...immunogenic, meaning that they elicit an immune response from the body. Several factors contribute to the...a foreign antigen, triggering a humoral immune response. ADAs can inactivate the drug and increase drug...adverse immune reaction to the treatment. These responses vary depending on the person. However, in silico...to be presented by T cells to elicit an immune response. T cell epitopes are found in either the therapeutic...

...from mouse, and showed that it can alter motor responses in C. elegans. Find the split BoTN/B plasmids ...expression across the majority of cellular pathways. Despite several years of research, the mechanisms of miRNA...connection between specific genes and an immune response has been a longstanding challenge. Using shRNA...with no deleterious effects on the in vivo immune response other than what would be the anticipated effect...

... immunogenicity, meaning they induce an immune response in the host. So why use a gamma-retrovirus in...meaning it does not induce the same high immune response as retroviruses. This virus can also transduce...population. Some adenoviruses are known to cause respiratory disease across species, as well as cancer in ...been engineered to induce a lower inflammatory response within hosts. Relative to the other viruses discussed...

...novel optogenetic variant of AcrIIA4.” CASANOVA responds to blue light quickly. Within minutes of inactivating...has high signal:noise ratio, high sensitivity, responds quickly, is photostable, and is compatible with...proteins, which change in protein conformation in response to light, offers a way to spatially and temporally...photoswitchable cPYP, which changes in conformation in response to blue light (445nm). The discovery and applications...

...science or even to discuss potential solutions. Despite all the talk, not much was being done to address...practices could be an actionable way to tackle widespread irreproducibility. Luckily, there were other ...meeting by the collaborators who could participate. Despite the group not having a public website, all the ...practices could be an actionable way to address the widespread issue of irreproducibility. Use your network...

...from Elizabeth Hubbard.   Haoyi Qiu: Pain response in mechanical allodynia Haoyi Qiu is a M.Sc. ...vivo firing frequency of PV neurons affect the response to light touch in mechanical allodynia. ...experimental approach. (B) CR-Cre mice demonstrate pain response due to blue light stimulation of dual virus-expressing...virus-expressing CR neurons. (C) Duration of painful responses in the left and right paw due to blue light activation...

...there’s no guarantee you’ll get a response on the first try (or any response at all). And while this method...free, you can always reach out to the PI or corresponding author of the paper it’s published in. That’... amount of money in reagents and consumables, especially for things like plates and gels, which either...

... of p53 tetramerization in response to DNA damage controls the p53 response. Gaglia G, Lahav G. Mol Syst...interact in cells and produce background signal (especially for some older split-GFP constructs or certain...functionality or binding of your target proteins, especially if the termini are important for their interaction...

...editing these cells to avoid a negative immune response (e.g., graft vs. host) as well as the introduction...allogenic therapies to prevent a graft vs. host response. Off-target effects are also important safety ... considerations for all CRISPR therapies, but especially concerning when using a systemic approach. Regarding... will not work in a meaningful way. Delivery, especially for systemic approaches, has its own unique set...

...held on Friday 16th and Saturday 17th September respectively. Join us to discuss advocacy efforts toward ...for students interested in leading the process despite the recent advance. Similarly, grad students throughout...currently compiling a database of institutional responses to the FLSA ruling. Similarly, from purely a salary...ways. Workshops will be run by experts in their respective fields: David Cameron, PhD - Director of Media...