... PMID: 23287718 Cui, Z., Tian, R., Huang, Z., Jin, Z., Li, L., Liu, J., Huang, Z., Xie, H., Liu, D., Mo... Liu, Y., Gu, Z., Dickerson, K. E., Xie, S., Hon, G. C., Xuan, Z., Zhang, M. Q., Shao, Z., & Xu, J. (2017...Topkar, V. V., Nguyen, N. T., Zheng, Z., Gonzales, A. P. W., Li, Z., Peterson, R. T., Yeh, J. J., Aryee... 35236982 Bubeck, F., Hoffmann, M. D., Harteveld, Z., Aschenbrenner, S., Bietz, A., Waldhauer, M. C., ...H., Zhou, R., Lang, B., Meng, B., Weng, H., & Hu, Z. (2022). FrCas9 is a CRISPR/Cas9 system with high ... 24463574 Gao, S., Wang, Y., Qi, T., Wei, J., Hu, Z., Liu, J., Sun, S., Liu, H., & Wang, Y. (2023). Genome...Sun, N., Zeina, C. M., Gao, X., Rees, H. A., Lin, Z., & Liu, D. R. (2018). Evolved Cas9 variants with ...

...0334-z (Link opens in a new window) PMID: 31659156 (Link opens in a new window) Luo, J., Deng, Z. L., ... Yu, X., Farina, E. M., Yan, S., Zhao, C., Zheng, Z., Shu, Y., Wu, X., Lei, J., Li, Y., Zhang, W., Yang... nucleus, normally as double-stranded circular episomes. Due to this, and to the strong host’s immune ...genome and instead are maintained in the cell as episomes. This highly reduces the potential for insertional...nonenveloped viruses from the Adenoviridae family. Episome Genetic element inside the cell that remains as...

...Cho YK, Morimoto TK, Chuong AS, Carpenter EJ, Tian Z, et al. 2014. Independent optical excitation of distinct...These tools have been instrumental in neurological disorder research, helping scientists to better understand...Halorhodopsins are light-gated inward chloride pumps isolated from halobacteria. Wild-type halorhodopsin, known...

...) PMID: 27720486 (Link opens in a new window) Wu, Z., Asokan, A., & Samulski, R. J. (2006). Adeno-associated...typically processed into a double-stranded circular episome which can concatemerize, producing high molecular...majority of rAAV DNA is thought to be maintained in episomes or concatemers. This avoids the effects local ... and the expression of neighboring genes. rAAV episomes can develop chromatin-like organization and persist...period of years without damaging the host cell. Episomal stability allows for long-term transgene expression...in the field of gene therapy to treat genetic disorders. rAAV vectors are favored over other viral delivery...trans-splicing or overlapping vectors: a quantitative comparison . Molecular Therapy, 4 (4), 383–391. https://...