No Llamas Required - Synthetic Nanobodies Against Membrane Proteins
Type
Blog Post
...sybodies against membrane proteins
Developing antibodies against proteins embedded in membranes is tricky because...to 1012 members) in comparison to other display systems using phage and yeast (109-1010 members). This ...develop antibodies against unstable targets like membrane proteins that may unfold due to camelid high body...synthetic nanobodies, called sybodies, against membrane protein targets in as little as 3 weeks (Zimmermann...lab can quickly select for sybodies targeting a membrane protein of interest using the Sybody Generation... the process for selection of sybodies against membrane proteins. Image from Zimmermann et al., 2018.
...SARS-CoV-2 Receptor Binding Domain found on the membrane-bound spike protein, in a remarkable 12 working...