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We narrowed to 7 results for: Cno

Showing: 1 - 7 of 7 results

  1. Viral Vectors 101: Chemogenetics

    Type
    Blog Post
    ...clozapine-N-oxide (CNO). However, concerns have been raised over the reliability of using CNO as a DREADD agonist...called deschloroclozapine (DCZ) shows promise as a CNO alternative (Nagai et al., 2019). Regardless of which...

  2. Top Requested Lentivirus and AAV of 2016

    Type
    Blog Post
    ...activated by the small molecule clozapine N-oxide (CNO) (Krashes et al., 2011). Viruses expressing pAAV-hSyn-DIO-hM4D..., or non-human primates. To activate the DREADD, CNO is delivered either through drinking water or intravenously...

  3. GPCRs: How Do They Work and How Do We Study Them?

    Type
    Blog Post
    ...small molecule ligands such as clozapine-N-oxide (CNO). DREADDs are ideal for chemogenetics as they are...acetylcholine, and are only activated upon binding of CNO thus showing no constitutive activity. There are ...

  5. Chemogenetics Guide

    Type
    Guide
    ...respond to nM concentrations of clozapine N ‐oxide (CNO). CNO is a metabolite of the antipsychotic clozapine...Compound 21 has similar potency as CNO, while DCZ is more potent than either CNO or Compound 21. Both Compound...pharmacologically inert in mice and rats. However, CNO is back-metabolized to clozapine and other clozapine...off-target effects. More recent studies have shown that CNO does not cross the blood-brain barrier in rats, and...species may be entirely due to back-metabolism of CNO to clozapine, demonstrating the need for alternative... seem to have the same back-metabolism issues as CNO and are attractive alternatives for experiments. ...Reference Rq(R165L) Human M3 muscarinic Arrestin-2/-3 CNO* Increase Arrestin translocation Arrestin signalling...
Showing: 1 - 7 of 7 results