...abasic site cleavage, and PARP1 hyperactivation, forming nuclear condensates that disrupt RNA processing...comparing conformational selection and induced fit binding models, her team identified conformational selection...Emily King, Kleinstiver Lab, Harvard) is a 96-well platform for parallel characterization of hundreds of base... at the meeting: PM577a, a lipid nanoparticle-formulated prime editor delivered to the liver to correct...decisively beyond proof of concept, with multiple platforms now demonstrating durability, tunability, and ...described Wave Life Science’s GalNAc-conjugated AIMer platform, which engages endogenous ADAR for hepatocyte-...structures, molecular simulations, and structure informed diffusion models become more widely available,...