pU6-tevopreq1-GG-acceptor Citations (36)
Originally described in: Engineered pegRNAs improve prime editing efficiency.Nelson JW, Randolph PB, Shen SP, Everette KA, Chen PJ, Anzalone AV, An M, Newby GA, Chen JC, Hsu A, Liu DR Nat Biotechnol. 2021 Oct 4. pii: 10.1038/s41587-021-01039-7. doi: 10.1038/s41587-021-01039-7. PubMed Journal
Articles Citing pU6-tevopreq1-GG-acceptor
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Mutation-specific reporter for optimization and enrichment of prime editing.
Schene IF, Joore IP, Baijens JHL, Stevelink R, Kok G, Shehata S, Ilcken EF, Nieuwenhuis ECM, Bolhuis DP, van Rees RCM, Spelier SA, van der Doef HPJ, Beekman JM, Houwen RHJ, Nieuwenhuis EES, Fuchs SA.
Nat Commun. 2022 Mar 1;13(1):1028. doi: 10.1038/s41467-022-28656-3.
PubMed
Associated Plasmids |
| Designing and executing prime editing experiments in mammalian cells. Doman JL, Sousa AA, Randolph PB, Chen PJ, Liu DR. Nat Protoc. 2022 Nov;17(11):2431-2468. doi: 10.1038/s41596-022-00724-4. Epub 2022 Aug 8. PubMed |
Efficient prime editing in mouse brain, liver and heart with dual AAVs.
Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR.
Nat Biotechnol. 2023 May 4. doi: 10.1038/s41587-023-01758-z.
PubMed
Associated Plasmids |
| Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing. Brooks DL, Carrasco MJ, Qu P, Peranteau WH, Ahrens-Nicklas RC, Musunuru K, Alameh MG, Wang X. Nat Commun. 2023 Jun 10;14(1):3451. doi: 10.1038/s41467-023-39246-2. PubMed |
| Prime editing strategies to mediate exon skipping in DMD gene. Happi Mbakam C, Roustant J, Rousseau J, Yameogo P, Lu Y, Bigot A, Mamchaoui K, Mouly V, Lamothe G, Tremblay JP. Front Med (Lausanne). 2023 May 25;10:1128557. doi: 10.3389/fmed.2023.1128557. eCollection 2023. PubMed |
CRISPR prime editing for unconstrained correction of oncogenic KRAS variants.
Jang G, Kweon J, Kim Y.
Commun Biol. 2023 Jun 30;6(1):681. doi: 10.1038/s42003-023-05052-1.
PubMed
Associated Plasmids |
| Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need. Brooks DL, Whittaker MN, Qu P, Musunuru K, Ahrens-Nicklas RC, Wang X. Am J Hum Genet. 2023 Dec 7;110(12):2003-2014. doi: 10.1016/j.ajhg.2023.10.005. Epub 2023 Nov 3. PubMed |
| Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene. Hasan MN, Hyodo T, Biswas M, Rahman ML, Mihara Y, Karnan S, Ota A, Tsuzuki S, Hosokawa Y, Konishi H. PLoS One. 2023 Nov 9;18(11):e0294146. doi: 10.1371/journal.pone.0294146. eCollection 2023. PubMed |
| Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. Liu M, Zhang C, Gong X, Zhang T, Lian MM, Chew EGY, Cardilla A, Suzuki K, Wang H, Yuan Y, Li Y, Naik MY, Wang Y, Zhou B, Soon WZ, Aizawa E, Li P, Low JH, Tandiono M, Montagud E, Moya-Rull D, Rodriguez Esteban C, Luque Y, Fang M, Khor CC, Montserrat N, Campistol JM, Izpisua Belmonte JC, Foo JN, Xia Y. Cell Stem Cell. 2024 Jan 4;31(1):52-70.e8. doi: 10.1016/j.stem.2023.12.003. PubMed |
| Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress. Couly S, Yasui Y, Foncham S, Grammatikakis I, Lal A, Shi L, Su TP. Cell Mol Life Sci. 2024 Jan 9;81(1):14. doi: 10.1007/s00018-023-05023-z. PubMed |
| Successful Correction by Prime Editing of a Mutation in the RYR1 Gene Responsible for a Myopathy. Godbout K, Rousseau J, Tremblay JP. Cells. 2023 Dec 22;13(1):31. doi: 10.3390/cells13010031. PubMed |
| Prime-Editing of human ACTB in induced pluripotent stem cells to model human ACTB Loss-of-Function diseases and compensatory mechanisms. Binder S, Ramachandran H, Hildebrandt B, Dobner J, Rossi A. Stem Cell Res. 2024 Mar;75:103304. doi: 10.1016/j.scr.2024.103304. Epub 2024 Jan 3. PubMed |
| Enhancing prime editor activity by directed protein evolution in yeast. Weber Y, Bock D, Ivascu A, Mathis N, Rothgangl T, Ioannidi EI, Blaudt AC, Tidecks L, Vadovics M, Muramatsu H, Reichmuth A, Marquart KF, Kissling L, Pardi N, Jinek M, Schwank G. Nat Commun. 2024 Mar 7;15(1):2092. doi: 10.1038/s41467-024-46107-z. PubMed |
| Massively parallel screen uncovers many rare 3' UTR variants regulating mRNA abundance of cancer driver genes. Fu T, Amoah K, Chan TW, Bahn JH, Lee JH, Terrazas S, Chong R, Kosuri S, Xiao X. Nat Commun. 2024 Apr 18;15(1):3335. doi: 10.1038/s41467-024-46795-7. PubMed |
| Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor. Hwang HY, Gim D, Yi H, Jung H, Lee J, Kim D. Nucleic Acids Res. 2024 Jun 10;52(10):5792-5803. doi: 10.1093/nar/gkae310. PubMed |
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells.
Bulcaen M, Kortleven P, Liu RB, Maule G, Dreano E, Kelly M, Ensinck MM, Thierie S, Smits M, Ciciani M, Hatton A, Chevalier B, Ramalho AS, Casadevall I Solvas X, Debyser Z, Vermeulen F, Gijsbers R, Sermet-Gaudelus I, Cereseto A, Carlon MS.
Cell Rep Med. 2024 May 21;5(5):101544. doi: 10.1016/j.xcrm.2024.101544. Epub 2024 May 1.
PubMed
Associated Plasmids |
| Multimodal framework to resolve variants of uncertain significance in TSC2. Biar CG, Pfeifer C, Carvill GL, Calhoun JD. bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.597916. doi: 10.1101/2024.06.07.597916. PubMed |
| Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools. Celotti M, Derks LLM, van Es J, van Boxtel R, Clevers H, Geurts MH. STAR Protoc. 2024 Sep 20;5(3):103189. doi: 10.1016/j.xpro.2024.103189. Epub 2024 Jul 12. PubMed |
| The FXR1 network acts as a signaling scaffold for actomyosin remodeling. Chen X, Fansler MM, Janjos U, Ule J, Mayr C. Cell. 2024 Sep 5;187(18):5048-5063.e25. doi: 10.1016/j.cell.2024.07.015. Epub 2024 Aug 5. PubMed |
Creation of de novo cryptic splicing for ALS and FTD precision medicine.
Wilkins OG, Chien MZYJ, Wlaschin JJ, Barattucci S, Harley P, Mattedi F, Mehta PR, Pisliakova M, Ryadnov E, Keuss MJ, Thompson D, Digby H, Knez L, Simkin RL, Diaz JA, Zanovello M, Brown AL, Darbey A, Karda R, Fisher EMC, Cunningham TJ, Le Pichon CE, Ule J, Fratta P.
Science. 2024 Oct 4;386(6717):61-69. doi: 10.1126/science.adk2539. Epub 2024 Oct 3.
PubMed
Associated Plasmids |
| mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes. Zwakenberg S, Westland D, van Es RM, Rehmann H, Anink J, Ciapaite J, Bosma M, Stelloo E, Liv N, Sobrevals Alcaraz P, Verhoeven-Duif NM, Jans JJM, Vos HR, Aronica E, Zwartkruis FJT. Mol Cell. 2024 Nov 21;84(22):4368-4384.e6. doi: 10.1016/j.molcel.2024.10.009. Epub 2024 Oct 31. PubMed |
| Prime Editor Gene Therapy and TREX1 Mosaicism in Retinal Vasculopathy with Cerebral Leukoencephalopathy. Chauvin SD, Holley JA, Poddar S, Miner CA, Kumble L, Fu J, Laue-Gizzi H, Hardy TA, Miner JJ. J Clin Immunol. 2024 Dec 13;45(1):54. doi: 10.1007/s10875-024-01846-y. PubMed |
| U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations. Walter DM, Cho K, Sivakumar S, Denney D, Lee IT, Dohlman AB, Heinz JM, Shurberg E, Jiang KX, Gupta AA, Frampton GM, Meyerson M. bioRxiv [Preprint]. 2025 Sep 18:2025.03.21.644128. doi: 10.1101/2025.03.21.644128. PubMed |
| Universal Prime Editing Therapeutic Strategy for RyR1-Related Myopathies: A Protective Mutation Rescues Leaky RyR1 Channel. Godbout K, Dugas M, Reiken SR, Ramezani S, Falle A, Rousseau J, Wronska AE, Lamothe G, Canet G, Lu Y, Planel E, Marks AR, Tremblay JP. Int J Mol Sci. 2025 Mar 21;26(7):2835. doi: 10.3390/ijms26072835. PubMed |
| Effects of heterozygous SMG1 mutations on nonsense-mediated mRNA decay in human pluripotent stem cell model. Lee C, Lee JS, Kwon Y, Shin A, Jeong TY, Yang J, Hwang JW, Kim HI, Choi HJ, Kim YK, Choi M, Kim K, Sun W, Chae JH. Mol Cells. 2025 Jul;48(7):100225. doi: 10.1016/j.mocell.2025.100225. Epub 2025 May 20. PubMed |
| Protocol to perform multiplexed assays of variant effect using curated loci prime editing. Biar CG, Bodkin N, Carvill GL, Calhoun JD. STAR Protoc. 2025 Jun 20;6(2):103851. doi: 10.1016/j.xpro.2025.103851. Epub 2025 May 25. PubMed |
| Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. Zhu J, Xiong Y, Zhang Y, Liang H, Cheng K, Lu Y, Cai G, Wu Y, Fan Y, Chen X, Zhu H, Ding Z, Zhang W. Cancer Commun (Lond). 2025 Aug;45(8):1038-1071. doi: 10.1002/cac2.70036. Epub 2025 May 29. PubMed |
| Insights into pegRNA design from editing of the cardiomyopathy-associated phospholamban R14del mutation. Yao B, Yang Q, Snijders Blok CJB, Daniels MA, Doevendans PA, Schiffelers R, Sluijter JPG, Lei Z. FEBS Lett. 2025 Sep;599(17):2543-2554. doi: 10.1002/1873-3468.70097. Epub 2025 Jun 24. PubMed |
| In Vitro Correction of Point Mutations in the DYSF Gene Using Prime Editing. Bouchard C, Rousseau J, Lamothe G, Dubost M, Bastrenta L, Ramezani S, Tremblay JP. Int J Mol Sci. 2025 Jun 12;26(12):5647. doi: 10.3390/ijms26125647. PubMed |
| Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools. Liu Z, Chen S, Sun Y. Research (Wash D C). 2025 Jul 2;8:0770. doi: 10.34133/research.0770. eCollection 2025. PubMed |
| In vivo prime editing rescues alternating hemiplegia of childhood in mice. Sousa AA, Terrey M, Sakai HA, Simmons CQ, Arystarkhova E, Morsci NS, Anderson LC, Xie J, Suri-Payer F, Laux LC, Roze E, Forlani S, Gao G, Frost S, Frost N, Sweadner KJ, George AL Jr, Lutz CM, Liu DR. Cell. 2025 Aug 7;188(16):4275-4294.e23. doi: 10.1016/j.cell.2025.06.038. Epub 2025 Jul 21. PubMed |
| Precise correction of G6PD Viangchan mutation in iPSCs by prime editing strategy. Netsawang C, Tongbaen M, Jearawiriyapaisarn N, Leecharoenkiat K. Sci Rep. 2025 Aug 18;15(1):30192. doi: 10.1038/s41598-025-15463-1. PubMed |
| Prime editing for the investigation of aberrant splicing defect associated with a pathogenic PRPH2 variant. Lopes da Costa B, Helms KM, Theodore K, Tsai YT, Caruso SM, Liu S, Lima de Carvalho JR, Nolan ND, Tahir S, Makinson CD, Tsang SH, Quinn PMJ. Mol Ther Nucleic Acids. 2025 Oct 13;36(4):102740. doi: 10.1016/j.omtn.2025.102740. eCollection 2025 Dec 9. PubMed |
| A single non-coding SNP in FPGS modulates folate drug efficacy in acute lymphoblastic leukemia: data-driven exploration and experimental validation. Yu W, Li C, Meng Y, Li Q, Gao M, Tang W, Li Y, Tan Z, Zhou X, Liu Z, Xu Y, Hua Z. Mol Biomed. 2025 Nov 21;6(1):114. doi: 10.1186/s43556-025-00353-9. PubMed |
| Investigating and correcting a rare pathogenic mutation in GDF11. Congdon ST, Bennett J, Opinya R, Agosto AR, Dossias O, Kokko C, Levesque AA, Koob AO, Silver AC, Thomas-Charles CA. HGG Adv. 2026 Jan 15;7(1):100559. doi: 10.1016/j.xhgg.2025.100559. Epub 2025 Dec 18. PubMed |
| Overcoming the eIF2alpha Brake in Human Cell-Derived Translation Systems. Aleksashin NA, Shelke RR, Yin T, Cate JHD. bioRxiv [Preprint]. 2025 Dec 7:2025.11.16.688697. doi: 10.1101/2025.11.16.688697. PubMed |
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