Chemogenetics Guide
Type
Guide
...G-protein coupled receptors (GPCRs) . The largest class of cell surface receptors, GPCRs are seven-pass transmembrane...activates G-proteins to modulate downstream signaling. GPCRs have been shown to be involved in a wide variety...inflammation and neurotransmission. This, and the fact that GPCR ligands can have high potency, which is potentially...development into chemogenetic tools. Studies of GPCRs led to development of mutated receptors that while...that couples to β-arrestin to activate noncanonical GPCR signaling independent of G proteins. This DREADD... manipulate neuronal activity indirectly through GPCR signaling, another class of chemogenetic receptors...