...) Zhang Pooled Barcoding Libraries ID Name Description PI 115643 Morris CellTag Barcode Library Version... the CellTag barcoding library. Version 1 of the Celltag library contains 19973 barcodes to combinatorially...of the CellTag barcoding library. Version 2 of the Celltag library contains 4934 barcodes to combinatorially...of the CellTag barcoding library. Version 3 of the Celltag library contains 5737 barcodes to combinatorially...Lentivirus Pooled CRISPR Libraries Cas9 Pooled Barcoding Libraries Control Addgene's lentiviruses are made...direct fluorescence. Morris 115644 Morris CellTag Barcode Library Version 2 Ready-to-use lentiviral particles...direct fluorescence. Morris 115645 Morris CellTag Barcode Library Version 3 Ready-to-use lentiviral particles...

...-AAV1 AAV-FLEX-Arch-GFP Optogenetics Ed Boyden AV-1-PV2527 99039-AAV1 pAAV-CamKII-ArchT-GFP (PV2527) Optogenetics...AAV5 pAAV-FLEX-ArchT-tdTomato Optogenetics Ed Boyden AV-5-PV2527 99039-AAV5 pAAV-CamKII-ArchT-GFP (PV2527...-AAV9 AAV-FLEX-Arch-GFP Optogenetics Ed Boyden AV-9-PV2527 99039-AAV9 pAAV-CamKII-ArchT-GFP (PV2527) Optogenetics...PV2509 29777-AAV5 pAAV-CAG-ArchT-GFP Ed Boyden AV-9-PV2509 29777-AAV9 pAAV-CAG-ArchT-GFP Ed Boyden AV-9-PV3446...provide high-quality AAV vectors to the academic research community. The Penn Vector Core will produce viral-based...Deisseroth AV-1-36857M 100038-AAV1 pENN.AAV.hSynap.Flex.ArcLightDco.WPRE.SV40 Vincent Pieribone AV-1-36857P...36857P 100037-AAV1 pAAV.hSynap.ArcLightD.WPRE.SV40 Vincent Pieribone AV-1-51473 51473-AAV1 pAAV-hSyn1-mRuby2...

...window) encourages researchers to assemble and share tools for Parkinson's Disease research. This collection...Neurodegeneration Research Collection , which includes other areas of this research topic. Michael J. ...Shared Research Tools Labs affiliated with MJFF have also generated a number of Shared Research Tools ... Disease Plasmid Resource MJFF Plasmids Shared Research Tools (Link opens in a new window) The Michael...SNCA , and other proteins of interest. Browse or search the table below. ID Plasmid Gene/Insert Mutations...editing tools deposited with Addgene. Browse or search the table below. ID Plasmid Description Gene/Insert...

...Broswe plasmids and other research tools for use in Rett Syndrome research....The (Link opens in a new window) Rett Syndrome Research Trust (RSRT) was launched in 2008 to drive the...Rett Syndrome plasmid resource for the scientific research community. Background Rett Syndrome Rett syndrome...account for almost 46% of all Rett syndrome cases. Research Milestones 1992 - MECP2 is discovered by Adrian...syndrome and restore functional MECP2 in cells. Search (Link opens in a new window) JAX Mice for mouse...plasmids, please see Addgene's Plasmids for Stem Cell Research page. CRISPR Tools CRISPR technology is a promising... that express or target the MECP2 gene. Use the search bar or sort buttons to find plasmids based on: ...

...promotes and advocates for zebrafish research in the international research community. The Latin American Zebrafish...based gene editing make the zebrafish a stalwart research model. With more than 70% of human disease genes...model system for human disease and translational research, including the study of cancer, inflammation and...plasmids containing your zebrafish gene of interest? Search Addgene's collection for plasmids that contain ...plasmids that contain tools for use in zebrafish research. This includes plasmids for genome editing, empty...Periklis Pantazis Lab Multibow: digital spectral barcodes for cell tracing - Sean Megason Lab Zebrabow -...Bimolecular fluorescence complementation (BiFC) tools - Marco Morsch Lab. A vertebrate model to study ALS-linked...

...mutant clones for your course-based undergraduate research experience (CURE) projects....Collection Blog post: Course-Based Undergraduate Research Experiences (CUREs) (Link opens in a new window...develops protein-centric Course-based Undergraduate Research Experiences (CUREs) centered on a single enzyme...national group of educational leaders providing research opportunities to their students and other members...educators interested in integrating MDH-related research into their teaching laboratories. They encourage...and mutants provides a shared experience for the research community and facilitates scientific collaborations...available to download from each plasmid page. Use the search bar or sort buttons to find plasmids based on: ...

... help you get started using CRISPR in your own research. CRISPR Basics In this section, we will introduce...same chromosome. Most multiplex systems enable researchers to target anywhere from 2–7 genetic loci by cloning...later in the guide. Increasing fidelity of Cas9 Researchers have also enhanced specificity by engineering... overcome the CRISPR systems that bacteria and archaea use to protect against these foreign nucleic acids...Base Editing To overcome low HDR efficiency, researchers have developed base editors to specifically convert...Figure 5: Overview of base editing More recently, researchers have developed base editors that can catalyze...Base Edit CRISPR Prime Editing Prime editing is a “search and replace” gene editing method in which Moloney...

...proving to be just as useful (if not more so) for research applications, eclipsing past genome engineering...-strand break. CRISPR systems, found in 95% of archaeal and 48% of bacterial genomes, are highly diverse...proteins to the CRISPR-Cas complex. Recently, researchers have begun to use anti-CRISPRs as off-switches...activity due to rationally designed mutations. Researchers have expanded the CRISPR field beyond SpCas9,...allowing multiple Cas9s to be used together. Researchers have engineered mutant Cas enzymes with alternative...Despite the ethical controversies surrounding non-research applications, it’s clear that CRISPR is a truly...truly disruptive technology for basic research. The beauty of CRISPR is that it’s adaptable to almost any...

...AAV5 pAAV-CAG-FLEX-Archon1-KGC-EGFP-ER2 AAV production plasmid encoding for Archon1 fluorescent voltage...Li 115892-AAV8 pAAV-Syn-Archon1-KGC-GFP-ER2 AAV-mediated expression of Archon1-KGC-GFP-ER2 under the Syn...AAV8 pAAV-Syn-FLEX-rc [Archon1-KGC-GFP-ER2] AAV-mediated expression of Archon1-KGC-GFP-ER2 under the Syn...development of biomolecular tools for neuroscience research. Browse the BRAIN Initiative collection of plasmids...Initiative BRAIN Initiative Collection The Brain Research through Advancing Innovative Neurotechnologies...and circuits during behavior. Long desired by researchers, the revolutionary dynamic picture of the brain...emphasizes their rapid and broad dissemination to the research community. Browse plasmids , viral preps , and...

...highest-possible quality of research output, RESOLUTE expects to accelerate the pace of research in the field of ...global benefit of basic academic research as well as applied research in small biotech and pharmaceutical...mission is to develop data and reagents to boost the research focused on Solute carrier proteins (SLCs). Browse...mission is to develop data and reagents to boost the research focused on SLCs. Through the coupling of an inclusive...support from the European Union's Horizon 2020 research and innovation programme and EFPIA. Figure 1: ...Overexpression Library 213694 Superti-Furga Inducible barcoded overexpression library of human SLC proteins. ...