We narrowed to 5,246 results for: U6

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AAV N-SpyCas9-Intein, U6-gRNA scaffold (F+E)

Plasmid

#120293

Purpose

AAV Vector for expression of N-terminal SpyCas9 fragment with Intein and a U6-driven F+E gRNA scaffold

Depositor

Dominik Niopek

Article

Hoffmann et al Nucleic Acids Res. 2019 Apr 15. pii: 545

Insert

N-terminal fragment of SpyCas9

Use

AAV and CRISPR

Tags

SV40-NLS and split-intein

Expression

Mammalian

Available Since

Jan. 9, 2019

Availability

Academic Institutions and Nonprofits only

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pRC11-U6-DR-crRNA-BsmbI(x2); EFS-Puro-WPRE

Plasmid

#123360

Purpose

Lentiviral vector with empty U6 cassette containing LbCpf1 direct repeat, and constitutive expression of puromycin resistance.

Depositor

Sidi Chen

Article

Chow et al Nat Methods. 2019 May;16(5):405-408. doi

Insert

Empty LbCpf1 crRNA cloning cassette

Use

CRISPR and Lentiviral

Expression

Mammalian

Promoter

U6

Available Since

May 14, 2019

Availability

Academic Institutions and Nonprofits only

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pDF0582 huDisCas7-11 R1045-GGGS-R1122 U6-NT guide

Plasmid

#186991

Purpose

AAV transgene plasmid for Cas7-11-R1045-GGGS-R1122, with U6 promoter-driven expression of non-targeting crRNA guide

Depositor

Omar Abudayyeh, Jonathan Gootenberg

Article

Kato et al Cell. 2022 May 25. pii: S0092-8674(22)00

Insert

cas7-11-r1045-gggs-r1122, non-targeting crRNA guide

Use

AAV

Mutation

r1045-gggs-r1122 deletion

Available Since

Sept. 6, 2022

Availability

Academic Institutions and Nonprofits only

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pLKO.1-puro U6 sgRNA BfuAI stuffer G-tract

Plasmid

#138524

Purpose

Expresses a guide RNA of choice cloned into the BfuI site extended at the 3' end to incorporate a 220-nt PRC2-binding G-tract repeat RNA sequence.

Depositor

Richard Jenner

Article

Beltran et al Nat Struct Mol Biol. 2019 Oct;26(10):899

Insert

PRC2-binding G-tract repeat RNA

Use

CRISPR and Lentiviral

Expression

Mammalian

Promoter

U6

Available Since

Aug. 5, 2020

Availability

Academic Institutions and Nonprofits only

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(pRZ75) AAV: U6-gRNA(cs1)-EF1a-Cre-P2A-mCherry

Plasmid

#254581

Purpose

AAV backbone expressing Cre recombinase and mCherry from the EF1a promoter and one U6-driven sgRNA with SapI spacer and capture sequence in scaffold

Depositor

Jesse Engreitz

Insert

Cre

Use

AAV

Available Since

May 13, 2026

Availability

Academic Institutions and Nonprofits only

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pPD783 U6 sgRNA Rosa26 Cas9-T2A-BFP-P2A-Ad4E4orf6

Plasmid

#253871

Purpose

NHEJ Inhibitor 2 with Cas9 and Rosa26 sgRNA

Depositor

Joshua Leonard

Article

Dreyer et al ACS Synth Biol. 2025 May 16;14(5):1464-1

Insert

Cas9-T2A-BFP-P2A-Ad4E4orf6

Use

Synthetic Biology

Expression

Mammalian

Promoter

CBh

Available Since

April 13, 2026

Availability

Academic Institutions and Nonprofits only

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pscAAV-KIKO-U6-gOsmr-p2a-mCherry-STOP-pA-400

Plasmid

#249130

Purpose

all-in-one HDRT-based knockin-knockout (KIKO) design to insert mCherry (=knockin) at gOsmr cut site, disrupting Osmr expression

Depositor

Matthew Krummel

Article

Kuhn et al J Exp Med. 2026 May 4;223(5):e20251228.

Insert

gOsmr, mCherry (Osmr Mouse, Synthetic)

Use

AAV

Available Since

March 4, 2026

Availability

Academic Institutions and Nonprofits only

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pAAV-U6-DR36(DjCas13d-SapI)-CMV-intron-GFP-pA

Plasmid

#192500

Purpose

To express DjCas13d compatible gRNA and GFP

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

DjCas13d

Use

AAV

Mutation

No

Promoter

CMV

Available Since

Aug. 27, 2025

Availability

Academic Institutions and Nonprofits only

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(829) SB Tet-ON dCasphi-[myc-ZIM3-HA] U6-gStop

Plasmid

#195622

Purpose

Sleeping Beauty Tet-ON plasmid for induced expression of dCasphi-ZIM3 CRISPRi construct

Depositor

Tonia Rex

Insert

dCasphi

Tags

C-Myc (NLS), HA tag, and ZIM3

Expression

Mammalian

Mutation

P749A and P753A

Promoter

Tight TRE promoter; Tet-ON (doxycycline)

Available Since

July 1, 2025

Availability

Academic Institutions and Nonprofits only

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(915) SB EF1a dCasphi-[myc-ZIM3-HA] U6-gStop

Plasmid

#195623

Purpose

Sleeping Beauty EF1a plasmid for constitutive expression of dCasphi-ZIM3 CRISPRi construct

Depositor

Tonia Rex

Insert

dCasphi

Tags

C-Myc (NLS), HA tag, and ZIM3

Expression

Mammalian

Mutation

P749A and P753A

Promoter

EF1a (Mlu1/EcoR1)

Available Since

July 1, 2025

Availability

Academic Institutions and Nonprofits only

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(942) pAAV EF1a dCasphi-[myc-ZIM3-HA] U6-gStop

Plasmid

#195624

Purpose

pAAV EF1a plasmid for constitutive expression of dCasphi-ZIM3 CRISPRi construct

Depositor

Tonia Rex

Insert

dCasphi

Use

AAV

Tags

C-Myc (NLS), HA tag, and ZIM3

Expression

Mammalian

Mutation

P749A and P753A

Promoter

EF1a (Mlu1/EcoR1)

Available Since

July 1, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-GFP-pA U6 shRNA (Rat NPAS4 #1)

Plasmid

#233270

Purpose

To express GFP from a CMV promoter and to express and shRNA targeting Rat Npas4

Depositor

Jonathan Ploski, Glenn Schafe

Article

Ploski et al PLoS One. 2011;6(8):e23760. doi: 10.1371

Insert

GFP and shRNA targeting Rat NPAS4 (Npas4 Rat)

Use

AAV

Tags

GFP

Available Since

May 30, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-GFP-pA U6 shRNA (Rat NPAS4 #5)

Plasmid

#233271

Purpose

To express GFP from a CMV promoter and to express and shRNA targeting Rat Npas4

Depositor

Jonathan Ploski, Glenn Schafe

Article

Ploski et al PLoS One. 2011;6(8):e23760. doi: 10.1371

Insert

GFP and shRNA targeting Rat NPAS4 (Npas4 Rat)

Use

AAV

Tags

GFP

Available Since

May 30, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-GFP-pA U6 shRNA (Rat Nurr1 #1)

Plasmid

#233273

Purpose

To express GFP from a CMV promoter and to express an shRNA targeting Rat Nurr1

Depositor

Jonathan Ploski, Glenn Schafe

Insert

GFP and shRNA targeting Rat Nurr1 (Nr4a2 Rat)

Use

AAV

Available Since

May 30, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-CMV-GFP-pA U6 shRNA (Rat Nurr1 #5)

Plasmid

#233274

Purpose

To express GFP from a CMV promoter and to express an shRNA targeting Rat Nurr1

Depositor

Jonathan Ploski, Glenn Schafe

Insert

GFP and shRNA targeting Rat Nurr1 (Nr4a2 Rat)

Use

AAV

Available Since

May 30, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-U6-DR30(SapI) 0.5 Syn-intron-CasRx-pA

Plasmid

#233038

Purpose

To express a RfxCas13d-compatible gRNA and to express HA Tagged CasRx from a 0.5 bp synapsin promoter

Depositor

Jonathan Ploski

Article

Back et al Mol Ther Methods Clin Dev. 2025 Aug 20;3

Insert

RfxCas13d-compatible gRNA expression cassette and CasRx

Use

AAV

Available Since

March 4, 2025

Availability

Academic Institutions and Nonprofits only

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pAAV-MYL2-inteinC-SpC aa714-1368-U6-Camk2d sgRNA7

Plasmid

#226916

Purpose

Expresses Sp cas9C by MYL2 promoter and sgRNA targeting murine Camk2d intron7 5' splice site by U6 promoter

Depositor

Yuxuan Guo

Article

Liu et al Circ Res. 2025 Jan 16. doi: 10.1161/CIRC

Insert

MYL2, inteinC, nSp Cas9C

Use

AAV

Promoter

MYL2

Available Since

Jan. 16, 2025

Availability

Academic Institutions and Nonprofits only

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pAV-puro-U6+27-F30-Tornado-Acyclovir-IRE#A4

Plasmid

#216823

Purpose

Expresses acyclovir-controllable IRE variant #A4 as circular RNA in mammalian cells using the Tornado expression system.

Depositor

Samie Jaffrey

Article

Hagen et al Cell Chem Biol. 2024 Aug 23:S2451-9456(2

Insert

Tornado-Acyclovir-IRE#A4

Expression

Mammalian

Promoter

U6+27

Available Since

Aug. 27, 2024

Availability

Academic Institutions and Nonprofits only

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pAV-puro-U6+27-F30-Tornado-Acyclovir-IRE#A8

Plasmid

#216824

Purpose

Expresses acyclovir-controllable IRE variant #A8 as circular RNA in mammalian cells using the Tornado expression system.

Depositor

Samie Jaffrey

Article

Hagen et al Cell Chem Biol. 2024 Aug 23:S2451-9456(2

Insert

Tornado-Acyclovir-IRE#A8

Expression

Mammalian

Promoter

U6+27

Available Since

Aug. 27, 2024

Availability

Academic Institutions and Nonprofits only

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pAV-puro-U6+27-F30-Tornado-Squash-FTL-IRE

Plasmid

#216828

Purpose

Expresses a circular RNA containing a Squash aptamer and an IRE (FTL derived) in mammalian cells, using the Tornado expression system.

Depositor

Samie Jaffrey

Article

Hagen et al Cell Chem Biol. 2024 Aug 23:S2451-9456(2

Insert

Tornado-Squash-FTL-IRE

Expression

Mammalian

Promoter

U6+27

Available Since

Aug. 27, 2024

Availability

Academic Institutions and Nonprofits only

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