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Enter a sequence to perform a BLAST-based search of Addgene plasmid sequence databases.

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We narrowed to 6 results for: Cno

Showing: 1 - 6 of 6 results

  1. Viral Vectors 101: Chemogenetics

    Type
    Blog Post
    Published
    July 11, 2023, 1:15 p.m.
    ...clozapine-N-oxide (CNO). However, concerns have been raised over the reliability of using CNO as a DREADD agonist...called deschloroclozapine (DCZ) shows promise as a CNO alternative (Nagai et al., 2019). Regardless of which...

  2. Top Requested Lentivirus and AAV of 2016

    Type
    Blog Post
    Published
    Jan. 6, 2017, 3:56 p.m.
    ...activated by the small molecule clozapine N-oxide (CNO) (Krashes et al., 2011). Viruses expressing pAAV-hSyn-DIO-hM4D..., or non-human primates. To activate the DREADD, CNO is delivered either through drinking water or intravenously...

  3. GPCRs: How Do They Work and How Do We Study Them?

    Type
    Blog Post
    Published
    Feb. 11, 2021, 2:15 p.m.
    ...small molecule ligands such as clozapine-N-oxide (CNO). DREADDs are ideal for chemogenetics as they are...acetylcholine, and are only activated upon binding of CNO thus showing no constitutive activity. There are ...
Showing: 1 - 6 of 6 results