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pBABE-puro Citations (165)

Plasmid Article: Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.
Morgenstern JP, Land H Nucleic Acids Res. 1990 Jun 25;18(12):3587-96.
PubMed

Articles Citing pBABE-puro

Articles
Smad6 suppresses TGF-beta-induced growth inhibition in COLO-357 pancreatic cancer cells and is overexpressed in pancreatic cancer. Kleeff J, Maruyama H, Friess H, Buchler MW, Falb D, Korc M. Biochem Biophys Res Commun. 1999 Feb 16;255(2):268-73. PubMed
Human pancreatic duct epithelial cell model for KRAS transformation. Radulovich N, Qian JY, Tsao MS. Methods Enzymol. 2008;439:1-13. doi: 10.1016/S0076-6879(07)00401-6. PubMed
Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Abu-Yousif AO, Smith KA, Getsios S, Green KJ, Van Dross RT, Pelling JC. Cancer Res. 2008 Apr 15;68(8):3057-65. doi: 10.1158/0008-5472.CAN-07-2763. PubMed
Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Chapman EJ, Kelly G, Knowles MA. Mol Cancer Res. 2008 Jul;6(7):1154-68. doi: 10.1158/1541-7786.MCR-07-2168. PubMed
Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. Han S, Ritzenthaler JD, Sun X, Zheng Y, Roman J. Am J Respir Cell Mol Biol. 2009 Mar;40(3):325-31. doi: 10.1165/rcmb.2008-0197OC. Epub 2008 Sep 5. PubMed
Systematic identification of cis-silenced genes by trans complementation. Lee JH, Bugarija B, Millan EJ, Walton NM, Gaetz J, Fernandes CJ, Yu WH, Mekel-Bobrov N, Vallender TW, Snyder GE, Xiang AP, Lahn BT. Hum Mol Genet. 2009 Mar 1;18(5):835-46. doi: 10.1093/hmg/ddn409. Epub 2008 Dec 2. PubMed
NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells. Singh S, Zahid M, Saeed M, Gaikwad NW, Meza JL, Cavalieri EL, Rogan EG, Chakravarti D. J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):56-66. doi: 10.1016/j.jsbmb.2009.07.003. Epub 2009 Jul 21. PubMed
Ageing-related chromatin defects through loss of the NURD complex. Pegoraro G, Kubben N, Wickert U, Göhler H, Hoffmann K, Misteli T. Nat Cell Biol. 2009 Oct . 11(10):1261-7. PubMed

Associated Plasmids

Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. PLoS One. 2009 . 4(11):e7982. PubMed
Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis JW, Shi Z, Ravosa MJ, Crawford S, Frazier S, Stack MS. Mol Cancer Res. 2010 Feb;8(2):145-58. doi: 10.1158/1541-7786.MCR-09-0045. Epub 2010 Feb 9. PubMed
PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling. Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N. Cancer Res. 2010 Sep 1;70(17):6804-14. doi: 10.1158/0008-5472.CAN-10-0409. Epub 2010 Aug 10. PubMed
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Loewer S, Cabili MN, Guttman M, Loh YH, Thomas K, Park IH, Garber M, Curran M, Onder T, Agarwal S, Manos PD, Datta S, Lander ES, Schlaeger TM, Daley GQ, Rinn JL. Nat Genet. 2010 Dec;42(12):1113-7. Epub 2010 Nov 7. PubMed

Associated Plasmids

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. Jagani Z, Mora-Blanco EL, Sansam CG, McKenna ES, Wilson B, Chen D, Klekota J, Tamayo P, Nguyen PT, Tolstorukov M, Park PJ, Cho YJ, Hsiao K, Buonamici S, Pomeroy SL, Mesirov JP, Ruffner H, Bouwmeester T, Luchansky SJ, Murtie J, Kelleher JF, Warmuth M, Sellers WR, Roberts CW, Dorsch M. Nat Med. 2010 Dec;16(12):1429-33. doi: 10.1038/nm.2251. Epub 2010 Nov 14. PubMed
Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. Tamama K, Kawasaki H, Kerpedjieva SS, Guan J, Ganju RK, Sen CK. J Cell Biochem. 2011 Mar;112(3):804-17. doi: 10.1002/jcb.22961. PubMed
Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase. Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R. J Biol Chem. 2011 Apr 29;286(17):14744-52. doi: 10.1074/jbc.M111.221259. Epub 2011 Mar 3. PubMed
Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. Wu N, Castel D, Debily MA, Vigano MA, Alibert O, Mantovani R, Iljin K, Romeo PH, Gidrol X. J Biol Chem. 2011 Jun 10;286(23):20870-9. doi: 10.1074/jbc.M110.169433. Epub 2011 Apr 10. PubMed
The role of Pea3 group transcription factors in esophageal squamous cell carcinoma. Yuen HF, McCrudden CM, Chan KK, Chan YP, Wong ML, Chan KY, Khoo US, Law S, Srivastava G, Lappin TR, Chan KW, El-Tanani M. Am J Pathol. 2011 Aug;179(2):992-1003. doi: 10.1016/j.ajpath.2011.04.004. Epub 2011 May 31. PubMed
Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT). Alvarez MB, Childress P, Philip BK, Gerard-O'Riley R, Hanlon M, Herbert BS, Robling AG, Pavalko FM, Bidwell JP. J Cell Physiol. 2012 May;227(5):1873-82. doi: 10.1002/jcp.22915. PubMed

Associated Plasmids

Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-beta in endothelial cells. Xie L, Vo-Ransdell C, Abel B, Willoughby C, Jang S, Sowa G. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1161-74. doi: 10.1152/ajpcell.00486.2010. Epub 2011 Aug 10. PubMed
The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement. Tai AW, Salloum S. PLoS One. 2011;6(10):e26300. doi: 10.1371/journal.pone.0026300. Epub 2011 Oct 12. PubMed
Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Wang C, Youle RJ. Oncogene. 2012 Jun 28;31(26):3177-89. doi: 10.1038/onc.2011.497. Epub 2011 Nov 7. PubMed
Calpain 2-dependent IkappaBalpha degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts. Fenouille N, Grosso S, Yunchao S, Mary D, Pontier-Bres R, Imbert V, Czerucka D, Caroli-Bosc FX, Peyron JF, Lagadec P. J Pathol. 2012 May;227(1):118-29. doi: 10.1002/path.3034. Epub 2012 Feb 9. PubMed
Identification of a link between Wnt/beta-catenin signalling and the cell fusion pathway. Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T. Nat Commun. 2011 Nov 22;2:548. doi: 10.1038/ncomms1551. PubMed
Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Campbell HG, Mehta R, Neumann AA, Rubio C, Baird M, Slatter TL, Braithwaite AW. Oncogene. 2013 Feb 14;32(7):827-36. doi: 10.1038/onc.2012.102. Epub 2012 Apr 9. PubMed
Genome-wide screen for miRNA targets using the MISSION target ID library. Coussens MJ, Forbes K, Kreader C, Sago J, Cupp C, Swarthout J. J Vis Exp. 2012 Apr 6;(62):e3303. doi: 10.3791/3303. PubMed
Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, Patel B, Pham K, Lu J, Sheppard B, Norgaard P, Hong J, Higgins P, Kim JS, Luesch H, Law BK. Oncogene. 2013 Mar 7;32(10):1316-29. doi: 10.1038/onc.2012.138. Epub 2012 Apr 30. PubMed
Role of the tripartite motif protein 27 in cancer development. Zoumpoulidou G, Broceno C, Li H, Bird D, Thomas G, Mittnacht S. J Natl Cancer Inst. 2012 Jun 20;104(12):941-52. doi: 10.1093/jnci/djs224. Epub 2012 May 3. PubMed
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U. EMBO J. 2012 Jun 29;31(13):2839-51. doi: 10.1038/emboj.2012.132. Epub 2012 May 8. PubMed
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Whitsett TG, Cheng E, Inge L, Asrani K, Jameson NM, Hostetter G, Weiss GJ, Kingsley CB, Loftus JC, Bremner R, Tran NL, Winkles JA. Am J Pathol. 2012 Jul;181(1):111-20. doi: 10.1016/j.ajpath.2012.03.026. Epub 2012 May 23. PubMed
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, Vallentin A, Vial H, Vidal M, Szakacs G. PLoS One. 2012;7(5):e37378. doi: 10.1371/journal.pone.0037378. Epub 2012 May 24. PubMed
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X. Cell. 2012 Jun 22;149(7):1565-77. doi: 10.1016/j.cell.2012.04.039. PubMed
The scaffold protein MEK Partner 1 is required for the survival of estrogen receptor positive breast cancer cells. Marina M, Wang L, Conrad SE. Cell Commun Signal. 2012 Jul 9;10(1):18. doi: 10.1186/1478-811X-10-18. PubMed
Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments. Boyd NL, Nunes SS, Krishnan L, Jokinen JD, Ramakrishnan VM, Bugg AR, Hoying JB. Tissue Eng Part A. 2013 Jan;19(1-2):211-23. doi: 10.1089/ten.tea.2011.0408. Epub 2012 Sep 12. PubMed
Role for telomerase in Listeria monocytogenes infection. Samba-Louaka A, Stavru F, Cossart P. Infect Immun. 2012 Dec;80(12):4257-63. doi: 10.1128/IAI.00614-12. Epub 2012 Sep 24. PubMed
Defining Akt actions in muscle differentiation. Gardner S, Anguiano M, Rotwein P. Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1292-300. doi: 10.1152/ajpcell.00259.2012. Epub 2012 Oct 17. PubMed
Role of transcriptional corepressor ETO2 in erythroid cells. Fujiwara T, Alqadi YW, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. Exp Hematol. 2013 Mar;41(3):303-15.e1. doi: 10.1016/j.exphem.2012.10.015. Epub 2012 Nov 2. PubMed
Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system. Karimova M, Abi-Ghanem J, Berger N, Surendranath V, Pisabarro MT, Buchholz F. Nucleic Acids Res. 2013 Jan;41(2):e37. doi: 10.1093/nar/gks1037. Epub 2012 Nov 9. PubMed

Associated Plasmids

ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Thomas C, Rajapaksa G, Nikolos F, Hao R, Katchy A, McCollum CW, Bondesson M, Quinlan P, Thompson A, Krishnamurthy S, Esteva FJ, Gustafsson JA. Breast Cancer Res. 2012 Nov 16;14(6):R148. doi: 10.1186/bcr3358. PubMed
Monitoring nutrient signaling through the longevity protein p66(SHC(1)). Ranieri SC, Pani G. Methods Mol Biol. 2013;965:341-53. doi: 10.1007/978-1-62703-239-1_23. PubMed
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ. Cancer Cell. 2013 Feb 11;23(2):143-58. doi: 10.1016/j.ccr.2012.12.008. Epub 2013 Jan 24. PubMed
Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells. Junk DJ, Cipriano R, Stampfer M, Jackson MW. PLoS One. 2013;8(2):e53776. doi: 10.1371/journal.pone.0053776. Epub 2013 Feb 4. PubMed
Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function. Goutte-Gattat D, Shuaib M, Ouararhni K, Gautier T, Skoufias DA, Hamiche A, Dimitrov S. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8579-84. doi: 10.1073/pnas.1302955110. Epub 2013 May 8. PubMed
Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Chen QK, Lee K, Radisky DC, Nelson CM. Differentiation. 2013 Oct;86(3):126-32. doi: 10.1016/j.diff.2013.03.003. Epub 2013 May 6. PubMed
Transforming growth factor beta induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Ding ZY, Jin GN, Liang HF, Wang W, Chen WX, Datta PK, Zhang MZ, Zhang B, Chen XP. Cell Signal. 2013 Oct;25(10):1981-92. doi: 10.1016/j.cellsig.2013.05.027. Epub 2013 May 28. PubMed
Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from Xenophagic killing. O'Seaghdha M, Wessels MR. PLoS Pathog. 2013;9(6):e1003394. doi: 10.1371/journal.ppat.1003394. Epub 2013 Jun 6. PubMed
CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells. Lau WM, Doucet M, Huang D, Weber KL, Kominsky SL. Biochem Biophys Res Commun. 2013 Jul 26;437(2):261-6. doi: 10.1016/j.bbrc.2013.06.063. Epub 2013 Jun 27. PubMed
Enpp1: a potential facilitator of breast cancer bone metastasis. Lau WM, Doucet M, Stadel R, Huang D, Weber KL, Kominsky SL. PLoS One. 2013 Jul 5;8(7):e66752. doi: 10.1371/journal.pone.0066752. Print 2013. PubMed
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Fogel AI, Dlouhy BJ, Wang C, Ryu SW, Neutzner A, Hasson SA, Sideris DP, Abeliovich H, Youle RJ. Mol Cell Biol. 2013 Sep;33(18):3675-88. doi: 10.1128/MCB.00079-13. Epub 2013 Jul 22. PubMed
A pharmacological model reveals biased dependency on PI3K isoforms for tumor cell growth. Wang X, Li JP, Yang Y, Ding J, Meng LH. Acta Pharmacol Sin. 2013 Sep;34(9):1201-7. doi: 10.1038/aps.2013.81. Epub 2013 Jul 29. PubMed
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Oncogene. 2014 Jun 26;33(26):3463-72. doi: 10.1038/onc.2013.301. Epub 2013 Aug 5. PubMed
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Kitade M, Factor VM, Andersen JB, Tomokuni A, Kaji K, Akita H, Holczbauer A, Seo D, Marquardt JU, Conner EA, Lee SB, Lee YH, Thorgeirsson SS. Genes Dev. 2013 Aug 1;27(15):1706-17. doi: 10.1101/gad.214601.113. PubMed
AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation. Jackstadt R, Jung P, Hermeking H. Cell Death Dis. 2013 Aug 15;4:e775. doi: 10.1038/cddis.2013.282. PubMed
Elucidation of the role of LMO2 in human erythroid cells. Inoue A, Fujiwara T, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. Exp Hematol. 2013 Dec;41(12):1062-76.e1. doi: 10.1016/j.exphem.2013.09.003. Epub 2013 Sep 13. PubMed
A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. Fujiwara T, Ikeda T, Nagasaka Y, Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Ichinohasama R, Tomosugi N, Harigae H. PLoS One. 2013 Sep 27;8(9):e75568. doi: 10.1371/journal.pone.0075568. eCollection 2013. PubMed
DNMT1-interacting RNAs block gene-specific DNA methylation. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alo F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. Nature. 2013 Nov 21;503(7476):371-6. doi: 10.1038/nature12598. Epub 2013 Oct 9. PubMed
BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. Morotti A, Panuzzo C, Crivellaro S, Pergolizzi B, Familiari U, Berger AH, Saglio G, Pandolfi PP. Leukemia. 2014 Jun;28(6):1326-33. doi: 10.1038/leu.2013.370. Epub 2013 Dec 9. PubMed
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PubMed
Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors. Lezcano C, Lee CW, Larson AR, Menzies AM, Kefford RF, Thompson JF, Mihm MC Jr, Ogino S, Long GV, Scolyer RA, Murphy GF. Mod Pathol. 2014 Sep;27(9):1193-202. doi: 10.1038/modpathol.2013.226. Epub 2014 Jan 17. PubMed
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ. Elife (Cambridge). 2014 Feb 25;3:e01612. doi: 10.7554/eLife.01612. PubMed

Associated Plasmids

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity. Ablett MP, O'Brien CS, Sims AH, Farnie G, Clarke RB. Oncotarget. 2014 Feb 15;5(3):599-612. PubMed
ERbeta regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Nikolos F, Thomas C, Rajapaksa G, Bado I, Gustafsson JA. Mol Cancer Res. 2014 Jun;12(6):843-54. doi: 10.1158/1541-7786.MCR-13-0663. Epub 2014 Mar 11. PubMed
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. Serra RW, Fang M, Park SM, Hutchinson L, Green MR. Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313. PubMed
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Gokturk C, Sanjiv K, Stromberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2. PubMed
Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia. Fujiwara T, Fukuhara N, Funayama R, Nariai N, Kamata M, Nagashima T, Kojima K, Onishi Y, Sasahara Y, Ishizawa K, Nagasaki M, Nakayama K, Harigae H. Ann Hematol. 2014 Sep;93(9):1515-22. doi: 10.1007/s00277-014-2090-4. Epub 2014 Apr 30. PubMed
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. Kohsaka S, Shukla N, Ameur N, Ito T, Ng CK, Wang L, Lim D, Marchetti A, Viale A, Pirun M, Socci ND, Qin LX, Sciot R, Bridge J, Singer S, Meyers P, Wexler LH, Barr FG, Dogan S, Fletcher JA, Reis-Filho JS, Ladanyi M. Nat Genet. 2014 Jun;46(6):595-600. doi: 10.1038/ng.2969. Epub 2014 May 4. PubMed
Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. Gotz R, Sendtner M. PLoS One. 2014 Jun 24;9(6):e100944. doi: 10.1371/journal.pone.0100944. eCollection 2014. PubMed
Cellular migration and invasion uncoupled: increased migration is not an inexorable consequence of epithelial-to-mesenchymal transition. Schaeffer D, Somarelli JA, Hanna G, Palmer GM, Garcia-Blanco MA. Mol Cell Biol. 2014 Sep 15;34(18):3486-99. doi: 10.1128/MCB.00694-14. Epub 2014 Jul 7. PubMed
The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response. Cao X, Kong CM, Mathi KM, Lim YP, Cacheux-Rataboul V, Wang X. BMC Biochem. 2014 Aug 7;15:17. doi: 10.1186/1471-2091-15-17. PubMed
The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Ravi D, Bhalla S, Gartenhaus RB, Crombie J, Kandela I, Sharma J, Mazar A, Evens AM. Clin Cancer Res. 2014 Dec 1;20(23):6023-33. doi: 10.1158/1078-0432.CCR-14-1532. Epub 2014 Oct 14. PubMed
Metformin and erlotinib synergize to inhibit basal breast cancer. Lau YK, Du X, Rayannavar V, Hopkins B, Shaw J, Bessler E, Thomas T, Pires MM, Keniry M, Parsons RE, Cremers S, Szabolcs M, Maurer MA. Oncotarget. 2014 Nov 15;5(21):10503-17. PubMed
An increase in integrin-linked kinase non-canonically confers NF-kappaB-mediated growth advantages to gastric cancer cells by activating ERK1/2. Tseng PC, Chen CL, Shan YS, Chang WT, Liu HS, Hong TM, Hsieh CY, Lin SH, Lin CF. Cell Commun Signal. 2014 Nov 15;12:69. doi: 10.1186/s12964-014-0069-3. PubMed
Arhgef7 promotes activation of the Hippo pathway core kinase Lats. Heidary Arash E, Song KM, Song S, Shiban A, Attisano L. EMBO J. 2014 Dec 17;33(24):2997-3011. doi: 10.15252/embj.201490230. Epub 2014 Nov 25. PubMed
Focus formation: a cell-based assay to determine the oncogenic potential of a gene. Alvarez A, Barisone GA, Diaz E. J Vis Exp. 2014 Dec 31;(94). doi: 10.3791/51742. PubMed
hTERT-immortalized ovine microglia propagate natural scrapie isolates. Munoz-Gutierrez JF, Schneider DA, Baszler TV, Greenlee JJ, Nicholson EM, Stanton JB. Virus Res. 2015 Feb 16;198:35-43. doi: 10.1016/j.virusres.2014.10.028. Epub 2015 Jan 12. PubMed
Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein. Kiss K, Kucsma N, Brozik A, Tusnady GE, Bergam P, van Niel G, Szakacs G. Biochem J. 2015 Apr 1;467(1):127-39. doi: 10.1042/BJ20141085. PubMed
Rapid, specific, no-wash, far-red fluorogen activation in subcellular compartments by targeted fluorogen activating proteins. Telmer CA, Verma R, Teng H, Andreko S, Law L, Bruchez MP. ACS Chem Biol. 2015 May 15;10(5):1239-46. doi: 10.1021/cb500957k. Epub 2015 Feb 16. PubMed

Associated Plasmids

PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. Mol Cell Biol. 2015 May;35(10):1741-53. doi: 10.1128/MCB.01475-14. Epub 2015 Mar 9. PubMed
Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5alpha. Coren LV, Trivett MT, Jain S, Ayala VI, Del Prete GQ, Ohlen C, Ott DE. Retrovirology. 2015 Feb 7;12:11. doi: 10.1186/s12977-015-0137-9. PubMed
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. EMBO Mol Med. 2015 Jun 12;7(8):1048-62. doi: 10.15252/emmm.201404837. PubMed
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed
Simultaneous Inhibition of EGFR/VEGFR and Cyclooxygenase-2 Targets Stemness-Related Pathways in Colorectal Cancer Cells. Valverde A, Penarando J, Canas A, Lopez-Sanchez LM, Conde F, Hernandez V, Peralbo E, Lopez-Pedrera C, de la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A. PLoS One. 2015 Jun 24;10(6):e0131363. doi: 10.1371/journal.pone.0131363. eCollection 2015. PubMed
High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells. Saito Y, Fujiwara T, Ohashi K, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H. PLoS One. 2015 Sep 1;10(9):e0137079. doi: 10.1371/journal.pone.0137079. eCollection 2015. PubMed
Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells. Andersen RK, Zaher W, Larsen KH, Ditzel N, Drews K, Wruck W, Adjaye J, Abdallah BM, Kassem M. Stem Cell Res Ther. 2015 Oct 8;6:196. doi: 10.1186/s13287-015-0188-9. PubMed
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways. Vasseur R, Skrypek N, Duchene B, Renaud F, Martinez-Maqueda D, Vincent A, Porchet N, Van Seuningen I, Jonckheere N. Biochim Biophys Acta. 2015 Dec;1849(12):1375-84. doi: 10.1016/j.bbagrm.2015.10.014. Epub 2015 Oct 22. PubMed
Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. Coffey RT, Shi Y, Long MJ, Marr MT 2nd, Hedstrom L. J Biol Chem. 2016 Jan 6. pii: jbc.M115.691584. PubMed
Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, Pirker C, Schmid JA, Loewe R, Wagner EF, Berger W, Petzelbauer P. J Invest Dermatol. 2016 May;136(5):967-77. doi: 10.1016/j.jid.2016.01.020. Epub 2016 Jan 30. PubMed
MiRNA-146b-5p upregulates migration and invasion of different Papillary Thyroid Carcinoma cells. Lima CR, Geraldo MV, Fuziwara CS, Kimura ET, Santos MF. BMC Cancer. 2016 Feb 16;16:108. doi: 10.1186/s12885-016-2146-z. PubMed
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z. Oncogene. 2016 Mar 14. doi: 10.1038/onc.2016.40. PubMed
The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1alpha. Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. PubMed
CLOCK promotes 3T3-L1 cell proliferation via Wnt signaling. Zhu Z, Hua B, Xu L, Yuan G, Li E, Li X, Sun N, Yan Z, Lu C, Qian R. IUBMB Life. 2016 Jul;68(7):557-68. doi: 10.1002/iub.1512. Epub 2016 May 18. PubMed
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT. Choudhary KS, Rohatgi N, Halldorsson S, Briem E, Gudjonsson T, Gudmundsson S, Rolfsson O. PLoS Comput Biol. 2016 Jun 2;12(6):e1004924. doi: 10.1371/journal.pcbi.1004924. eCollection 2016 Jun. PubMed
Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Madureira PA, Bharadwaj AG, Bydoun M, Garant K, O'Connell P, Lee P, Waisman DM. Oncotarget. 2016 Jul 26;7(30):47720-47737. doi: 10.18632/oncotarget.10279. PubMed
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9015-20. doi: 10.1073/pnas.1603883113. Epub 2016 Jul 22. PubMed
Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8. PubMed
BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM. Elife. 2016 Aug 16;5. pii: e16620. doi: 10.7554/eLife.16620. PubMed
RNF168 and USP10 regulate topoisomerase IIalpha function via opposing effects on its ubiquitylation. Guturi KK, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. Nat Commun. 2016 Aug 25;7:12638. doi: 10.1038/ncomms12638. PubMed
Familial Alzheimer's disease-associated presenilin 1 mutants promote gamma-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH. Sci Signal. 2016 Sep 6;9(444):ra89. doi: 10.1126/scisignal.aaf1371. PubMed
LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A. Oncotarget. 2016 Dec 13;7(50):81981-81994. doi: 10.18632/oncotarget.11962. PubMed
Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT. Nature. 2016 Oct 6;538(7623):123-126. doi: 10.1038/nature19754. Epub 2016 Sep 14. PubMed
An alternative splicing program promotes adipose tissue thermogenesis. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. Elife. 2016 Sep 16;5. pii: e17672. doi: 10.7554/eLife.17672. PubMed
A novel isoform of the human mitochondrial complex I subunit NDUFV3. Dibley MG, Ryan MT, Stroud DA. FEBS Lett. 2017 Jan;591(1):109-117. doi: 10.1002/1873-3468.12527. Epub 2016 Dec 30. PubMed
LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. Nat Cell Biol. 2017 Jan;19(1):60-67. doi: 10.1038/ncb3453. Epub 2016 Dec 19. PubMed
Immuno-engineered organoids for regulating the kinetics of B-cell development and antibody production. Purwada A, Singh A. Nat Protoc. 2017 Jan;12(1):168-182. doi: 10.1038/nprot.2016.157. Epub 2016 Dec 22. PubMed
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. Nakajima S, Aikawa C, Nozawa T, Minowa-Nozawa A, Toh H, Nakagawa I. PLoS One. 2017 Jan 13;12(1):e0170138. doi: 10.1371/journal.pone.0170138. eCollection 2017. PubMed
Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. Hsia HC, Hutti JE, Baldwin AS. J Biol Chem. 2017 Mar 31;292(13):5405-5417. doi: 10.1074/jbc.M116.771964. Epub 2017 Feb 10. PubMed
Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity. Chen NM, Neesse A, Dyck ML, Steuber B, Koenig AO, Lubeseder-Martellato C, Winter T, Forster T, Bohnenberger H, Kitz J, Reuter-Jessen K, Griesmann H, Gaedcke J, Grade M, Zhang JS, Tsai WC, Siveke J, Schildhaus HU, Strobel P, Johnsen SA, Ellenrieder V, Hessmann E. Gastroenterology. 2017 May;152(6):1507-1520.e15. doi: 10.1053/j.gastro.2017.01.043. Epub 2017 Feb 8. PubMed
Cancer cells exhibit clonal diversity in phenotypic plasticity. Mathis RA, Sokol ES, Gupta PB. Open Biol. 2017 Feb;7(2). pii: 160283. doi: 10.1098/rsob.160283. PubMed
Multivalent Small-Molecule Pan-RAS Inhibitors. Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, Yang WS, Tong L, Olive KP, Ferrando A, Stockwell BR. Cell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006. PubMed
Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Jacquin E, Leclerc-Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Autophagy. 2017 May 4;13(5):854-867. doi: 10.1080/15548627.2017.1287653. Epub 2017 Feb 15. PubMed
NRAS destines tumor cells to the lungs. Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT. EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978. PubMed
Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kalpha-selective Inhibitors in Breast Cancer. Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed
The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-beta- catenin signaling axis. Valverde A, Penarando J, Canas A, Lopez-Sanchez LM, Conde F, Guil-Luna S, Hernandez V, Villar C, Morales-Estevez C, de la Haba-Rodriguez J, Aranda E, Rodriguez-Ariza A. Oncotarget. 2017 Mar 28;8(13):21754-21769. doi: 10.18632/oncotarget.15567. PubMed
TCF7L1 promotes skin tumorigenesis independently of beta-catenin through induction of LCN2. Ku AT, Shaver TM, Rao AS, Howard JM, Rodriguez CN, Miao Q, Garcia G, Le D, Yang D, Borowiak M, Cohen DN, Chitsazzadeh V, Diwan AH, Tsai KY, Nguyen H. Elife. 2017 May 3;6. pii: e23242. doi: 10.7554/eLife.23242. PubMed
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM. Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027. PubMed
Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Dagg RA, Pickett HA, Neumann AA, Napier CE, Henson JD, Teber ET, Arthur JW, Reynolds CP, Murray J, Haber M, Sobinoff AP, Lau LMS, Reddel RR. Cell Rep. 2017 Jun 20;19(12):2544-2556. doi: 10.1016/j.celrep.2017.05.087. PubMed
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover. Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vagbo CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB. Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117. PubMed
Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells. Zarei M, Lal S, Parker SJ, Nevler A, Vaziri-Gohar A, Dukleska K, Mambelli-Lisboa NC, Moffat C, Blanco FF, Chand SN, Jimbo M, Cozzitorto JA, Jiang W, Yeo CJ, Londin E, Seifert EL, Metallo CM, Brody JR, Winter JM. Cancer Res. 2017 Jun 26. pii: canres.0015.2017. doi: 10.1158/0008-5472.CAN-17-0015. PubMed
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. Yoo BH, Khan IA, Koomson A, Gowda P, Sasazuki T, Shirasawa S, Gujar S, Rosen KV. Autophagy. 2018;14(1):134-151. doi: 10.1080/15548627.2017.1370171. Epub 2017 Dec 21. PubMed
Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells. Ishihara S, Inman DR, Li WJ, Ponik SM, Keely PJ. Cancer Res. 2017 Nov 15;77(22):6179-6189. doi: 10.1158/0008-5472.CAN-17-0569. Epub 2017 Sep 28. PubMed
Survival of pancreatic cancer cells lacking KRAS function. Muzumdar MD, Chen PY, Dorans KJ, Chung KM, Bhutkar A, Hong E, Noll EM, Sprick MR, Trumpp A, Jacks T. Nat Commun. 2017 Oct 23;8(1):1090. doi: 10.1038/s41467-017-00942-5. PubMed
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. Nat Genet. 2017 Dec;49(12):1693-1704. doi: 10.1038/ng.3990. Epub 2017 Nov 6. PubMed
Development of a genetic sensor that eliminates p53 deficient cells. Mircetic J, Dietrich A, Paszkowski-Rogacz M, Krause M, Buchholz F. Nat Commun. 2017 Nov 13;8(1):1463. doi: 10.1038/s41467-017-01688-w. PubMed
Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, Fenizia C, Zanchettin G, Pierobon ES, Hatakeyama S, Sperti C, Merigliano S, Sandri M, Filippakopoulos P, Costelli P, Sartorelli V, Caretti G. Nat Commun. 2017 Nov 22;8(1):1707. doi: 10.1038/s41467-017-01645-7. PubMed
PPARdelta Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth. Martin-Martin N, Zabala-Letona A, Fernandez-Ruiz S, Arreal L, Camacho L, Castillo-Martin M, Cortazar AR, Torrano V, Astobiza I, Zuniga-Garcia P, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcarcel-Jimenez L, Arruabarrena-Aristorena A, Piva M, Sanchez-Mosquera P, Aransay AM, Gomez-Munoz A, Barrio R, Sutherland JD, Carracedo A. Cancer Res. 2018 Jan 15;78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908. Epub 2017 Nov 29. PubMed
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh JM, Mayer U, Carding SR, Wileman T, Beale R, Florey O. EMBO J. 2018 Feb 15;37(4). pii: embj.201797840. doi: 10.15252/embj.201797840. Epub 2018 Jan 9. PubMed
Establishment of a Screening System to Identify Novel GATA-2 Transcriptional Regulators. Ohashi K, Fujiwara T, Onodera K, Saito Y, Ichikawa S, Kobayashi M, Okitsu Y, Fukuhara N, Onishi Y, Harigae H. Tohoku J Exp Med. 2018 Jan;244(1):41-52. doi: 10.1620/tjem.244.41. PubMed
Endosomal Rab cycles regulate Parkin-mediated mitophagy. Yamano K, Wang C, Sarraf SA, Munch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ. Elife. 2018 Jan 23;7. pii: 31326. doi: 10.7554/eLife.31326. PubMed
MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Giuliano CJ, Lin A, Smith JC, Palladino AC, Sheltzer JM. Elife. 2018 Feb 8;7. pii: 32838. doi: 10.7554/eLife.32838. PubMed
Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Rockfield S, Flores I, Nanjundan M. Oncotarget. 2017 Dec 28;9(4):5344-5367. doi: 10.18632/oncotarget.23747. eCollection 2018 Jan 12. PubMed
Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators. O'Geen H, Ren C, Coggins NB, Bates SL, Segal DJ. PLoS One. 2018 Mar 27;13(3):e0193818. doi: 10.1371/journal.pone.0193818. eCollection 2018. PubMed

Associated Plasmids

Real-time imaging of specific genomic loci in eukaryotic cells using the ANCHOR DNA labelling system. Germier T, Sylvain A, Silvia K, David L, Kerstin B. Methods. 2018 Jun 1;142:16-23. doi: 10.1016/j.ymeth.2018.04.008. Epub 2018 Apr 13. PubMed
Pituitary somatolactotropes evade an oncogenic response to Ras. Roof AK, Trudeau T, Gutierrez-Hartmann A. Mol Cell Endocrinol. 2018 Nov 15;476:165-172. doi: 10.1016/j.mce.2018.05.006. Epub 2018 May 9. PubMed
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice. Karlin J, Allen J, Ahmad SF, Hughes G, Sheridan V, Odedra R, Farrington P, Cadogan EB, Riches LC, Garcia-Trinidad A, Thomason AG, Patel B, Vincent J, Lau A, Pike KG, Hunt TA, Sule A, Valerie NCK, Biddlestone-Thorpe L, Kahn J, Beckta JM, Mukhopadhyay N, Barlaam B, Degorce SL, Kettle J, Colclough N, Wilson J, Smith A, Barrett IP, Zheng L, Zhang T, Wang Y, Chen K, Pass M, Durant ST, Valerie K. Mol Cancer Ther. 2018 Aug;17(8):1637-1647. doi: 10.1158/1535-7163.MCT-17-0975. Epub 2018 May 16. PubMed
Precision Tagging: A Novel Seamless Protein Tagging by Combinational Use of Type II and Type IIS Restriction Endonucleases. Xu Z, Rui YN, Hagan JP, Kim DH. Bio Protoc. 2018 Feb 5;8(3). doi: 10.21769/BioProtoc.2721. PubMed
In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Wei R, Wong JPC, Lyu P, Xi X, Tong O, Zhang SD, Yuen HF, Shirasawa S, Kwok HF. J Cell Mol Med. 2018 Sep;22(9):4097-4105. doi: 10.1111/jcmm.13686. Epub 2018 May 30. PubMed
Involvement of NADPH Oxidase 1 in Liver Kinase B1-Mediated Effects on Tumor Angiogenesis and Growth. Zulato E, Ciccarese F, Nardo G, Pinazza M, Agnusdei V, Silic-Benussi M, Ciminale V, Indraccolo S. Front Oncol. 2018 Jun 4;8:195. doi: 10.3389/fonc.2018.00195. eCollection 2018. PubMed
LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and gamma-irradiation. Zulato E, Ciccarese F, Agnusdei V, Pinazza M, Nardo G, Iorio E, Curtarello M, Silic-Benussi M, Rossi E, Venturoli C, Panieri E, Santoro MM, Di Paolo V, Quintieri L, Ciminale V, Indraccolo S. Biochem Pharmacol. 2018 Oct;156:479-490. doi: 10.1016/j.bcp.2018.09.019. Epub 2018 Sep 15. PubMed
Nuclear envelope assembly defects link mitotic errors to chromothripsis. Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D. Nature. 2018 Sep;561(7724):551-555. doi: 10.1038/s41586-018-0534-z. Epub 2018 Sep 19. PubMed
RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer. Zarei M, Lal S, Vaziri-Gohar A, O'Hayer K, Gunda V, Singh PK, Brody JR, Winter JM. Mol Cancer Res. 2019 Feb;17(2):508-520. doi: 10.1158/1541-7786.MCR-18-0557. Epub 2018 Sep 28. PubMed
Proteomic Profiling of Iron-Treated Ovarian Cells Identifies AKT Activation that Modulates the CLEAR Network. Rockfield S, Guergues J, Rehman N, Smith A, Bauckman KA, Stevens SM Jr, Nanjundan M. Proteomics. 2018 Dec;18(23):e1800244. doi: 10.1002/pmic.201800244. Epub 2018 Oct 30. PubMed
IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC. Wang J, Zhang ZG, Ding ZY, Dong W, Liang HF, Chu L, Zhang BX, Chen XP. J Surg Res. 2018 Nov;231:116-125. doi: 10.1016/j.jss.2018.04.056. Epub 2018 Jun 17. PubMed
MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. Kalkat M, Resetca D, Lourenco C, Chan PK, Wei Y, Shiah YJ, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, Boutros PC, Raught B, Penn LZ. Mol Cell. 2018 Dec 6;72(5):836-848.e7. doi: 10.1016/j.molcel.2018.09.031. Epub 2018 Nov 8. PubMed
SOX2 as a novel contributor of oxidative metabolism in melanoma cells. Andreucci E, Pietrobono S, Peppicelli S, Ruzzolini J, Bianchini F, Biagioni A, Stecca B, Calorini L. Cell Commun Signal. 2018 Nov 22;16(1):87. doi: 10.1186/s12964-018-0297-z. PubMed
FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Zhang ZQ, Chen J, Huang WQ, Ning D, Liu QM, Wang C, Zhang L, Ren L, Chu L, Liang HF, Fan HN, Zhang BX, Chen XP. Mol Oncol. 2019 Apr;13(4):792-810. doi: 10.1002/1878-0261.12429. Epub 2019 Jan 24. PubMed
Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer. Murillo MM, Rana S, Spencer-Dene B, Nye E, Stamp G, Downward J. Cell Rep. 2018 Dec 26;25(13):3545-3553.e2. doi: 10.1016/j.celrep.2018.12.003. PubMed
KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs. Liu H, Sun M, Liu Z, Kong C, Kong W, Ye J, Gong J, Huang DCS, Qian F. J Control Release. 2019 Feb 28;296:40-53. doi: 10.1016/j.jconrel.2019.01.014. Epub 2019 Jan 15. PubMed
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M. Cell Rep. 2019 Feb 19;26(8):2028-2036.e6. doi: 10.1016/j.celrep.2019.01.083. PubMed
FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21. Zhang L, Chen J, Ning D, Liu Q, Wang C, Zhang Z, Chu L, Yu C, Liang HF, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Feb 26;38(1):101. doi: 10.1186/s13046-019-1058-6. PubMed
Detection of ubiquitination activity and identification of ubiquitinated substrates using TR-TUBE. Yoshida Y, Saeki Y, Tsuchiya H, Tanaka K. Methods Enzymol. 2019;618:135-147. doi: 10.1016/bs.mie.2018.12.032. Epub 2019 Feb 1. PubMed
Annexin A2 Regulates AKT Upon H(2)O(2)-Dependent Signaling Activation in Cancer Cells. Castaldo SA, Ajime T, Serrao G, Anastacio F, Rosa JT, Giacomantonio CA, Howarth A, Hill R, Madureira PA. Cancers (Basel). 2019 Apr 7;11(4). pii: cancers11040492. doi: 10.3390/cancers11040492. PubMed
CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, Takai D, Fukayama M, Sekido Y, Niki T, Matsubara D, Murakami Y. Cancer Sci. 2019 Jul;110(7):2284-2295. doi: 10.1111/cas.14040. Epub 2019 May 29. PubMed
Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAF(V600E)-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. Robb R, Yang L, Shen C, Wolfe AR, Webb A, Zhang X, Vedaie M, Saji M, Jhiang S, Ringel MD, Williams TM. Clin Cancer Res. 2019 Aug 1;25(15):4749-4760. doi: 10.1158/1078-0432.CCR-18-3625. Epub 2019 May 16. PubMed
PI3Kalpha inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment. Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH. Cancer Lett. 2019 Sep 10;459:145-155. doi: 10.1016/j.canlet.2019.05.040. Epub 2019 Jun 4. PubMed
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2. Sloat SR, Whitley BN, Engelhart EA, Hoppins S. Mol Biol Cell. 2019 Aug 1;30(17):2309-2319. doi: 10.1091/mbc.E19-05-0291. Epub 2019 Jun 12. PubMed
DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFbeta1 signaling and is associated with poor prognosis in hepatocellular carcinoma. Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X. J Exp Clin Cancer Res. 2019 Jun 22;38(1):273. doi: 10.1186/s13046-019-1220-1. PubMed
Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. Cheng YP, Li S, Chuang WL, Li CH, Chen GJ, Chang CC, Or CR, Lin PY, Chang CC. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133366. doi: 10.3390/ijms20133366. PubMed
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