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Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice.

Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR
Stem Cell Res Ther. 2011 Mar 4. 2(2):11. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
24414pEnt L1L3 tTA-2
24415pEnt L1L3 EF1a-tTA-3
24416pEnt R3L2 TetO(fl)-2
24417pEnt R3L2 TetO(sh) mCh-Rs1-2Human 5HT4B receptor with D100A mutation, generating the RASSL Rs1. Construct expresses both mCherry and Rs1 via a P2A ribosomal skip sequence. Plasmid also known as pEntR3L2 TetO-mCh-Rs1.
24418pRosa26 R1-ccdB-R2 RexNeo PI-SceI
24419Exp-Rosa-EF1a-tTA-mCh-Rs1-TetO(sh)-2Human 5HT4B receptor with D100A mutation, generating the RASSL Rs1. Expresses mCherry and Rs1 via P2A ribosomal skip sequence. Expresses tTA under EF1α promoter. Rosa26 homology arms for integration.
26797Exp-pcDNA3.2delCMV(EF1α-tTA/TetO-mCh-Rs1)Human 5HT4B receptor with D100A mutation, generating the RASSL Rs1. Construct expresses both mCherry and Rs1 via a P2A ribosomal skip sequence. Expresses tTA under EF1α promoter separately.
26798pEnt L1L3-MCS
26799pEnt R3L2-MCS
26803pEnt L1L3 EF1a-tTA-2
27105pEnt L1L3 tTA-3
27106pEnt L1L3 rtTA-3
27107pEnt R3L2 TetO(fl)-3
29496pcDNA3.2 GW delCMV

Antibodies from Article