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TDP-43_CTD_F313A

Plasmid

#248869

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with F313A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_F313A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed F313A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_F316A

Plasmid

#248870

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with F316A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_F316A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed F316A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_S342A

Plasmid

#248888

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with S342A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_S342A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed S342A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_M336A

Plasmid

#248884

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with M336A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_M336A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed M336A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_S333A

Plasmid

#248882

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with S333A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_S333A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed S333A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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TDP-43_CTD_W334A

Plasmid

#248883

Purpose

Expresses 6xHis-tagged C-terminal domain of TDP-43 with W334A.

Depositor

Nicolas Fawzi

Article

Rizuan et al Nat Commun. 2025 Nov 26;16(1):10528. doi

Insert

TDP-43_CTD_W334A (TARDBP Human)

Tags

6xHis-tags

Expression

Bacterial

Mutation

changed W334A

Available Since

Dec. 2, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV-mTDGa.1-BioID2-HA

Plasmid

#232028

Purpose

mammalian expression (CMV promoter) of murine TDGa.1 (catalytic mutant N151A) fused to BioID2-HA

Depositor

Primo Schaer

Article

Richina et al Cell Mol Life Sci. 2025 Nov 25. doi: 10.

Insert

Tdg (Tdg Mouse)

Tags

BioID2-HA

Expression

Mammalian

Mutation

N151A (site-directed mutagenesis: aac -> gcc)

Promoter

CMV

Available Since

Nov. 26, 2025

Availability

Academic Institutions and Nonprofits only

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pCMV-mTDGa.2-BioID2-HA

Plasmid

#232029

Purpose

mammalian expression (CMV promoter) of TDGa.2 (SIM mutant E321Q) fused to BioID2-HA

Depositor

Primo Schaer

Article

Richina et al Cell Mol Life Sci. 2025 Nov 25. doi: 10.

Insert

Tdg (Tdg Mouse)

Tags

BioID2-HA

Expression

Mammalian

Mutation

K341A (site directed mutagenesis: aag -> aag)

Promoter

CMV

Available Since

Nov. 26, 2025

Availability

Academic Institutions and Nonprofits only

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pPgk-NLS-BioID2-HA

Plasmid

#232031

Purpose

mammalian expression (murine Pgk promoter) of nuclear targeted BioID2-HA

Depositor

Primo Schaer

Article

Richina et al Cell Mol Life Sci. 2025 Nov 25. doi: 10.

Inserts

NLS
Pgk1 promoter (Pgk1 amplified from expression plasmid, Mouse)

Tags

NLS

Expression

Mammalian

Mutation

Pgk1 promoter variant

Promoter

murine Pgk1

Available Since

Nov. 26, 2025

Availability

Academic Institutions and Nonprofits only

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GFP-CDKL5(isoform-2)

Plasmid

#245901

Purpose

Mammalian expression of CDKL5 isoform2 (1-1030) with N-terminal GFP

Depositor

Ben Goult

Article

Otani et al bioRxiv 2025.08.27.672337; doi: https://

Insert

CDKL5-1 (CDKL5 Human)

Tags

GFP-Avitag

Expression

Mammalian

Mutation

N8D, E569G

Promoter

CMV

Available Since

Nov. 7, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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GFP-CDKL5(isoform1)_L960D

Plasmid

#245900

Purpose

Mammalian expression of CDKL5 isoform1 (1-960) L960D with N-terminal GFP

Depositor

Ben Goult

Article

Otani et al bioRxiv 2025.08.27.672337; doi: https://

Insert

CDKL5-2 (CDKL5 Human)

Tags

GFP-Avitag

Expression

Mammalian

Mutation

N8D, E569G, L960D

Promoter

CMV

Available Since

Oct. 23, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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CDKL5(isoform1)-GFP

Plasmid

#245903

Purpose

Mammalian expression of CDKL5 isoform1 (1-960) with C-terminal GFP

Depositor

Ben Goult

Article

Otani et al bioRxiv 2025.08.27.672337; doi: https://

Insert

CDKL5-2 (CDKL5 Human)

Tags

GFP

Expression

Mammalian

Mutation

N8D, E569G

Promoter

CMV

Available Since

Oct. 23, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pX330_mouseH3.1

Plasmid

#244241

Purpose

Expresses SpCas9 and a sgRNA targeting the mouse histone H3.1 loci for knock-in.

Depositor

Kazuhiro Maeshima

Article

Minami et al Sci Adv. 2025 Mar 28;11(13):eadu8400. do

Insert

sgRNA targeting mouse histone H3.1 (H3c1 Mouse)

Use

CRISPR

Expression

Mammalian

Promoter

U6

Available Since

Oct. 7, 2025

Availability

Academic Institutions and Nonprofits only

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pX330_H3.2

Plasmid

#244239

Purpose

Expresses SpCas9 and a sgRNA targeting the human histone H3.2 loci for knock-in.

Depositor

Kazuhiro Maeshima

Article

Minami et al Sci Adv. 2025 Mar 28;11(13):eadu8400. do

Insert

sgRNA targeting human histone H3.2 (H3C14, H3C15 Human)

Use

CRISPR

Expression

Mammalian

Promoter

U6

Available Since

Oct. 7, 2025

Availability

Academic Institutions and Nonprofits only

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pINDUCER20-ABL2(K281M)

Plasmid

#215470

Purpose

Dox-inducible lentiviral transfer vector with Arg kinase-dead (K281M)

Depositor

Johanna Ivaska

Article

Conway et al Nat Cell Biol. 2025 May 26. doi: 10.1038

Insert

ABL2 (ABL2 Human)

Use

Lentiviral

Mutation

K281M (kinase-inactivating)

Promoter

mCMV, Doxycycline-inducible

Available Since

Sept. 3, 2025

Availability

Industry, Academic Institutions, and Nonprofits

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pAAV TRE-Tight CheRiff-mKate2

Plasmid

#182493

Purpose

Expression of CheRiff channelrhodopsin linked to mKate2 from a Tet-inducible promoter

Depositor

Thomas Oertner

Article

Lamothe-Molina et al Nat Commun. 2022 Oct 26;13(1):6376. doi:

Insert

CheRiff (#51697 Adam Cohen Lab)

Use

AAV

Tags

mKate2 (Evrogen)

Expression

Mammalian

Promoter

TRE-Tight (Clontech)

Available Since

Aug. 8, 2025

Availability

Academic Institutions and Nonprofits only

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NPM1c-TurboID-MSCV-IRES-GFP

Plasmid

#240129

Purpose

Expresses mutant NPM1c-TurboID fusion in mammalian cells

Depositor

Timothy Ley

Article

Kramer et al J Clin Invest. 2025 Aug 7:e195929. doi:

Insert

NPM1c (NPM1 Human)

Use

Retroviral

Tags

IRES-GFP and TurboID

Expression

Mammalian

Mutation

C-terminal frameshift mutation as seen in Acute M…

Available Since

Aug. 7, 2025

Availability

Academic Institutions and Nonprofits only

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TurboID-NPM1c-MSCV-IRES-GFP

Plasmid

#240130

Purpose

Expresses TurboID-NPM1c fusion in mammalian cells

Depositor

Timothy Ley

Article

Kramer et al J Clin Invest. 2025 Aug 7:e195929. doi:

Insert

NPM1c (NPM1 Human)

Use

Retroviral

Tags

IRES-GFP and TurboID

Expression

Mammalian

Mutation

C-terminal frameshift mutation as seen in Acute M…

Available Since

Aug. 7, 2025

Availability

Academic Institutions and Nonprofits only

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pYI2216

Plasmid

#228349

Purpose

2,4-Diacetylphloroglucinol (DAPG)-regulatable ALX-0081 expression

Depositor

Jun Ishii

Article

Tominaga et al Nat Commun. 2024 Dec 19;15(1):10653. doi

Insert

MFalpha(2xAdv)-LE-ALX-0081-3A-FLAG-His

Use

Affinity Reagent/ Antibody

Tags

AAA linker followed by FLAG-His6 and MF_ secretio…

Expression

Yeast

Promoter

2,4-Diacetylphloroglucinol-regulatable synthetic …

Available Since

March 28, 2025

Availability

Academic Institutions and Nonprofits only

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pscAAV.T7-SP6-BC(p11-14)-CAG-EGFP-SV40pA-T7

Plasmid

#231350

Purpose

Self complementary AAV genome with barcodeless T7 RNA polymerase promoter and SP6-driven barcode, for tracking AAV concatemers via SpECTr. Also expresses EGFP from CAG promoter.

Depositor

Viviana Gradinaru

Article

Coughlin et al Nat Biotechnol. 2025 Mar 20. doi: 10.103

Insert

T7-SP6-BC(p11-14)

Use

AAV

Available Since

March 20, 2025

Availability

Academic Institutions and Nonprofits only

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