Cancer and the Immune System: Deciphering the Relationship
Type
Blog Post
Published
March 14, 2017, 2:30 p.m.
...cells. These cells produce inflammatory cytokines - interleukin (IL)-12 and interferon gamma (IFNγ) - and...help escape immuno-surveillance, and curb cytokine and chemokine production in the tumor microenvironment...their microenvironment by producing C-C motif chemokine 22 (CCL22) and TGFβ. T-regs are suppressive immune...tolerance beyond direct proximity to the tumor; chemokine-aided activation of APCs produces modified dendritic...cancer. Surgical removal causes increases in tumor cytokines like TGFβ and IL-6. However, when strengthened...pathway, VEGF production, and CTLA4 and CD protein blocking. Other molecular targets under research include...response. Antibodies targeting the tumor-augmenting cytokines produced in the tumor microenvironment TGFβ, IL...