pHR_SFFV Citations (16)
Originally described in: Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors.Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA Cell. 2016 Feb 11;164(4):780-91. doi: 10.1016/j.cell.2016.01.012. Epub 2016 Jan 28. PubMed Journal
Articles Citing pHR_SFFV
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Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.
Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA.
Cell. 2016 Oct 6;167(2):419-432.e16. doi: 10.1016/j.cell.2016.09.011. Epub 2016 Sep 29.
PubMed
Associated Plasmids |
| GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma. Charan M, Dravid P, Cam M, Audino A, Gross AC, Arnold MA, Roberts RD, Cripe TP, Pertsemlidis A, Houghton PJ, Cam H. Int J Cancer. 2020 Jun 1;146(11):3184-3195. doi: 10.1002/ijc.32743. Epub 2019 Nov 6. PubMed |
| A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Goglia AG, Wilson MZ, Jena SG, Silbert J, Basta LP, Devenport D, Toettcher JE. Cell Syst. 2020 Mar 25;10(3):240-253.e6. doi: 10.1016/j.cels.2020.02.005. Epub 2020 Mar 18. PubMed |
| Discriminatory Power of Combinatorial Antigen Recognition in Cancer T Cell Therapies. Dannenfelser R, Allen GM, VanderSluis B, Koegel AK, Levinson S, Stark SR, Yao V, Tadych A, Troyanskaya OG, Lim WA. Cell Syst. 2020 Sep 23;11(3):215-228.e5. doi: 10.1016/j.cels.2020.08.002. Epub 2020 Sep 10. PubMed |
| Conditional guide RNA through two intermediate hairpins for programmable CRISPR/Cas9 function: building regulatory connections between endogenous RNA expressions. Lin J, Liu Y, Lai P, Ye H, Xu L. Nucleic Acids Res. 2020 Nov 18;48(20):11773-11784. doi: 10.1093/nar/gkaa842. PubMed |
| Immune receptor inhibition through enforced phosphatase recruitment. Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. Nature. 2020 Oct;586(7831):779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21. PubMed |
| DMA-tudor interaction modules control the specificity of in vivo condensates. Courchaine EM, Barentine AES, Straube K, Lee DR, Bewersdorf J, Neugebauer KM. Cell. 2021 Jul 8;184(14):3612-3625.e17. doi: 10.1016/j.cell.2021.05.008. Epub 2021 Jun 10. PubMed |
| Generation of CAR-T Cells by Lentiviral Transduction. Okuma A. Methods Mol Biol. 2021;2312:3-14. doi: 10.1007/978-1-0716-1441-9_1. PubMed |
| FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB. Sun R, Lim SO. FEBS J. 2022 Aug;289(15):4549-4563. doi: 10.1111/febs.16383. Epub 2022 Feb 11. PubMed |
Modular design of synthetic receptors for programmed gene regulation in cell therapies.
Zhu I, Liu R, Garcia JM, Hyrenius-Wittsten A, Piraner DI, Alavi J, Israni DV, Liu B, Khalil AS, Roybal KT.
Cell. 2022 Apr 14;185(8):1431-1443.e16. doi: 10.1016/j.cell.2022.03.023.
PubMed
Associated Plasmids |
| Controllable DNA hybridization by host-guest complexation-mediated ligand invasion. Xiao L, Wang LL, Wu CQ, Li H, Zhang QL, Wang Y, Xu L. Nat Commun. 2022 Oct 8;13(1):5936. doi: 10.1038/s41467-022-33738-3. PubMed |
Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function.
McCutcheon SR, Swartz AM, Brown MC, Barrera A, McRoberts Amador C, Siklenka K, Humayun L, Isaacs JM, Reddy TE, Nair S, Antonia S, Gersbach CA.
bioRxiv. 2023 May 1:2023.05.01.538906. doi: 10.1101/2023.05.01.538906. Preprint.
PubMed
Associated Plasmids |
| Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. Hamid MHBA, Cespedes PF, Jin C, Chen JL, Gileadi U, Antoun E, Liang Z, Gao F, Teague R, Manoharan N, Maldonado-Perez D, Khalid-Alham N, Cerundolo L, Ciaoca R, Hester SS, Pinto-Fernandez A, Draganov SD, Vendrell I, Liu G, Yao X, Kvalvaag A, Dominey-Foy DCC, Nanayakkara C, Kanellakis N, Chen YL, Waugh C, Clark SA, Clark K, Sopp P, Rahman NM, Verrill C, Kessler BM, Ogg G, Fernandes RA, Fisher R, Peng Y, Dustin ML, Dong T. Nat Immunol. 2024 May;25(5):834-846. doi: 10.1038/s41590-024-01802-3. Epub 2024 Apr 1. PubMed |
| Proximity labeling reveals dynamic changes in the SQSTM1 protein network. Rondon-Ortiz AN, Zhang L, Ash PEA, Basu A, Puri S, van der Spek SJF, Wang Z, Dorrian L, Emili A, Wolozin B. J Biol Chem. 2024 Sep;300(9):107621. doi: 10.1016/j.jbc.2024.107621. Epub 2024 Aug 3. PubMed |
| Structures of butyrophilin multimers reveal a plier-like mechanism for Vgamma9Vdelta2 T cell receptor activation. Zhang M, Wang Y, Cai N, Qu Y, Ma X, Xue J, Chen X, Zhang X, Xiao J, Zhang Y. Immunity. 2025 Jul 8;58(7):1660-1669.e7. doi: 10.1016/j.immuni.2025.05.011. Epub 2025 Jun 11. PubMed |
| Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response. Sun Y, Tang Y, Ortiz P, Nassif Rausseo B, Pazdrak B, Elzohary L, Katailiha A, Talukder A, Yee C, Davis RE, Lizee G. Front Immunol. 2025 Sep 30;16:1572342. doi: 10.3389/fimmu.2025.1572342. eCollection 2025. PubMed |
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