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...latently infected cells. To truly cure HIV-1, researchers need to vanquish these hidden viral reservoirs...“shock and kill” the HIV-infected reservoir, researchers have previously used histone deacetylase (HDAC...could permit some viral protein production, so researchers are also interested in precisely excising the... were used for proof-of-concept studies, but researchers believe that using CRISPR/Cas9 could improve ...represent exciting advances in preclinical HIV-1 research that should be pursued in animal models, and it...benefit many others and accelerate the pace of research. We at Addgene hope to see the problem of in vivo...updated CRISPR Guide! Find CRISPR Plasmids for Your Research Browse gRNA Design Tools  ...

... discovery. Over 150,000 plasmids empowering researchers worldwide. Countless breakthroughs enabled by...characterized antibodies, and our contributions to key research papers are already inspiring higher standards ...as DNA or bacterial stabs — ‌and reinventing our search experience so you can find exactly what you need... evolving rapidly, and with it, the needs of researchers worldwide. Through our growing community on Bluesky...incredible journey. Together, we're not just sharing research materials — we're accelerating the future of science...critical to enhance reproducibility in biomedical research. eLife, 13, e100211. https://doi.org/10.7554/eLife...

...Addgene's Empty gRNA Expression Vectors page and search the table for "Drosophila". Activate ID Plasmid...

... off-target effects of CRISPR. Browse, sort, or search the tables below for CRISPR-FokI plasmids. Plasmids...

...expand the toolbox for researchers looking to study norepinephrine, the Patriarchi lab continues to work...sensors was developed, named GRABNE, which helped researchers visualize norepinephrine (Feng et al., 2019).... and were only available as green probes. The Patriarchi Lab aimed to overcome these limitations by developing...nLightG. Many thanks to Mike Waring and Tommaso Patriarchi for their assistance with this blog post. References...Benke, D., Weber, B., Bohacek, J., Reiner, A., … Patriarchi, T. (2023). Sensitive multicolor indicators for...

...for jobs posted online as one part of their job search. This is especially true of scientists seeking ...Follow job boards and check them regularly Use your research skills to determine which job boards list positions...clearly describe that the roles do not involve bench research. I am always surprised at how many applicants ...diffrent types of positions (for example, bench research vs. project managment) your resume should also...post for additioanal advice for the science career search.  You might also enjoy the other posts in the Addgene... job search...

...collection of plasmids is available in an easily searchable format on Addgene’s Michael Davidson Fluorescent...to either the N-or the C-terminus. Even if a researcher’s gene of interest isn’t in the ORF collection...in the Davidson lab for the last four years. “Researchers can make their own target if it is not already...can essentially cut and paste quite quickly. Researchers should keep in mind that a very simple sequential...deposit the tools he and his team created with the research community at large, "[Fluorescent proteins are...been very adamant that we distribute to as many researchers as we could, and Addgene is a wonderful vehicle...

..., I moved to Albion six years ago to work as a research associate after having earned a PhD in Developmental...the University of Paris VII. During my years in research, I developed several new plasmids, including: ... believe that a lot of European students and researchers are craving, like I was, for a better way to ...Biology. She has worked in a range of labs - cancer research, microbiology, virology, and genetics - before...scientists together from all over the world to exchange research materials in an easy way. She has a passion for...she can help the scientists in Europe with their research.   Europe, we are all geared up to answer your...

...Choosing a Research Project Finding and Joining Your Dream Lab Advice for Choosing a Research Project Advice... to get advice on choosing a lab, picking your research topic, starting a lab, and more. Before we start...others out, they'll help you too; both with your research and with getting published.” Connie Cepko 1....interested in leaving academia should present their research at conferences to obtain a “crash-course in all...tuned for the follow up blogs on "Choosing Your Research Project," “Advice for Starting Your Lab,” “Fun...

...localization. HiBiT-tagged targets in translational research Researchers can incorporate HiBiT with a wide range ...with knock-in models, ectopic models provide researchers with a means to quickly iterate, work across ...use of HiBiT provides a means to quickly answer research questions before creating knock-ins.  ... Cracking the code of 'undruggable' targets Researchers can design drugs to bind to well-defined ligand-binding...CRISPR knock-in HiBiT-tagged EGFR cells allowed researchers to track endogenous activity of EGFR, including...advances detection of endogenous proteins As researchers continue to improve more physiologically and ...

...biomedical research". The family entered the biomedical field’s spotlight after researchers discovered...animals have impacted humans through biomedical research. The Camelid family is composed of camels, llamas... llamas and alpacas (Figure 1). At the time, researchers were already on a quest for smaller forms of ...experiments, due to their simple structure    sdAbs in research These advantages have contributed to sdAbs becoming...variable domains (aka nanomice), which gives researchers the “best of both worlds” - a familiar lab model...

...Plasmids from a variety of research labs and hopes that these will help researchers build their knowledge ...efficiently in humans. This is why we cannot stop searching for novel solutions to treat rare diseases like...causes, and potential cures. We encourage any researchers working on ACVR1 or any of the pathways that ...about Addgene's Previous Work with Rare Disease Researchers Check Out Potentiall HIV Treatments with CRIPSR... Find ACVR1 Plasmids Find Plasmids for Disease Research on OurSpecial Collections Page ...

...Overview of CRISPR interference. Browse, sort, or search the tables below for CRISPR interference plasmids...

...Addgene's Empty gRNA Expression Vectors page and search the table for "Plant". Activate ID Plasmid Gene...

...Addgene's Empty gRNA Expression Vectors page and search the table for "Yeast". Activate ID Plasmid Gene...

...Arabidopsis research and teaching community through the TRAINED initiative (Translating Research on Arabidopsis...Ohio, ABRC ships more than 100,000 samples to researchers and educators in 60 countries each year. Introducing...Arabidopsis Arabidopsis is an important model system for research and is used by scientists around the globe. As...Educational Resources). Arabidopsis is used in research to explore a variety of phenomena, and so too ...Park Conservatory. Do you use Arabidopsis in your research? Are you a biology teacher or professor? Whether...

...Fluorophores In this post, Luke Lavis from Janelia Research Campus reminds us that, although fluorescent proteins.... To learn how you can use minigenomes in your research, check out this post! R Bodies: Membrane-Rupturing... post, Jessica Polka, formerly a postdoctoral researcher in the Silver Lab at Harvard University, describes...Genome Editing CRISPR has revolutionized how researchers make knockouts and other types of genome edits...In this post, Chris Richardson, a postdoctoral researcher in Jacob Corn’s lab, describes how you can better...Addgene Blog useful resources for the biological research community! ...

...job specifically looked for a researcher with 3 years+ of cancer research experience, a PhD or a Master...what leaving academia feels like for a lot of researchers. For many years I struggled with the questions...lie ahead of me? Like a considerable number of researchers, I had high hopes of securing tenure in a British...time in the lab, my colleagues and what I was researching, but I decided I needed a new challenge. Looking...widely available, especially for life science researchers. Many biotechnology companies are looking for...

... of RNA targeting with CRISPR. Browse, sort, or search the tables below for CRISPR plasmids designed for...

...modular approach made ZFNs highly appealing to researchers.  TALENs In 2010, transcription activator-like...at introducing point mutations. In 2016, the researchers at the Broad Institute envisioned a new strategy...consider the ethics and broader implications of our research.  Want the Genome Editing Trading Card seen in...understanding of the base editing enzymes. Kartik’s research focuses on the use of molecular dynamics simulations...our CRISPR guide Find CRISPR plasmids for your research Browse plasmids for base editing References Anzalone...PJ, Wilson C, Newby GA, Raguram A, Liu DR (2019) Search-and-replace genome editing without double-strand...specificity of a homing endonuclease. Nucleic Acids Research 30:3870–3879 . https://doi.org/10.1093/nar/gkf495...