Adapting Toehold Switches to Detect Zika Virus
Type
Blog Post
...Organization has declared a global health emergency and called for the fast-tracked development of diagnostics...was a new class of programmable riboregulators, called toehold switches, which allow for the rational ...outbreak was reported, and we felt that, given the critical need for low-cost, field-based diagnostics, our...Our motivation was underscored by the potential scale of the emerging outbreak, as many as 2.2 billion...timeline to develop our paper-based platform into clinically relevant diagnostics for the Zika virus was daunting...ability to complete the project on such a short timescale.
Our article ultimately reported the development...that has transformed the assay’s capabilities. Specifically this includes primer directed isothermal RNA...