mTOR Pathway
Type
Collection
...complexes, mTORC1 and mTORC2. Each complex contains a unique
subunit: raptor for mTORC1, and rictor...rictor for mTORC2. Background mTORC1 & mTORC2 The better-characterized mTORC1 responds to various signals...mutations in negative regulators of mTORC1. The hyperactivation of mTORC1 in cancer promotes the conditions...stress, oxygen, energy levels, and growth factors. mTORC1 integrates these signals to determine the nutritional...switch from anabolic to catabolic processes. Active mTORC1 promotes protein and lipid synthesis, and increases...glycolysis to fuel these energy-intensive processes. mTORC1 also blocks catabolic processes including autophagy...Cancer Impact Enhanced signaling through either mTORC1 or mTORC2 correlates with poor prognosis in many...