... scientific discovery through the creation of innovative technologies. To date his group has develop several...E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon...Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJK, Buchthal J,...

...https://doi.org/10.1038/s41551-019-0501-5  Liu J-J, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck...Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F (2015) In vivo...S, Koopal B, Schmid-Burgk J, Zetsche B, Gao L, Makarova KS, Koonin EV, Zhang F (2019) Engineering of CRISPR-Cas12b...

...their initial assumption. Eugene Koonin and Kira Makarova, longtime collaborators of Omar and Jonathan and.... Using computational observations, Koonin and Makarova found that Cas7-11 appeared to have derived from...Özcan A, Krajeski R, Ioannidi E, Lee B, Gardner A, Makarova KS, Koonin EV, Abudayyeh OO, Gootenberg JS. Programmable...

... in DMD patient myoblasts. They observed a 13% removal rate of exon 51, which resulted in appropriately...evaluated separately, increasing the time to clinical approval. Even with the challenges precision editing faces...Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. In vivo genome...

...doi.org/10.1016/j.omtm.2022.07.010 Issa, S. S., Shaimardanova, A. A., Solovyeva, V. V., & Rizvanov, A. A. ...Lavzin, M., Ritola, K. D., Lindo, S., Michael, S., Kuleshova, E., Ojala, D., Huang, C.-C., Gerfen, C. R., Schiller...Hantman, A. W., Looger, L. L., Schaffer, D. V., & Karpova, A. Y. (2016). A Designer AAV Variant Permits Efficient...

...Epigenetics began as a correlative field in which covalent modifications to DNA or histones, the proteins...downstream of Tet1 to restore the DNA after cytosine removal. Recently, Albert Cheng’s lab developed Casilio-ME...lab has deposited pX330a dCas9-LSD1 for targeted removal of H3K4me1/2 and H3K9me2 histone modifications....

..., Sullender M, Hegde M, Vaimberg EW, Donovan KF, Smith I, Tothova Z, Wilen C, Orchard R, Virgin HW, Listgarten...inactivation. Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier...

...nucleic acids, or glycans. Fluorophores can also be covalently attached to self-labeling proteins. Some common...a genetically encoded enzyme variant tag that covalently reacts with a small substrate ligand motif attached... or the degree of labeling (DOL), and thorough removal of unconjugated dye molecules are critical for ...

...from Madame Curie), chemotherapy, and surgical removal of the tumor. However, these conventional therapies...the immune system from fighting cancer. Surgical removal causes increases in tumor cytokines like TGFβ and..."Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts...

... neuroscience research. Institute for Protein Innovation Collection : Antibodies to highly conserved proteins...

...generally ready for shipment within 8 weeks after the approval of the MTA by your institution. Our final step...

...includes pLX_305_Ovalbumin, a plasmid that enables introduction of the model antigen, Ovalbumin, into cell...

...Functional siRNAs and miRNAs exhibit strand bias . Khvorova A et. al. Cell . 2003. 115:209-216. PubMed . A...

...Chapter 2: The Centre for Synthetic Biology and Innovation - A shared space for bringing synthetic biology...researcher at the Centre for Synthetic Biology and Innovation, Imperial College London and lectures synthetic...

...produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory...

...we are here to make it fast and easy. Fast Approval: The UBMTA used by Addgene is internationally ...and familiarity with the UBMTA result in quick approvals, so your plasmid requests can get to your lab ...

...request will be reviewed by Addgene for legal approvals and technical compatibility with our production...not need to be placed immediately upon request approval. Once approved, the request will remain in your...

...new partnership with the Institute for Protein Innovation (IPI), in which Addgene will distribute recombinant...the year, we’ll be celebrating with stories of innovation and impact made possible by the sharing of tools...

...Global Head Muscle Diseases at Novartis, opened with a discussion of the Novartis industry postdoctoral program...

...produced with the AAV retro helper plasmid from the Karpova and Schaffer labs. See the Retrograde AAV Inventory...