... tools. Studies of GPCRs led to development of mutated receptors that while unresponsive to endogenous...experimental setup) were not possible. To overcome this limitation, the inhibitory KORD DREADD was developed to ...PSEMs). PSAM domains were first named for the mutations that allowed them to respond to their cognate ...anti-smoking drug varenicline. This PSAM carries mutations at L131G, Q139L, and Y217F and is termed PSAM4...Krashes, M. J., … Roth, B. L. (2015). A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of...