... Depositor Collections IGVF Consortium Impact of Genomic Variation on Function (IGVF) Consortium... a new window) (Link opens in a new window) The Impact of Genomic Variation on Function (IGVF) Consortium...variation affects genome function, which in turn impacts phenotype. The National Human Genome Research Institute...These joint efforts will produce a catalog of the impact of genomic variants on genome function and phenotypes...systematically perturbs the genome to assess the impact of genomic variation on genome function and phenotype...

...weight (53 kDa) when run on an SDS-PAGE gel. Cancer Impact p53 is the most frequently mutated gene (>50%) ...disorder known as Li-Fraumeni syndrome. Recently some impacts of p53 mutations have been characterized as gain-of-function...

...EXtracellular Plasmid RESource (EXPRESs) Consortium Impact of Genomic Variation on Function (IGVF) Consortium...

...course-based undergraduate research experiences (CURE) impacts student learning and attitudinal outcomes: A study...

...consider and quantify the impact of scientific publications. Ventures like Impact Story seek to find ways...holiday season want the work you are doing to have an impact, to move science forward, or perhaps even society...and has been to publish in journals with a high “impact factor,” a measure that dates back to 1975 and ... of other ways to define and measure scientific impact. Even if we stick to citation counts for a moment...October entitled “Rise of the Rest: The Growing Impact of Non-Elite Journals” found that the proportion...half.   The effect of online access on scientific impact Partly, the story has to do with online accessibility...journal publications really the best way to measure impact? As that Nature report also noted, papers detailing...

...to the amount you are dispensing can negatively impact your experimental results. This protocol will guide...

... survival and cytoskeletal organization. Cancer Impact Enhanced signaling through either mTORC1 or mTORC2...

... across regions, with Europe most impacted and China least impacted. The inferred weekend effect is, in...date range is, they could be the most impacted or least impacted. These results highlight the instability... last six months, COVID-19 has had a tremendous impact on our world -- as of June 4, 2020, COVID-19 has...unique PIs/labs placing orders per day) on dates impacted by each effect. The inferred parameters suggest...methods for fundamental scientific discovery and high-impact applications.       Alvin Hsu is a graduate student...

...the lab could make a big difference in our global impact as scientists. Many scientists are already leading...toward responsibility in our lab’s environmental impact, but we can all do more to make research more environmentally...and companies have the potential to make a huge impact directly on waste, but also on culture. Encourage...your workplace and you could end up making a huge impact on how waste is handled. A lot of places have small...

...architecture of my cells,” or “How does this mutation impact the types of cells found in my tissue.” It is based...antibody performs differently and some antibodies impact the performance of other antibodies. But, once ...the right protocol, multiplex IF can give you impactful and beautiful results. Performing an immunofluorescence...fixation maintains sample morphology with minimal impact to the target epitope. There are multiple methods...exclusive to IF, but they can have a significant impact on the outcome of your IF experiment. Many of the...choose for your experiment will have a significant impact on the protocol you use and the ultimate outcome...

...acknowledge Shannon Boye and cite Boye, et al. 2016. Impact of Heparan Sulfate Binding on Transduction of Retina...

...environmental impact on a scale of 1-10: the lower the score, the lower the environmental impact in terms ... product? How can we consider the environmental impact of those processes? Who even regulates them? You...

...cascade that starts at the plasma membrane. Cancer Impact Ras is ubiquitously expressed in all cells and ...

...response initiatives. Accelerate the translational impact of research Universities have also been stepping...research synergies and accelerating the translational impact of research activities. By streamlining the development...by coming together, we can create a significant impact on both clinical care and public health for this...

...this time more visible and thereby have a positive impact on science. ReFigure saves time, knowledge and ...definitely give you credit for it and increase your impact! Download ReFigure extension and visit ReFigure.org... with Joe Akin. She envisions a world where the impact of teaching and doing science is rapid, concrete...

...the focus shifts to choosing an unexplored and impactful research topic that aligns with your interests...when selecting a research project. What will the impact be in a best case scenario? If you get your dream...what will your paper look like? What will be the impact on your field? You want to choose a research question...

...are crucial in demonstrating the true innovation, impact and, in turn, the big picture of the project. For... For example, how can future regulations impact your work? What design variables need consideration? Enrich...project is an innovative solution with a strong impact, or a journalist does not understand the high-level...

...realizing it. Yet, this selection is crucial as it will impact downstream outcomes of an experiment, including...Grimm & Lavis, 2022). These variations directly impact the way you can utilize these dyes. The most-used...emission of labeled agonists and antagonists, impacting the interpretation of experimental results. It's...dopamine D2/D3 receptors (Allikalt et al., 2020) Impact of labeling process: The process of dye labeling... on the respective fluorochrome. Brightness is impacted by both the excitation coefficient, characterizing...multiple dyes during analysis. Image resolution is impacted by several factors. Firstly, brighter dyes enable...

...lost during fixation with these chemicals, which impacts sample structure and could also cause your target...destroy it for others. That said, organic solvents’ impact on lipids means that they are able to permeabilize....   Figure 1: Choice of fixation method impacts antibody binding. Formaldehyde cross-links the ...detergent has different chemical properties that will impact the level of permeabilization and membrane integrity...

...week to celebrate the scientists who make a big impact in open science. Depositors consistently contribute...depositor fun facts for a quick way to grasp the big impacts depositors have on science globally. *All data ...