. The Bonferroni does this...arranging all calculated p values from smallest to largest and ranking them (1 being the smallest value). ...calculates the cut off for significance by finding the largest p value where its rank divided by the total number...

  11. 22 Hot Plasmid Technologies from 2014

    Type
    Blog Post
    ...mechanism for sgRNA delivery and providing a means for large scale functional screens. For more information on... kinases Receptor tyrosine kinases (RTKs) are a large class of cell-surface receptors which play a critical...

  14. Important Considerations When Using AAVs

    Type
    Blog Post
    ...preferential tropism for different brain regions is largely due the ability of different serotypes to infect...is fine and a researcher should aim to inject a larger amount of vector using a serotype with strong CNS... of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps." Journal...

  17. Sequencing Options for CRISPR Genotyping

    Type
    Blog Post
    ...require high read counts (fast multiplexing) Requires large cell population, senstive to time since cell fixing...; Pattanayak et al. 2013). This approach misses larger mismatches (e.g. six nucleotides) that may still...
Showing: 341 - 360 of 464 results