pLentiCMV Puro DEST ERKKTRClover Citations (37)
Originally described in: High-sensitivity measurements of multiple kinase activities in live single cells.Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW Cell. 2014 Jun 19;157(7):1724-34. doi: 10.1016/j.cell.2014.04.039. PubMed Journal
Articles Citing pLentiCMV Puro DEST ERKKTRClover
| Articles |
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Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2.
Park H, Kim NY, Lee S, Kim N, Kim J, Heo WD.
Nat Commun. 2017 Jun 23;8(1):30. doi: 10.1038/s41467-017-00060-2.
PubMed
Associated Plasmids |
| Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding. Jung SR, Kushmerick C, Seo JB, Koh DS, Hille B. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5579-E5588. doi: 10.1073/pnas.1700331114. Epub 2017 Jun 26. PubMed |
| Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Goglia AG, Wilson MZ, DiGiorno DB, Toettcher JE. Methods Mol Biol. 2017;1636:3-20. doi: 10.1007/978-1-4939-7154-1_1. PubMed |
| Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Yang JM, Bhattacharya S, West-Foyle H, Hung CF, Wu TC, Iglesias PA, Huang CH. Nat Commun. 2018 Nov 7;9(1):4673. doi: 10.1038/s41467-018-07150-9. PubMed |
Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.
Kim J , Lee S, Jung K, Oh WC, Kim N, Son S, Jo Y, Kwon HB, Heo WD.
Nat Commun. 2019 Jan 14;10(1):211. doi: 10.1038/s41467-018-08217-3.
PubMed
Associated Plasmids |
| Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer. Humphries BA, Buschhaus JM, Chen YC, Haley HR, Qyli T, Chiang B, Shen N, Rajendran S, Cutter A, Cheng YH, Chen YT, Cong J, Spinosa PC, Yoon E, Luker KE, Luker GD. Mol Cancer Res. 2019 May;17(5):1142-1154. doi: 10.1158/1541-7786.MCR-18-0836. Epub 2019 Feb 4. PubMed |
| Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. Kennedy SP, Han JZR, Portman N, Nobis M, Hastings JF, Murphy KJ, Latham SL, Cadell AL, Miladinovic D, Marriott GR, O'Donnell YEI, Shearer RF, Williams JT, Munoz AG, Cox TR, Watkins DN, Saunders DN, Timpson P, Lim E, Kolch W, Croucher DR. Breast Cancer Res. 2019 Mar 21;21(1):43. doi: 10.1186/s13058-019-1127-y. PubMed |
| Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mclaurin JD, Weiner OD. Mol Biol Cell. 2019 Jun 15;30(13):1610-1620. doi: 10.1091/mbc.E18-09-0560. Epub 2019 May 1. PubMed |
| Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gumus ZH, Holt LJ. Elife. 2019 Aug 13;8. pii: 38805. doi: 10.7554/eLife.38805. PubMed |
| Optical control of protein phosphatase function. Courtney TM, Deiters A. Nat Commun. 2019 Sep 26;10(1):4384. doi: 10.1038/s41467-019-12260-z. PubMed |
| Three dimensional in vitro models of cancer: Bioprinting multilineage glioblastoma models. Hermida MA, Kumar JD, Schwarz D, Laverty KG, Di Bartolo A, Ardron M, Bogomolnijs M, Clavreul A, Brennan PM, Wiegand UK, Melchels FP, Shu W, Leslie NR. Adv Biol Regul. 2020 Jan;75:100658. doi: 10.1016/j.jbior.2019.100658. Epub 2019 Oct 17. PubMed |
| Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. Rahman SMT, Zhou W, Deiters A, Haugh JM. J Biol Chem. 2020 Jun 19;295(25):8494-8504. doi: 10.1074/jbc.RA119.012079. Epub 2020 May 5. PubMed |
| Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy. Wang SJ, Li R, Ng TSC, Luthria G, Oudin MJ, Prytyskach M, Kohler RH, Weissleder R, Lauffenburger DA, Miller MA. Sci Adv. 2020 May 22;6(21):eaaz8521. doi: 10.1126/sciadv.aaz8521. eCollection 2020 May. PubMed |
Kinetic Heterogeneity of Cancer Cell Fractional Killing.
Inde Z, Forcina GC, Denton K, Dixon SJ.
Cell Rep. 2020 Jul 7;32(1):107845. doi: 10.1016/j.celrep.2020.107845.
PubMed
Associated Plasmids |
| In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Luthria G, Li R, Wang S, Prytyskach M, Kohler RH, Lauffenburger DA, Mitchison TJ, Weissleder R, Miller MA. Nat Commun. 2020 Jul 14;11(1):3521. doi: 10.1038/s41467-020-17147-y. PubMed |
| An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. Dev Cell. 2020 Sep 14;54(5):608-623.e5. doi: 10.1016/j.devcel.2020.08.001. Epub 2020 Sep 1. PubMed |
| Zn(2+) influx activates ERK and Akt signaling pathways. Anson KJ, Corbet GA, Palmer AE. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11). pii: 2015786118. doi: 10.1073/pnas.2015786118. PubMed |
| Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA. Nat Nanotechnol. 2021 Jul;16(7):830-839. doi: 10.1038/s41565-021-00897-1. Epub 2021 May 6. PubMed |
| Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosis. Vagapova ER, Lebedev TD, Prassolov VS. Sci Rep. 2021 May 27;11(1):11234. doi: 10.1038/s41598-021-90701-w. PubMed |
| Ventral stress fibers induce plasma membrane deformation in human fibroblasts. Ghilardi SJ, Aronson MS, Sgro AE. Mol Biol Cell. 2021 Aug 19;32(18):1707-1723. doi: 10.1091/mbc.E21-03-0096. Epub 2021 Jun 30. PubMed |
| Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes. Lebedev T, Vagapova E, Spirin P, Rubtsov P, Astashkova O, Mikheeva A, Sorokin M, Vladimirova U, Suntsova M, Konovalov D, Roumiantsev A, Stocking C, Buzdin A, Prassolov V. Oncogene. 2021 Nov;40(44):6258-6272. doi: 10.1038/s41388-021-02018-7. Epub 2021 Sep 23. PubMed |
Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation.
Katsuno-Kambe H, Teo JL, Ju RJ, Hudson J, Stehbens SJ, Yap AS.
Elife. 2021 Oct 18;10. pii: 67915. doi: 10.7554/eLife.67915.
PubMed
Associated Plasmids |
| Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway. Krause HB, Bondarowicz H, Karls AL, McClean MN, Kreeger PK. APL Bioeng. 2021 Nov 2;5(4):046101. doi: 10.1063/5.0059011. eCollection 2021 Dec. PubMed |
Deciphering cell signaling networks with massively multiplexed biosensor barcoding.
Yang JM, Chi WY, Liang J, Takayanagi S, Iglesias PA, Huang CH.
Cell. 2021 Dec 9;184(25):6193-6206.e14. doi: 10.1016/j.cell.2021.11.005. Epub 2021 Nov 26.
PubMed
Associated Plasmids |
| Selective Inhibition of HDAC Class I Sensitizes Leukemia and Neuroblastoma Cells to Anticancer Drugs. Vagapova E, Kozlov M, Lebedev T, Ivanenko K, Leonova O, Popenko V, Spirin P, Kochetkov S, Prassolov V. Biomedicines. 2021 Dec 6;9(12). pii: biomedicines9121846. doi: 10.3390/biomedicines9121846. PubMed |
| The Different Impact of ERK Inhibition on Neuroblastoma, Astrocytoma, and Rhabdomyosarcoma Cell Differentiation. Lebedev TD, Vagapova ER, Prassolov VS. Acta Naturae. 2021 Oct-Dec;13(4):69-77. doi: 10.32607/actanaturae.11461. PubMed |
| DUSP4 Inactivation Leads to Reduced Extracellular SignalRegulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells. Kamada H, Yasuhira S, Shibazaki M, Amano H, Maesawa C. J Invest Dermatol. 2022 Sep;142(9):2499-2507.e6. doi: 10.1016/j.jid.2022.02.007. Epub 2022 Feb 19. PubMed |
| Apelin signaling dependent endocardial protrusions promote cardiac trabeculation in zebrafish. Qi J, Rittershaus A, Priya R, Mansingh S, Stainier DYR, Helker CSM. Elife. 2022 Feb 28;11. pii: 73231. doi: 10.7554/eLife.73231. PubMed |
| Identification of cell type-specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors. Lebedev TD, Khabusheva ER, Mareeva SR, Ivanenko KA, Morozov AV, Spirin PV, Rubtsov PM, Snezhkina AV, Kudryavtseva AV, Sorokin MI, Buzdin AA, Prassolov VS. J Biol Chem. 2022 Aug;298(8):102226. doi: 10.1016/j.jbc.2022.102226. Epub 2022 Jul 1. PubMed |
| Subtype of Neuroblastoma Cells with High KIT Expression Are Dependent on KIT and Its Knockdown Induces Compensatory Activation of Pro-Survival Signaling. Lebedev T, Buzdin A, Khabusheva E, Spirin P, Suntsova M, Sorokin M, Popenko V, Rubtsov P, Prassolov V. Int J Mol Sci. 2022 Jul 13;23(14):7724. doi: 10.3390/ijms23147724. PubMed |
| Relating individual cell division events to single-cell ERK and Akt activity time courses. Stern AD, Smith GR, Santos LC, Sarmah D, Zhang X, Lu X, Iuricich F, Pandey G, Iyengar R, Birtwistle MR. Sci Rep. 2022 Oct 27;12(1):18077. doi: 10.1038/s41598-022-23071-6. PubMed |
| MGL S3 Chimeric Enzyme Drives Apoptotic Death of EGFR-Dependent Cancer Cells through ERK Downregulation. Bondarev N, Ivanenko K, Khabusheva E, Lebedev T, Manukhov I, Prassolov V. Int J Mol Sci. 2022 Oct 24;23(21):12807. doi: 10.3390/ijms232112807. PubMed |
| Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress. Hanson RL, Batchelor E. Mol Syst Biol. 2022 Dec;18(12):e11401. doi: 10.15252/msb.202211401. PubMed |
| mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs. Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P. Nat Commun. 2023 Feb 27;14(1):1121. doi: 10.1038/s41467-023-36651-5. PubMed |
| On the inference of ERK signaling dynamics from protein biosensor measurements. Rahman SMT, Haugh JM. Mol Biol Cell. 2023 May 15;34(6):ar60. doi: 10.1091/mbc.E22-10-0476. Epub 2023 Mar 8. PubMed |
| Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons. Hyeon B, Lee H, Kim N, Heo WD. Mol Brain. 2023 Jul 4;16(1):56. doi: 10.1186/s13041-023-01046-6. PubMed |
| Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk. Zhou W, Ryan A, Janosko CP, Shoger KE, Haugh JM, Gottschalk RA, Deiters A. RSC Chem Biol. 2023 Aug 25;4(10):765-773. doi: 10.1039/d2cb00157h. eCollection 2023 Oct 4. PubMed |
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