...surprising. However, the molecular and cellular mechanisms behind the immune defects in CDG patients are...The primary focus of his lab’s research is the mechanisms by which proteins assemble into functional multi-subunit...development since 2000 and have shown several mechanisms by which they affect brain and muscle development...

...daughter strands are methylated. These regulatory mechanisms in E. coli permit controlled copying of chromosomes...also interacts with DnaA directly. Both of these mechanisms stabilize DnaA binding and lead to breaking of... or sequences necessary for initiation or the mechanisms utilized to regulate their replication, but their...

... have a specialized role within an organism. Mechanisms of epigenetic modifications The main mechanism.... Chromatin remodeling can occur by two main mechanisms, either through histone modifications, which ...development and progression of cancer through different mechanisms. New FRET based tools to study epigenetics Epigenetic...

...developing novel technologies to analyze molecular mechanisms of genome functions such as epigenetic regulation...epigenetic regulation. To elucidate molecular mechanisms of regulation of genome functions, we need to...will markedly accelerate research of regulation mechanisms of genome functions in the hope of developing...

... a wide range of organisms and cell lines. In C. elegans, one of the model organisms which I use to study...methods – could greatly streamline editing in other organisms and systems, allowing rapid progress in a wide...

...vectors to study the neural circuitry behind the mechanisms of sleep and anesthesia. In Cre transgenic mice...optogenetics to understand the cellular and molecular mechanisms of the brain in vivo. Many thanks to our guest...rhodopsins: structures, functions, and molecular mechanisms." Chemical reviews 114.1 (2013): 126-163. PubMed...

...organs, and most importantly escape the immune mechanisms of the host. The cause, manifestation, diagnosis...this phase are able to outsmart the host immune mechanisms altogether and escape future immune surveillance...of colorectal cancer. Strategic immune evasion mechanisms - The tumor microenvironment Through interactions...

...plasmids due to lower activation of DNA-silencing mechanisms. While minicircles are typically smaller than...) studies focused on better understanding the mechanisms of reprogramming, and 2) studies with clinical...Hochedlinger. "Induced pluripotency: history, mechanisms, and applications." Genes & Development 24, no...

...listed? Help us serve you! Let us know about other organisms we should include by emailing us at [email protected] narrow your keyword search to one of these organisms. Help us continue to develop resources for your...

...scientists to edit the genome of virtually any organisms on this planet, CRISPR-Cas systems were merely... to quickly detect the presence of infectious organisms (ex: SARS-CoV-2) and genetic mutations. By providing...

... editing tool of choice for a number of model organisms: mammalian cells, yeast, drosophila, plants, worms...obligate thermophiles without the need to grow the organisms at lower than optimal temperatures. GeoCas9’s ...

...inner structures of delicate plants and other organisms without destroying the original, which could provide...Do you look for the beauty in the microscopic organisms on your lab bench? Let us know in the comments...

...versatile and can be applied across cell types and organisms by replacing the transcription factor binding ...the PhiC31 recombinase can work in other model organisms including mouse and fish, SPARC is likely generalizable...

... can function to break membranes of different organisms. And finally, we demonstrated that R bodies can...speculatively, R bodies might endow divergent organisms with new functions. For inspiration, we can look...

...investigate the susceptibility of cells from different organisms to SARS-CoV-2 (Chu et al., 2020). An additional...for the advancement of scientific research, and mechanisms to maintain and grow these critical organizations...

...cleavage. Secondly, fluorescence imaging of living organisms can be challenging due to issues with tissue autofluorescence...dynamics of apoptosis both in vitro and in living organisms to better study and understand these diseases ...

...Viral delivery has several advantages over other mechanisms. For one, many viral platforms, such as AAV or...analyte. This can be difficult to achieve in whole organisms, but AAVs make it possible. In AAV systems, different...

...mutagenizing a population (typically cells or small organisms) and then assaying for a functional or phenotypical... events. To put it another way, only cells or organisms with the desired phenotype will survive and be...

...basics.  Mesophiles vs. extremophiles Mesophilic organisms are your regular next-door microbes which grow...cold conditions. However, many of the detailed mechanisms that allow extremophiles to survive under these...

... Fig. 1 CRISPR activator and repressor mechanisms Want to transiently induce expression? Check...post-translational level, unlike most of the other mechanisms described. Fig. 3 dTag mechanism of protein...