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pLenti CMV Puro DEST (w118-1) Citations (154)

Originally described in: A versatile viral system for expression and depletion of proteins in mammalian cells.
Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK, Kaufman PD. PLoS One. 2009 Aug 6;4(8):e6529.
PubMed Journal

Articles Citing pLenti CMV Puro DEST (w118-1)

Articles
EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. White RE, Ramer PC, Naresh KN, Meixlsperger S, Pinaud L, Rooney C, Savoldo B, Coutinho R, Bodor C, Gribben J, Ibrahim HA, Bower M, Nourse JP, Gandhi MK, Middeldorp J, Cader FZ, Murray P, Munz C, Allday MJ. J Clin Invest. 2012 Apr;122(4):1487-502. doi: 10.1172/JCI58092. Epub 2012 Mar 12. PubMed
A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications. Thoma CR, Stroebel S, Rosch N, Calpe B, Krek W, Kelm JM. J Biomol Screen. 2013 Dec;18(10):1330-7. doi: 10.1177/1087057113499071. Epub 2013 Sep 30. PubMed
Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes. Slim CL, Lazaro-Dieguez F, Bijlard M, Toussaint MJ, de Bruin A, Du Q, Musch A, van Ijzendoorn SC. PLoS Biol. 2013 Dec;11(12):e1001739. doi: 10.1371/journal.pbio.1001739. Epub 2013 Dec 17. PubMed
PGC-1alpha and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function. Birket MJ, Casini S, Kosmidis G, Elliott DA, Gerencser AA, Baartscheer A, Schumacher C, Mastroberardino PG, Elefanty AG, Stanley EG, Mummery CL. Stem Cell Reports. 2013 Dec 12;1(6):560-74. doi: 10.1016/j.stemcr.2013.11.008. eCollection 2013. PubMed
Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer. Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN. Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23. PubMed
Placental lactogen is expressed but is not translated into protein in breast cancer. Tuttle TR, Hugo ER, Tong WS, Ben-Jonathan N. PLoS One. 2014 Jan 24;9(1):e87325. doi: 10.1371/journal.pone.0087325. eCollection 2014. PubMed
Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Leyton-Mange JS, Mills RW, Macri VS, Jang MY, Butte FN, Ellinor PT, Milan DJ. Stem Cell Reports. 2014 Feb 6;2(2):163-70. doi: 10.1016/j.stemcr.2014.01.003. eCollection 2014 Feb 11. PubMed
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R. Dev Cell. 2014 Mar 10;28(5):483-96. doi: 10.1016/j.devcel.2014.01.021. Epub 2014 Feb 27. PubMed
Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation. Busch M, Schwindt H, Brandt A, Beier M, Gorldt N, Romaniuk P, Toska E, Roberts S, Royer HD, Royer-Pokora B. Hum Mol Genet. 2014 Aug 1;23(15):3958-74. doi: 10.1093/hmg/ddu111. Epub 2014 Mar 11. PubMed
The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN. PLoS Pathog. 2014 May 15;10(5):e1004136. doi: 10.1371/journal.ppat.1004136. eCollection 2014 May. PubMed
LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. He TY, Tsai LH, Huang CC, Chou MC, Lee H. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S703-10. doi: 10.1245/s10434-014-3824-1. Epub 2014 May 31. PubMed
Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Mulvihill MM, Benjamin DI, Ji X, Le Scolan E, Louie SM, Shieh A, Green M, Narasimhalu T, Morris PJ, Luo K, Nomura DK. Chem Biol. 2014 Jul 17;21(7):831-40. doi: 10.1016/j.chembiol.2014.05.008. Epub 2014 Jun 19. PubMed
ERbeta- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Monsivais D, Dyson MT, Yin P, Coon JS, Navarro A, Feng G, Malpani SS, Ono M, Ercan CM, Wei JJ, Pavone ME, Su E, Bulun SE. Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul 3. PubMed
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis. Siow D, Sunkara M, Dunn TM, Morris AJ, Wattenberg B. J Lipid Res. 2015 Apr;56(4):898-908. doi: 10.1194/jlr.M057539. Epub 2015 Feb 17. PubMed
WNT/beta-catenin signaling inhibits CBP-mediated RelA acetylation and expression of proinflammatory NF-kappaB target genes. Ma B, Fey M, Hottiger MO. J Cell Sci. 2015 Jul 15;128(14):2430-6. doi: 10.1242/jcs.168542. Epub 2015 May 28. PubMed
Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Mol Cancer. 2015 Jul 16;14:133. doi: 10.1186/s12943-015-0400-7. PubMed
Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer. Kwak EL, Ahronian LG, Siravegna G, Mussolin B, Godfrey JT, Clark JW, Blaszkowsky LS, Ryan DP, Lennerz JK, Iafrate AJ, Bardelli A, Hong TS, Corcoran RB. Cancer Discov. 2015 Dec;5(12):1271-81. doi: 10.1158/2159-8290.CD-15-0748. Epub 2015 Oct 2. PubMed
The adherens junctions control susceptibility to Staphylococcus aureus alpha-toxin. Popov LM, Marceau CD, Starkl PM, Lumb JH, Shah J, Guerrera D, Cooper RL, Merakou C, Bouley DM, Meng W, Kiyonari H, Takeichi M, Galli SJ, Bagnoli F, Citi S, Carette JE, Amieva MR. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14337-42. doi: 10.1073/pnas.1510265112. Epub 2015 Oct 21. PubMed
Autophagy positively regulates DNA damage recognition by nucleotide excision repair. Qiang L, Zhao B, Shah P, Sample A, Yang S, He YY. Autophagy. 2016;12(2):357-68. doi: 10.1080/15548627.2015.1110667. Epub 2015 Nov 13. PubMed
Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. Rajagopal A, Homan EP, Joeng KS, Suzuki M, Bertin T, Cela R, Munivez E, Dawson B, Jiang MM, Gannon F, Crawford S, Lee BH. Mol Genet Metab. 2015 Dec 2. pii: S1096-7192(15)30085-8. doi: 10.1016/j.ymgme.2015.11.015. PubMed
MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains. Bijlard M, de Jonge JC, Klunder B, Nomden A, Hoekstra D, Baron W. PLoS One. 2016 May 12;11(5):e0155317. doi: 10.1371/journal.pone.0155317. eCollection 2016. PubMed
MYC Is a Crucial Mediator of TGFbeta-Induced Invasion in Basal Breast Cancer. Cichon MA, Moruzzi ME, Shqau TA, Miller E, Mehner C, Ethier SP, Copland JA, Radisky ES, Radisky DC. Cancer Res. 2016 Jun 15;76(12):3520-30. doi: 10.1158/0008-5472.CAN-15-3465. Epub 2016 Apr 13. PubMed
Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Autophagy. 2016 Aug 2;12(8):1340-54. doi: 10.1080/15548627.2016.1187365. Epub 2016 May 31. PubMed
Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. Harrington KM, Clevenger CV. J Biol Chem. 2016 Oct 7;291(41):21388-21406. Epub 2016 Aug 3. PubMed
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2. PubMed
Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Shahriari K, Shen F, Worrede-Mahdi A, Liu Q, Gong Y, Garcia FU, Fatatis A. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.436. PubMed
Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection. Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM. PLoS Pathog. 2016 Dec 21;12(12):e1006102. doi: 10.1371/journal.ppat.1006102. eCollection 2016 Dec. PubMed
Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK-p90RSK-mTOR Signaling Network. Chatterjee S, Huang EH, Christie I, Kurland BF, Burns TF. Mol Cancer Ther. 2017 May;16(5):793-804. doi: 10.1158/1535-7163.MCT-16-0677. Epub 2017 Feb 6. PubMed
Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma. Barasch N, Gong X, Kwei KA, Varma S, Biscocho J, Qu K, Xiao N, Lipsick JS, Pelham RJ, West RB, Pollack JR. PLoS One. 2017 Feb 17;12(2):e0171265. doi: 10.1371/journal.pone.0171265. eCollection 2017. PubMed
Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation. Realegeno S, Puschnik AS, Kumar A, Goldsmith C, Burgado J, Sambhara S, Olson VA, Carroll D, Damon I, Hirata T, Kinoshita T, Carette JE, Satheshkumar PS. J Virol. 2017 May 12;91(11). pii: JVI.00011-17. doi: 10.1128/JVI.00011-17. Print 2017 Jun 1. PubMed
Reactivation of the p90RSK-CDC25C pathway leads to bypass of the ganetespib induced G2/M arrest and mediates acquired resistance to ganetespib in KRAS mutant NSCLC. Chatterjee S, Huang EH, Christie I, Burns TF. Mol Cancer Ther. 2017 May 31. pii: molcanther.0114.2017. doi: 10.1158/1535-7163.MCT-17-0114. PubMed
AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR. Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE. J Virol. 2017 Jul 5. pii: JVI.00391-17. doi: 10.1128/JVI.00391-17. PubMed
Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes. Debaize L, Jakobczyk H, Rio AG, Gandemer V, Troadec MB. Mol Cytogenet. 2017 Jul 20;10:27. doi: 10.1186/s13039-017-0328-2. eCollection 2017. PubMed
Lysine-52 stabilizes the MYC oncoprotein through an SCF(Fbxw7)-independent mechanism. De Melo J, Kim SS, Lourenco C, Penn LZ. Oncogene. 2017 Dec 7;36(49):6815-6822. doi: 10.1038/onc.2017.268. Epub 2017 Aug 14. PubMed
Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Bosse KR, Raman P, Zhu Z, Lane M, Martinez D, Heitzeneder S, Rathi KS, Kendsersky NM, Randall M, Donovan L, Morrissy S, Sussman RT, Zhelev DV, Feng Y, Wang Y, Hwang J, Lopez G, Harenza JL, Wei JS, Pawel B, Bhatti T, Santi M, Ganguly A, Khan J, Marra MA, Taylor MD, Dimitrov DS, Mackall CL, Maris JM. Cancer Cell. 2017 Sep 11;32(3):295-309.e12. doi: 10.1016/j.ccell.2017.08.003. PubMed
A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z. PubMed

Associated Plasmids

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Ehrnstrom B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damas JK, Espevik T, Stenvik J. Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017. PubMed
Fluorescently-tagged human eIF3 for single-molecule spectroscopy. Johnson AG, Petrov AN, Fuchs G, Majzoub K, Grosely R, Choi J, Puglisi JD. Nucleic Acids Res. 2018 Jan 25;46(2):e8. doi: 10.1093/nar/gkx1050. PubMed
Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer. Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz S. Cancer Discov. 2018 Feb;8(2):164-173. doi: 10.1158/2159-8290.CD-17-1009. Epub 2017 Dec 1. PubMed
Defective STIM-mediated store operated Ca(2+) entry in hepatocytes leads to metabolic dysfunction in obesity. Arruda AP, Pers BM, Parlakgul G, Guney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS. Elife. 2017 Dec 15;6. pii: 29968. doi: 10.7554/eLife.29968. PubMed
AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. Nat Commun. 2018 Apr 12;9(1):1411. doi: 10.1038/s41467-018-03771-2. PubMed
A rare variant in MLKL confers susceptibility to ApoE varepsilon4-negative Alzheimer's disease in Hong Kong Chinese population. Wang B, Bao S, Zhang Z, Zhou X, Wang J, Fan Y, Zhang Y, Li Y, Chen L, Jia Y, Li J, Li M, Zheng W, Mu N, Wang L, Yu Z, Wong DSM, Zhang Y, Kwan J, Ka-Fung Mak H, Ambalavanan A, Zhou S, Cai W, Zheng J, Huang S, Rouleau GA, Yang W, Rogaeva E, Ma X, St George-Hyslop P, Chu LW, Song YQ. Neurobiol Aging. 2018 Aug;68:160.e1-160.e7. doi: 10.1016/j.neurobiolaging.2018.03.006. Epub 2018 Mar 10. PubMed
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Shah P, Zhao B, Qiang L, He YY. Nucleic Acids Res. 2018 Jun 1;46(10):5050-5060. doi: 10.1093/nar/gky239. PubMed
Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins. Smolkin T, Nir-Zvi I, Duvshani N, Mumblat Y, Kessler O, Neufeld G. J Cell Sci. 2018 May 4;131(9). pii: jcs.208298. doi: 10.1242/jcs.208298. PubMed
CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Ophinni Y, Inoue M, Kotaki T, Kameoka M. Sci Rep. 2018 May 17;8(1):7784. doi: 10.1038/s41598-018-26190-1. PubMed
Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Zhang Y, Paikari A, Sumazin P, Ginter Summarell CC, Crosby JR, Boerwinkle E, Weiss MJ, Sheehan VA. Blood. 2018 Jul 19;132(3):321-333. doi: 10.1182/blood-2017-11-814335. Epub 2018 Jun 8. PubMed
The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage. Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W. Nucleic Acids Res. 2018 Sep 6;46(15):7747-7756. doi: 10.1093/nar/gky579. PubMed
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc(-) Activity. Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, Lotze MT, Zeh HJ, Kang R, Tang D. Curr Biol. 2018 Aug 6;28(15):2388-2399.e5. doi: 10.1016/j.cub.2018.05.094. Epub 2018 Jul 26. PubMed
Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease. Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R. Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298. PubMed
Heterozygous WNT1 variant causing a variable bone phenotype. Alhamdi S, Lee YC, Chowdhury S, Byers PH, Gottschalk M, Taft RJ, Joeng KS, Lee BH, Bird LM. Am J Med Genet A. 2018 Nov;176(11):2419-2424. doi: 10.1002/ajmg.a.40347. Epub 2018 Sep 24. PubMed
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, Yang H, Carbone M, Therrien M, Affar EB. Nat Commun. 2018 Oct 22;9(1):4385. doi: 10.1038/s41467-018-06854-2. PubMed
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. Aries IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A. J Exp Med. 2018 Nov 7. pii: jem.20180570. doi: 10.1084/jem.20180570. PubMed

Associated Plasmids

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio AG, Serandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zornig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB. Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. PubMed
Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen. Petrova E, Gracias S, Beauclair G, Tangy F, Jouvenet N. Viruses. 2019 Jan 15;11(1). pii: v11010068. doi: 10.3390/v11010068. PubMed
ONECUT2 is a driver of neuroendocrine prostate cancer. Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH. Nat Commun. 2019 Jan 17;10(1):278. doi: 10.1038/s41467-018-08133-6. PubMed
A cytosolic chaperone complex controls folding and degradation of type III CD38. Wu Y, Zhang J, Fang L, Lee HC, Zhao YJ. J Biol Chem. 2019 Mar 15;294(11):4247-4258. doi: 10.1074/jbc.RA118.005844. Epub 2019 Jan 22. PubMed
FACT subunit Spt16 controls UVSSA recruitment to lesion-stalled RNA Pol II and stimulates TC-NER. Wienholz F, Zhou D, Turkyilmaz Y, Schwertman P, Tresini M, Pines A, van Toorn M, Bezstarosti K, Demmers JAA, Marteijn JA. Nucleic Acids Res. 2019 May 7;47(8):4011-4025. doi: 10.1093/nar/gkz055. PubMed
A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cao JY, Poddar A, Magtanong L, Lumb JH, Mileur TR, Reid MA, Dovey CM, Wang J, Locasale JW, Stone E, Cole SPC, Carette JE, Dixon SJ. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed
TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma. Zhang J, Liu P, Tao J, Wang P, Zhang Y, Song X, Che L, Sumazin P, Ribback S, Kiss A, Schaff Z, Cigliano A, Dombrowski F, Cossu C, Pascale RM, Calvisi DF, Monga SP, Chen X. Am J Pathol. 2019 May;189(5):1077-1090. doi: 10.1016/j.ajpath.2019.01.016. Epub 2019 Feb 19. PubMed
Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z. JCI Insight. 2019 Mar 7;5. pii: 126939. doi: 10.1172/jci.insight.126939. PubMed
Development of a Synthetic 3-ketosteroid Delta(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Sci Rep. 2019 Apr 12;9(1):5969. doi: 10.1038/s41598-019-42046-8. PubMed
Critical role for Piccolo in synaptic vesicle retrieval. Ackermann F, Schink KO, Bruns C, Izsvak Z, Hamra FK, Rosenmund C, Garner CC. Elife. 2019 May 10;8. pii: 46629. doi: 10.7554/eLife.46629. PubMed
Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer. Ni Y, Schmidt KR, Werner BA, Koenig JK, Guldner IH, Schnepp PM, Tan X, Jiang L, Host M, Sun L, Howe EN, Wu J, Littlepage LE, Nakshatri H, Zhang S. Nat Commun. 2019 Jun 28;10(1):2860. doi: 10.1038/s41467-019-10743-7. PubMed
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jimenez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M. Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013. PubMed
A Human Stem Cell Model of Fabry Disease Implicates LIMP-2 Accumulation in Cardiomyocyte Pathology. Birket MJ, Raibaud S, Lettieri M, Adamson AD, Letang V, Cervello P, Redon N, Ret G, Viale S, Wang B, Biton B, Guillemot JC, Mikol V, Leonard JP, Hanley NA, Orsini C, Itier JM. Stem Cell Reports. 2019 Aug 13;13(2):380-393. doi: 10.1016/j.stemcr.2019.07.004. Epub 2019 Aug 1. PubMed
Notch3 promotes prostate cancer-induced bone lesion development via MMP-3. Ganguly SS, Hostetter G, Tang L, Frank SB, Saboda K, Mehra R, Wang L, Li X, Keller ET, Miranti CK. Oncogene. 2020 Jan;39(1):204-218. doi: 10.1038/s41388-019-0977-1. Epub 2019 Aug 29. PubMed
The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. Ngo AM, Shurtleff MJ, Popova KD, Kulsuptrakul J, Weissman JS, Puschnik AS. Elife. 2019 Sep 13;8. pii: 48469. doi: 10.7554/eLife.48469. PubMed
MicroRNA-338-5p reverses chemoresistance and inhibits invasion of esophageal squamous cell carcinoma cells by targeting Id-1. Han L, Cui D, Li B, Xu WW, Lam AKY, Chan KT, Zhu Y, Lee NPY, Law SYK, Guan XY, Qin YR, Chan KW, Ma S, Tsao SW, Cheung ALM. Cancer Sci. 2019 Dec;110(12):3677-3688. doi: 10.1111/cas.14220. Epub 2019 Nov 17. PubMed
Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells. Liu R, Li X, Zhao G. Acta Biochim Biophys Sin (Shanghai). 2019 Nov 18;51(11):1134-1141. doi: 10.1093/abbs/gmz104. PubMed
Phase separation-deficient TDP43 Schmidt. Nat Commun. 2019 PubMed
MX 2 is a novel regulator of cell cycle in melanoma cells. Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Oy GF, Troen G, Florenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A. Pigment Cell Melanoma Res. 2019 Oct 29. doi: 10.1111/pcmr.12837. PubMed
Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A. PLoS One. 2019 Nov 13;14(11):e0221288. doi: 10.1371/journal.pone.0221288. eCollection 2019. PubMed
Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Sung YC, Jin PR, Chu LA, Hsu FF, Wang MR, Chang CC, Chiou SJ, Qiu JT, Gao DY, Lin CC, Chen YS, Hsu YC, Wang J, Wang FN, Yu PL, Chiang AS, Wu AY, Ko JJ, Lai CP, Lu TT, Chen Y. Nat Nanotechnol. 2019 Dec;14(12):1160-1169. doi: 10.1038/s41565-019-0570-3. Epub 2019 Nov 18. PubMed
A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations. Overeem AW, Li Q, Qiu YL, Carton-Garcia F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van IJzendoorn SCD. Hepatology. 2019 Nov 21. doi: 10.1002/hep.31002. PubMed
cMyc and ERK activity are associated with resistance to ALK inhibitory treatment in glioblastoma. Berberich A, Schmitt LM, Pusch S, Hielscher T, Rubmann P, Hucke N, Latzer P, Hessling B, Lemke D, Kessler T, Platten M, Wick W. J Neurooncol. 2020 Jan;146(1):9-23. doi: 10.1007/s11060-019-03348-z. Epub 2019 Nov 28. PubMed
HDAC8 affects MGMT levels in glioblastoma cell lines via interaction with the proteasome receptor ADRM1. Santos-Barriopedro I, Li Y, Bahl S, Seto E. Genes Cancer. 2019;10(5-6):119-133. doi: 10.18632/genesandcancer.197. PubMed
APOBEC3A is a prominent cytidine deaminase in breast cancer. Cortez LM, Brown AL, Dennis MA, Collins CD, Brown AJ, Mitchell D, Mertz TM, Roberts SA. PLoS Genet. 2019 Dec 16;15(12):e1008545. doi: 10.1371/journal.pgen.1008545. eCollection 2019 Dec. PubMed
Lipid droplets can promote drug accumulation and activation. Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R. Nat Chem Biol. 2020 Feb;16(2):206-213. doi: 10.1038/s41589-019-0447-7. Epub 2020 Jan 13. PubMed
Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage. Mandemaker IK, Zhou D, Bruens ST, Dekkers DH, Verschure PJ, Edupuganti RR, Meshorer E, Demmers JAA, Marteijn JA. J Cell Sci. 2020 May 11;133(9). pii: jcs.235473. doi: 10.1242/jcs.235473. PubMed
Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes. Joshi BS, de Beer MA, Giepmans BNG, Zuhorn IS. ACS Nano. 2020 Apr 28;14(4):4444-4455. doi: 10.1021/acsnano.9b10033. Epub 2020 Apr 16. PubMed
Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation. Rashid A, Wang R, Zhang L, Yue J, Yang M, Yen A. Exp Cell Res. 2020 Sep 1;394(1):111989. doi: 10.1016/j.yexcr.2020.111989. Epub 2020 Apr 10. PubMed
CD300LF Polymorphisms of Inbred Mouse Strains Confer Resistance to Murine Norovirus Infection in a Cell Type-Dependent Manner. Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. J Virol. 2020 Aug 17;94(17). pii: JVI.00837-20. doi: 10.1128/JVI.00837-20. Print 2020 Aug 17. PubMed
Kinetic Heterogeneity of Cancer Cell Fractional Killing. Inde Z, Forcina GC, Denton K, Dixon SJ. Cell Rep. 2020 Jul 7;32(1):107845. doi: 10.1016/j.celrep.2020.107845. PubMed

Associated Plasmids

A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo. Chien JC, Tabet E, Pinkham K, da Hora CC, Chang JC, Lin S, Badr CE, Lai CP. Nucleic Acids Res. 2020 Aug 14. pii: 5892751. doi: 10.1093/nar/gkaa669. PubMed

Associated Plasmids

Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. Igarashi K, Yui Y, Watanabe K, Kumai J, Nishizawa Y, Miyaura C, Inada M, Sasagawa S. BMC Cancer. 2020 Aug 24;20(1):802. doi: 10.1186/s12885-020-07310-5. PubMed
A simple protein-based surrogate neutralization assay for SARS-CoV-2. Abe KT, Li Z, Samson R, Samavarchi-Tehrani P, Valcourt EJ, Wood H, Budylowski P, Dupuis AP 2nd, Girardin RC, Rathod B, Wang JH, Barrios-Rodiles M, Colwill K, McGeer AJ, Mubareka S, Gommerman JL, Durocher Y, Ostrowski M, McDonough KA, Drebot MA, Drews SJ, Rini JM, Gingras AC. JCI Insight. 2020 Oct 2;5(19). pii: 142362. doi: 10.1172/jci.insight.142362. PubMed
FOXO3 is targeted by miR-223-3p and promotes osteogenic differentiation of bone marrow mesenchymal stem cells by enhancing autophagy. Long C, Cen S, Zhong Z, Zhou C, Zhong G. Hum Cell. 2021 Jan;34(1):14-27. doi: 10.1007/s13577-020-00421-y. Epub 2020 Sep 13. PubMed
MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression. Aikin TJ, Peterson AF, Pokrass MJ, Clark HR, Regot S. Elife. 2020 Sep 17;9. pii: 60541. doi: 10.7554/eLife.60541. PubMed
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ. Mol Cell. 2021 Feb 18;81(4):767-783.e11. doi: 10.1016/j.molcel.2020.12.006. Epub 2020 Dec 16. PubMed
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Cell. 2021 Jan 7;184(1):106-119.e14. doi: 10.1016/j.cell.2020.12.004. Epub 2020 Dec 9. PubMed
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells. Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C. Cell. 2021 Jan 21;184(2):352-369.e23. doi: 10.1016/j.cell.2020.11.042. Epub 2020 Dec 23. PubMed
Aberrant Induction of a Mesenchymal/Stem Cell Program Engages Senescence in Normal Mammary Epithelial Cells. Bryson BL, Tamagno I, Taylor SE, Parameswaran N, Chernosky NM, Balasubramaniam N, Jackson MW. Mol Cancer Res. 2021 Apr;19(4):651-666. doi: 10.1158/1541-7786.MCR-19-1181. Epub 2020 Dec 22. PubMed
Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer. Zhu Y, Lam AKY, Shum DKY, Cui D, Zhang J, Yan DD, Li B, Xu WW, Lee NPY, Chan KT, Law S, Tsao SW, Cheung ALM. Theranostics. 2021 Jan 1;11(6):2722-2741. doi: 10.7150/thno.49547. eCollection 2021. PubMed
A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC). Low JL, Lau DP, Zhang X, Kwang XL, Rohatgi N, Chan JV, Chong FT, Wong SQR, Leong HS, Thangavelu MT, Rikka S, Skanderup AMJ, Tan DSW, Periyasamy G, Koh JLY, Iyer NG, DasGupta R. EBioMedicine. 2021 Feb;64:103220. doi: 10.1016/j.ebiom.2021.103220. Epub 2021 Jan 30. PubMed
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Srivastava S, Sahu U, Zhou Y, Hogan AK, Sathyan KM, Bodner J, Huang J, Wong KA, Khalatyan N, Savas JN, Ntziachristos P, Ben-Sahra I, Foltz DR. Sci Adv. 2021 Jan 27;7(5). pii: 7/5/eabc9781. doi: 10.1126/sciadv.abc9781. Print 2021 Jan. PubMed
Dual Fluorescence Cytometry Assay to Assess Cellular Protein Levels. Ngo AM, Wang R, Puschnik AS. Bio Protoc. 2020 Apr 20;10(8):e3597. doi: 10.21769/BioProtoc.3597. eCollection 2020 Apr 20. PubMed
Creb5 establishes the competence for Prg4 expression in articular cartilage. Zhang CH, Gao Y, Jadhav U, Hung HH, Holton KM, Grodzinsky AJ, Shivdasani RA, Lassar AB. Commun Biol. 2021 Mar 12;4(1):332. doi: 10.1038/s42003-021-01857-0. PubMed
Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy. Liu Z, Guo C, Das SK, Yu X, Pradhan AK, Li X, Ning Y, Chen S, Liu W, Windle JJ, Bear HD, Manjili MH, Fisher PB, Wang XY. Cancer Res. 2021 May 1;81(9):2429-2441. doi: 10.1158/0008-5472.CAN-20-2604. Epub 2021 Mar 16. PubMed
Genetic variation of staphylococcal LukAB toxin determines receptor tropism. Perelman SS, James DBA, Boguslawski KM, Nelson CW, Ilmain JK, Zwack EE, Prescott RA, Mohamed A, Tam K, Chan R, Narechania A, Pawline MB, Vozhilla N, Moustafa AM, Kim SY, Dittmann M, Ekiert DC, Bhabha G, Shopsin B, Planet PJ, Koralov SB, Torres VJ. Nat Microbiol. 2021 Jun;6(6):731-745. doi: 10.1038/s41564-021-00890-3. Epub 2021 Apr 19. PubMed
Identification of therapeutic targets of the hijacked super-enhancer complex in EVI1-rearranged leukemia. Kiehlmeier S, Rafiee MR, Bakr A, Mika J, Kruse S, Muller J, Schweiggert S, Herrmann C, Sigismondo G, Schmezer P, Krijgsveld J, Groschel S. Leukemia. 2021 Apr 28. pii: 10.1038/s41375-021-01235-z. doi: 10.1038/s41375-021-01235-z. PubMed
NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487. Hanna BMF, Michel M, Helleday T, Mortusewicz O. Int J Mol Sci. 2021 Apr 27;22(9). pii: ijms22094542. doi: 10.3390/ijms22094542. PubMed
ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur MK, Sewastianik T, Ogiya D, An G, Gao S, Yang L, Ji T, Bianchi G, Wen K, Tai YT, Munshi N, Richardson P, Carrasco R, Cang Y, Anderson KC. Sci Adv. 2021 Jun 4;7(23). pii: 7/23/eabg2697. doi: 10.1126/sciadv.abg2697. Print 2021 Jun. PubMed
PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2. Vandsemb EN, Rye MB, Steiro IJ, Elsaadi S, Ro TB, Slordahl TS, Sponaas AM, Borset M, Abdollahi P. FEBS J. 2021 Jun 6. doi: 10.1111/febs.16058. PubMed
RASAL2 Confers Collateral MEK/EGFR Dependency in Chemoresistant Triple-Negative Breast Cancer. Koh SB, Ross K, Isakoff SJ, Melkonjan N, He L, Matissek KJ, Schultz A, Mayer EL, Traina TA, Carey LA, Rugo HS, Liu MC, Stearns V, Langenbucher A, Saladi SV, Ramaswamy S, Lawrence MS, Ellisen LW. Clin Cancer Res. 2021 Sep 1;27(17):4883-4897. doi: 10.1158/1078-0432.CCR-21-0714. Epub 2021 Jun 24. PubMed
Role of L1CAM in retinoblastoma tumorigenesis: identification of novel therapeutic targets. Drager O, Metz K, Busch M, Dunker N. Mol Oncol. 2021 Jul 6. doi: 10.1002/1878-0261.13054. PubMed
Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Ning B, Huang Z, Youngquist BM, Scott JW, Niu A, Bojanowski CM, Zwezdaryk KJ, Saba NS, Fan J, Yin XM, Cao J, Lyon CJ, Li CZ, Roy CJ, Hu TY. Nat Nanotechnol. 2021 Sep;16(9):1039-1044. doi: 10.1038/s41565-021-00939-8. Epub 2021 Jul 22. PubMed
The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment. Janska L, Anandi L, Kirchberger NC, Marinkovic ZS, Schachtner LT, Guzelsoy G, Carmona-Fontaine C. Dis Model Mech. 2021 Aug 1;14(8). pii: 271783. doi: 10.1242/dmm.048942. Epub 2021 Aug 18. PubMed

Associated Plasmids

Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Buongervino S, Lane MV, Garrigan E, Zhelev DV, Dimitrov DS, Bosse KR. Mol Cancer Ther. 2021 Nov;20(11):2228-2239. doi: 10.1158/1535-7163.MCT-20-1034. Epub 2021 Aug 31. PubMed
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells. Cuevas-Velazquez CL, Vellosillo T, Guadalupe K, Schmidt HB, Yu F, Moses D, Brophy JAN, Cosio-Acosta D, Das A, Wang L, Jones AM, Covarrubias AA, Sukenik S, Dinneny JR. Nat Commun. 2021 Sep 14;12(1):5438. doi: 10.1038/s41467-021-25736-8. PubMed

Associated Plasmids

MEST promotes lung cancer invasion and metastasis by interacting with VCP to activate NF-kappaB signaling. Wang Y, Zhang J, Li YJ, Yu NN, Liu WT, Liang JZ, Xu WW, Sun ZH, Li B, He QY. J Exp Clin Cancer Res. 2021 Sep 24;40(1):301. doi: 10.1186/s13046-021-02107-1. PubMed
RBL1/p107 Expression Levels Are Modulated by Multiple Signaling Pathways. Ventura E, Iannuzzi CA, Pentimalli F, Giordano A, Morrione A. Cancers (Basel). 2021 Oct 8;13(19). pii: cancers13195025. doi: 10.3390/cancers13195025. PubMed
RNA-responsive elements for eukaryotic translational control. Zhao EM, Mao AS, de Puig H, Zhang K, Tippens ND, Tan X, Ran FA, Han I, Nguyen PQ, Chory EJ, Hua TY, Ramesh P, Thompson DB, Oh CY, Zigon ES, English MA, Collins JJ. Nat Biotechnol. 2022 Apr;40(4):539-545. doi: 10.1038/s41587-021-01068-2. Epub 2021 Oct 28. PubMed
UBR7 acts as a histone chaperone for post-nucleosomal histone H3. Hogan AK, Sathyan KM, Willis AB, Khurana S, Srivastava S, Zasadzinska E, Lee AS, Bailey AO, Gaynes MN, Huang J, Bodner J, Rosencrance CD, Wong KA, Morgan MA, Eagen KP, Shilatifard A, Foltz DR. EMBO J. 2021 Dec 15;40(24):e108307. doi: 10.15252/embj.2021108307. Epub 2021 Nov 17. PubMed
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway. Smith AE, Ferraro E, Safonov A, Morales CB, Lahuerta EJA, Li Q, Kulick A, Ross D, Solit DB, de Stanchina E, Reis-Filho J, Rosen N, Arribas J, Razavi P, Chandarlapaty S. Nat Commun. 2021 Nov 18;12(1):6667. doi: 10.1038/s41467-021-27093-y. PubMed
Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma. Safaric Tepes P, Segovia D, Jevtic S, Ramirez D, Lyons SK, Sordella R. Lab Invest. 2021 Nov 26. pii: 10.1038/s41374-021-00704-4. doi: 10.1038/s41374-021-00704-4. PubMed
Uveal melanoma-associated mutations in PLCbeta4 are constitutively activating and promote melanocyte proliferation and tumorigenesis. Phan HTN, Kim NH, Wei W, Tall GG, Smrcka AV. Sci Signal. 2021 Dec 14;14(713):eabj4243. doi: 10.1126/scisignal.abj4243. Epub 2021 Dec 14. PubMed
Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, Yoon JC. Cell Rep. 2021 Dec 14;37(11):110104. doi: 10.1016/j.celrep.2021.110104. PubMed
STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kogel D. Cancers (Basel). 2022 Jan 11;14(2). pii: cancers14020339. doi: 10.3390/cancers14020339. PubMed
De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer. Steiner S, Seleznik GM, Reding T, Stopic M, Lenggenhager D, Ten Buren E, Eshmuminov D, Endhardt K, Hagedorn C, Heidenblut AM, Bratus-Neuenschwander A, Grossmann J, Trachsel C, Jabbar KS, Hahn SA, Berg JV, Graf R, Gupta A. Oncogene. 2022 Mar;41(10):1507-1517. doi: 10.1038/s41388-022-02182-4. Epub 2022 Jan 26. PubMed
SARS-CoV-2 Virus-Like Particle Neutralizing Capacity in Blood Donors Depends on Serological Profile and Donor-Declared SARS-CoV-2 Vaccination History. Drews SJ, Hu Q, Samson R, Abe KT, Rathod B, Colwill K, Gingras AC, Yi QL, O'Brien SF. Microbiol Spectr. 2022 Feb 23;10(1):e0226221. doi: 10.1128/spectrum.02262-21. Epub 2022 Feb 16. PubMed
A FBXO7/EYA2-SCF(FBXW7) axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells. Shen JZ, Qiu Z, Wu Q, Zhang G, Harris R, Sun D, Rantala J, Barshop WD, Zhao L, Lv D, Won KA, Wohlschlegel J, Sangfelt O, Laman H, Rich JN, Spruck C. Mol Cell. 2022 Mar 17;82(6):1123-1139.e8. doi: 10.1016/j.molcel.2022.01.022. Epub 2022 Feb 18. PubMed
Identification of new ETV6 modulators through a high-throughput functional screening. Neveu B, Richer C, Cassart P, Caron M, Jimenez-Cortes C, St-Onge P, Fuchs C, Garnier N, Gobeil S, Sinnett D. iScience. 2022 Feb 2;25(3):103858. doi: 10.1016/j.isci.2022.103858. eCollection 2022 Mar 18. PubMed
Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity. LaCroix R, Lin B, Kang TY, Levchenko A. Elife. 2022 Feb 24;11. pii: 66869. doi: 10.7554/eLife.66869. PubMed
DELETE_Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Forcina GC, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi CR, Dixon SJ. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2118646119. doi: 10.1073/pnas.2118646119. Epub 2022 Mar 10. PubMed
KSR induces RAS-independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors. Paniagua G, Jacob HKC, Brehey O, Garcia-Alonso S, Lechuga CG, Pons T, Musteanu M, Guerra C, Drosten M, Barbacid M. Mol Oncol. 2022 Sep;16(17):3066-3081. doi: 10.1002/1878-0261.13213. Epub 2022 Apr 12. PubMed
Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Skylar-Scott MA, Huang JY, Lu A, Ng AHM, Duenki T, Liu S, Nam LL, Damaraju S, Church GM, Lewis JA. Nat Biomed Eng. 2022 Apr;6(4):449-462. doi: 10.1038/s41551-022-00856-8. Epub 2022 Mar 24. PubMed
Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. Liu J, Knopp KA, Rackaityte E, Wang CY, Laurie MT, Sunshine S, Puschnik AS, DeRisi JL. mBio. 2022 Jun 28;13(3):e0020522. doi: 10.1128/mbio.00205-22. Epub 2022 May 3. PubMed
Therapeutical Significance of Serpina3n Subsequent Cerebral Ischemia via Cytotoxic Granzyme B Inactivation. Aslam MS, Aslam MS, Aslam KS, Iqbal A, Yuan L. Biomed Res Int. 2022 May 29;2022:1557010. doi: 10.1155/2022/1557010. eCollection 2022. PubMed
Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons. Prael Iii FJ, Kim K, Du Y, Spitznagel BD, Sulikowski GA, Delpire E, Weaver CD. Front Cell Dev Biol. 2022 Jun 24;10:912812. doi: 10.3389/fcell.2022.912812. eCollection 2022. PubMed
Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1. Janssen M, Schmidt C, Bruch PM, Blank MF, Rohde C, Waclawiczek A, Heid D, Renders S, Gollner S, Vierbaum L, Besenbeck B, Herbst SA, Knoll M, Kolb C, Przybylla A, Weidenauer K, Ludwig AK, Fabre M, Gu M, Schlenk RF, Stolzel F, Bornhauser M, Rollig C, Platzbecker U, Baldus C, Serve H, Sauer T, Raffel S, Pabst C, Vassiliou G, Vick B, Jeremias I, Trumpp A, Krijgsveld J, Muller-Tidow C, Dietrich S. Blood. 2022 Dec 15;140(24):2594-2610. doi: 10.1182/blood.2021014241. PubMed
A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus. Park BJ, Yoo JR, Heo ST, Kim M, Lee KH, Song YJ. PLoS Negl Trop Dis. 2022 Aug 2;16(8):e0010666. doi: 10.1371/journal.pntd.0010666. eCollection 2022 Aug. PubMed
TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. Yousefi M, Lee WS, Yan B, Cui L, Yong CL, Yap X, Tay KSL, Qiao W, Tan D, Nurazmi NI, Linster M, Smith GJD, Lee YH, Carette JE, Ooi EE, Chan KR, Ooi YS. PLoS Pathog. 2022 Aug 8;18(8):e1010763. doi: 10.1371/journal.ppat.1010763. eCollection 2022 Aug. PubMed
Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3. Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Huttenhain R, Carette JE, Krogan NJ. Nat Commun. 2022 Sep 8;13(1):5282. doi: 10.1038/s41467-022-32758-3. PubMed
Early Mechanisms of Chemoresistance in Retinoblastoma. Zhang MG, Kuznetsoff JN, Owens DA, Gallo RA, Kalahasty K, Cruz AM, Kurtenbach S, Correa ZM, Pelaez D, Harbour JW. Cancers (Basel). 2022 Oct 10;14(19):4966. doi: 10.3390/cancers14194966. PubMed
The serine protease matriptase inhibits migration and proliferation in multiple myeloma cells. Steiro I, Vandsemb EN, Elsaadi S, Misund K, Sponaas AM, Borset M, Abdollahi P, Slordahl TS. Oncotarget. 2022 Oct 20;13:1175-1186. doi: 10.18632/oncotarget.28300. PubMed
Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone. Koyanagi A, Onishi I, Muraoka K, Sato I, Sato S, Kimura T, Kishida A, Yamamoto K, Kitagawa M, Kurata M. Bioengineering (Basel). 2022 Sep 21;9(10):490. doi: 10.3390/bioengineering9100490. PubMed
Relating individual cell division events to single-cell ERK and Akt activity time courses. Stern AD, Smith GR, Santos LC, Sarmah D, Zhang X, Lu X, Iuricich F, Pandey G, Iyengar R, Birtwistle MR. Sci Rep. 2022 Oct 27;12(1):18077. doi: 10.1038/s41598-022-23071-6. PubMed
Hypoxia regulates CD9 expression and dissemination of B lymphoblasts. Rouger-Gaudichon J, Cousin E, Jakobczyk H, Debaize L, Rio AG, Forestier A, Arnaud MP, Villacreces A, Praloran V, Jacamo R, Galibert MD, Troadec MB, Gandemer V. Leuk Res. 2022 Dec;123:106964. doi: 10.1016/j.leukres.2022.106964. Epub 2022 Sep 28. PubMed
DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis. Joshi BS, Garcia Romeu H, Aliyandi A, de Vries MP, Zuhorn IS. Pharmaceutics. 2022 Nov 17;14(11):2485. doi: 10.3390/pharmaceutics14112485. PubMed
A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Hou YN, Cai Y, Li WH, He WM, Zhao ZY, Zhu WJ, Wang Q, Mai X, Liu J, Lee HC, Stjepanovic G, Zhang H, Zhao YJ. Nat Commun. 2022 Dec 22;13(1):7898. doi: 10.1038/s41467-022-35581-y. PubMed
High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells. Hennig P, Di Filippo M, Bilfeld G, Mellett M, Beer HD. Cell Death Dis. 2022 Dec 29;13(12):1077. doi: 10.1038/s41419-022-05530-0. PubMed
ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, Susa K, Mori T, Sohara E, Rai T, Uchida S. Commun Biol. 2023 Jan 11;6(1):29. doi: 10.1038/s42003-023-04416-x. PubMed
M6PR- and EphB4-Rich Exosomes Secreted by Serglycin-Overexpressing Esophageal Cancer Cells Promote Cancer Progression. Yan D, Cui D, Zhu Y, Chan CKW, Choi CHJ, Liu T, Lee NPY, Law S, Tsao SW, Ma S, Cheung ALM. Int J Biol Sci. 2023 Jan 1;19(2):625-640. doi: 10.7150/ijbs.79875. eCollection 2023. PubMed
Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis. Huet-Calderwood C, Rivera-Molina F, Toomre D, Calderwood DA. Methods Mol Biol. 2023;2608:17-38. doi: 10.1007/978-1-0716-2887-4_2. PubMed
Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Choi KM, Ko CY, An SM, Cho SH, Rowland DJ, Kim JH, Fasoli A, Chaudhari AJ, Bers DM, Yoon JC. Mol Metab. 2023 Mar;69:101679. doi: 10.1016/j.molmet.2023.101679. Epub 2023 Jan 25. PubMed
DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat. Liu Y, Huang Z, Liu H, Ji Z, Arora A, Cai D, Wang H, Liu M, Simko EAJ, Zhang Y, Periz G, Liu Z, Wang J. Neuron. 2023 Apr 19;111(8):1205-1221.e9. doi: 10.1016/j.neuron.2023.01.022. Epub 2023 Feb 22. PubMed
Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma. Walentynowicz KA, Engelhardt D, Cristea S, Yadav S, Onubogu U, Salatino R, Maerken M, Vincentelli C, Jhaveri A, Geisberg J, McDonald TO, Michor F, Janiszewska M. Cell Rep. 2023 Mar 28;42(3):112235. doi: 10.1016/j.celrep.2023.112235. Epub 2023 Mar 14. PubMed
Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors. Ngo AM, Puschnik AS. J Virol. 2023 Apr 27;97(4):e0194822. doi: 10.1128/jvi.01948-22. Epub 2023 Mar 27. PubMed
Tumor Suppressor Role of INPP4B in Chemoresistant Retinoblastoma. Miroschnikov N, Drager O, Van Meenen D, Metz K, Budeus B, Dunker N, Busch MA. J Oncol. 2023 Mar 8;2023:2270097. doi: 10.1155/2023/2270097. eCollection 2023. PubMed
Vesicle-associated membrane protein 2 is a cargo-selective v-SNARE for a subset of GPCRs. Chen H, Weinberg ZY, Kumar GA, Puthenveedu MA. J Cell Biol. 2023 Jul 3;222(7):e202207070. doi: 10.1083/jcb.202207070. Epub 2023 Apr 6. PubMed
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3. Smith CN, Kihn K, Williamson ZA, Chow KM, Hersh LB, Korotkov KV, Deredge D, Blackburn JS. PLoS One. 2023 May 23;18(5):e0285964. doi: 10.1371/journal.pone.0285964. eCollection 2023. PubMed
Host MOSPD2 enrichment at the parasitophorous vacuole membrane varies between Toxoplasma strains and involves complex interactions. Ferrel A, Romano J, Panas MW, Coppens I, Boothroyd JC. mSphere. 2023 Jun 21:e0067022. doi: 10.1128/msphere.00670-22. PubMed
Construction of Fosmid-based SARS-CoV-2 replicons for antiviral drug screening and replication analyses in biosafety level 2 facilities. Takazawa S, Kotaki T, Nakamura S, Utsubo C, Kameoka M. Virus Res. 2023 Sep;334:199176. doi: 10.1016/j.virusres.2023.199176. Epub 2023 Jul 22. PubMed
Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. Wang Y, Hollingsworth LR, Sangare LO, Paredes-Santos TC, Krishnamurthy S, Penn BH, Wu H, Saeij JPJ. bioRxiv [Preprint]. 2023 Dec 14:2023.12.13.571530. doi: 10.1101/2023.12.13.571530. PubMed

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