pAAV2/9n Citations (55)
Originally described in: AAV packaging plasmidsUnpublished
Articles Citing pAAV2/9n
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| In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System. Prasad M, Jagadeeshan S, Scaltriti M, Allon I, Elkabets M. J Vis Exp. 2020 Jan 9;(155). doi: 10.3791/60410. PubMed |
| Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes. Kohama Y, Higo S, Masumura Y, Shiba M, Kondo T, Ishizu T, Higo T, Nakamura S, Kameda S, Tabata T, Inoue H, Motooka D, Okuzaki D, Takashima S, Miyagawa S, Sawa Y, Hikoso S, Sakata Y. Sci Rep. 2020 Sep 18;10(1):15348. doi: 10.1038/s41598-020-72216-y. PubMed |
| CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain. Mathiesen SN, Lock JL, Schoderboeck L, Abraham WC, Hughes SM. Mol Ther Methods Clin Dev. 2020 Oct 20;19:447-458. doi: 10.1016/j.omtm.2020.10.011. eCollection 2020 Dec 11. PubMed |
| A comparison of AAV-vector production methods for gene therapy and preclinical assessment. Davidsson M, Negrini M, Hauser S, Svanbergsson A, Lockowandt M, Tomasello G, Manfredsson FP, Heuer A. Sci Rep. 2020 Dec 9;10(1):21532. doi: 10.1038/s41598-020-78521-w. PubMed |
| Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3(Mashl/+), Mouse Model of Alternating Hemiplegia of Childhood. Hunanyan AS, Kantor B, Puranam RS, Elliott C, McCall A, Dhindsa J, Pagadala P, Wallace K, Poe J, Gunduz T, Asokan A, Koeberl DD, ElMallah MK, Mikati MA. Hum Gene Ther. 2021 Apr;32(7-8):405-419. doi: 10.1089/hum.2020.191. Epub 2021 Feb 12. PubMed |
| Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. De Gasparo R, Pedotti M, Simonelli L, Nickl P, Muecksch F, Cassaniti I, Percivalle E, Lorenzi JCC, Mazzola F, Magri D, Michalcikova T, Haviernik J, Honig V, Mrazkova B, Polakova N, Fortova A, Tureckova J, Iatsiuk V, Di Girolamo S, Palus M, Zudova D, Bednar P, Bukova I, Bianchini F, Mehn D, Nencka R, Strakova P, Pavlis O, Rozman J, Gioria S, Sammartino JC, Giardina F, Gaiarsa S, Pan-Hammarstrom Q, Barnes CO, Bjorkman PJ, Calzolai L, Piralla A, Baldanti F, Nussenzweig MC, Bieniasz PD, Hatziioannou T, Prochazka J, Sedlacek R, Robbiani DF, Ruzek D, Varani L. Nature. 2021 May;593(7859):424-428. doi: 10.1038/s41586-021-03461-y. Epub 2021 Mar 25. PubMed |
| Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models. Roy DS, Zhang Y, Aida T, Choi S, Chen Q, Hou Y, Lea NE, Skaggs KM, Quay JC, Liew M, Maisano H, Le V, Jones C, Xu J, Kong D, Sullivan HA, Saunders A, McCarroll SA, Wickersham IR, Feng G. Neuron. 2021 Aug 18;109(16):2590-2603.e13. doi: 10.1016/j.neuron.2021.06.005. Epub 2021 Jun 30. PubMed |
Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL.
Cell. 2021 Oct 14;184(21):5465-5481.e16. doi: 10.1016/j.cell.2021.09.005. Epub 2021 Sep 27.
PubMed
Associated Plasmids |
| Neuronal Menin Overexpression Rescues Learning and Memory Phenotype in CA1-Specific alpha7 nAChRs KD Mice. Batool S, Akhter B, Zaidi J, Visser F, Petrie G, Hill M, Syed NI. Cells. 2021 Nov 24;10(12). pii: cells10123286. doi: 10.3390/cells10123286. PubMed |
| A fast, aqueous, reversible three-day tissue clearing method for adult and embryonic mouse brain and whole body. Kosmidis S, Negrean A, Dranovsky A, Losonczy A, Kandel ER. Cell Rep Methods. 2021 Nov 22;1(7):100090. doi: 10.1016/j.crmeth.2021.100090. Epub 2021 Oct 11. PubMed |
| Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice. Yang MS, Park MJ, Lee J, Oh B, Kang KW, Kim Y, Lee SM, Lim JO, Jung TY, Park JH, Park SC, Lim YS, Hwang SB, Lyoo KS, Kim DI, Kim B. Mol Ther. 2022 May 4;30(5):1994-2004. doi: 10.1016/j.ymthe.2022.01.010. Epub 2022 Jan 7. PubMed |
| Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, Yang R, Tian M, Landstrom AP, Henriquez C, Bursac N. Nat Commun. 2022 Feb 2;13(1):620. doi: 10.1038/s41467-022-28251-6. PubMed |
| Frequency- and spike-timing-dependent mitochondrial Ca(2+) signaling regulates the metabolic rate and synaptic efficacy in cortical neurons. Stoler O, Stavsky A, Khrapunsky Y, Melamed I, Stutzmann G, Gitler D, Sekler I, Fleidervish I. Elife. 2022 Feb 22;11. pii: 74606. doi: 10.7554/eLife.74606. PubMed |
| Differential T cell immune responses to deamidated adeno-associated virus vector. Bing SJ, Justesen S, Wu WW, Sajib AM, Warrington S, Baer A, Thorgrimsen S, Shen RF, Mazor R. Mol Ther Methods Clin Dev. 2022 Jan 18;24:255-267. doi: 10.1016/j.omtm.2022.01.005. eCollection 2022 Mar 10. PubMed |
Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Abeta42-Mediated Neurotoxicity.
Li X, Zhang Y, Ai HW.
ACS Sens. 2022 Feb 28. doi: 10.1021/acssensors.1c01381.
PubMed
Associated Plasmids |
| CMYA5 establishes cardiac dyad architecture and positioning. Lu F, Ma Q, Xie W, Liou CL, Zhang D, Sweat ME, Jardin BD, Naya FJ, Guo Y, Cheng H, Pu WT. Nat Commun. 2022 Apr 21;13(1):2185. doi: 10.1038/s41467-022-29902-4. PubMed |
| Dietary intervention preserves beta cell function in mice through CTCF-mediated transcriptional reprogramming. Wang RR, Qiu X, Pan R, Fu H, Zhang Z, Wang Q, Chen H, Wu QQ, Pan X, Zhou Y, Shan P, Wang S, Guo G, Zheng M, Zhu L, Meng ZX. J Exp Med. 2022 Jul 4;219(7). pii: 213256. doi: 10.1084/jem.20211779. Epub 2022 Jun 2. PubMed |
Neural circuit pathology driven by Shank3 mutation disrupts social behaviors.
Kim S, Kim YE, Song I, Ujihara Y, Kim N, Jiang YH, Yin HH, Lee TH, Kim IH.
Cell Rep. 2022 Jun 7;39(10):110906. doi: 10.1016/j.celrep.2022.110906.
PubMed
Associated Plasmids |
| Targeting miR-30d reverses pathological cardiac hypertrophy. Li J, Sha Z, Zhu X, Xu W, Yuan W, Yang T, Jin B, Yan Y, Chen R, Wang S, Yao J, Xu J, Wang Z, Li G, Das S, Yang L, Xiao J. EBioMedicine. 2022 Jul;81:104108. doi: 10.1016/j.ebiom.2022.104108. Epub 2022 Jun 22. PubMed |
| PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y. EMBO J. 2022 Aug 16;41(16):e110439. doi: 10.15252/embj.2021110439. Epub 2022 Jul 4. PubMed |
A luciferase prosubstrate and a red bioluminescent calcium indicator for imaging neuronal activity in mice.
Tian X, Zhang Y, Li X, Xiong Y, Wu T, Ai HW.
Nat Commun. 2022 Jul 8;13(1):3967. doi: 10.1038/s41467-022-31673-x.
PubMed
Associated Plasmids |
| TOB is an effector of the hippocampus-mediated acute stress response. Youssef MMM, Hamada HT, Lai ESK, Kiyama Y, El-Tabbal M, Kiyonari H, Nakano K, Kuhn B, Yamamoto T. Transl Psychiatry. 2022 Jul 29;12(1):302. doi: 10.1038/s41398-022-02078-7. PubMed |
| Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. Guo T, Pan X, Jiang G, Zhang D, Qi J, Shao L, Wang Z, Xu H, Zhao Y. J Neurosci. 2022 Aug 9;42(38):7309-17. doi: 10.1523/JNEUROSCI.1060-22.2022. PubMed |
| Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates. Yao Y, Wang J, Liu Y, Qu Y, Wang K, Zhang Y, Chang Y, Yang Z, Wan J, Liu J, Nakashima H, Lawler SE, Chiocca EA, Cho CF, Bei F. Nat Biomed Eng. 2022 Nov;6(11):1257-1271. doi: 10.1038/s41551-022-00938-7. Epub 2022 Oct 10. PubMed |
| Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4. D'Amato G, Phansalkar R, Naftaly JA, Fan X, Amir ZA, Rios Coronado PE, Cowley DO, Quinn KE, Sharma B, Caron KM, Vigilante A, Red-Horse K. Dev Cell. 2022 Nov 21;57(22):2517-2532.e6. doi: 10.1016/j.devcel.2022.10.007. Epub 2022 Nov 7. PubMed |
| Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y, Teng ZQ, Liu CM. EMBO Mol Med. 2022 Dec 7;14(12):e15795. doi: 10.15252/emmm.202215795. Epub 2022 Nov 17. PubMed |
| DOK7 Promotes NMJ Regeneration After Nerve Injury. Kosco ED, Jing H, Chen P, Xiong WC, Samuels IS, Mei L. Mol Neurobiol. 2023 Mar;60(3):1453-1464. doi: 10.1007/s12035-022-03143-4. Epub 2022 Dec 5. PubMed |
| Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in the MEN1 Conditional Knockout Mouse: Behavioral Restoration and Gain of Function following the Reintroduction of MEN1 Gene. Ulfat AK, Batool S, Iqbal F, Syed NI. Cells. 2022 Dec 12;11(24):4019. doi: 10.3390/cells11244019. PubMed |
| Delivering Base Editors In Vivo by Adeno-Associated Virus Vectors. Lim CKW, Miskalis AJ, Perez-Pinera P, Gaj T. Methods Mol Biol. 2023;2606:135-158. doi: 10.1007/978-1-0716-2879-9_11. PubMed |
| Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy. Xu J, Contractor A, Zhu Y. STAR Protoc. 2022 Dec 16;3(4):101907. doi: 10.1016/j.xpro.2022.101907. Epub 2022 Dec 6. PubMed |
| Lactate metabolism is essential in early-onset mitochondrial myopathy. Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P. Sci Adv. 2023 Jan 4;9(1):eadd3216. doi: 10.1126/sciadv.add3216. Epub 2023 Jan 4. PubMed |
| High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography. Florea M, Nicolaou F, Pacouret S, Zinn EM, Sanmiguel J, Andres-Mateos E, Unzu C, Wagers AJ, Vandenberghe LH. Mol Ther Methods Clin Dev. 2022 Dec 16;28:146-159. doi: 10.1016/j.omtm.2022.12.009. eCollection 2023 Mar 9. PubMed |
| Recombinant Adeno-associated Viral Vectors Serotypes 6 and 9 are Able to Transduce Human Tracheal Epithelial Cells but Not Human Induced Pluripotent Stem Cells. Belova L, Demchenko A, Kochergin-Nikitsky K, Kondrateva E, Slesarenko Y, Salikhova D, Lavrov A, Efremova A, Bukharova T, Goldshtein D, Smirnikhina S. Mol Biotechnol. 2023 Sep;65(9):1539-1546. doi: 10.1007/s12033-023-00668-4. Epub 2023 Jan 27. PubMed |
| Ploidy-stratified single cardiomyocyte transcriptomics map Zinc Finger E-Box Binding Homeobox 1 to underly cardiomyocyte proliferation before birth. Bak ST, Harvald EB, Ellman DG, Mathiesen SB, Chen T, Fang S, Andersen KS, Fenger CD, Burton M, Thomassen M, Andersen DC. Basic Res Cardiol. 2023 Mar 2;118(1):8. doi: 10.1007/s00395-023-00979-2. PubMed |
| Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality. Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H. iScience. 2023 Mar 23;26(4):106487. doi: 10.1016/j.isci.2023.106487. eCollection 2023 Apr 21. PubMed |
| Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice. Bu W, Creighton CJ, Heavener KS, Gutierrez C, Dou Y, Ku AT, Zhang Y, Jiang W, Urrutia J, Jiang W, Yue F, Jia L, Ibrahim AA, Zhang B, Huang S, Li Y. Sci Adv. 2023 May 12;9(19):eade0059. doi: 10.1126/sciadv.ade0059. Epub 2023 May 12. PubMed |
| Cortical somatostatin interneuron subtypes form cell-type-specific circuits. Wu SJ, Sevier E, Dwivedi D, Saldi GA, Hairston A, Yu S, Abbott L, Choi DH, Sherer M, Qiu Y, Shinde A, Lenahan M, Rizzo D, Xu Q, Barrera I, Kumar V, Marrero G, Pronneke A, Huang S, Kullander K, Stafford DA, Macosko E, Chen F, Rudy B, Fishell G. Neuron. 2023 Sep 6;111(17):2675-2692.e9. doi: 10.1016/j.neuron.2023.05.032. Epub 2023 Jun 29. PubMed |
| Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, Li X, Li M, Li J, Cheng S, Liu Y, Xu Y, Yan W. Nat Commun. 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PubMed |
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC.
Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19.
PubMed
Associated Plasmids |
| Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography. Shastry S, Chu W, Barbieri E, Greback-Clarke P, Smith WK, Cummings C, Minzoni A, Pancorbo J, Gilleskie G, Ritola K, Daniele MA, Johnson TF, Menegatti S. Biotechnol J. 2024 Jan;19(1):e2300230. doi: 10.1002/biot.202300230. Epub 2023 Sep 28. PubMed |
| N-glycomic profiling of capsid proteins from adeno-associated virus serotypes. Xie Y, Butler M. Glycobiology. 2023 Sep 29:cwad074. doi: 10.1093/glycob/cwad074. PubMed |
| Whole-Body Disposition and Physiologically Based Pharmacokinetic Modeling of Adeno-Associated Viruses and the Transgene Product. Liu S, Chowdhury EA, Xu V, Jerez A, Mahmood L, Ly BQ, Le HK, Nguyen A, Rajwade A, Meno-Tetang G, Shah DK. J Pharm Sci. 2024 Jan;113(1):141-157. doi: 10.1016/j.xphs.2023.10.005. Epub 2023 Oct 5. PubMed |
| AAV-mediated skeletal muscle specific irisin expression does not contribute to weight loss in mice. Bagon BB, Lee J, Matienzo ME, Lim S, Park JI, Kang S, Kim K, Lee CM, Moon C, Kim DI, Park MJ. Biochem Biophys Res Commun. 2023 Nov 19;682:111-117. doi: 10.1016/j.bbrc.2023.10.004. Epub 2023 Oct 4. PubMed |
| Human BST2 inhibits rabies virus release independently of cysteine-linked dimerization and asparagine-linked glycosylation. Tanwattana N, Wanasen N, Jantraphakorn Y, Srisutthisamphan K, Chailungkarn T, Boonrungsiman S, Lumlertdacha B, Lekchareonsuk P, Kaewborisuth C. PLoS One. 2023 Nov 3;18(11):e0292833. doi: 10.1371/journal.pone.0292833. eCollection 2023. PubMed |
A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences.
Gleichman AJ, Kawaguchi R, Sofroniew MV, Carmichael ST.
Nat Commun. 2023 Nov 16;14(1):7426. doi: 10.1038/s41467-023-42746-w.
PubMed
Associated Plasmids |
| Complement C3 From Astrocytes Plays Significant Roles in Sustained Activation of Microglia and Cognitive Dysfunctions Triggered by Systemic Inflammation After Laparotomy in Adult Male Mice. Chen Y, Chu JM, Wong GT, Chang RC. J Neuroimmune Pharmacol. 2024 Mar 1;19(1):8. doi: 10.1007/s11481-024-10107-z. PubMed |
| Enhancing prime editor activity by directed protein evolution in yeast. Weber Y, Bock D, Ivascu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. PubMed |
| Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. Mohr ME, Li S, Trouten AM, Stairley RA, Roddy PL, Liu C, Zhang M, Sucov HM, Tao G. iScience. 2024 Feb 15;27(3):109219. doi: 10.1016/j.isci.2024.109219. eCollection 2024 Mar 15. PubMed |
| Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection. Liu H, Zhang Y, Yip M, Ren L, Liang J, Chen X, Liu N, Du A, Wang J, Chang H, Oh H, Zhou C, Xing R, Xu M, Guo P, Gessler D, Xie J, Tai PWL, Gao G, Wang D. Mol Ther Methods Clin Dev. 2024 Mar 12;32(2):101230. doi: 10.1016/j.omtm.2024.101230. eCollection 2024 Jun 13. PubMed |
| Transient sensorimotor projections in the developmental song learning period. Louder MIM, Kuroda M, Taniguchi D, Komorowska-Muller JA, Morohashi Y, Takahashi M, Sanchez-Valpuesta M, Wada K, Okada Y, Hioki H, Yazaki-Sugiyama Y. Cell Rep. 2024 May 28;43(5):114196. doi: 10.1016/j.celrep.2024.114196. Epub 2024 May 7. PubMed |
| The Blood-Brain Barrier Is Unaffected in the Ndufs4(-/-) Mouse Model of Leigh Syndrome. Reynaud-Dulaurier R, Clement R, Yjjou S, Cresson C, Saoudi Y, Faideau M, Decressac M. Int J Mol Sci. 2024 Apr 29;25(9):4828. doi: 10.3390/ijms25094828. PubMed |
| Airway basal cells from human-induced pluripotent stem cells: a new frontier in cystic fibrosis research. Demchenko A, Belova L, Balyasin M, Kochergin-Nikitsky K, Kondrateva E, Voronina E, Pozhitnova V, Tabakov V, Salikhova D, Bukharova T, Goldshtein D, Kondratyeva E, Kyian T, Amelina E, Zubkova O, Popova O, Ozharovskaia T, Lavrov A, Smirnikhina S. Front Cell Dev Biol. 2024 Apr 26;12:1336392. doi: 10.3389/fcell.2024.1336392. eCollection 2024. PubMed |
| Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations. Kojima L, Seiriki K, Rokujo H, Nakazawa T, Kasai A, Hashimoto H. iScience. 2024 May 3;27(6):109878. doi: 10.1016/j.isci.2024.109878. eCollection 2024 Jun 21. PubMed |
| AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model. Willimann M, Tiyaboonchai A, Adachi K, Li B, Waldburger L, Nakai H, Grompe M, Thony B. bioRxiv [Preprint]. 2024 May 29:2024.05.29.596409. doi: 10.1101/2024.05.29.596409. PubMed |
| Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory in mice. Chung M, Imanaka K, Huang Z, Watarai A, Wang MY, Tao K, Ejima H, Aida T, Feng G, Okuyama T. Nat Commun. 2024 Jun 12;15(1):4531. doi: 10.1038/s41467-024-48430-x. PubMed |
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