FgH1tUTG Citations (75)
Originally described in: An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo.Aubrey BJ, Kelly GL, Kueh AJ, Brennan MS, O'Connor L, Milla L, Wilcox S, Tai L, Strasser A, Herold MJ Cell Rep. 2015 Mar 3;10(8):1422-32. doi: 10.1016/j.celrep.2015.02.002. Epub 2015 Feb 26. PubMed Journal
Articles Citing FgH1tUTG
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| Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons. Bohnsack JP, Patel VK, Morrow AL. J Pharmacol Exp Ther. 2017 Oct;363(1):1-11. doi: 10.1124/jpet.117.242446. Epub 2017 Aug 10. PubMed |
| Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation. House IG, House CM, Brennan AJ, Gilan O, Dawson MA, Whisstock JC, Law RH, Trapani JA, Voskoboinik I. EMBO Rep. 2017 Oct;18(10):1775-1785. doi: 10.15252/embr.201744351. Epub 2017 Aug 14. PubMed |
| CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA. Nature. 2017 Sep 7;549(7670):101-105. doi: 10.1038/nature23643. Epub 2017 Aug 16. PubMed |
| Generation of Genetic Knockouts in Myeloid Cell Lines Using a Lentiviral CRISPR/Cas9 System. Baker PJ, Masters SL. Methods Mol Biol. 2018;1714:41-55. doi: 10.1007/978-1-4939-7519-8_3. PubMed |
| ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Leong WZ, Tan SH, Ngoc PCT, Amanda S, Yam AWY, Liau WS, Gong Z, Lawton LN, Tenen DG, Sanda T. Genes Dev. 2017 Dec 1;31(23-24):2343-2360. doi: 10.1101/gad.302646.117. Epub 2018 Jan 11. PubMed |
| Identification and validation of the role of matrix metalloproteinase-1 in cervical cancer. Tian R, Li X, Gao Y, Li Y, Yang P, Wang K. Int J Oncol. 2018 Apr;52(4):1198-1208. doi: 10.3892/ijo.2018.4267. Epub 2018 Feb 7. PubMed |
| JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Kim SK, Knight DA, Jones LR, Vervoort S, Ng AP, Seymour JF, Bradner JE, Waibel M, Kats L, Johnstone RW. Genes Dev. 2018 Jun 1;32(11-12):849-864. doi: 10.1101/gad.307504.117. Epub 2018 Jun 15. PubMed |
| MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway. Wilson KR, Liu H, Healey G, Vuong V, Ishido S, Herold MJ, Villadangos JA, Mintern JD. PLoS One. 2018 Jul 12;13(7):e0200540. doi: 10.1371/journal.pone.0200540. eCollection 2018. PubMed |
| USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. Palazon-Riquelme P, Worboys JD, Green J, Valera A, Martin-Sanchez F, Pellegrini C, Brough D, Lopez-Castejon G. EMBO Rep. 2018 Oct;19(10). pii: embr.201744766. doi: 10.15252/embr.201744766. Epub 2018 Sep 11. PubMed |
| Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis. Goldie SJ, Cottle DL, Tan FH, Roslan S, Srivastava S, Brady R, Partridge DD, Auden A, Smyth IM, Jane SM, Dworkin S, Darido C. Cell Death Dis. 2018 Oct 19;9(11):1072. doi: 10.1038/s41419-018-0901-6. PubMed |
| P38 MAPK inhibition prevents polybrene-induced senescence of human mesenchymal stem cells during viral transduction. Griukova A, Deryabin P, Sirotkina M, Shatrova A, Nikolsky N, Borodkina A. PLoS One. 2018 Dec 26;13(12):e0209606. doi: 10.1371/journal.pone.0209606. eCollection 2018. PubMed |
| Resveratrol enhances pluripotency of mouse embryonic stem cells by activating AMPK/Ulk1 pathway. Suvorova II, Knyazeva AR, Petukhov AV, Aksenov ND, Pospelov VA. Cell Death Discov. 2019 Feb 4;5:61. doi: 10.1038/s41420-019-0137-y. eCollection 2019. PubMed |
| Optimization of lentiviral transduction parameters and its application for CRISPR-based secretome modification of human endometrial mesenchymal stem cells. Deryabin P, Griukova A, Shatrova A, Petukhov A, Nikolsky N, Borodkina A. Cell Cycle. 2019 Mar - Apr;18(6-7):742-758. doi: 10.1080/15384101.2019.1593650. Epub 2019 Mar 28. PubMed |
| Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma. Passero FC Jr, Ravi D, McDonald JT, Beheshti A, David KA, Evens AM. Br J Haematol. 2020 Jan;188(2):295-308. doi: 10.1111/bjh.16160. Epub 2019 Aug 26. PubMed |
| Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria. Ly A, Liao Y, Pietrzak H, Ioannidis LJ, Sidwell T, Gloury R, Doerflinger M, Triglia T, Qin RZ, Groom JR, Belz GT, Good-Jacobson KL, Shi W, Kallies A, Hansen DS. Cell Rep. 2019 Nov 19;29(8):2257-2269.e6. doi: 10.1016/j.celrep.2019.10.087. PubMed |
| ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. Wang L, Tan TK, Durbin AD, Zimmerman MW, Abraham BJ, Tan SH, Ngoc PCT, Weichert-Leahey N, Akahane K, Lawton LN, Rokita JL, Maris JM, Young RA, Look AT, Sanda T. Nat Commun. 2019 Dec 9;10(1):5622. doi: 10.1038/s41467-019-13515-5. PubMed |
| TBK1 and IKKepsilon Act Redundantly to Mediate STING-Induced NF-kappaB Responses in Myeloid Cells. Balka KR, Louis C, Saunders TL, Smith AM, Calleja DJ, D'Silva DB, Moghaddas F, Tailler M, Lawlor KE, Zhan Y, Burns CJ, Wicks IP, Miner JJ, Kile BT, Masters SL, De Nardo D. Cell Rep. 2020 Apr 7;31(1):107492. doi: 10.1016/j.celrep.2020.03.056. PubMed |
An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells.
Bowling S, Sritharan D, Osorio FG, Nguyen M, Cheung P, Rodriguez-Fraticelli A, Patel S, Yuan WC, Fujiwara Y, Li BE, Orkin SH, Hormoz S, Camargo FD.
Cell. 2020 Jun 11;181(6):1410-1422.e27. doi: 10.1016/j.cell.2020.04.048. Epub 2020 May 14.
PubMed
Associated Plasmids |
| Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia. Zhang C, Amanda S, Wang C, Tan TK, Ali MZ, Leong WZ, Ng LM, Kitajima S, Li Z, Yeoh AEJ, Tan SH, Sanda T. Haematologica. 2020 May 15. pii: haematol.2019.245639. doi: 10.3324/haematol.2019.245639. PubMed |
| Autophagy alleviates amiodarone-induced hepatotoxicity. Wandrer F, Frangez Z, Liebig S, John K, Vondran F, Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H. Arch Toxicol. 2020 Jul 10. pii: 10.1007/s00204-020-02837-9. doi: 10.1007/s00204-020-02837-9. PubMed |
| Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection. Doerflinger M, Deng Y, Whitney P, Salvamoser R, Engel S, Kueh AJ, Tai L, Bachem A, Gressier E, Geoghegan ND, Wilcox S, Rogers KL, Garnham AL, Dengler MA, Bader SM, Ebert G, Pearson JS, De Nardo D, Wang N, Yang C, Pereira M, Bryant CE, Strugnell RA, Vince JE, Pellegrini M, Strasser A, Bedoui S, Herold MJ. Immunity. 2020 Sep 15;53(3):533-547.e7. doi: 10.1016/j.immuni.2020.07.004. Epub 2020 Jul 30. PubMed |
| Characterization of the role of Samsn1 loss in multiple myeloma development. Friend NL, Hewett DR, Panagopoulos V, Noll JE, Vandyke K, Mrozik KM, Fitter S, Zannettino ACW. FASEB Bioadv. 2020 Aug 5;2(9):554-572. doi: 10.1096/fba.2020-00027. eCollection 2020 Sep. PubMed |
| Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma. Jia Y, Zhou J, Tan TK, Chung TH, Wong RWJ, Chooi JY, Lim JSL, Sanda T, Ooi M, De Mel S, Soekojo C, Chen Y, Zhang E, Cai Z, Shen P, Ruan J, Chng WJ. Blood Cancer J. 2021 Feb 12;11(2):32. doi: 10.1038/s41408-021-00421-7. PubMed |
| Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Huang H, Hu J, Maryam A, Huang Q, Zhang Y, Ramakrishnan S, Li J, Ma H, Ma VWS, Cheuk W, So GYK, Wang W, Cho WCS, Zhang L, Chan KM, Wang X, Chin YR. Nat Commun. 2021 Apr 14;12(1):2242. doi: 10.1038/s41467-021-22445-0. PubMed |
| Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Malone CF, Dharia NV, Kugener G, Forman AB, Rothberg MV, Abdusamad M, Gonzalez A, Kuljanin M, Robichaud AL, Conway AS, Dempster JM, Paolella BR, Dumont N, Hovestadt V, Mancias JD, Younger ST, Root DE, Golub TR, Vazquez F, Stegmaier K. Cancer Discov. 2021 Sep;11(9):2282-2299. doi: 10.1158/2159-8290.CD-20-1213. Epub 2021 Apr 21. PubMed |
| The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer. Vervoort SJ, Welsh SA, Devlin JR, Barbieri E, Knight DA, Offley S, Bjelosevic S, Costacurta M, Todorovski I, Kearney CJ, Sandow JJ, Fan Z, Blyth B, McLeod V, Vissers JHA, Pavic K, Martin BP, Gregory G, Demosthenous E, Zethoven M, Kong IY, Hawkins ED, Hogg SJ, Kelly MJ, Newbold A, Simpson KJ, Kauko O, Harvey KF, Ohlmeyer M, Westermarck J, Gray N, Gardini A, Johnstone RW. Cell. 2021 Jun 10;184(12):3143-3162.e32. doi: 10.1016/j.cell.2021.04.022. Epub 2021 May 17. PubMed |
| Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, Fan Z, Jabbari JS, Martin BP, Fareh M, Kelly MJ, Dupere-Richer D, Sandow JJ, Feran B, Knight D, Khong T, Spencer A, Harrison SJ, Gregory G, Wickramasinghe VO, Webb AI, Taberlay PC, Bromberg KD, Lai A, Papenfuss AT, Smyth GK, Allan RS, Licht JD, Landau DA, Abdel-Wahab O, Shortt J, Vervoort SJ, Johnstone RW. Mol Cell. 2021 May 20;81(10):2183-2200.e13. doi: 10.1016/j.molcel.2021.04.015. PubMed |
| ANLN Enhances Triple-Negative Breast Cancer Stemness Through TWIST1 and BMP2 and Promotes its Spheroid Growth. Maryam A, Chin YR. Front Mol Biosci. 2021 Jul 1;8:700973. doi: 10.3389/fmolb.2021.700973. eCollection 2021. PubMed |
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis.
Zhang Q, Agius SC, Flanigan SF, Uckelmann M, Levina V, Owen BM, Davidovich C.
Nat Commun. 2021 Jul 28;12(1):4592. doi: 10.1038/s41467-021-24866-3.
PubMed
Associated Plasmids |
| TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. Hu J, Lai Y, Huang H, Ramakrishnan S, Pan Y, Ma VWS, Cheuk W, So GYK, He Q, Geoffrey Lau C, Zhang L, Cho WCS, Chan KM, Wang X, Rebecca Chin Y. Br J Cancer. 2022 Jan;126(1):57-71. doi: 10.1038/s41416-021-01596-3. Epub 2021 Oct 30. PubMed |
| Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma. Jia Y, Zhou J, Tan TK, Chung TH, Chen Y, Chooi JY, Sanda T, Fullwood MJ, Xiong S, Toh SHM, Balan K, Wong RWJ, Lim JSL, Zhang E, Cai Z, Shen P, Chng WJ. Cancer Res. 2022 Feb 1;82(3):406-418. doi: 10.1158/0008-5472.CAN-21-0921. Epub 2021 Dec 10. PubMed |
| Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Davidson S, Yu CH, Steiner A, Ebstein F, Baker PJ, Jarur-Chamy V, Hrovat Schaale K, Laohamonthonkul P, Kong K, Calleja DJ, Harapas CR, Balka KR, Mitchell J, Jackson JT, Geoghegan ND, Moghaddas F, Rogers KL, Mayer-Barber KD, De Jesus AA, De Nardo D, Kile BT, Sadler AJ, Poli MC, Kruger E, Goldbach Mansky R, Masters SL. Sci Immunol. 2022 Feb 11;7(68):eabi6763. doi: 10.1126/sciimmunol.abi6763. Epub 2022 Feb 11. PubMed |
| PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Srinivas US, Tay NSC, Jaynes P, Anbuselvan A, Ramachandran GK, Wardyn JD, Hoppe MM, Hoang PM, Peng Y, Lim S, Lee MY, Peethala PC, An O, Shendre A, Tan BWQ, Jemimah S, Lakshmanan M, Hu L, Jakhar R, Sachaphibulkij K, Lim LHK, Pervaiz S, Crasta K, Yang H, Tan P, Liang C, Ho L, Khanchandani V, Kappei D, Yong WP, Tan DSP, Bordi M, Campello S, Tam WL, Frezza C, Jeyasekharan AD. Oncogene. 2022 Mar;41(13):1986-2002. doi: 10.1038/s41388-022-02219-8. Epub 2022 Mar 2. PubMed |
| Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86. Liu H, Wilson KR, Firth AM, Macri C, Schriek P, Blum AB, Villar J, Wormald S, Shambrook M, Xu B, Lim HJ, McWilliam HEG, Hill AF, Edgington-Mitchell LE, Caminschi I, Lahoud MH, Segura E, Herold MJ, Villadangos JA, Mintern JD. Nat Commun. 2022 Apr 11;13(1):1934. doi: 10.1038/s41467-022-29524-w. PubMed |
| Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling. Rethnam M, Tan DQ, Tan SH, Li J, Yokomori R, Li Y, Yang H, Sanda T, Suda T. Blood Adv. 2022 Sep 27;6(18):5330-5344. doi: 10.1182/bloodadvances.2021006306. PubMed |
| Deficiency in coatomer complex I causes aberrant activation of STING signalling. Steiner A, Hrovat-Schaale K, Prigione I, Yu CH, Laohamonthonkul P, Harapas CR, Low RRJ, De Nardo D, Dagley LF, Mlodzianoski MJ, Rogers KL, Zillinger T, Hartmann G, Gantier MP, Gattorno M, Geyer M, Volpi S, Davidson S, Masters SL. Nat Commun. 2022 Apr 28;13(1):2321. doi: 10.1038/s41467-022-29946-6. PubMed |
| Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells. Deryabin PI, Borodkina AV. Hum Reprod. 2022 Jun 30;37(7):1505-1524. doi: 10.1093/humrep/deac112. PubMed |
| The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFbeta and Hippo pathways. Gomez-Marin E, Posavec-Marjanovic M, Zarzuela L, Basurto-Cayuela L, Guerrero-Martinez JA, Arribas G, Yerbes R, Ceballos-Chavez M, Rodriguez-Paredes M, Tome M, Duran RV, Buschbeck M, Reyes JC. Nucleic Acids Res. 2022 Sep 23;50(17):9838-9857. doi: 10.1093/nar/gkac766. PubMed |
| A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. Lim HJ, Wubben JM, Garcia CP, Cruz-Gomez S, Deng J, Mak JYW, Hachani A, Anderson RJ, Painter GF, Goyette J, Amarasinghe SL, Ritchie ME, Roquilly A, Fairlie DP, Gaus K, Rossjohn J, Villadangos JA, McWilliam HEG. J Cell Biol. 2022 Dec 5;221(12):e202110125. doi: 10.1083/jcb.202110125. Epub 2022 Sep 21. PubMed |
| The escape of Candida albicans from macrophages is enabled by the fungal toxin candidalysin and two host cell death pathways. Olivier FAB, Hilsenstein V, Weerasinghe H, Weir A, Hughes S, Crawford S, Vince JE, Hickey MJ, Traven A. Cell Rep. 2022 Sep 20;40(12):111374. doi: 10.1016/j.celrep.2022.111374. PubMed |
| Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia. Moujalled DM, Brown FC, Chua CC, Dengler MA, Pomilio G, Anstee NS, Litalien V, Thompson E, Morley T, MacRaild S, Tiong IS, Morris R, Dun K, Zordan A, Shah J, Banquet S, Halilovic E, Morris E, Herold MJ, Lessene G, Adams JM, Huang DCS, Roberts AW, Blombery P, Wei AH. Blood. 2023 Feb 9;141(6):634-644. doi: 10.1182/blood.2022016090. PubMed |
| Genetic deletion of HPV E7 oncogene effectively regresses HPV driven oral squamous carcinoma tumour growth. Ferreira DA, McMillan NAJ, Idris A. Biomed Pharmacother. 2022 Nov;155:113782. doi: 10.1016/j.biopha.2022.113782. Epub 2022 Sep 30. PubMed |
| Analysis of a hit-and-run tumor model by HPV in oropharyngeal cancers. Ferreira DA, Idris A, McMillan NAJ. J Med Virol. 2023 Jan;95(1):e28260. doi: 10.1002/jmv.28260. Epub 2022 Nov 4. PubMed |
| A Myb enhancer-guided analysis of basophil and mast cell differentiation. Matsumura T, Totani H, Gunji Y, Fukuda M, Yokomori R, Deng J, Rethnam M, Yang C, Tan TK, Karasawa T, Kario K, Takahashi M, Osato M, Sanda T, Suda T. Nat Commun. 2022 Nov 18;13(1):7064. doi: 10.1038/s41467-022-34906-1. PubMed |
| Hyperactivation of p53 using CRISPRa kills human papillomavirus-driven cervical cancer cells. Idres YM, Lai AJ, McMillan NAJ, Idris A. Virus Genes. 2023 Apr;59(2):312-316. doi: 10.1007/s11262-022-01960-2. Epub 2022 Dec 6. PubMed |
| Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma. Pandey GK, Landman N, Neikes HK, Hulsman D, Lieftink C, Beijersbergen R, Kolluri KK, Janes SM, Vermeulen M, Badhai J, van Lohuizen M. Cell Rep Med. 2023 Feb 21;4(2):100915. doi: 10.1016/j.xcrm.2022.100915. Epub 2023 Jan 18. PubMed |
| Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, Guo F, Chin HS, Chen GB, Ang CH, Lin Q, Hong W, Fu NY. Cell Rep. 2023 Feb 28;42(2):112065. doi: 10.1016/j.celrep.2023.112065. Epub 2023 Jan 31. PubMed |
| Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs. Diepstraten ST, Young S, La Marca JE, Wang Z, Kluck RM, Strasser A, Kelly GL. Cell Death Differ. 2023 Apr;30(4):1005-1017. doi: 10.1038/s41418-023-01117-0. Epub 2023 Feb 8. PubMed |
| ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas. Jiang B, Weinstock DM, Donovan KA, Sun HW, Wolfe A, Amaka S, Donaldson NL, Wu G, Jiang Y, Wilcox RA, Fischer ES, Gray NS, Wu W. Cell Chem Biol. 2023 Apr 20;30(4):383-393.e6. doi: 10.1016/j.chembiol.2023.03.007. Epub 2023 Apr 3. PubMed |
| Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma. Zhou J, Toh SH, Tan TK, Balan K, Lim JQ, Tan TZ, Xiong S, Jia Y, Ng SB, Peng Y, Jeyasekharan AD, Fan S, Lim ST, Ong CJ, Ong CK, Sanda T, Chng WJ. Mol Cancer. 2023 Apr 10;22(1):69. doi: 10.1186/s12943-023-01767-1. PubMed |
| Akt3 promotes cancer stemness in triple-negative breast cancer through YB1-Snail/Slug signaling axis. Tian Y, Li J, Cheung TC, Tam V, Lau CG, Wang X, Chin YR. Genes Dis. 2022 Sep 1;10(2):301-306. doi: 10.1016/j.gendis.2022.08.006. eCollection 2023 Mar. PubMed |
| Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer. Wei Y, Zhang L, Wang C, Li Z, Luo M, Xie G, Yang X, Li M, Ren S, Zhao D, Gao R, Gong JN. Animal Model Exp Med. 2023 Jun;6(3):245-254. doi: 10.1002/ame2.12330. Epub 2023 Jun 4. PubMed |
| Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC). Priesmeier L, Schoger E, Cyganek L, Cecilia Zelarayan L. Stem Cell Res. 2023 Sep;71:103163. doi: 10.1016/j.scr.2023.103163. Epub 2023 Jul 5. PubMed |
| Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression. Page EC, Heatley SL, Rehn J, Thomas PQ, Yeung DT, White DL. Front Oncol. 2023 Jul 6;13:1177871. doi: 10.3389/fonc.2023.1177871. eCollection 2023. PubMed |
| Oncogene-Induced Senescence Is a Crucial Antitumor Defense Mechanism of Human Endometrial Stromal Cells. Toropov AL, Deryabin PI, Shatrova AN, Borodkina AV. Int J Mol Sci. 2023 Sep 14;24(18):14089. doi: 10.3390/ijms241814089. PubMed |
| p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP. Ouyang H, Wu S, Li W, Grey MJ, Wu W, Hansen SH. Cell Rep. 2023 Dec 26;42(12):113486. doi: 10.1016/j.celrep.2023.113486. Epub 2023 Nov 22. PubMed |
| ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors. Wang L, Tan TK, Kim H, Kappei D, Tan SH, Look AT, Sanda T. Cell Rep. 2023 Dec 26;42(12):113541. doi: 10.1016/j.celrep.2023.113541. Epub 2023 Dec 5. PubMed |
| Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Voon HPJ, Hii L, Garvie A, Udugama M, Krug B, Russo C, Chueh AC, Daly RJ, Morey A, Bell TDM, Turner SJ, Rosenbluh J, Daniel P, Firestein R, Mann JR, Collas P, Jabado N, Wong LH. Genome Biol. 2023 Dec 8;24(1):284. doi: 10.1186/s13059-023-03122-5. PubMed |
Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate.
Matsui S, Granitto M, Buckley M, Ludwig K, Koigi S, Shiley J, Zacharias WJ, Mayhew CN, Lim HW, Iwafuchi M.
Mol Cell. 2024 Jan 4:S1097-2765(23)01026-2. doi: 10.1016/j.molcel.2023.12.007.
PubMed
Associated Plasmids |
| Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo. Dibra D, Xiong S, Moyer SM, El-Naggar AK, Qi Y, Su X, Kong EK, Korkut A, Lozano G. Sci Adv. 2024 Feb 16;10(7):eadk1835. doi: 10.1126/sciadv.adk1835. Epub 2024 Feb 14. PubMed |
| Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC. Cell Death Dis. 2024 Feb 19;15(2):152. doi: 10.1038/s41419-024-06488-x. PubMed |
| The cholesterol biosynthesis enzyme FAXDC2 couples Wnt/beta-catenin to RTK/MAPK signaling. Madan B, Wadia SR, Patnaik S, Harmston N, Tan E, Tan IBH, Nes WD, Petretto E, Virshup DM. J Clin Invest. 2024 Jan 23;134(6):e171222. doi: 10.1172/JCI171222. PubMed |
| Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/beta-catenin addiction in cancer. Zhong Z, Virshup DM. Sci Adv. 2024 Apr 5;10(14):eadk1031. doi: 10.1126/sciadv.adk1031. Epub 2024 Apr 3. PubMed |
| Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers. Diepstraten ST, Yuan Y, La Marca JE, Young S, Chang C, Whelan L, Ross AM, Fischer KC, Pomilio G, Morris R, Georgiou A, Litalien V, Brown FC, Roberts AW, Strasser A, Wei AH, Kelly GL. Cancer Cell. 2024 May 13;42(5):850-868.e9. doi: 10.1016/j.ccell.2024.04.004. Epub 2024 Apr 25. PubMed |
| Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition. Beauchamp E, Gamma JM, Cromwell CR, Moussa EW, Pain R, Kostiuk MA, Acevedo-Morantes C, Iyer A, Yap M, Vincent KM, Postovit LM, Julien O, Hubbard BP, Mackey JR, Berthiaume LG. J Transl Med. 2024 May 7;22(1):431. doi: 10.1186/s12967-024-05150-6. PubMed |
| TruD technology for the study of epi- and endothelial tubes in vitro. Hansen SH. PLoS One. 2024 May 10;19(5):e0301099. doi: 10.1371/journal.pone.0301099. eCollection 2024. PubMed |
| Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape. Wu X, Go M, Nguyen JV, Kuchel NW, Lu BGC, Zeglinski K, Lowes KN, Calleja DJ, Mitchell JP, Lessene G, Komander D, Call ME, Call MJ. Nat Commun. 2024 Jul 23;15(1):6219. doi: 10.1038/s41467-024-50566-9. PubMed |
| Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myeloma. Xiong S, Zhou J, Tan TK, Chung TH, Tan TZ, Toh SH, Tang NXN, Jia Y, See YX, Fullwood MJ, Sanda T, Chng WJ. Nat Commun. 2024 Aug 9;15(1):6810. doi: 10.1038/s41467-024-50910-z. PubMed |
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