We narrowed to 48 results for: hyper

1. Rett Syndrome: A History of Research and Therapeutic Outlooks

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   Blog Post

   ...They introduced a mouse MECP2 guide RNA and a hyperactive version of the human RNA base editing enzyme ...

2. Five Popular Model Organisms, Part 2

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   Blog Post

   ...cardiovascular disease, specifically stroke and hypertension (Iannaccone et al., 2009). Rodents have also...

3. A Control for All Seasons

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   Blog Post

   ...well-studied kinase known to prevent tau hyperphosphorylation. You could run brain samples from both groups...

4. Viral Vectors 101: Optogenetic Tools

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   Blog Post

   ...Na+) against the concentration gradient and hyperpolarize the cell (Mattis et al., 2012). Bicistronic ...

5. PiggyBac-ing Through the Genome Editing Field

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   ...that of the wildtype piggyBac™ transposase or hyperactive transposase mutants [7], it is generally not ...

6. Starter Guide to induced Pluripotent Stem Cells (iPSCs) Part 2:  Reprogramming and Transdifferentiation

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   Blog Post

   ...liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med, 2000. 6(5): p. 568-72. PubMed PMID...

7. Optogenetics Guide

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   Guide

   ..., Chrimson, ChrimsonR, Chronos Inhibitory (Hyperpolarizing) ChR Variants. Alternatively, ChR variants ...chloride channels, these variants result in the hyperpolarization of neurons. Examples of anion channel variants...NpHR (from Natronomonas pharaoni ), causes hyperpolarization (inhibition) of the cell when triggered with... a light-activated outward proton pump that hyperpolarizes (inhibits) the cell when triggered by green-yellow...

8. CRISPR Guide

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   Guide

   ...spectrum of single-nucleotide variants (somatic hypermutation) in a larger editing window. These systems are...REPAIR , developed by the Feng Zhang lab , used a hyperactive adenosine deaminase that acts on RNA, ADAR2(E488Q...Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nature Methods . 13 (12)...