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...publications, focused on somatic variants found in lung adenocarcinoma as well as variants found across cancer types...Research Plasmids and Resources Addgene has a large variety of resources for use in cancer signaling studies...

... base editors are available with multiple Cas9 variants including high fidelity Cas9’s. Further advancements...fusions, modifying the linker region between Cas variant and deaminase to adjust the editing window, or ...systems create a wide spectrum of single-nucleotide variants (somatic hypermutation) in a wider editing window...

... a large number of zinc fingers that recognize various nucleotide triplets. With some trial and error,...from each other by two amino acids, their repeat-variable di-residue (RVD). Ultimately, it is this RVD that...31 repeats can be assembled and inserted into a variety of backbones in just a few steps ( Figure 2 ). ...

...combination of gene variation and lifestyle or environmental factors. For example, variations of Apolipoprotein...et al. Nat Commun. 2022) Endogenously tag gene variants for Alzheimer's disease and related dementias ...

...nervous system function. While there is wide variability in symptoms even within patients with the same...repository Tissue Banks (Link opens in a new window) Harvard Brain Bank (Link opens in a new window) Autism ...algorithms for data analysis to calculate heart rate variability (Link opens in a new window) Protocols.io - protocol...

...ChETA, C1V1 (t/t) Inhibitory Arch and variants eNpHR and variants InSynC (non-opsin) Jaws WiChR stGtACR...AAVrg PHPeB Clear Filters ID Name Promoter Opsin Variant Tag Activity Serotype PI 20071 pACAGW-ChR2-Venus-AAV...

...enzyme responsible for bioluminescence found in a variety of organisms, ranging from bacteria to aquatic ...the protein is available, making it ideal for a variety of applications. To learn more and plan your experiment...Highlighted Tools Modified/Novel Luciferases Engineered variants of luciferases with altered emission, substrate...

...whose expression levels can be controlled by a variety of small molecules, light, and temperature, in ...#1000000037) contains specific bacterial promoters that vary in strength and that can be used to reliably drive...constructs. The Zinc Finger Consortium page contains a variety of reagents for engineering and expressing zinc...

...Enhancers were evaluated in mouse brains, using various delivery methods including intracerebroventricular...contains best-in-class AAV plasmids to target a variety of cell populations in different brain regions...., G., Johansen, N. J., Hooper, M., Omstead, V., Vargas, S., Lerma, M. N., Taskin, N., Weed, N., Laird,...

...expression, the system has been engineered with a variety of improvements. A synthetic Tet Response Element...). rtTA3 and Tet-On 3G : further improved rtTA variants with lower background activity and greater sensitivity...Lentiviral Tet-On inducible RNAi with miR-E (miR-30 variant)-based backbone rtTA-Advanced TRE3G Johannes Zuber...

...often closely related to its function. There are a variety of methods for determining subcellular localization...fluorescent fusion proteins that are targeted to various organelles or subcellular structures. To compare... General Structures Eukaryotic cells contain a variety of organelles and subcellular structures, each ...

...including calcium sensors, under the control of various promoters. Sensor Green Calcium Sensors GCaMP8 ...Calcium Sensor: GCaMP7c 105321 pGP-AAV-syn-jGCaMP7c variant 1513-WPRE Syn jGCaMP7c none Constitutive 1 Douglas...Douglas Kim 105322 pGP-AAV-syn-FLEX-jGCaMP7c variant 1513-WPRE Syn jGCaMP7c none Cre 1 Douglas Kim Calcium...

...to generate and characterize single nucleotide variant lines in an isogenic cellular background. All cell...create cell lines with endogenously-tagged gene variants or to differentiate human iPSCs into other cell...

...for AAV production or direct transfection, slow variant Kaspar Podgorski 135421-AAV1 pAAV-syn-FLEX-axon-jYCaMP1s...for AAV production or direct transfection, slow variant Kaspar Podgorski 135424-AAV1 pAAV-syn-jYCaMP1s ...for AAV production or direct transfection, slow variant Kaspar Podgorski 135630-AAV1 pAAV-S5E2-dTom-nlsdTom...

... community demonstrating AAV performance under various experimental conditions. Protocols Written and ...and scientists across the research community on various aspects of viral vectors, including troubleshooting...

... with EF1alpha addition of an mCherry reporter variant nuclear reporters via an H2B fusion shuttle plasmid...fusion for gene activation CRISPR/Cas9 Plasmid Variants Figure 1: Schematic of the CRISPR Collection. ...

...Find plasmids to overexpress various fluorescent markers and tag your proteins of interest with fluorescent...codon-optimized fluorescent proteins (FPs) in a variety of plasmids allows for constitutive overexpression...

...Addgene's CRISPR collections feature plasmids for a variety of organisms, including mammals, plants, bacteria...an empty vector for your experiment based on a variety of factors. Browse Plasmids by Model Organism Bacteria...

...applications. The specific QC experiments performed varies for each antibody catalog item. Whenever possible...primers targeting the heavy chain and/or light chain variable regions. The PCR product is purified, sequenced...

...stably integrate transgenes of interest into a variety of cell types. Wild-type gamma-retroviruses have...the Weinberg Lab page for additional resistance variants. Bob Weinberg 1773 pBABE-hygro-hTERT MoMLV Expression...