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Showing: 1 - 12 of 12 results

  1. Impact of Genomic Variation on Function (IGVF) Consortium Collection

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    Collection
    ... Depositor Collections IGVF Consortium Impact of Genomic Variation on Function (IGVF) Consortium... a new window) (Link opens in a new window) The Impact of Genomic Variation on Function (IGVF) Consortium...variation affects genome function, which in turn impacts phenotype. The National Human Genome Research Institute...These joint efforts will produce a catalog of the impact of genomic variants on genome function and phenotypes...systematically perturbs the genome to assess the impact of genomic variation on genome function and phenotype...

  2. p53 Pathway

    Type
    Collection
    ...weight (53 kDa) when run on an SDS-PAGE gel. Cancer Impact p53 is the most frequently mutated gene (>50%) ...disorder known as Li-Fraumeni syndrome. Recently some impacts of p53 mutations have been characterized as gain-of-function...

  3. Plasmid Collections

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    Collection
    ...Migration Consortium Center for Genome Engineering Impact of Genomic Variation on Function (IGVF) Consortium...

  5. mTOR Pathway

    Type
    Collection
    ... survival and cytoskeletal organization. Cancer Impact Enhanced signaling through either mTORC1 or mTORC2...

  7. Ras Pathway

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    Collection
    ...cascade that starts at the plasma membrane. Cancer Impact Ras is ubiquitously expressed in all cells and ...

  8. TALENs for Endogenous Zebrafish Genes

    Type
    Collection
    ...TCCGGGATCCGGGCTGCGgctgctgttcctcctgCGCCCTGCGGAGCGGCGA Impact homolog (mouse) TAL3462 & TAL3463 TGGACAAATTAGAGGATCatgacgataataatctGCAGTCTCAGATAGAGGA...

  9. Rett Syndrome

    Type
    Collection
    ...trans-splicing, and protein replacement to reverse the impacts of this disease. Addgene is working with the RSRT...

  11. CRISPR Guide

    Type
    Collection
    ...throughout the genome, called off-targets, that can impact your experiment. There are many online tools available...Terns, M. P. (2018). CRISPR-Based Technologies: Impact of RNA-Targeting Systems. Molecular Cell , 72 (...
Showing: 1 - 12 of 12 results