pMCB320 Citations (29)
Originally described in: Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.Han K, Jeng EE, Hess GT, Morgens DW, Li A, Bassik MC Nat Biotechnol. 2017 Mar 20. doi: 10.1038/nbt.3834. PubMed Journal
Articles Citing pMCB320
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| Optimal control nodes in disease-perturbed networks as targets for combination therapy. Hu Y, Chen CH, Ding YY, Wen X, Wang B, Gao L, Tan K. Nat Commun. 2019 May 16;10(1):2180. doi: 10.1038/s41467-019-10215-y. PubMed |
| SLC19A1 Is an Importer of the Immunotransmitter cGAMP. Ritchie C, Cordova AF, Hess GT, Bassik MC, Li L. Mol Cell. 2019 Jul 25;75(2):372-381.e5. doi: 10.1016/j.molcel.2019.05.006. Epub 2019 May 21. PubMed |
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.
Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC.
Cell Host Microbe. 2019 Oct 9;26(4):551-563.e6. doi: 10.1016/j.chom.2019.08.017. Epub 2019 Sep 17.
PubMed
Associated Plasmids |
| Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway. Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC. Cell Rep. 2020 Feb 4;30(5):1417-1433.e7. doi: 10.1016/j.celrep.2020.01.013. PubMed |
| Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers. He B, Gao P, Ding YY, Chen CH, Chen G, Chen C, Kim H, Tasian SK, Hunger SP, Tan K. Sci Adv. 2020 Jul 24;6(30):eaba3064. doi: 10.1126/sciadv.aba3064. eCollection 2020 Jul. PubMed |
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.
Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, Lowe SW, Curtis C, Yeo GW, Winslow MM, Bassik MC, Attardi LD.
Mol Cell. 2020 Nov 5;80(3):452-469.e9. doi: 10.1016/j.molcel.2020.10.022.
PubMed
Associated Plasmids |
| LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Bohnert V, Maduke M, Bassik MC, Li L. Mol Cell. 2020 Nov 19;80(4):578-591.e5. doi: 10.1016/j.molcel.2020.10.021. Epub 2020 Nov 9. PubMed |
| Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK. Curr Biol. 2021 Jul 12;31(13):2895-2905.e7. doi: 10.1016/j.cub.2021.04.075. Epub 2021 May 13. PubMed |
A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains.
Morgens DW, Nandakumar D, Didychuk AL, Yang KJ, Glaunsinger BA.
PLoS Pathog. 2022 Jan 18;18(1):e1010236. doi: 10.1371/journal.ppat.1010236. eCollection 2022 Jan.
PubMed
Associated Plasmids |
| The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, Cruz PHC, Vandenbon A, Suzuki Y, Kawahara Y, Hatada I, Bassik MC, Takeuchi O. Nat Commun. 2022 Oct 28;13(1):6435. doi: 10.1038/s41467-022-34078-y. PubMed |
| A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, Levin-Konigsberg R, Bassik MC, Stigloher C, Wehman AM. Curr Biol. 2023 Feb 27;33(4):607-621.e7. doi: 10.1016/j.cub.2022.12.041. Epub 2023 Jan 17. PubMed |
| Protocol for performing pooled CRISPR-Cas9 loss-of-function screens. Mathiowetz AJ, Roberts MA, Morgens DW, Olzmann JA, Li Z. STAR Protoc. 2023 Mar 30;4(2):102201. doi: 10.1016/j.xpro.2023.102201. PubMed |
The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection.
McCollum CO, Didychuk AL, Liu D, Murray-Nerger LA, Cristea IM, Glaunsinger BA.
PLoS Pathog. 2023 Apr 17;19(4):e1011163. doi: 10.1371/journal.ppat.1011163. eCollection 2023 Apr.
PubMed
Associated Plasmids |
| Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging. Yeo RW, Zhou OY, Zhong BL, Sun ED, Navarro Negredo P, Nair S, Sharmin M, Ruetz TJ, Wilson M, Kundaje A, Dunn AR, Brunet A. Nat Aging. 2023 Jul;3(7):866-893. doi: 10.1038/s43587-023-00449-3. Epub 2023 Jul 13. PubMed |
| Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus. Morgens DW, Gulyas L, Souza AS, Glaunsinger BA. bioRxiv. 2023 Jul 8:2023.07.08.548212. doi: 10.1101/2023.07.08.548212. Preprint. PubMed |
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA.
Dev Cell. 2023 Jul 18:S1534-5807(23)00331-3. doi: 10.1016/j.devcel.2023.07.001.
PubMed
Associated Plasmids |
| Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states. Riepe C, Wachalska M, Deol KK, Amaya AK, Porteus MH, Olzmann JA, Kopito RR. Mol Biol Cell. 2024 Feb 1;35(2):ar15. doi: 10.1091/mbc.E23-08-0336. Epub 2023 Nov 29. PubMed |
| DNA-PKcs suppresses illegitimate chromosome rearrangements. Wang J, Sadeghi CA, Frock RL. Nucleic Acids Res. 2024 May 22;52(9):5048-5066. doi: 10.1093/nar/gkae140. PubMed |
| A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Ganga AK, Sweeney LK, Ramos AR, Bishop CS, Hamel V, Guichard P, Breslow DK. bioRxiv [Preprint]. 2024 Apr 3:2024.04.02.587836. doi: 10.1101/2024.04.02.587836. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. bioRxiv [Preprint]. 2024 May 30:2024.05.30.596681. doi: 10.1101/2024.05.30.596681. PubMed |
| Alpha-defensin binding expands human adenovirus tropism. Zhao C, Porter JM, Burke PC, Arnberg N, Smith JG. PLoS Pathog. 2024 Jun 20;20(6):e1012317. doi: 10.1371/journal.ppat.1012317. eCollection 2024 Jun. PubMed |
| The extracellular matrix integrates mitochondrial homeostasis. Zhang H, Tsui CK, Garcia G, Joe LK, Wu H, Maruichi A, Fan W, Pandovski S, Yoon PH, Webster BM, Durieux J, Frankino PA, Higuchi-Sanabria R, Dillin A. Cell. 2024 Aug 8;187(16):4289-4304.e26. doi: 10.1016/j.cell.2024.05.057. Epub 2024 Jun 27. PubMed |
| GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer. Drainas AP, Hsu WH, Dallas AE, Poltorack CD, Kim JW, He A, Coles GL, Baron M, Bassik MC, Sage J. Cell Rep. 2024 Aug 27;43(8):114606. doi: 10.1016/j.celrep.2024.114606. Epub 2024 Aug 8. PubMed |
| A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Ganga AK, Sweeney LK, Rubio Ramos A, Wrinn CM, Bishop CS, Hamel V, Guichard P, Breslow DK. Curr Biol. 2024 Oct 21;34(20):4824-4834.e6. doi: 10.1016/j.cub.2024.08.058. Epub 2024 Sep 23. PubMed |
| CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells. Ruetz TJ, Pogson AN, Kashiwagi CM, Gagnon SD, Morton B, Sun ED, Na J, Yeo RW, Leeman DS, Morgens DW, Tsui CK, Li A, Bassik MC, Brunet A. Nature. 2024 Oct;634(8036):1150-1159. doi: 10.1038/s41586-024-07972-2. Epub 2024 Oct 2. PubMed |
| Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Jena KK, Mambu J, Boehmer D, Sposito B, Millet V, de Sousa Casal J, Muendlein HI, Spreafico R, Fenouil R, Spinelli L, Wurbel S, Riquier C, Galland F, Naquet P, Chasson L, Elkins M, Mitsialis V, Ketelut-Carneiro N, Bugda Gwilt K, Thiagarajah JR, Ruan HB, Lin Z, Lien E, Shao F, Chou J, Poltorak A, Ordovas-Montanes J, Fitzgerald KA, Snapper SB, Broggi A, Zanoni I. Cell. 2024 Dec 26;187(26):7533-7550.e23. doi: 10.1016/j.cell.2024.10.010. Epub 2024 Nov 4. PubMed |
| Prostaglandin E2 inhibits adipogenesis through the cilia-dependent activation of ROCK2. Lee MD, Hilgendorf KI. J Cell Sci. 2025 Oct 15;138(20):jcs264193. doi: 10.1242/jcs.264193. Epub 2025 Oct 24. PubMed |
| A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia. Elliott SD, Ready PJ, Wrinn CM, Ma Q, Edward M, Niescier RF, Escobar I, Sun J, Ganga AK, McAtee CK, Atis IS, Koleske AJ, Bordey A, Breslow DK. Sci Adv. 2025 Oct 31;11(44):eaeb7238. doi: 10.1126/sciadv.aeb7238. Epub 2025 Oct 29. PubMed |
| A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology. Sun J, Atis IS, Empke SLL, Khokha MK, Breslow DK. Dev Cell. 2025 Nov 20:S1534-5807(25)00666-5. doi: 10.1016/j.devcel.2025.10.015. PubMed |
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