Chemogenetics Guide
Type
Guide
...respond to nM concentrations of clozapine N ‐oxide (CNO). CNO is a metabolite of the antipsychotic clozapine...Compound 21 has similar potency as CNO, while DCZ is more potent than either CNO or Compound 21. Both Compound...pharmacologically inert in mice and rats. However, CNO is back-metabolized to clozapine and other clozapine...off-target effects. More recent studies have shown that CNO does not cross the blood-brain barrier in rats, and...species may be entirely due to back-metabolism of CNO to clozapine, demonstrating the need for alternative... seem to have the same back-metabolism issues as CNO and are attractive alternatives for experiments. ...Reference Rq(R165L) Human M3 muscarinic Arrestin-2/-3 CNO* Increase Arrestin translocation Arrestin signalling...